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Anti- cytokine therapies

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https://read.qxmd.com/read/30760316/immunoregulatory-potential-of-mesenchymal-stem-cells-following-activation-by-macrophage-derived-soluble-factors
#1
Laura Saldaña, Fátima Bensiamar, Gema Vallés, Francisco J Mancebo, Eduardo García-Rey, Nuria Vilaboa
BACKGROUND: Immunoregulatory capacity of mesenchymal stem cells (MSC) is triggered by the inflammatory environment, which changes during tissue repair. Macrophages are essential in mediating the inflammatory response after injury and can adopt a range of functional phenotypes, exhibiting pro-inflammatory and anti-inflammatory activities. An accurate characterization of MSC activation by the inflammatory milieu is needed for improving the efficacy of regenerative therapies. In this work, we investigated the immunomodulatory functions of MSC primed with factors secreted from macrophages polarized toward a pro-inflammatory or an anti-inflammatory phenotype...
February 13, 2019: Stem Cell Research & Therapy
https://read.qxmd.com/read/30759363/plausible-biochemical-mechanisms-of-chemotherapy-induced-cognitive-impairment-chemobrain-a-condition-that-significantly-impairs-the-quality-of-life-of-many-cancer-survivors
#2
REVIEW
Xiaojia Ren, Diana Boriero, Luksana Chaiswing, Subbarao Bondada, Daret K St Clair, D Allan Butterfield
Increasing numbers of cancer patients survive and live longer than five years after therapy, but very often side effects of cancer treatment arise at same time. One of the side effects, chemotherapy-induced cognitive impairment (CICI), also called "chemobrain" or "chemofog" by patients, brings enormous challenges to cancer survivors following successful chemotherapeutic treatment. Decreased abilities of learning, memory, attention, executive function and processing speed in cancer survivors with CICI, are some of the challenges that greatly impair survivors' quality of life...
February 10, 2019: Biochimica et biophysica acta. Molecular basis of disease
https://read.qxmd.com/read/30756174/modulation-of-bone-turnover-by-cissus-quadrangularis-after-ovariectomy-in-rats
#3
Juan M Guerra, Martha A Hanes, Cordelia Rasa, Nagarajan Loganathan, Wendy Innis-Whitehouse, Ednia Gutierrez, Saraswathy Nair, Jameela Banu
In women, age-related bone loss is associated with increased risk of bone fracture. Existing therapies are associated with severe side effects; thus, there is a need to find alternative medicines with less or optimal side effects. Cissus quadrangularis (CQ), an Ayurvedic medicine used to enhance fracture healing, was tested for its bone protective properties and studied to discern the mechanism by which it is beneficial to bone. Female Sprague Dawley rats were either sham operated or ovariectomized and were fed CQ for 3 months...
February 12, 2019: Journal of Bone and Mineral Metabolism
https://read.qxmd.com/read/30746216/programmed-cell-death-protein-1-programmed-death-ligand-1-blockade-enhances-the-antitumor-efficacy-of-adoptive-cell-therapy-against-non-small-cell-lung-cancer
#4
Jingyi Chen, Yusong Chen, Fenglan Feng, Cheng Chen, Haikang Zeng, Shuai Wen, Xin Xu, Jianxing He, Jin Li
Background: Cytokine-induced killer (CIK) cells and natural killer (NK) cells are employed by two different approaches to adoptive cell immunotherapy for cancer. It has been reported that adoptive cell immunotherapy could prolong the overall survival (OS) of advanced cancer patients. The introduction of agents that induce immune checkpoint blockades has improved the efficacy of immune-mediated therapy for metastatic cancers. However, the effects of combining a checkpoint inhibitor with CIK cells or NK cells to target non-small cell lung cancer (NSCLC)remain unknown...
December 2018: Journal of Thoracic Disease
https://read.qxmd.com/read/30745461/combined-blockade-of-tnf-%C3%AE-and-il-17a-alleviates-progression-of-collagen-induced-arthritis-without-causing-serious-infections-in-mice
#5
Fang Shen, Akash H Verma, Amy Volk, Brian Jones, Bianca M Coleman, Matthew J Loza, Ravi Malaviya, Beverley Moore, Daniel Weinstock, M Merle Elloso, Sarah L Gaffen, Tatiana Ort
The cytokines TNF-α and IL-17A are elevated in a variety of autoimmune diseases, including rheumatoid arthritis. Both cytokines are targets of several biologic drugs used in the clinic, but unfortunately many patients are refractory to these therapies. IL-17A and TNF-α are known to mediate signaling synergistically to drive expression of inflammatory genes. Hence, combined blockade of TNF-α and IL-17A represents an attractive treatment strategy in autoimmune settings where monotherapy is not fully effective...
February 11, 2019: Journal of Immunology: Official Journal of the American Association of Immunologists
https://read.qxmd.com/read/30744018/ultrasensitive-immunosensor-array-for-tnf-%C3%AE-detection-in-artificial-saliva-using-polymer-coated-magnetic-microparticles-onto-screen-printed-gold-electrode
#6
Lassaad Barhoumi, Francesca G Bellagambi, Federico M Vivaldi, Abdoullatif Baraket, Yohann Clément, Nadia Zine, Mounir Ben Ali, Abdelhamid Elaissari, Abdelhamid Errachid
Tumor necrosis factor-α (TNF-α) is a biomarker of inflammation that occurs in patients suffering from heart failure (HF). Saliva can be sampled in a non-invasive way, and it is currently gaining importance as matrix alternative to blood in diagnostic and therapy monitoring. This work presents the development of an immunosensor array based on eight screen-printed gold electrodes to detect TNF-α in saliva samples. Two different functionalization strategies of electrodes were compared. In the first, anti-TNF-α antibodies were chemically bonded onto the electrode by functionalization with 4-carboxymethylaniline...
February 8, 2019: Sensors
https://read.qxmd.com/read/30743078/protective-effects-of-berberine-hydrochloride-on-dss-induced-ulcerative-colitis-in-rats
#7
Lei Zhu, PeiQing Gu, Hong Shen
BACKGROUND: Berberine hydrochloride is one the effective compound among Rhizoma Coptidis, Cortex Phellodendri, and other plants. There are several clinical functions of berberine hydrochloride including anti-inflammation, antitumor and immunoregulatory. However, the anti-inflammatory of berberine hydrochloride in ulcerative colitis is barely understood. In this study, we aimed to explore the effects of berberine hydrochloride on dextran sulfate sodium (DSS)-induced rats model of ulcerative colitis...
February 8, 2019: International Immunopharmacology
https://read.qxmd.com/read/30740801/ginsenoside-rf-relieves-mechanical-hypersensitivity-depression-like-behavior-and-inflammatory-reactions-in-chronic-constriction-injury-rats
#8
Yangyi Li, Chengbo Chen, Shunyuan Li, Changcheng Jiang
The aim of this study was to investigate whether ginsenoside Rf can effectively relieve pain hypersensitivity in a neuropathic pain rat model. Neuropathic pain was induced in rats by chronic constriction injury (CCI) to the right sciatic nerve. Ginsenoside Rf was administered intraperitoneally after CCI surgery. The von Frey filament test and forced swimming test were performed to examine pain hypersensitivity and depression-like behavior in rats. Western blot was used to measure the levels of inflammatory cytokines in the dorsal root ganglion (DRG) and the spinal cord...
February 11, 2019: Phytotherapy Research: PTR
https://read.qxmd.com/read/30740473/-in-vitro-expansion-of-anti-viral-t-cells-from-cord-blood-by-accelerated-co-cultured-dendritic-cells
#9
Klaudia Kuranda, Sophie Caillat-Zucman, Sylvaine You, Roberto Mallone
Hematopoietic stem cell transplantation (HSCT) using unrelated cord blood (CB) donors is a suitable approach when an HLA-matched donor is not available. However, one important drawback is the risk of life-threatening viral infections prior to immune reconstitution, particularly from adenoviruses (AdVs). Although adoptive therapy with ex vivo expanded virus-reactive donor T cells has proven effective to treat these infections in HSCT recipients, the manufacturing process is complex and requires large numbers of cells, which is incompatible with CB donor units...
June 14, 2019: Molecular Therapy. Methods & Clinical Development
https://read.qxmd.com/read/30740105/targeting-tregs-in-juvenile-idiopathic-arthritis-and-juvenile-dermatomyositis-insights-from-other-diseases
#10
REVIEW
Romy E Hoeppli, Anne M Pesenacker
Regulatory T cells (Tregs) are believed to be dysfunctional in autoimmunity. Juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis (JDM) result from a loss of normal immune regulation in specific tissues such as joints or muscle and skin, respectively. Here, we discuss recent findings in regard to Treg biology in oligo-/polyarticular JIA and JDM, as well as what we can learn about Treg-related disease mechanism, treatment and biomarkers in JIA/JDM from studies of other diseases. We explore the potential use of Treg immunoregulatory markers and gene signatures as biomarkers for disease course and/or treatment success...
2019: Frontiers in Immunology
https://read.qxmd.com/read/30736340/tumor-associated-macrophages-induce-endocrine-therapy-resistance-in-er-breast-cancer-cells
#11
Andrés M Castellaro, María C Rodriguez-Baili, Cecilia E Di Tada, Germán A Gil
Antiestrogenic adjuvant treatments are first-line therapies in patients with breast cancer positive for estrogen receptor (ER+). Improvement of their treatment strategies is needed because most patients eventually acquire endocrine resistance and many others are initially refractory to anti-estrogen treatments. The tumor microenvironment plays essential roles in cancer development and progress; however, the molecular mechanisms underlying such effects remain poorly understood. Breast cancer cell lines co-cultured with TNF-α-conditioned macrophages were used as pro-inflammatory tumor microenvironment models...
February 6, 2019: Cancers
https://read.qxmd.com/read/30735730/encapsulated-human-mesenchymal-stem-cells-emscs-as-a-novel-anti-cancer-agent-targeting-breast-cancer-stem-cells-development-of-3d-primed-therapeutic-mscs
#12
Saurabh Mandal, Frank Arfuso, Gautam Sethi, Arun Dharmarajan, Sudha Warrier
Breast cancer is a leading cause of mortality in women across the globe. The major reason for its recurrence and high mortality is due to the presence of a drug refractory and self-renewing population of cells, the cancer stem cells (CSCs). Mesenchymal stem cells (MSCs) have recently emerged as a promising cell-based therapeutic agent for the treatment of different cancer types. However, the anti-tumor effect of MSCs has been indicated to be substantially reduced by their in vivo tumor-trophic migration property and direct cell-to-cell integration with tumor stromal elements...
February 5, 2019: International Journal of Biochemistry & Cell Biology
https://read.qxmd.com/read/30723161/insights-into-ligand-binding-by-a-viral-tumor-necrosis-factor-tnf-decoy-receptor-yield-a-selective-soluble-human-type-2-tnf-receptor
#13
Sergio M Pontejo, Carolina Sanchez, Begoña Ruiz-Argüello, Antonio Alcami
Etanercept is a soluble form of the tumor necrosis factor receptor 2 (TNFR2) that inhibits pathological tumor necrosis factor (TNF) responses in rheumatoid arthritis and other inflammatory diseases. However, besides TNF, etanercept blocks also lymphotoxin-α (LTα), which has no clear therapeutical value and might aggravate some of the adverse effects associated with etanercept. Poxviruses encode soluble TNFR2 homologs, termed viral TNF decoy receptors (vTNFRs), that display unique specificity properties. For instance, cytokine response modifier D (CrmD) inhibits mouse and human TNF and mouse LTα, but it is inactive against human LTα...
February 5, 2019: Journal of Biological Chemistry
https://read.qxmd.com/read/30720466/tofacitinib-enhances-delivery-of-antibody-based-therapeutics-to-tumor-cells-through-modulation-of-inflammatory-cells
#14
Nathan Simon, Antonella Antignani, Stephen M Hewitt, Massimo Gadina, Christine Alewine, David FitzGerald
The routes by which antibody-based therapeutics reach malignant cells are poorly defined. Tofacitinib, an FDA-approved JAK inhibitor, reduced tumor-associated inflammatory cells and allowed increased delivery of antibody-based agents to malignant cells. Alone, tofacitinib exhibited no antitumor activity, but combinations with immunotoxins or an antibody drug conjugate resulted in increased anti-tumor responses. Quantification using flow cytometry revealed that antibody-based agents accumulated in malignant cells at higher percentages following tofacitinib treatment...
February 5, 2019: JCI Insight
https://read.qxmd.com/read/30717773/immunotherapy-of-triple-negative-breast-cancer-with-cathepsin-d-targeting-antibodies
#15
Yahya Ashraf, Hanane Mansouri, Valérie Laurent-Matha, Lindsay B Alcaraz, Pascal Roger, Séverine Guiu, Danielle Derocq, Gautier Robin, Henri-Alexandre Michaud, Helène Delpech, Marta Jarlier, Martine Pugnière, Bruno Robert, Anthony Puel, Lucie Martin, Flavie Landomiel, Thomas Bourquard, Oussama Achour, Ingrid Fruitier-Arnaudin, Alexandre Pichard, Emmanuel Deshayes, Andrei Turtoi, Anne Poupon, Joëlle Simony-Lafontaine, Florence Boissière-Michot, Nelly Pirot, Florence Bernex, William Jacot, Stanislas du Manoir, Charles Theillet, Jean-Pierre Pouget, Isabelle Navarro-Teulon, Nathalie Bonnefoy, André Pèlegrin, Thierry Chardès, Pierre Martineau, Emmanuelle Liaudet-Coopman
BACKGROUND: Triple-negative breast cancer (TNBC) treatment is currently restricted to chemotherapy. Hence, tumor-specific molecular targets and/or alternative therapeutic strategies for TNBC are urgently needed. Immunotherapy is emerging as an exciting treatment option for TNBC patients. The aspartic protease cathepsin D (cath-D), a marker of poor prognosis in breast cancer (BC), is overproduced and hypersecreted by human BC cells. This study explores whether cath-D is a tumor cell-associated extracellular biomarker and a potent target for antibody-based therapy in TNBC...
February 4, 2019: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/30712124/in-vitro-effect-of-low-level-laser-therapy-on-the-proliferative-apoptosis-modulation-and-oxi-inflammatory-markers-of-premature-senescent-hydrogen-peroxide-induced-dermal-fibroblasts
#16
Daíse Raquel Maldaner, Verônica Farina Azzolin, Fernanda Barbisan, Moisés Henrique Mastela, Cibele Ferreira Teixeira, Alexandre Dihel, Thiago Duarte, Neida Luiza Pellenz, Luiz Fernando Cuozzo Lemos, Carla Maria Uggeri Negretto, Ivana Beatrice Mânica da Cruz, Marta Maria Medeiros Frescura Duarte
Skin aging is a complex biological process induced by intrinsic and extrinsic factors which is characterized by clinical and cellular changes, especially dermal fibroblasts. It is possible that, some procedures, such as low-level laser therapy (LLLT), could decelerate this process. To test this hypothesis, this study evaluated the in vitro LLLT on dermal fibroblast cell line (HFF-1) with premature senescence H2 O2 -induced. HFF-1 cells were cultured in standardized conditions, and initially H2 O2 exposed at different concentrations...
February 2, 2019: Lasers in Medical Science
https://read.qxmd.com/read/30711418/aesculus-hippocastanum-l-seed-extract-shows-virucidal-and-antiviral-activities-against-respiratory-syncytial-virus-rsv-and-reduces-lung-inflammation-in-vivo
#17
Franco Maximilano Salinas, Luciana Vázquez, María Virginia Gentilini, Ailin O Donohoe, Eleonora Regueira, Mercedes Soledad Nabaes Jodar, Mariana Viegas, Flavia Mariana Michelini, Gladys Hermida, Laura Edith Alché, Carlos Alberto Bueno
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease and bronchiolitis in children worldwide. No vaccine or specific, effective treatment is currently available. β-escin is one of the main bioactive constituents of Aesculus hippocastanum L. (Hippocastanaceae) seed extract (AH), and both β-escin and AH have demonstrated a beneficial role in clinical therapy because of their anti-edematous, anti-inflammatory and antioxidative effects. Besides, we have reported that β-escin and AH show virucidal, antiviral and immunomodulatory activities against the enveloped viruses HSV-1, VSV and Dengue virus in vitro...
January 31, 2019: Antiviral Research
https://read.qxmd.com/read/30710527/correction-of-defective-t-regulatory-cells-from-patients-with-crohn-s-disease-by-ex-vivo-ligation-of-retinoic-acid-receptor-alpha
#18
Rimma Goldberg, Cristiano Scotta, Dianne Cooper, Einat Nissim-Eliraz, Eilam Nir, Scott Tasker, Peter M Irving, Jeremy Sanderson, Paul Lavender, Fowzia Ibrahim, Jonathan Corcoran, Toby Prevost, Nahum Y Shpigel, Federica Marelli-Berg, Giovanna Lombardi, Graham M Lord
BACKGROUND & AIMS: Crohn's disease (CD) is characterized by an imbalance of effector and regulatory T cells in the intestinal mucosa. The efficacy of anti-adhesion therapies led us to investigate whether impaired trafficking of T-regulatory (Treg) cells contributes to the pathogenesis of CD. We also investigated whether proper function could be restored to Treg cells by ex vivo expansion in the presence of factors that activate their regulatory activities. METHODS: We measured levels of the integrin α4β7 on Treg cells isolated from peripheral blood or lamina propria of patients with CD and healthy individuals (controls)...
January 17, 2019: Gastroenterology
https://read.qxmd.com/read/30710119/molecular-hydrogen-attenuates-gefitinib-induced-exacerbation-of-naphthalene-evoked-acute-lung-injury-through-a-reduction-in-oxidative-stress-and-inflammation
#19
Yasuhiro Terasaki, Tetsuya Suzuki, Kozue Tonaki, Mika Terasaki, Naomi Kuwahara, Jumi Ohsiro, Masumi Iketani, Mayumi Takahashi, Makoto Hamanoue, Yusuke Kajimoto, Seisuke Hattori, Hideo Kawaguchi, Akira Shimizu, Ikuroh Ohsawa
Although inhibition of epidermal growth factor receptor (EGFR)-mediated cell signaling by the EGFR tyrosine kinase inhibitor gefitinib is highly effective against advanced non-small cell lung cancer, this drug might promote severe acute interstitial pneumonia. We previously reported that molecular hydrogen (H2 ) acts as a therapeutic and preventive anti-oxidant. Here, we show that treatment with H2 effectively protects the lungs of mice from severe damage caused by oral administration of gefitinib after intraperitoneal injection of naphthalene, the toxicity of which is related to oxidative stress...
February 1, 2019: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://read.qxmd.com/read/30709867/a-novel-angiotensin-1-7-glycosylated-mas-receptor-agonist-for-treating-vascular-cognitive-impairment-and-inflammation-related-memory-dysfunction
#20
Meredith Hay, Robin Polt, Michael L Heien, Todd W Vanderah, Tally M Largen-Milnes, Kathleen E Rodgers, Torsten Falk, Mitchell J Bartlett, Kristian Doyle, John Konhilas
A growing body of evidence indicates that decreased brain blood flow, increased reactive oxygen species production (ROS), and pro-inflammatory mechanisms accelerate the progression of neurodegenerative diseases such as vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer's disease and related dementias (ADRD). There is an urgent clinical need for safe and effective therapies for the treatment and prevention of cognitive impairment known to occur in patients with VCID and chronic inflammatory diseases such as heart failure (HF), hypertension and diabetes...
February 1, 2019: Journal of Pharmacology and Experimental Therapeutics
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