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JOURNAL ARTICLE
Predictors of mortality in periprosthetic fractures of the hip: Results from the national PPF study.
Ahmed Abdul Hadi Harb Nasser, Rohan Prakash, Charles Handford, Khabab Osman, Govind Singh Chauhan, Rajpal Nandra, Ansar Mahmood, Varun Dewan, Jerome Davidson, Mohammed Al-Azzawi, Christian Smith, Mothana Gawad, Ioannis Palaiologos, Rory Cuthbert, Warran Wignadasan, Daniel Banks, James Archer, Abdulrahman Odeh, Thomas Moores, Muaaz Tahir, Margaret Brooks, Gurdeep Biring, Stevan Jordan, Zain Elahi, Mohammed Shaath, Manoj Veettil, Chiranjit De, Charles Handford, Mohit Bansal, Akshdeep Bawa, Ahmed Mattar, Varun Tandra, Audrina Daadipour, Ahmed Taha, Shafat Gangoo, Sriram Srinivasan, Mandishona Tarisai, Basil Budair, Krishna Subbaraman, Farrukh Khan, Austin Gomindes, Arjun Samuel, Niel Kang, Karan Kapur, Elizabeth Mainwaring, Hannah Bridgwater, Andre Lo, Usman Ahmed, Tahir Khaleeq, Ahmed El-Bakoury, Ramy Rashed, Hazem Hosny, Rathan Yarlagadda, Jonathan Keenan, Ahmed Hamed, Bryan Riemer, Arham Qureshi, Vatsal Gupta, Matthew Waites, Sabri Bleibleh, David Westacott, Jonathan Phillips, Jamie East, Daniel Huntley, Saqib Masud, Yusuf Mirza, Sandeep Mishra, David Dunlop, Mohamed Khalefa, Balakumar Balasubramanian, Mahesh Thibbaiah, Olivia Payton, James Berstock, Krisna Deano, Khaled Sarraf, Kartik Logishetty, George Lee, Hariharan Subbiah-Ponniah, Nirav Shah, Aakaash Venkatesan, James Cheseldene-Culley, Joseph Ayathamattam, Samantha Tross, Sukhwinder Randhawa, Faisal Mohammed, Ramla Ali, Jonathan Bird, Kursheed Khan, Muhammad Adeel Akhtar, Andrew Brunt, Panagiotis Roupakiotis, Padmanabhan Subramanian, Nelson Bua, Mounir Hakimi, Samer Bitar, Majed Al Najjar, Ajay Radhakrishnan, Charlie Gamble, Andrew James, Catherine Gilmore, Dan Dawson, Rajesh Sofat, Mohamed Antar, Aashish Raghu, Sam Heaton, Waleed Tawfeek, Christerlyn Charles, Henry Burnand, Sean Duffy, Luke Taylor, Laura Magill, Rita Perry, Michala Pettitt, Kelvin Okoth, Thomas Pinkney
INTRODUCTION: Periprosthetic fractures (PPFs) around the hip joint are increasing in prevalence. In this collaborative study, we aimed to investigate the impact of patient demographics, fracture characteristics, and modes of management on in-hospital mortality of PPFs involving the hip. METHODS: Using a multi-centre cohort study design, we retrospectively identified adults presenting with a PPF around the hip over a 10-year period. Univariate and multivariable logistic regression analyses were performed to study the independent correlation between patient, fracture, and treatment factors on mortality...
December 2023: Injury
#22
JOURNAL ARTICLE
Mukesh Bhatta, Aashish Baniya, Diwakar Koirala, Karun Bhattarai, Abhishek Shah
INTRODUCTION AND IMPORTANCE: Kawasaki disease (KD) is an acute febrile systemic vasculitis that predominantly affects small to medium sized vessels and mostly occurs in children below 5 years of age. The morbidity and mortality mostly occur due to cardiac involvement. CASE PRESENTATION: The authors present a case of a 5-year-old male child from hilly region of Nepal who presented with fever for 7 days along with strawberry tongue and non-exudative conjunctivitis without rashes, extremity changes or lymphadenopathy...
November 2023: Annals of Medicine and Surgery
#23
Rachel NeMoyer, Tiffany Vaughan, James Witten, Rashed Mahboubi, Miza Salim Hammoud, Shawn Shah, Munir Ahmad, Hani Najm, Robert Stewart, Tara Karamlou
No abstract text is available yet for this article.
October 2023: JTCVS techniques
#24
Umesh Kumar Pabani, Zahid Khan, Layla Ali, Shuheda K Shah, Jebriel Ali Khan
Toxic epidermal necrolysis (TEN) is a life-threatening, blistering dermatitis. It is characterized by fever and the development of mucocutaneous lesions, which lead to necrosis and sloughing of the epidermis. It is commonly triggered by medications and infections. We present the case of a 75-year-old male who presented to the hospital with a fever and widespread exfoliating skin rash involving 41% of his body surface area (BSA). He has a past medical history of gout, hypertension, asthma, and depression. He was recently started on allopurinol by his general practitioner (GP) for hyperuricemia...
September 2023: Curēus
#25
JOURNAL ARTICLE
Anuradha J Punchihewage-Don, Nur A Hasan, Shah M Rashed, Salina Parveen
Investigating the chicken microbiome is important to establish control measures for pathogens to protect consumers. This study aimed at evaluating the comparative efficiency of human pathogen detection through 16S rRNA sequencing of organic and conventional chickens processed using whole carcass enrichment (WCE) and rinse (WCR) methods. Organic and conventional whole broiler carcasses (n=31) were vigorously shaken with 500 mL buffered peptone water (BPW). For the rinse method, a 30 mL aliquot was mixed with 30 mL of BPW...
October 5, 2023: Journal of Food Protection
#26
JOURNAL ARTICLE
Yash Saraswat, Kamal Shah
Monkeypox is a disease caused by the monkeypox virus, which is a type of orthopox virus that comes from the virus family Poxviridae. Its first case reported in animals and humans was in 1958 and 1970, respectively. It is a viral zoonosis disease with two modes of transmission: animal to human (via direct contact or eating the meat of an infected animal) and human to human (via contact or contact with skin lesions, body fluids, and infected person's contaminated objects). The literature depicts that monkeypox is less contagious among individuals in contrast to smallpox; the infection chain of monkeypox is nearly five to six patients approximately...
September 14, 2023: Current Pharmaceutical Biotechnology
#27
JOURNAL ARTICLE
Samuel L Cytryn, Ryan H Moy, Darren Cowzer, Ronak H Shah, Joanne F Chou, Smita S Joshi, Geoffrey Y Ku, Steven B Maron, Avni Desai, Jessica Yang, Ryan Sugarman, Devika Rao, Zoe Goldberg, Carmelina Charalambous, Maria Lapshina, Ariel Antoine, Fiona Socolow, Nikhil Trivedi, Marinela Capanu, Hans Gerdes, Mark A Schattner, Marc Simmons, Mario E Lacouture, Viktoriya Paroder, Laura H Tang, Jinru Shia, David H Ilson, David B Solit, Michael F Berger, Yelena Y Janjigian
BACKGROUND: The addition of nivolumab to chemotherapy improves survival in patients with advanced oesophagogastric (oesophageal, gastric, or gastro-oesophageal junction) adenocarcinoma; however, outcomes remain poor. We assessed the safety and activity of regorafenib in combination with nivolumab and chemotherapy in the first-line treatment of advanced oesophagogastric adenocarcinoma. METHODS: This investigator-initiated, single-arm, phase 2 trial in adult patients (aged ≥18 years) with previously untreated, HER2-negative, metastatic oesophagogastric adenocarcinoma was done at the Memorial Sloan Kettering Cancer Center (New York, NY, USA)...
October 2023: Lancet Oncology
#28
Pandharinath Khade, Avani Shah, Vidya Kharkar
COVID-19 is a global pandemic caused by a novel zoonotic RNA virus named SARS-CoV-2. Various cutaneous manifestations associated with COVID-19 have been described, including urticarial rash, confluent erythematous rash, papulovesicular exanthem, chilblain-like acral pattern, livedo reticularis, and purpuric vasculitis pattern. Here, we are presenting a case of a 45-year-old male with mucocutaneous features of Stevens-Johnson syndrome.
June 16, 2023: JMIR dermatology
#29
Ahmed Ali Aziz, Maleeha Saleem, Sara L Wallach, Shazia M Shah
Monkeypox (MPX) virus is endemic in Africa. However, since May 2022, many cases have been reported worldwide in many non-endemic regions as well. The virus usually spreads from animals to humans or from humans to humans through respiratory droplets or after contact with infected lesions. In the recent outbreak of MPX, many cases did not have any travel history to endemic areas and were reported in men who have sex with men (MSM) along with the diagnosis of other sexually transmitted diseases (STDs). However, MPX is not yet considered a sexually transmitted infection (STI), even though a relationship between MPX and other STIs may exist with a possible facilitating action on their spreading...
July 2023: Curēus
#30
Carine M Lama, Miguel A Hernandez-Rovira, Neha Mehta-Shah, Aaron Russell, Amy C M Musiek
No abstract text is available yet for this article.
August 2023: JAAD Case Reports
#31
JOURNAL ARTICLE
Nor Atikah Husna Ahmad Nasir, Mohd Hafis Yuswan, Nor Nadiah Abd Karim Shah, Aswir Abd Rashed, Kazunori Kadota, Yus Aniza Yusof
This study introduced a D-optimal design mixture to assess the physicochemical properties of a hydrocolloid-based functional food fortified with C. lentillifera . The combination incorporated vital jelly constituents, including extract (10-15%), sweeteners (20-29%), gelling agents (k-carrageenan and locust bean gum (LBG)), and preservatives (0-0.05%). The dependent variables were pH, Total Soluble Solid (TSS) value, and moisture content (MS). By employing the D-optimal design approach, a quadratic polynomial model was developed, demonstrating strong correlations with the experimental data with coefficient determinations (R2 ) of 0...
June 29, 2023: Gels
#32
JOURNAL ARTICLE
Lars H Lund, Carolyn S P Lam, Patricia E Pizzato, Anders Gabrielsen, Erik Michaëlsson, Karin Nelander, Hans Ericsson, Julie Holden, Folke Folkvaljon, Andrea Mattsson, Anna Collén, Malin Aurell, Carl Whatling, Stephan Baldus, Grzegorz Drelich, Assen Goudev, Béla Merkely, Niklas Bergh, Sanjiv J Shah
AIMS: Mitiperstat (formerly AZD4831) is a novel selective myeloperoxidase inhibitor. Currently, no effective therapies target comorbidity-induced systemic inflammation, which may be a key mechanism underlying heart failure with preserved or mildly reduced ejection fraction (HFpEF/HFmrEF). Circulating neutrophils secrete myeloperoxidase, causing oxidative stress, microvascular endothelial dysfunction, interstitial fibrosis, cardiomyocyte remodelling and diastolic dysfunction. Mitiperstat may therefore improve function of the heart and other organs, and ameliorate heart failure symptoms and exercise intolerance...
July 20, 2023: European Journal of Heart Failure
#33
JOURNAL ARTICLE
Katrina A Williamson, Mark Yun, Matthew J Koster, Courtney Arment, Asha Patnaik, Tara W Chang, Adam C Bledsoe, Sutthichai Sae-Tia, Aditya S Shah, Jonathan Samuels, John M Davis Iii, Qingping Yao
OBJECTIVES: Whipple's disease (WD) results from infection of the bacteria Tropheryma whipplei (TW). This disease is characterized by macrophage infiltration of intestinal mucosa and primarily affects Caucasian males. Genetic studies of host susceptibility are scarce. Nucleotide-binding oligomerization domain containing protein 2 (NOD2) is an innate immune sensor, resides mainly in monocytes/macrophages and contributes to defense against infection and inflammatory regulation. NOD2 mutations are associated with autoinflammatory diseases...
July 19, 2023: Rheumatology
#34
Lecia V Sequist, James Chih-Hsin Yang, Nobuyuki Yamamoto, Kenneth O'Byrne, Vera Hirsh, Tony Mok, Sarayut Lucien Geater, Sergey Orlov, Chun-Ming Tsai, Michael Boyer, Wu-Chou Su, Jaafar Bennouna, Terufumi Kato, Vera Gorbunova, Ki Hyeong Lee, Riyaz Shah, Dan Massey, Victoria Zazulina, Mehdi Shahidi, Martin Schuler
PURPOSE: The LUX-Lung 3 study investigated the efficacy of chemotherapy compared with afatinib, a selective, orally bioavailable ErbB family blocker that irreversibly blocks signaling from epidermal growth factor receptor (EGFR/ErbB1), human epidermal growth factor receptor 2 (HER2/ErbB2), and ErbB4 and has wide-spectrum preclinical activity against EGFR mutations. A phase II study of afatinib in EGFR mutation-positive lung adenocarcinoma demonstrated high response rates and progression-free survival (PFS)...
June 1, 2023: Journal of Clinical Oncology
#35
JOURNAL ARTICLE
Ibrahim Alissa, Anroop B Nair, Bandar Aldhubiab, Hiral Shah, Jigar Shah, Vivek Mewada, Rashed M Almuqbil, Shery Jacob
Clinical application of treprostinil in pulmonary arterial hypertension is hampered by adverse effects caused by its high dosing frequency. The objective of this investigation was to Formulate an adhesive-type transdermal patch of treprostinil and evaluate it both in vitro and in vivo. A 32 -factorial design was utilized to optimize the selected independent variables (X1 : drug amount, X2 : enhancer concentration) on the response variables (Y1 : drug release, Y2 : transdermal flux). The optimized patch was evaluated for various pharmaceutical properties, skin irritation, and pharmacokinetics in rats...
April 12, 2023: Pharmaceutics
#36
JOURNAL ARTICLE
Carolyn S P Lam, Lars H Lund, Sanjiv J Shah, Adriaan A Voors, David Erlinge, Antti Saraste, Carlo Pirazzi, Erik L Grove, Anders Barasa, Morten Schou, Ahmed Aziz, Sara Svedlund, Jan VAN Wijngaarden, Eva-Lotte Lindstedt, Andreas Gustavsson, Karin Nelander, Pavlo Garkaviy, Li-Ming Gan, Anders Gabrielsen
BACKGROUND: Inflammation is a key driver of heart failure (HF) with preserved left ventricular ejection fraction (LVEF). AZD4831 inhibits extracellular myeloperoxidase, reduces inflammation and improves microvascular function in preclinical disease models. METHODS: In this double-blind phase 2a study (SATELLITE; NCT03756285), patients with symptomatic HF, LVEF ≥40%, and elevated B-type natriuretic peptides were randomized 2:1 to once-daily oral AZD4831 5 mg or placebo for 90 days...
April 16, 2023: Journal of Cardiac Failure
#37
JOURNAL ARTICLE
Ahmed S Alnaim, Hiral Shah, Anroop B Nair, Vivek Mewada, Smit Patel, Shery Jacob, Bandar Aldhubiab, Mohamed A Morsy, Rashed M Almuqbil, Pottathil Shinu, Jigar Shah
Poor aqueous solubility besides extensive hepatic first effect significantly decreases the oral absorption of levosulpiride, which in turn minimizes its therapeutic effectiveness. Niosomes have been extensively investigated as a transdermal vesicular nanocarrier to increase the delivery of low permeable compounds into and across the skin. This research work was to design, develop and optimize levosulpiride-loaded niosomal gel and to evaluate its prospects for transdermal delivery. The Box-Behnken design was used to optimize niosomes by analyzing the impact of three factors (cholesterol; X1 , Span 40; X2 , and sonication time; X3 ) on the responses (particle size, Y1 , and entrapment efficiency, Y2 )...
March 10, 2023: Gels
#38
Vedant Shah, Harsh Patel, Jaykumar Oza, Palak Patel, Haripriya Radhakrishnan, Janani Arunachalam, Soumyadeep Bag, Tumpa Patra, Saketh Palasamudram Shekar
COVID-19 usually presents with classic signs and symptoms, but it can involve multiple systems in atypical cases. SARS-CoV-2 has a complex interaction with the host immune system leading to atypical manifestations. In our case, a 32-year-old male patient presented with fatigue, sores on hands and feet, headache, productive cough with blood-tinged mucus, conjunctival hyperemia, purpuric rash on hands and feet, and splinter hemorrhages of fingernails for 2 weeks. The patient's SARS-CoV-2 antigen and PCR test were positive...
2023: SN comprehensive clinical medicine
#39
REVIEW
María Claudia Ortega-López
The clinical presentation, disease course, and outcome of SARS-CoV-2 infection in pediatrics differ from the presentation in adults. In a review by Hoang et al., the prevalence of dermatological manifestations was estimated in 0.25% of a total of 2,445 children with confirmed COVID-19. Similarly, the prevalence of skin manifestations was reported in 3% of 100 children in the Parri's study. A systematic review by Shah et al. analyzed 13 studies with 149 children who met eligibility criteria. The acral erythematous maculopapular lesion was the most common, as well as erythema multiforme, varicella rash, and presentations similar to Kawasaki disease...
May 27, 2022: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
#40
Chunnu Kumar Yadav, Rajat Ranka, Prasan Kumar Panda, Bishal Pratap Shah, Mayank Kumar Mishra, Vijay Krishnan
INTRODUCTION: Adverse drug reactions (ADR) are defined as any harmful or unpleasant events or injuries resulting from the use of any particular drug. Among those antibiotics that cause adverse reactions, amoxicillin is one of them. Catatonia and vasculitic rash are its rare adverse effects. CASE PRESENTATION: A case of a 23-year-old postpartum female with a history of taking empirical Amoxiclav (amoxicillin-clavulanic acid 625mg) injection and oral tablets for episiotomy wounds...
March 8, 2023: Current Drug Safety
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