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Ciclosporin or cyclosporine, dog or canine

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https://read.qxmd.com/read/30763883/in-vitro-metabolic-profiles-of-motolimod-by-using-liquid-chromatography-tandem-mass-spectrometry-metabolic-stability-metabolite-characterization-and-species-comparison
#1
Zeyun Li, Songfeng Zhao, Yongliang Yuan, Lizhen Zhang, Zhizhen Song, Xin Tian, Xiaojian Zhang
Motolimod (VTX-2337) is an agonist of toll-like receptor 8 (TLR8) with potential immune-stimulating and antineoplastic activities. The purpose of this study was to investigate the in vitro metabolic profiles of VTX-2337. The average in vitro T1/2 values were 6.93, 8.71, 7.39, 2.85, and 10.58 min in the liver microsomes of mouse, rat, dog, monkey and human respectively, suggesting that VTX-2337 suffered from extensive metabolism. The metabolites were further profiled and identified by using ultra-high performance liquid chromatography coupled with diode array detector and Q-Exactive-Orbitrap tandem mass spectrometer (UHPLC-DAD-Q-Exactive-Orbitrap-MS) operated in positive ion mode...
February 7, 2019: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/30763782/maxillary-shape-after-primary-cleft-closure-and-before-alveolar-bone-graft-in-two-different-management-protocols-a-comparative-morphometric-study
#2
F Girinon, S Ketoff, Q Hennocq, N Kogane, N Ullman, N Kadlub, E Galliani, C Neiva-Vaz, M P Vazquez, A Picard, R H Khonsari
AIM AND SCOPE: Result assessment in cleft surgery is a technical challenge and requires the development of dedicated morphometric tools. Two cohorts of patients managed according to two different protocols were assessed at similar ages and their palatal shape was compared using geometric morphometrics. Material and Methods Ten patients (protocol №1) benefited from early lip closure (1-3 months) and secondary combined soft and hard palate closure (6-9 months); 11 patients (protocol №2) benefited from later combined lip and soft palate closure (6 months) followed by hard palate closure (18 months)...
February 11, 2019: Journal of Stomatology, Oral and Maxillofacial Surgery
https://read.qxmd.com/read/30763605/regulation-of-permeability-transition-pore-opening-in-mitochondria-by-external-nad-h
#3
Ekaterina S Kharechkina, Anna B Nikiforova, Vera V Teplova, Irina V Odinokova, Olga V Krestinina, Yulia L Baburina, Svetlana A Kruglova, Alexey G Kruglov
BACKGROUND: The opening of the permeability transition pore (PTP) in mitochondria plays a critical role in the pathogenesis of numerous diseases. Mitochondrial matrix pyridine nucleotides are potent regulators of the PTP, but the role of extramitochondrial nucleotides is unclear. METHODS: The PTP opening was explored in isolated mitochondria and mitochondria in permeabilized differentiated and undifferentiated cells in the presence of added NAD(P)(H) in combination with Mg2+ , adenine nucleotides (AN), and the inhibitors of AN translocase (ANT), voltage-dependent anion channel (VDAC), and cyclophilin D...
February 11, 2019: Biochimica et biophysica acta. General subjects
https://read.qxmd.com/read/30763391/socioeconomic-vulnerability-associated-to-toxoplasma-gondii-exposure-in-southern-brazil
#4
Marcelle Mareze, Aline do Nascimento Benitez, Ana Pérola Drulla Brandão, Fernanda Pinto-Ferreira, Ana Carolina Miura, Felippe Danyel Cardoso Martins, Eloiza Teles Caldart, Alexander Welker Biondo, Roberta Lemos Freire, Regina Mitsuka-Breganó, Italmar Teodorico Navarro
Human toxoplasmosis, a protozoonosis caused by Toxoplasma gondii, has been described as a worldwide foodborne disease with important public health impact. Despite infection has reportedly varied due to differences in alimentary, cultural and hygienic habits and geographic region, social vulnerability influence on toxoplasmosis distribution remains to be fully established. Accordingly, the present study has aimed to assess T. gondii seroprevalence and factors associated to social vulnerability for infection in households of Ivaiporã, southern Brazil, with 33...
2019: PloS One
https://read.qxmd.com/read/30763163/inspiratory-muscle-activation-via-ventral-lower-thoracic-high-frequency-spinal-cord-stimulation
#5
Krzysztof E Kowalski, Jaroslaw Richard Romaniuk, Peter A Kirkwood, Anthony F DiMarco
In animals, high frequency spinal cord stimulation (HF-SCS) applied on the ventral epidural surface at T2 level results in negative airway pressure generation consistent with inspiratory muscle activation. In the present study, in anesthetized dogs, we found that ventral HF-SCS (500Hz) applied at all thoracic levels resulted in negative airway pressure generation. In the region of the lower thoracic spinal cord, negative airway pressure generation was most pronounced at the T9 level. At this spinal level, airway pressure generation was monitored: 1) during ventral HF-SCS over a wide range of stimulus amplitudes (0...
February 14, 2019: Journal of Applied Physiology
https://read.qxmd.com/read/30762995/adequately-prepared-a-study-using-an-innovative-computer-application-to-measure-clinical-crown-convergence-angles-achieved-by-students-at-a-uk-dental-school
#6
K J Strain, J Tiu, J Mackie, S J Bonsor, R J Ibbetson
This study examined the total occlusal convergence angles created for full coverage crown preparations by students at a UK dental school. Working casts of 82 clinical crown preparations were scanned using a 3D scanner. Stereolithographic files were uploaded to Preppr, a crown preparation analysis application. Mean bucco-lingual convergence angle were 19.6° (+/-11.7) and mesial-distally 17.8° (+/-11.1). Smallest bucco-lingual convergence angles were achieved for canine teeth with the largest on molar teeth...
February 5, 2019: European Journal of Prosthodontics and Restorative Dentistry
https://read.qxmd.com/read/30762910/comparative-pathophysiology-and-management-of-protein-losing-enteropathy
#7
REVIEW
Melanie D Craven, Robert J Washabau
Protein-losing enteropathy, or PLE, is not a disease but a syndrome that develops in numerous disease states of differing etiologies and often involving the lymphatic system, such as lymphangiectasia and lymphangitis in dogs. The pathophysiology of lymphatic disease is incompletely understood, and the disease is challenging to manage. Understanding of PLE mechanisms requires knowledge of lymphatic system structure and function, which are reviewed here. The mechanisms of enteric protein loss in PLE are identical in dogs and people, irrespective of the underlying cause...
February 14, 2019: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/30762518/influenza-virus-entry-via-the-gm3-ganglioside-mediated-platelet-derived-growth-factor-receptor-%C3%AE-signalling-pathway
#8
Pieter Vrijens, Sam Noppen, Talitha Boogaerts, Els Vanstreels, Roberto Ronca, Paola Chiodelli, Manon Laporte, Evelien Vanderlinden, Sandra Liekens, Annelies Stevaert, Lieve Naesens
The possible resistance of influenza virus against existing antiviral drugs calls for new therapeutic concepts. One appealing strategy is to inhibit virus entry, in particular at the stage of internalization. This requires a better understanding of virus-host interactions during the entry process, including the role of receptor tyrosine kinases (RTKs). To search for cellular targets, we evaluated a panel of 276 protein kinase inhibitors in a multicycle antiviral assay in Madin-Darby canine kidney cells. The RTK inhibitor Ki8751 displayed robust anti-influenza A and B virus activity and was selected for mechanistic investigations...
February 14, 2019: Journal of General Virology
https://read.qxmd.com/read/30762306/the-dog-canis-familiaris-as-a-translational-model-of-autism-it-is-high-time-we-move-from-promise-to-reality
#9
REVIEW
József Topál, Viktor Román, Borbála Turcsán
Selecting appropriate animal models for a particular human phenomenon is a difficult but important challenge. The difficulty lies in finding animal behaviors that are not only sufficiently relevant and analog to the complex human symptoms (face validity) but also have similar underlying biological and etiological mechanisms (translational or construct validity), and have "human-like" responses to treatment (predictive validity). Over the past several years, the domestic dog (Canis familiaris) has become increasingly proposed as a model for comparative and translational neuroscience...
February 14, 2019: Wiley Interdisciplinary Reviews. Cognitive Science
https://read.qxmd.com/read/30762295/molecular-characterization-of-anaplasma-and-ehrlichia-in-ixodid-ticks-and-reservoir-hosts-from-palestine-a-pilot-survey
#10
Taher Zaid, Suheir Ereqat, Abdelmajeed Nasereddin, Amer Al-Jawabreh, Ahmad Abdelkader, Ziad Abdeen
Tick-borne anaplasmosis and ehrlichiosis are clinically important emerging zoonoses usually overlooked by veterinarians and physicians alike. This study aimed at detecting and genetically characterizing Ehrlichia and Anaplasma species in ixodid ticks and their animal hosts from the West Bank, Palestine. A total of 723 ixodid ticks belonging to three genera (Rhipicephalus, Hyalomma, Haemaphysalis) were collected from dogs, sheep, goats and camels. In addition, 189 blood samples were collected from dogs, sheep, camels, horses and a goat from the West Bank, Palestine...
February 14, 2019: Veterinary Medicine and Science
https://read.qxmd.com/read/30762094/liraglutide-suppresses-atrial-electrophysiological-changes
#11
Hironori Nakamura, Shinichi Niwano, Hiroe Niwano, Hidehira Fukaya, Masami Murakami, Jun Kishihara, Akira Satoh, Tomoharu Yoshizawa, Naruya Ishizue, Tazuru Igarashi, Tamami Fujiishi, Junya Ako
We have shown that a dipeptidyl peptidase 4 (DPP-4) inhibitor suppresses atrial remodeling in a canine atrial fibrillation (AF) model. Glucagon-like peptide-1 (GLP-1) is increased by DPP-4 inhibitors. However, it is not clear whether GLP-1 is involved in the suppression of atrial remodeling. In this study, we evaluated the effect of liraglutide (a GLP-1 analog) on atrial electrophysiological changes using the same canine AF model. We established a canine AF model using continuous 3-week rapid atrial stimulation in seven beagle dogs divided into two groups: a liraglutide group with four dogs (3-week atrial pacing with liraglutide (150 µg/kg/day) administration) and a pacing control group with three dogs (3-week pacing without any medicine)...
February 14, 2019: Heart and Vessels
https://read.qxmd.com/read/30761980/association-between-insulin-like-growth-factor-i-levels-and-the-disease-progression-and-anemia-in-visceral-leishmaniasis
#12
Flaviane Alves de Pinho, Célia Maria Vieira Vendrame, Bruna Leal Lima Maciel, Lucilene Dos Santos Silva, Samantha Ive Miyashiro, Selma Maria Bezerra Jerônimo, Hiro Goto
We analyzed the association between insulin-like growth factor-I (IGF-I) and the pathogenesis of anemia during active visceral leishmaniasis (VL). Serum levels of IGF-I, IGF-binding protein 3 (IGFBP3), and cytokines were measured in samples from individuals with active VL and cured VL, asymptomatic Leishmania -infected, and noninfected individuals. Then, we extended our analysis to VL dogs to evaluate hematimetric parameters, bone marrow alterations, and cytokine and IGF-I expression. We identified a positive correlation between lower IGF-I and IGFBP3 levels in active VL patients and lower hemoglobin levels...
February 11, 2019: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/30761913/effects-of-calf-horn-as-chews-on-the-behavior-of-laboratory-dogs
#13
Daphne A Ketter, André Klima, Helmut Küchenhoff, Britta Dobenecker, Jörg Schmidt, Michael H Erhard, Dorothea Döring
It is increasingly required that non-human animals in laboratories are provided with adequate enrichment to promote the welfare of the animals. In a previous publication we showed that laboratory dogs intensively used the horn of calf hooves as chewing objects. In this report, we describe the effect of calf horn on selected behaviors of 62 laboratory dogs (60 beagles, two Foxhound crossbreds) in three research facilities (A, B, C). In addition, we assessed the dogs' tooth condition and fecal consistency. The selected behaviors: "aggressive behavior," "mounting," "tussle," "coprophagy," "manipulation" of the equipment and "abnormal behavior" did not change...
February 14, 2019: Journal of Applied Animal Welfare Science: JAAWS
https://read.qxmd.com/read/30761736/anti-tumour-activity-of-oncolytic-reovirus-against-canine-histiocytic-sarcoma-cells
#14
Masaya Igase, Kazuha Shousu, Noriyuki Fujiki, Masashi Sakurai, Makoto Bonkobara, Chung Chew Hwang, Matt Coffey, Shunsuke Noguchi, Yuki Nemoto, Takuya Mizuno
Canine histiocytic sarcoma is an aggressive, fatal neoplastic disease with a poor prognosis. Lomustine is generally accepted as the first-line systemic therapy, although this compound does not provide complete regression. Therefore, research into a novel approach against canine histiocytic sarcoma is needed. However, anti-tumour effects of oncolytic therapy using reovirus against histiocytic sarcoma are unknown. Here, we showed that reovirus has oncolytic activity in canine histiocytic sarcoma cell lines in vitro and in vivo...
February 14, 2019: Veterinary and Comparative Oncology
https://read.qxmd.com/read/30761421/preclinical-evaluation-of-a-novel-anterior-non-fusion-fixation-device-for-atlantoaxial-instability-an-in-vivo-comparison-study-in-a-canine-model
#15
Xuan Cai, Xiaoqing Yi, Haopeng Li, Xijing He
PURPOSE: The Anterior Atlantoaxial Non-Fusion Fixation System (AANFS) was a novel motion preservation device for atlantoaxial instability to replace traditional fusion techniques. The purpose of this in vivo study was to evaluate the clinical features and biomechanical properties of this new device in a canine model by comparing it with a conventional method. METHODS: Eighteen adult male canines were randomly divided into group 1, which received the AANFS replacement, group 2 which received the Harms rigid fixation procedures, and group 3, which served as the control group...
February 13, 2019: European Spine Journal
https://read.qxmd.com/read/30761411/the-role-of-a-curved-electrode-with-controllable-direction-in-the-radiofrequency-ablation-of-liver-tumors-behind-large-vessels
#16
An-Na Jiang, Song Wang, Wei Yang, Kun Zhao, Xiu-Mei Bai, Zhong-Yi Zhang, Wei Wu, Min-Hua Chen, Kun Yan
PURPOSE: To investigate the role of a novel curved radiofrequency ablation (RFA) electrode with controllable direction in the ablation of tumors behind large hepatic vessels in ex vivo bovine and in vivo canine liver experiments. MATERIALS AND METHODS: Approval from the institutional animal care and use committee was obtained. In ex vivo experiments, conventional multi-tines expandable electrodes, conventional monopolar straight electrodes and novel curved electrodes were used in the ablation of the bovine liver (n = 90)...
February 13, 2019: Cardiovascular and Interventional Radiology
https://read.qxmd.com/read/30761283/hunting-poses-only-a-low-risk-for-alveolar-echinococcosis
#17
Monika Wetscher, Klaus Hackländer, Viktoria Faber, Ninon Taylor, Herbert Auer, Georg G Duscher
The Austrian province of Tyrol belongs to the areas where the alveolar echinococcosis (AE) caused by the fox tapeworm Echinococcus multilocularis ( E. multilocularis ) is highly endemic. In Central Europe and since 2011 in Austria, a growing incidence of human cases of AE has been observed, presumably linked with increasing fox populations infected by the fox tapeworm E. multilocularis . Hunting and the related activities put hunters in a high-risk group, and they are considered particularly vulnerable for the contraction of an AE...
2019: Frontiers in Public Health
https://read.qxmd.com/read/30761085/physiological-stress-in-rescued-wild-koalas-are-influenced-by-habitat-demographics-environmental-stressors-and-clinical-intervention
#18
Edward Narayan, Tayla Vanderneut
Koalas are rescued from the wild often with incidence of burns from bushfire, injury from animal attacks, vehicle collision, and diseases. Exposure to environmental stressors (trauma and disease) could generate physiological stress and potentially impact the outcomes of clinical management intervention and rehabilitation of rescued wild koalas. It is important to quantify the stress physiology of wild koalas upon registering into clinical care. This study demonstrates the first report of physiological stress assessment in rescued wild koalas ( n = 22) to determine the potential influences of habitat-specific demographics, stressor category, and clinical diagnosis...
2019: Frontiers in Endocrinology
https://read.qxmd.com/read/30760347/investigating-clinical-and-cost-burdens-of-law-enforcement-related-k9-injuries-the-impact-of-the-bite-on-a-community-hospital
#19
Andre V Coombs, Stephanie A Eyerly-Webb, Rachele J Solomon, Rafael Sanchez, Seong K Lee, Eddy H Carrillo, Chauniqua Kiffin, Andrew A Rosenthal, Jill Whitehouse, Barbara Germain, Dafney L Davare
The decision to introduce canines (K9s) to a law enforcement (LE) agency does not typically involve the evaluation of the fiscal or clinical impact on local hospitals. This study compared injury, cost, and care associated with K9s to a common nonlethal force method, the Thomas A Swift Electrical Rifle (TASER), to highlight the cost and resources required to treat both patient types. Patients treated for LE-related K9 and TASER injuries at a Level I community-based trauma center (2011-2016) were evaluated for level of care required ( e...
January 1, 2019: American Surgeon
https://read.qxmd.com/read/30760179/cis-1-1-1-4-4-4-hexafluoro-2-butene-hfo-1336mzz-z-2018
#20
(no author information available yet)
Cis-1,1,1,4,4,4-hexafluoro-2-butene (HFO-1336mzz-Z) is a clear, colorless liquid that finds uses as a foam-blowing agent, refrigerant, fire extinguishing agent, and solvent. HFO-1336mzz-Z is not an acute dermal or eye irritant and has very low acute toxicity via inhalation exposure (4-h lethal concentration (LC50 ) > 102,000 ppm). The no-observed adverse effect level (NOAEL) and lowest-observed adverse effect level (LOAEL) for cardiac sensitization (in epinephrine-challenged dogs) were 12,500 ppm and 25,000 ppm, respectively...
February 13, 2019: Toxicology and Industrial Health
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