keyword
https://read.qxmd.com/read/38519817/a-high-threshold-of-biotherapeutic-aggregate-numbers-is-needed-to-induce-an-immunogenic-response-in-vitro-in-vivo-and-in-the-clinic
#21
JOURNAL ARTICLE
Joseph R Cohen, Stephen R Brych, Siddharth Prabhu, Vivian Bi, Ahmed Elbaradei, Joshua M Tokuda, Cathie Xiang, Martha Hokom, Xiaohong Cui, Claudia Ly, Nathan Amos, Jilin Sun, Dominador Calamba, Jonathan Herskovitz, Allyson Capili, Kimya Nourbakhsh, Anthony Merlo, Julia Carreon, Jette Wypych, Linda O Narhi, Vibha Jawa, Marisa K Joubert
BACKGROUND AND PURPOSE: There is concern that subvisible aggregates in biotherapeutic drug products pose a risk to patient safety. We investigated the threshold of biotherapeutic aggregates needed to induce immunogenic responses. METHODS AND RESULTS: Highly aggregated samples were tested in cell-based assays and induced cellular responses in a manner that depended on the number of particles. The threshold of immune activation varied by disease state (cancer, rheumatoid arthritis, allergy), concomitant therapies, and particle number...
March 22, 2024: Pharmaceutical Research
https://read.qxmd.com/read/38519053/targeting-refractory-recurrent-neuroblastoma-and-osteosarcoma-with-anti-cd3%C3%A3-anti-gd2-bispecific-antibody-armed-t-cells
#22
JOURNAL ARTICLE
Maxim Yankelevich, Archana Thakur, Shakeel Modak, Roland Chu, Jeffrey Taub, Alissa Martin, Dana Schalk, Amy Schienshang, Sarah Whitaker, Katie Rea, Daniel W Lee, Qin Liu, Anthony F Shields, Nai-Kong V Cheung, Lawrence G Lum
BACKGROUND: The survival benefit observed in children with neuroblastoma (NB) and minimal residual disease who received treatment with anti-GD2 monoclonal antibodies prompted our investigation into the safety and potential clinical benefits of anti-CD3×anti-GD2 bispecific antibody (GD2Bi) armed T cells (GD2BATs). Preclinical studies demonstrated the high cytotoxicity of GD2BATs against GD2+cell lines, leading to the initiation of a phase I/II study in recurrent/refractory patients...
March 21, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38519046/hybrid-hydrogels-for-immunoregulation-and-pro-angiogenesis-through-mild-heat-stimulation-to-accelerate-whole-process-diabetic-wound-healing
#23
JOURNAL ARTICLE
Qianru Guo, Tianyu Yin, Wei Huang, Rui Nan, Tao Xiang, Shaobing Zhou
Intense and persistent oxidative stress, excessive inflammation and impaired angiogenesis severely hinder diabetic wound healing. Bioactive hydrogel dressings with immunoregulatory and pro-angiogenic properties have great promise in treating diabetic wounds. However, the therapeutic effects of dressings always depend on drugs with side effects, expensive cytokines and cell therapies. Herein, a novel dynamic borate-bonds crosslinked hybrid multifunctional hydrogel dressings with photothermal properties are developed to regulate the microenvironment of diabetic wound sites and accelerate the whole process of its healing without additional medication...
March 22, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38518607/genipin-crosslinking-promotes-biomechanical-reinforcement-and-pro-regenerative-macrophage-polarization-in-bioartificial-tubular-substitutes
#24
JOURNAL ARTICLE
Jone Berasain, Paula Ávila-Fernández, Rocío Cárdenas-Pérez, Antoni Ignasi Cànaves-Llabrés, Miguel Etayo-Escanilla, Miguel Alaminos, Víctor Carriel, Óscar Darío García-García, Jesús Chato-Astrain, Fernando Campos
Traumatic nerve injuries are nowadays a significant clinical challenge and new substitutes with adequate biological and mechanical properties are in need. In this context, fibrin-agarose hydrogels (FA) have shown the possibility to generate tubular scaffolds with promising results for nerve repair. However, to be clinically viable, these scaffolds need to possess enhanced mechanical properties. In this line, genipin (GP) crosslinking has demonstrated to improve biomechanical properties with good biological properties compared to other crosslinkers...
March 20, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38515751/cd81-and-cd82-expressing-tumor-infiltrating-lymphocytes-in-the-nsclc-tumor-microenvironment-play-a-crucial-role-in-t-cell-activation-and-cytokine-production
#25
JOURNAL ARTICLE
Kwangmin Na, Seul Lee, Dong Kwon Kim, Young Seob Kim, Joon Yeon Hwang, Seong-San Kang, Sujeong Baek, Chai Young Lee, Seung Min Yang, Yu Jin Han, Mi Hyun Kim, Heekyung Han, Youngtaek Kim, Jae Hwan Kim, Seunghyun Jeon, Youngseon Byeon, Jii Bum Lee, Sun Min Lim, Min Hee Hong, Kyoung-Ho Pyo, Byoung Chul Cho
INTRODUCTION: To understand the immune system within the tumor microenvironment (TME) of non-small cell lung cancer (NSCLC), it is crucial to elucidate the characteristics of molecules associated with T cell activation. METHODS: We conducted an in-depth analysis using single-cell RNA sequencing data obtained from tissue samples of 19 NSCLC patients. T cells were classified based on the Tumor Proportion Score (TPS) within the tumor region, and molecular markers associated with activation and exhaustion were analyzed in T cells from high TPS areas...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38514793/early-induction-of-cytokine-release-syndrome-by-rapidly-generated-car-t-cells-in-preclinical-models
#26
JOURNAL ARTICLE
Arezoo Jamali, Naphang Ho, Angela Braun, Elham Adabi, Frederic B Thalheimer, Christian J Buchholz
Cytokine release syndrome (CRS) is a significant side-effect of conventional chimeric antigen receptor (CAR) T-cell therapy. To facilitate patient accessibility, short-term (st) CAR T cells, which are administered to patients only 24 h after vector exposure, are in focus of current investigations. Their impact on the incidence and severity of CRS has been poorly explored. Here, we evaluated CD19-specific stCAR T cells in preclinical models. In co-culture with tumor cells and monocytes, stCAR T cells exhibited anti-tumoral activity and potent release of CRS-related cytokines (IL-6, IFN-γ, TNF-α, GM-CSF, IL-2, IL-10)...
March 21, 2024: EMBO Molecular Medicine
https://read.qxmd.com/read/38514489/the-anticancer-effect-of-potential-probiotic-l-fermentum-and-l-plantarum-in-combination-with-5-fluorouracil-on-colorectal-cancer-cells
#27
JOURNAL ARTICLE
Sanaz Salek, Elham Moazamian, Afshin Mohammadi Bardbori, Seyedeh Azra Shamsdin
5-Fluorouracil (5-FU) is an effective chemotherapy drug in the treatment of colorectal cancer (CRC). However, auxiliary or alternative therapies must be sought due to its resistance and potential side effects. Certain probiotic metabolites exhibit anticancer properties. In this study evaluated the anticancer and potential therapeutic activities of cell extracts potential probiotic strains, Limosilactobacillus fermentum and Lactiplantibacillus plantarum isolated from the mule milk and the standard probiotic strain Lacticaseibacillus rhamnosus GG (LGG) against the human colon cancer cell line (HT-29) and the normal cell line (HEK-293) alone or in combination with 5-FU...
March 22, 2024: World Journal of Microbiology & Biotechnology
https://read.qxmd.com/read/38514392/improvement-of-high-density-lipoprotein-atheroprotective-properties-in-patients-with-systemic-lupus-erythematosus-after-belimumab-treatment
#28
JOURNAL ARTICLE
Anastasia-Georgia Dedemadi, Christina Gkolfinopoulou, Dimitra Nikoleri, Myrto Nikoloudaki, Hanna Ruhanen, Minna Holopainen, Reijo Kakela, Georgia Christopoulou, Stavros Bournazos, Pantelis Constantoulakis, Prodromos Sidiropoulos, George Bertsias, Angeliki Chroni
OBJECTIVE: Chronic inflammatory diseases, like Systemic Lupus Erythematosus (SLE), carry an increased risk for atherosclerosis and cardiovascular events, accompanied by impairment of atheroprotective properties of high-density lipoprotein (HDL). In SLE, serum BAFF (B cell-activating factor), a cytokine implicated in disease progression, has been correlated with subclinical atherosclerosis. We investigated the impact of treatment with belimumab -an anti-BAFF monoclonal antibody- on HDL atheroprotective properties and composition in SLE patients...
March 21, 2024: Rheumatology
https://read.qxmd.com/read/38514355/humoral-and-cellular-immunity-to-sars-cov-2-following-vaccination-with-non-mrna-vaccines-in-adolescent-young-adults-with-cancer-a-prospective-cohort-study
#29
JOURNAL ARTICLE
Archana Sasi, Jyotsna Dandotiya, Jyotsana Kaushal, Shuvadeep Ganguly, Akshay Binayke, K M Ambika, Akshi Shree, Farhana Jahan, Priyanka Sharma, Tejas Menon Suri, Amit Awasthi, Sameer Bakhshi
BACKGROUND: Data on SARS-CoV-2 vaccine responsiveness in adolescent/young adult (AYA) cancer patients are sparse. The present study assessed humoral and cellular immune responses post-vaccination in this population. METHODS: In this prospective study, patients aged 12-30 years undergoing cancer therapy ("on therapy") and survivors ("off therapy") were recruited. Anti-receptor binding domain (RBD) protein IgG levels were measured at baseline, four weeks post-first vaccine dose (T1), and six weeks post-second dose (T2)...
March 20, 2024: Vaccine
https://read.qxmd.com/read/38512973/protective-effect-of-sucrose-esters-from-cape-gooseberry-physalis-peruviana-l-in-tnbs-induced-colitis
#30
JOURNAL ARTICLE
Yanet C Ocampo, Jenny P Castro, Indira B Pájaro, Daneiva Caro, Elena Talero, Virginia Motilva, Luis A Franco
Phytotherapy is an attractive strategy to treat inflammatory bowel disease (IBD) that could be especially useful in developing countries. We previously demonstrated the intestinal anti-inflammatory effect of the total ethereal extract from the Physalis peruviana (Cape gooseberry) calyces in TNBS-induced colitis. This work investigates the therapeutic potential of Peruviose A and B, two sucrose esters that constitute the major metabolites of its calyces. The effect of the Peruvioses A and B mixture on TNBS-induced colitis was studied after 3 (preventive) and 15-days (therapy set-up) of colitis induction in rats...
2024: PloS One
https://read.qxmd.com/read/38512654/synergistic-effects-of-mesenchymal-stem-cell-derived-extracellular-vesicles-and-dexamethasone-on-macrophage-polarization-under-inflammatory-conditions
#31
JOURNAL ARTICLE
Zahra Mirsanei, Fatemeh Jamshidi-Adegani, Saeid Vakilian, Fateme Ahangari, Sara Soufihasanabad, Khamis Al-Riyami, Sara Soudi, Sahar Ghaffari Khaligh, Sulaiman Al-Hashmi, Seyed Mahmoud Hashemi
The undesirable inflammation and the excessive M1 macrophage activity may lead to inflammatory diseases. Corticosteroids and stem cell therapy are used in clinical practice to promote anti-inflammatory responses. However, this protocol has limitations and is associated with numerous side effects. In this study, the synergistic anti-inflammatory effects of dexamethasone (Dex) and mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) were evaluated to enhance the polarization of M1 inflammatory macrophages into the anti-inflammatory (M2) phenotype...
March 21, 2024: Inflammopharmacology
https://read.qxmd.com/read/38512652/neuroprotective-effects-of-rutin-against-cuprizone-induced-multiple-sclerosis-in-mice
#32
JOURNAL ARTICLE
Mariam A Nicola, Abdelraheim H Attaai, Mahmoud H Abdel-Raheem, Anber F Mohammed, Yasmin F Abu-Elhassan
Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of the central nervous system that injures the myelin sheath, provoking progressive axonal degeneration and functional impairments. No efficient therapy is available at present to combat such insults, and hence, novel safe and effective alternatives for MS therapy are extremely required. Rutin (RUT) is a flavonoid that exhibits antioxidant, anti-inflammatory, and neuroprotective effects in several brain injuries. The present study evaluated the potential beneficial effects of two doses of RUT in a model of pattern-III lesion of MS, in comparison to the conventional standard drug; dimethyl fumarate (DMF)...
March 21, 2024: Inflammopharmacology
https://read.qxmd.com/read/38512531/primary-vs-pre-emptive-anti-seizure-medication-prophylaxis-in-anti-cd19-car-t-cell-therapy
#33
JOURNAL ARTICLE
Umberto Pensato, Federica Pondrelli, Chiara de Philippis, Gian Maria Asioli, Alessandra Crespi, Alessandro Buizza, Daniele Mannina, Beatrice Casadei, Enrico Maffini, Laura Straffi, Simona Marcheselli, Pier Luigi Zinzani, Francesca Bonifazi, Maria Guarino, Stefania Bramanti
INTRODUCTION: Seizures may occur in up to 30% of non-Hodgkin lymphoma patients who received anti-CD19 CAR T-cell therapy, yet the optimal anti-seizure medication (ASM) prevention strategy has not been thoroughly investigated. METHODS: Consecutive patients affected by refractory non-Hodgkin lymphoma who received anti-CD19 CAR T-cells were included. Patients were selected and assessed using similar internal protocols. ASM was started either as a primary prophylaxis (PP-group) before CAR T-cells infusion or as a pre-emptive therapy (PET-group) only upon the onset of neurotoxicity development...
March 21, 2024: Neurological Sciences
https://read.qxmd.com/read/38511769/upregulation-of-pgc-1%C3%AE-expression-by-pioglitazone-mediates-prevention-of-sepsis-induced-acute-lung-injury
#34
JOURNAL ARTICLE
Jing Tang, Wenzhu Dong, Dan Wang, Qin Deng, Honggang Guo, Guibao Xiao
The imbalance between pro-inflammatory M1 and anti-inflammatory M2 macrophages plays a critical role in the pathogenesis of sepsis-induced acute lung injury (ALI). Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) may modulate macrophage polarization toward the M2 phenotype by altering mitochondrial activity. This study aimed to investigate the role of the PGC-1α agonist pioglitazone (PGZ) in modulating sepsis-induced ALI. A mouse model of sepsis-induced ALI was established using cecal ligation and puncture (CLP)...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38510674/chronic-ocular-small-vessel-disease-an-overview-of-diabetic-retinopathy-and-its-relationship-with-cardiovascular-health
#35
JOURNAL ARTICLE
Siva S R Iyer, Nila S Radhakrishnan, Ramak Roohipourmoallai, Cynthia M Guerin, Jeremy S Maylath, Nickolas Garson
Diabetic retinopathy (DR) is a potentially blinding disease originating from small vessel damage in the retina in chronic hyperglycemic states. DR has a complex multi-pathway driven pathogenesis resulting in diabetic macular edema and retinal ischemia, the former being the most common cause of vision impairment in DR. Hypoxia induced cytokines stimulate vascular endothelial growth factor (VEGF) production and subsequent angiogenesis with resultant mechanical retinal damage over time. Anti-VEGF therapy is effective for the treatment of center-involving diabetic macular edema...
May 2023: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38508971/mesenchymal-stem-cells-attenuates-hirschsprung-disease-associated-enterocolitis-by-reducing-m1-macrophages-infiltration-via-cox-2-dependewhant-mechanism
#36
JOURNAL ARTICLE
Xinyao Meng, Jun Xiao, Jing Wang, Minxian Sun, Xuyong Chen, Luyao Wu, Ke Chen, Zejian Li, ChenZhao Feng, Didi Zhuansun, Jixin Yang, Xiaojuan Wu, Donghai Yu, Wei Li, Yonghua Niu, Ying He, Mingfa Wei, Feng Chen, Bo Xiong, Jiexiong Feng, Tianqi Zhu
OBJECTIVE AND DESIGN: Hirschsprung disease-associated enterocolitis (HAEC) is a common life-threatening complication of Hirschsprung disease (HSCR). We aimed to investigate the effectiveness, long-term safety and the underlying mechanisms of Mesenchymal stem cells (MSCs) based therapy for HAEC. MATERIAL OR SUBJECTS: Specimens from HSCR and HAEC patients were used to assess the inflammatory condition. Ednrb knock-out mice was used as HAEC model. MSCs was intraperitoneally transplanted into HAEC mice...
March 4, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38506998/analysis-of-nanoparticles-effects-on-drug-induced-psoriasis
#37
JOURNAL ARTICLE
Ankit Shah, Chelsea Sanders, Simone Difilippantonio, Elijah Edmondson, Marina A Dobrovolskaia
Psoriasis, an auto-inflammatory disorder, has major manifestations in the skin but can affect other organs. Currently, this condition has no cure, and the treatments include anti-inflammatory medications. Nanoparticles are widely used for drug delivery and have found successful applications in therapy for cancer and infectious diseases. Nanoparticles can also be used to deliver anti-inflammatory drugs to sites of inflammation. Moreover, some nanotechnology platforms possess intrinsic anti-inflammatory properties and may benefit the therapy of inflammation-driven disorders...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38506555/antagonism-of-the-platelet-activating-factor-pathway-mitigates-inflammatory-adverse-events-driven-by-anti-erythrocyte-antibody-therapy-in-mice
#38
JOURNAL ARTICLE
Kevin Doyoon Won, Lazaro Gil Gonzalez, Yoelys Cruz-Leal, Alequis Pavon Oro, Alan H Lazarus
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by low platelet counts primarily due to antiplatelet autoantibodies. Anti-D is a donor-derived polyclonal Ab against the rhesus D Ag on erythrocytes used to treat ITP. Unfortunately, adverse inflammatory/hypersensitivity reactions and a Food and Drug Administration-issued black box warning have limited its clinical use. This underscores the imperative to understand the inflammatory pathway associated with anti-erythrocyte Ab-based therapies...
March 20, 2024: Journal of Immunology
https://read.qxmd.com/read/38506049/combining-vps34-inhibitors-with-sting-agonists-enhances-type-i-interferon-signaling-and-anti-tumor-efficacy
#39
JOURNAL ARTICLE
Yasmin Yu, Madhumita Bogdan, Muhammad Zaeem Noman, Santiago Parpal, Elisabetta Bartolini, Kris Van Moer, Simone Caroline Kleinendorst, Kristine Bilgrav Saether, Lionel Trésaugues, Camilla Silvander, Johan Lindström, Jodi Simeon, Mary Jane Timson, Hikmat Al-Hashimi, Bryan D Smith, Daniel L Flynn, Andrey Alexeyenko, Jenny Viklund, Martin Andersson, Jessica Martinsson, Katja Pokrovskaja Tamm, Angelo De Milito, Bassam Janji
An immunosuppressive tumor microenvironment promotes tumor growth and is one of the main factors limiting the response to cancer immunotherapy. We have previously reported that inhibition of vacuolar protein sorting 34 (VPS34), a crucial lipid kinase in the autophagy/endosomal trafficking pathway, decreases tumor growth in several cancer models, increases infiltration of immune cells and sensitizes tumors to anti-programmed cell death protein 1/programmed cell death 1 ligand 1 therapy by upregulation of C-C motif chemokine 5 (CCL5) and C-X-C motif chemokine 10 (CXCL10) chemokines...
March 20, 2024: Molecular Oncology
https://read.qxmd.com/read/38504666/out-of-the-core-the-impact-of-focal-ischemia-in-regions-beyond-the-penumbra
#40
REVIEW
Ludmila Koukalova, Martina Chmelova, Zuzana Amlerova, Lydia Vargova
The changes in the necrotic core and the penumbra following induction of focal ischemia have been the focus of attention for some time. However, evidence shows, that ischemic injury is not confined to the primarily affected structures and may influence the remote areas as well. Yet many studies fail to probe into the structures beyond the penumbra, and possibly do not even find any significant results due to their short-term design, as secondary damage occurs later. This slower reaction can be perceived as a therapeutic opportunity, in contrast to the ischemic core defined as irreversibly damaged tissue, where the window for salvation is comparatively short...
2024: Frontiers in Cellular Neuroscience
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