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Jiang Hu, Bingang Shi, Jianpeng Xie, Huitong Zhou, Jiqing Wang, Xiu Liu, Shaobin Li, Zhidong Zhao, Yuzhu Luo
Diacylglycerol acyltransferase-2 ( DGAT2 ) plays a key role in the synthesis of animal triglycerides (TGs). This study investigated the relative expression of the DGAT2 gene in tissues, variation in the gene, and its association with carcass and meat quality traits in yaks ( Bos grunniens ). DGAT2 was found to be expressed in twelve tissues investigated, but the highest expression was detected in subcutaneous fat, and moderate levels were observed in the liver, heart, longissimus dorsi muscle, and abomasum...
February 14, 2019: Animals: An Open Access Journal From MDPI
Tomáš Andrašina, Josef Jaroš, Tomáš Jůza, Tomáš Rohan, Dalibor Červinka, Michal Crha, Vlastimil Válek, Nahum S Goldberg
PURPOSE: To compare the accumulation and effect of liposomal doxorubicin in liver tissue treated by radiofrequency ablation (RFA) and irreversible electroporation (IRE) in in vivo porcine models. MATERIALS AND METHODS: Sixteen RFA and 16 IRE procedures were performed in healthy liver of two groups of three pigs. Multi-tined RFA parameters included: 100 W, target temperature 105°C for 7 min. 100 IRE pulses were delivered using two monopolar electrodes at 2250 V, 1 Hz, for 100 µsec...
February 13, 2019: Cardiovascular and Interventional Radiology
Serek Tekin, Erbil Seven, Muhammed Batur
PURPOSE: To determine the effects of antiglaucomatous drops on the conjunctival thickness. METHODS: Between March 2018 and May 2018, conjunctival thicknesses (epithelium + stroma) were measured with anterior segment OCT in 51 eyes of the control group and 49 eyes who had glaucoma diagnosis at the Van YYU Medical Faculty Ophthalmology Department and had been using antiglaucomatous drops for at least 6 months. At 12 o'clock direction, horizontal multisections were taken aiming at the conjunctiva 3-5 mm away from the limbus...
February 13, 2019: Journal of Ocular Pharmacology and Therapeutics
Magdalena Mazur-Kuśnirek, Zofia Antoszkiewicz, Krzysztof Lipiński, Joanna Kaliniewicz, Sylwia Kotlarczyk, Przemysław Żukowski
The aim of this study was to determine the effect of a polyphenol product (PP) (Proviox) and vitamin E on the antioxidant status and meat quality of broiler chickens exposed to high temperature. The experimental materials comprised 120 ROSS 308 broilers (6 treatments, 10 replications, 2 birds per replication). Dietary supplementation with vitamin E and PP was applied in the following experimental design: group I (negative control) - without supplementation; group II (positive control) - without supplementation; group III - supplementation with 100 mg vitamin E/kg; group IV - 200 mg vitamin E/kg; group V - 100 mg vitamin E/kg and 100 mg PP/kg; group VI - 200 mg PP/kg...
February 13, 2019: Archives of Animal Nutrition
Yvette Robbins, Hyun-Suk Park, Travis Tennant, Dana Hanson, Niki Whitley, Byungrok Min, Sang Hyon Oh
Objective: The objective of the present study was to investigate pork quality from Hereford×Berkshire (HB) female and intact male pigs reared outdoors in an alternative production system. Methods: Berkshire purebred sows were artificially inseminated, once in the fall and again in the spring of the following year, with semen from Hereford boars and managed free of antibiotics in an outdoor hoop structure until the last month of pregnancy, after which they were moved to a pasture-based unit of 0...
February 7, 2019: Asian-Australasian Journal of Animal Sciences
Hui Zhang, Yiwen Zhai, Min Wang, Shaojun Dong, Youxing Fang, Lingling Zhang
In recent years, upconversion materials have attracted considerable attention because of their unique physicochemical features. Numerous studies have focused on the synthesis of upconversion materials with different colors. However, an easier way to vary the upconversion colors without changing the materials' components has not been extensively studied. In this study, we realized the in situ color variation of the designed upconversion material with the help of a three-state fluorescence switching hybrid device...
February 11, 2019: Nanoscale
Jeannette C Bleeker, Irene L Kok, Sacha Ferdinandusse, Maaike de Vries, Terry G J Derks, Margot F Mulder, Monique Williams, Estela Rubio Gozalbo, Annet M Bosch, Dorine T van den Hurk, Monique G M de Sain-van der Velden, Hans R Waterham, Frits A Wijburg, Gepke Visser
BACKGROUND: Patients with very long chain acyl-CoA dehydrogenase deficiency (VLCADD), a long chain fatty acid oxidation disorder, are traditionally treated with a long chain triglyceride (LCT) restricted and medium chain triglyceride (MCT) supplemented diet. Introduction of VLCADD in newborn screening (NBS) programs has led to the identification of asymptomatic newborns with VLCADD, who may have a more attenuated phenotype and may not need dietary adjustments. OBJECTIVE: To define dietary strategies for individuals with VLCADD based on the predicted phenotype...
January 2019: Journal of Inherited Metabolic Disease
Steven Yergeau, Amy Raudenbush
The dataset contains irrigation water quality parameters including iron concentrations (ferrous, ferric, and total) and turbidity measurements from a blueberry farm in southern New Jersey. Data was collected from May through June for 14 weeks in 2015 using a SMART3 Colorimeter™. Water samples were taken from the pump at the irrigation well and compared to samples taken from driplines at individual fields. All samples were analyzed in the field following the equipment׳s manual, except for ferric iron, which was calculated from the ferrous iron and total iron concentrations...
February 2019: Data in Brief
Ali Khawaja, Robert Kotloff
A 31-year-old white man presented for evaluation of productive cough and dyspnea on exertion of 2 months' duration. Associated symptoms included wheezing, chest tightness, and postnasal drip. He was recently treated for pneumonia with a 7-day course of levofloxacin because of an abnormal chest radiograph demonstrating bilateral infiltrates, but his symptoms failed to improve. He had a medical history of mild intermittent asthma and was on no active treatment. He was a nonsmoker. He was born in the United States...
February 2019: Chest
Boris M Baranovski, Ronen Schuster, Omer Nisim, Ido Brami, Yotam Lior, Eli C Lewis
Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder which most commonly manifests as pulmonary emphysema. Accordingly, alpha-1 antitrypsin (AAT) augmentation therapy aims to reduce the progression of emphysema, as achieved by life-long weekly slow-drip infusions of plasma-derived affinity-purified human AAT. However, not all AATD patients will receive this therapy, due to either lack of medical coverage or low patient compliance. To circumvent these limitations, attempts are being made to develop lung-directed therapies, including inhaled AAT and locally-delivered AAT gene therapy...
September 19, 2018: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
Muhan Zhang, Daoying Wang, Xinglian Xu, Weimin Xu
The objective of this study was to unravelling the possible mechanism underlying drip loss and identify the protein markers associated with water holding capacity (WHC) of meat. Pectoralis major muscles from geese were assigned to high and low drip loss groups. The physio-chemical properties and proteome profiles were compared between these two groups. Label-free quantitative mass spectrometry was applied to investigate the differentially expressed proteins, and the results were confirmed with parallel reaction monitoring (PRM)...
February 2019: Food Research International
Hamed Vatankhah, Hosahalli S Ramaswamy
High pressure impregnation (HPI) is a novel technique to infuse desired fluids into porous biomaterials. In this study, the effect of 24 different pressure-time combination treatments were studied: come-up time (0 to 6 min), pressurization rate [100, 150, 200, 300 (MPa/min)] and pressure holding times (0-30 min) at 100, 300 & 600 MPa. Experiments were carried out based on HPI of ascorbic acid (AA) as a low viscosity aqueous (1%) Newtonian fluid. AA infusion reached 215 to 250 mg/kg when reaching operating pressure of 200 MPa irrespective to pressurization rate or come-up time...
February 2019: Food Research International
Jiri Fiedler, Svatopluk Ostry, Martin Bombic, Ludek Sterba, Petr Kostal
This video shows an urgent microsurgical embolectomy of the inferior division of the left middle cerebral artery in a patient treated by intravenous thrombolysis (IVT). Patient was eligible for endovascular mechanical thrombectomy1; however, the interventional radiologist was not comfortable performing the procedure given prior unsuccessful attempts to remove a calcified cerebral embolus.2 A 75-yr-old female presented with an acute ischemic stroke with isolated aphasia (NIHSS 9). Using the drip-and-ship concept, IVT (0...
February 4, 2019: Operative Neurosurgery (Hagerstown, Md.)
M Zampiga, F Soglia, M Petracci, A Meluzzi, F Sirri
This study was carried out to evaluate the effect of different digestible arginine-to-lysine (dig Arg:Lys) ratio in broiler diets on the occurrence of breast myopathies, productivity, and meat quality traits. A total of 1,755 1-day-old Ross 308 male chicks was randomly divided in 3 experimental groups (9 replications/group): CON, fed a 4 feeding-phases commercial diet (dig Arg:Lys ratio = 1.05, 1.05, 1.06, 1.07, respectively in starter, grower I, grower II and finisher phase), and ARG2 and ARG3 groups fed CON diet supplemented respectively with 20 and 30% higher levels of crystalline L-arginine (dig Arg:Lys ratio = 1...
January 31, 2019: Poultry Science
Zixiu Zeng, Yunling Zhang, Xiao Liang, Fengli Wang, Jiayi Zhao, Zhenmin Xu, Xiaohan Liu, Xuemei Liu
The aim of the present study was to examine the neuroprotective effect of Qingnao dripping pills (QNDP), especially the infiltration of neutrophils and macrophages, as well as the mitogen-activated protein kinase (MAPK) signal pathway. Adult male Sprague-Dawley rats were randomized to three groups: sham, MCAO, and QNDP. After 24 h of ischemia and reperfusion, neurological deficit scores and infarct volume were measured. Macrophages and neutrophil infiltration in the ischemic brain were respectively determined with CD68 and MPO immunofluorescence and western blot...
January 22, 2019: Journal of Pharmacological Sciences
Jiajie Wei, Rigel J Kishton, Matthew Angel, Crystal S Conn, Nicole Dalla-Venezia, Virginie Marcel, Anne Vincent, Frédéric Catez, Sabrina Ferré, Lilia Ayadi, Virginie Marchand, Devin Dersh, James S Gibbs, Ivaylo P Ivanov, Nathan Fridlyand, Yohann Couté, Jean-Jacques Diaz, Shu-Bing Qian, Louis M Staudt, Nicholas P Restifo, Jonathan W Yewdell
The MHC class I antigen presentation system enables T cell immunosurveillance of cancers and viruses. A substantial fraction of the immunopeptidome derives from rapidly degraded nascent polypeptides (DRiPs). By knocking down each of the 80 ribosomal proteins, we identified proteins that modulate peptide generation without altering source protein expression. We show that 60S ribosomal proteins L6 (RPL6) and RPL28, which are adjacent on the ribosome, play opposite roles in generating an influenza A virus-encoded peptide...
January 24, 2019: Molecular Cell
Derico Setyabrata, Yuan H Brad Kim
The objective of this study was to determine the effect of aging/freezing sequence on meat quality, oxidative stability and biochemical attributes of beef muscles. At 3 days postmortem, Longissimus lumborum and Semitendinosus muscles were obtained from 10 beef carcasses, cut into 3 sections and vacuum-packaged. The sections were randomly assigned to aging/freezing treatments (aging only, aging then freezing/thawing, and freezing then thaw/aging). Freezing first then-thaw/aging showed more enlarged gaps between muscle fibers and widely opened extracellular drip channels, resulting in more purge/exudate loss compared to other treatments (P < ...
January 23, 2019: Meat Science
Jiaxing Wang, Linlin Zhang, Liping Lu, Tianfang Kang
An electrochemiluminescence (ECL) based biosensor is described for determination of microRNAs in the A549 cell line. Firstly, graphene oxide (GO) is dripped onto a glassy carbon electrode surface to form an interface to which one end of the capture probe (with a stem-loop structure) can be anchored through π-interaction via dangling unpaired bases. The other end of the capture probe is directed away from the GO surface to make it stand upright. Target microRNAs can open the hairpin structure to form a double-stranded DNA-RNA structure...
February 1, 2019: Mikrochimica Acta
Bichen Li, Zhihui Chen, Hongyan Yao, Xin Guan, Zhimeng Yu, Furkan Halis Isikgor, Hikmet Coskun, Qing-Hua Xu, Jianyong Ouyang
The grain size and quality of hybrid organic-inorganic perovskite (HOIP) films greatly affect the performance of perovskite solar cells (PSCs). However, dripping an anti-solvent during the spin coating process induces rapid nucleation and reduces the grain size. Here, a facile method is developed to engineer clusters in precursor solution and obtain high-quality perovskite films with an enlarged grain size. A cluster interfacial modifier, chlorobenzene (CB), is added to precursor solution. The modifier increases the interfacial energy between the precursor cluster and the solvent...
February 1, 2019: Nanoscale
Guo Mengzhe, Wang Tianyun, Yang Jian, Hong Chang, Shuai Ji, Tang Daoquan
ETHNOPHARMACOLOGICAL RELEVANCE: Clopidogrel is the recommended treatment by current clinical practice guidelines to prevent adverse cardiovascular events in patients with coronary heart disease (CHD), but this treatment regimen still fails and 5%-40% patients display inadequate antiplatelet responses. Fufang Danshen Dripping Pill (FDDP) was used as the combination with clopidogrel to improve the therapeutic effect. However, the mechanism of the interaction between clopidogrel and FDDP has not been elucidated...
January 28, 2019: Journal of Ethnopharmacology
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