keyword
MENU ▼
Read by QxMD icon Read
search

anne c lee

keyword
https://read.qxmd.com/read/30998508/phase-1-trial-of-intrapleural-lti-01-single-chain-urokinase-in-complicated-parapneumonic-effusions-or-empyema
#1
Lutz Beckert, Ben Brockway, Graham Simpson, Anne Marie Southcott, Y C Gary Lee, Najib Rahman, Richard W Light, Steven Shoemaker, John Gillies, Andrey A Komissarov, Galina Florova, Timothy Ochran, William Bradley, Harrison Ndetan, Karan P Singh, Krishna Sarva, Steven Idell
BACKGROUND: Current dosing of intrapleural fibrinolytic therapy (IPFT) in adults with complicated parapneumonic effusion (CPE) / empyema is empiric, as dose-escalation trials have not previously been conducted. We hypothesized that LTI-01 (scuPA), which is relatively resistant to PA inhibitor-1 (PAI-1), would be well-tolerated. METHODS: This was an open-label, dose-escalation trial of LTI-01 IPFT at 50,000-800,000 IU daily for up to 3 days in adults with loculated CPE/empyema and failed pleural drainage...
April 18, 2019: JCI Insight
https://read.qxmd.com/read/30988516/author-correction-an-atlas-of-genetic-influences-on-osteoporosis-in-humans-and-mice
#2
John A Morris, John P Kemp, Scott E Youlten, Laetitia Laurent, John G Logan, Ryan C Chai, Nicholas A Vulpescu, Vincenzo Forgetta, Aaron Kleinman, Sindhu T Mohanty, C Marcelo Sergio, Julian Quinn, Loan Nguyen-Yamamoto, Aimee-Lee Luco, Jinchu Vijay, Marie-Michelle Simon, Albena Pramatarova, Carolina Medina-Gomez, Katerina Trajanoska, Elena J Ghirardello, Natalie C Butterfield, Katharine F Curry, Victoria D Leitch, Penny C Sparkes, Anne-Tounsia Adoum, Naila S Mannan, Davide S K Komla-Ebri, Andrea S Pollard, Hannah F Dewhurst, Thomas A D Hassall, Michael-John G Beltejar, Douglas J Adams, Suzanne M Vaillancourt, Stephen Kaptoge, Paul Baldock, Cyrus Cooper, Jonathan Reeve, Evangelia E Ntzani, Evangelos Evangelou, Claes Ohlsson, David Karasik, Fernando Rivadeneira, Douglas P Kiel, Jonathan H Tobias, Celia L Gregson, Nicholas C Harvey, Elin Grundberg, David Goltzman, David J Adams, Christopher J Lelliott, David A Hinds, Cheryl L Ackert-Bicknell, Yi-Hsiang Hsu, Matthew T Maurano, Peter I Croucher, Graham R Williams, J H Duncan Bassett, David M Evans, J Brent Richards
In the version of this article initially published, in Fig. 5a, the data in the right column of 'DAAM2 gRNA1' were incorrectly plotted as circles indicating 'untreated' rather than as squares indicating 'treated'. The error has been corrected in the HTML and PDF versions of the article.
April 15, 2019: Nature Genetics
https://read.qxmd.com/read/30988374/differential-regulation-of-gene-expression-in-lung-cancer-cells-by-diacyglycerol-lactones-and-a-phorbol-ester-via-selective-activation-of-protein-kinase-c-isozymes
#3
Mariana Cooke, Victoria Casado-Medrano, Jihyae Ann, Jeewoo Lee, Peter M Blumberg, Martin C Abba, Marcelo G Kazanietz
Despite our extensive knowledge on the biology of protein kinase C (PKC) and its involvement in disease, limited success has been attained in the generation of PKC isozyme-specific modulators acting via the C1 domain, the binding site for the lipid second messenger diacylglycerol (DAG) and the phorbol ester tumor promoters. Synthetic efforts had recently led to the identification of AJH-836, a DAG-lactone with preferential affinity for novel isozymes (nPKCs) relative to classical PKCs (cPKCs). Here, we compared the ability of AJH-836 and a prototypical phorbol ester (phorbol 12-myristate 13-acetate, PMA) to induce changes in gene expression in a lung cancer model...
April 15, 2019: Scientific Reports
https://read.qxmd.com/read/30987688/teaching-surgical-model-development-in-research-by-using-situated-learning-and-instructional-scaffolding
#4
Ryan R Kelly, Mary Ann McCrackin, Dayvia L Russell, Lee R Leddy, James J Cray, Amanda C LaRue
Resources detailing the scope, details, and duration for teaching and learning surgical model development in research are poorly described. Situated learning and instructional scaffolding are useful skill-building tools. Herein, we discuss educational theory in the context of a training paradigm for surgical researchers, using our experience with a nonunion femoral fracture model as an example. Stages of learning include cognitive, associative, and autonomous stages. In surgical training, the cognitive stage involves the acquisition of basic knowledge, including anatomy, surgical approach, instrumentation, and suturing, which can be taught by using books, videos, skeletons, and cadavers...
April 15, 2019: Journal of the American Association for Laboratory Animal Science: JAALAS
https://read.qxmd.com/read/30977859/cost-effectiveness-of-short-course-radiation-therapy-vs-long-course-chemoradiation-for-locally-advanced-rectal-cancer
#5
Ann C Raldow, Aileen B Chen, Marcia Russell, Percy P Lee, Theodore S Hong, David P Ryan, James C Cusack, Jennifer Y Wo
Importance: Although both short-course radiotherapy and long-course chemoradiotherapy have been practiced in parallel for more than 15 years, no cost-effectiveness analysis comparing these 2 approaches in patients with locally advanced rectal cancer has been published. Objective: To analyze the cost-effectiveness of short-course radiotherapy vs long-course chemoradiotherapy for the treatment of patients with locally advanced rectal cancer. Design, Setting, and Participants: This economic evaluation used a cost-effectiveness model simulating 10-year outcomes for 1 million hypothetical patients aged 65 years with locally advanced rectal cancer treated with either short-course radiotherapy or long-course chemoradiotherapy, followed by surgery and chemotherapy...
April 5, 2019: JAMA Network Open
https://read.qxmd.com/read/30958695/apoe-genotype-influences-the-gut-microbiome-structure-and-function-in-humans-and-mice-relevance-for-alzheimer-s-disease-pathophysiology
#6
Tam T T Tran, Simone Corsini, Lee Kellingray, Claire Hegarty, Gwénaëlle Le Gall, Arjan Narbad, Michael Müller, Noemi Tejera, Paul W O'Toole, Anne-Marie Minihane, David Vauzour
Apolipoprotein E ( APOE) genotype is the strongest prevalent genetic risk factor for Alzheimer's disease (AD). Numerous studies have provided insights into the pathologic mechanisms. However, a comprehensive understanding of the impact of APOE genotype on microflora speciation and metabolism is completely lacking. In this study, we investigated the association between APOE genotype and the gut microbiome composition in human and APOE-targeted replacement (TR) transgenic mice. Fecal microbiota amplicon sequencing from matched individuals with different APOE genotypes revealed no significant differences in overall microbiota diversity in group-aggregated human APOE genotypes...
April 8, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/30953760/heritability-and-genetic-variance-of-dementia-with-lewy-bodies
#7
Rita Guerreiro, Valentina Escott-Price, Dena G Hernandez, Celia Kun-Rodrigues, Owen A Ross, Tatiana Orme, Joao Luis Neto, Susana Carmona, Nadia Dehghani, John D Eicher, Claire Shepherd, Laura Parkkinen, Lee Darwent, Michael G Heckman, Sonja W Scholz, Juan C Troncoso, Olga Pletnikova, Ted Dawson, Liana Rosenthal, Olaf Ansorge, Jordi Clarimon, Alberto Lleo, Estrella Morenas-Rodriguez, Lorraine Clark, Lawrence S Honig, Karen Marder, Afina Lemstra, Ekaterina Rogaeva, Peter St George-Hyslop, Elisabet Londos, Henrik Zetterberg, Imelda Barber, Anne Braae, Kristelle Brown, Kevin Morgan, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Janice Holton, Yaroslau Compta, Vivianna Van Deerlin, Geidy E Serrano, Thomas G Beach, Suzanne Lesage, Douglas Galasko, Eliezer Masliah, Isabel Santana, Pau Pastor, Monica Diez-Fairen, Miquel Aguilar, Pentti J Tienari, Liisa Myllykangas, Minna Oinas, Tamas Revesz, Andrew Lees, Brad F Boeve, Ronald C Petersen, Tanis J Ferman, Neill Graff-Radford, Nigel J Cairns, John C Morris, Stuart Pickering-Brown, David Mann, Glenda M Halliday, John Hardy, John Q Trojanowski, Dennis W Dickson, Andrew Singleton, David J Stone, Jose Bras
Recent large-scale genetic studies have allowed for the first glimpse of the effects of common genetic variability in dementia with Lewy bodies (DLB), identifying risk variants with appreciable effect sizes. However, it is currently well established that a substantial portion of the genetic heritable component of complex traits is not captured by genome-wide significant SNPs. To overcome this issue, we have estimated the proportion of phenotypic variance explained by genetic variability (SNP heritability) in DLB using a method that is unbiased by allele frequency or linkage disequilibrium properties of the underlying variants...
April 3, 2019: Neurobiology of Disease
https://read.qxmd.com/read/30951673/recirculating-intestinal-iga-producing-cells-regulate-neuroinflammation-via-il-10
#8
Olga L Rojas, Anne-Katrin Pröbstel, Elisa A Porfilio, Angela A Wang, Marc Charabati, Tian Sun, Dennis S W Lee, Georgina Galicia, Valeria Ramaglia, Lesley A Ward, Leslie Y T Leung, Ghazal Najafi, Khashayar Khaleghi, Beatriz Garcillán, Angela Li, Rickvinder Besla, Ikbel Naouar, Eric Y Cao, Pailin Chiaranunt, Kyle Burrows, Hannah G Robinson, Jessica R Allanach, Jennifer Yam, Helen Luck, Daniel J Campbell, David Allman, David G Brooks, Michio Tomura, Ryan Baumann, Scott S Zamvil, Amit Bar-Or, Marc S Horwitz, Daniel A Winer, Arthur Mortha, Fabienne Mackay, Alexandre Prat, Lisa C Osborne, Clinton Robbins, Sergio E Baranzini, Jennifer L Gommerman
No abstract text is available yet for this article.
April 4, 2019: Cell
https://read.qxmd.com/read/30933320/biopharmacological-considerations-for-accelerating-drug-development-of-deguelin-a-rotenoid-with-potent-chemotherapeutic-and-chemopreventive-potential
#9
REVIEW
Rahel Sarah Varughese, Walter Sze-Tung Lam, Ahmad Abdurrahman Bin Hanifah Marican, S Hema Viganeshwari, Anuja Satish Bhave, Nicholas L Syn, Jigang Wang, Andrea Li-Ann Wong, Alan Prem Kumar, Peter E Lobie, Soo Chin Lee, Gautam Sethi, Boon Cher Goh, Lingzhi Wang
Deguelin is a rotenoid compound that exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants. An analysis of evidence from both in vitro and in vivo studies suggests that deguelin displays potent anticancer activity against multiple cancer types and exhibits chemopreventive potential in Akt-inducible transgenic mouse models. Deguelin appears to impede carcinogenesis by enhancing cell apoptosis and hindering malignant transformation and tumor cell propagation. Crucial oncogenic pathways likely targeted by deguelin include the epithelial-to-mesenchymal transition; angiogenesis-related pathways; and the phosphoinositide 3-kinase/Akt, Wnt, epidermal growth factor receptor, c-Met, and hedgehog signal transduction cascades...
April 1, 2019: Cancer
https://read.qxmd.com/read/30932051/how-data-science-can-advance-mental-health-research
#10
REVIEW
Tom C Russ, Eva Woelbert, Katrina A S Davis, Jonathan D Hafferty, Zina Ibrahim, Becky Inkster, Ann John, William Lee, Margaret Maxwell, Andrew M McIntosh, Rob Stewart
Accessibility of powerful computers and availability of so-called big data from a variety of sources means that data science approaches are becoming pervasive. However, their application in mental health research is often considered to be at an earlier stage than in other areas despite the complexity of mental health and illness making such a sophisticated approach particularly suitable. In this Perspective, we discuss current and potential applications of data science in mental health research using the UK Clinical Research Collaboration classification: underpinning research; aetiology; detection and diagnosis; treatment development; treatment evaluation; disease management; and health services research...
January 2019: Nature Human Behaviour
https://read.qxmd.com/read/30926973/multi-ancestry-genome-wide-gene-smoking-interaction-study-of-387-272-individuals-identifies-new-loci-associated-with-serum-lipids
#11
Amy R Bentley, Yun J Sung, Michael R Brown, Thomas W Winkler, Aldi T Kraja, Ioanna Ntalla, Karen Schwander, Daniel I Chasman, Elise Lim, Xuan Deng, Xiuqing Guo, Jingmin Liu, Yingchang Lu, Ching-Yu Cheng, Xueling Sim, Dina Vojinovic, Jennifer E Huffman, Solomon K Musani, Changwei Li, Mary F Feitosa, Melissa A Richard, Raymond Noordam, Jenna Baker, Guanjie Chen, Hugues Aschard, Traci M Bartz, Jingzhong Ding, Rajkumar Dorajoo, Alisa K Manning, Tuomo Rankinen, Albert V Smith, Salman M Tajuddin, Wei Zhao, Mariaelisa Graff, Maris Alver, Mathilde Boissel, Jin Fang Chai, Xu Chen, Jasmin Divers, Evangelos Evangelou, Chuan Gao, Anuj Goel, Yanick Hagemeijer, Sarah E Harris, Fernando P Hartwig, Meian He, Andrea R V R Horimoto, Fang-Chi Hsu, Yi-Jen Hung, Anne U Jackson, Anuradhani Kasturiratne, Pirjo Komulainen, Brigitte Kühnel, Karin Leander, Keng-Hung Lin, Jian'an Luan, Leo-Pekka Lyytikäinen, Nana Matoba, Ilja M Nolte, Maik Pietzner, Bram Prins, Muhammad Riaz, Antonietta Robino, M Abdullah Said, Nicole Schupf, Robert A Scott, Tamar Sofer, Alena Stancáková, Fumihiko Takeuchi, Bamidele O Tayo, Peter J van der Most, Tibor V Varga, Tzung-Dau Wang, Yajuan Wang, Erin B Ware, Wanqing Wen, Yong-Bing Xiang, Lisa R Yanek, Weihua Zhang, Jing Hua Zhao, Adebowale Adeyemo, Saima Afaq, Najaf Amin, Marzyeh Amini, Dan E Arking, Zorayr Arzumanyan, Tin Aung, Christie Ballantyne, R Graham Barr, Lawrence F Bielak, Eric Boerwinkle, Erwin P Bottinger, Ulrich Broeckel, Morris Brown, Brian E Cade, Archie Campbell, Mickaël Canouil, Sabanayagam Charumathi, Yii-Der Ida Chen, Kaare Christensen, Maria Pina Concas, John M Connell, Lisa de Las Fuentes, H Janaka de Silva, Paul S de Vries, Ayo Doumatey, Qing Duan, Charles B Eaton, Ruben N Eppinga, Jessica D Faul, James S Floyd, Nita G Forouhi, Terrence Forrester, Yechiel Friedlander, Ilaria Gandin, He Gao, Mohsen Ghanbari, Sina A Gharib, Bruna Gigante, Franco Giulianini, Hans J Grabe, C Charles Gu, Tamara B Harris, Sami Heikkinen, Chew-Kiat Heng, Makoto Hirata, James E Hixson, M Arfan Ikram, Yucheng Jia, Roby Joehanes, Craig Johnson, Jost Bruno Jonas, Anne E Justice, Tomohiro Katsuya, Chiea Chuen Khor, Tuomas O Kilpeläinen, Woon-Puay Koh, Ivana Kolcic, Charles Kooperberg, Jose E Krieger, Stephen B Kritchevsky, Michiaki Kubo, Johanna Kuusisto, Timo A Lakka, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Benjamin Lehne, Cora E Lewis, Yize Li, Jingjing Liang, Shiow Lin, Ching-Ti Liu, Jianjun Liu, Kiang Liu, Marie Loh, Kurt K Lohman, Tin Louie, Anna Luzzi, Reedik Mägi, Anubha Mahajan, Ani W Manichaikul, Colin A McKenzie, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Lili Milani, Karen L Mohlke, Yukihide Momozawa, Andrew P Morris, Alison D Murray, Mike A Nalls, Matthias Nauck, Christopher P Nelson, Kari E North, Jeffrey R O'Connell, Nicholette D Palmer, George J Papanicolau, Nancy L Pedersen, Annette Peters, Patricia A Peyser, Ozren Polasek, Neil Poulter, Olli T Raitakari, Alex P Reiner, Frida Renström, Treva K Rice, Stephen S Rich, Jennifer G Robinson, Lynda M Rose, Frits R Rosendaal, Igor Rudan, Carsten O Schmidt, Pamela J Schreiner, William R Scott, Peter Sever, Yuan Shi, Stephen Sidney, Mario Sims, Jennifer A Smith, Harold Snieder, John M Starr, Konstantin Strauch, Heather M Stringham, Nicholas Y Q Tan, Hua Tang, Kent D Taylor, Yik Ying Teo, Yih Chung Tham, Henning Tiemeier, Stephen T Turner, André G Uitterlinden, Diana van Heemst, Melanie Waldenberger, Heming Wang, Lan Wang, Lihua Wang, Wen Bin Wei, Christine A Williams, Gregory Wilson, Mary K Wojczynski, Jie Yao, Kristin Young, Caizheng Yu, Jian-Min Yuan, Jie Zhou, Alan B Zonderman, Diane M Becker, Michael Boehnke, Donald W Bowden, John C Chambers, Richard S Cooper, Ulf de Faire, Ian J Deary, Paul Elliott, Tõnu Esko, Martin Farrall, Paul W Franks, Barry I Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Bernardo L Horta, Jyh-Ming Jimmy Juang, Yoichiro Kamatani, Candace M Kammerer, Norihiro Kato, Jaspal S Kooner, Markku Laakso, Cathy C Laurie, I-Te Lee, Terho Lehtimäki, Patrik K E Magnusson, Albertine J Oldehinkel, Brenda W J H Penninx, Alexandre C Pereira, Rainer Rauramaa, Susan Redline, Nilesh J Samani, James Scott, Xiao-Ou Shu, Pim van der Harst, Lynne E Wagenknecht, Jun-Sing Wang, Ya Xing Wang, Nicholas J Wareham, Hugh Watkins, David R Weir, Ananda R Wickremasinghe, Tangchun Wu, Eleftheria Zeggini, Wei Zheng, Claude Bouchard, Michele K Evans, Vilmundur Gudnason, Sharon L R Kardia, Yongmei Liu, Bruce M Psaty, Paul M Ridker, Rob M van Dam, Dennis O Mook-Kanamori, Myriam Fornage, Michael A Province, Tanika N Kelly, Ervin R Fox, Caroline Hayward, Cornelia M van Duijn, E Shyong Tai, Tien Yin Wong, Ruth J F Loos, Nora Franceschini, Jerome I Rotter, Xiaofeng Zhu, Laura J Bierut, W James Gauderman, Kenneth Rice, Patricia B Munroe, Alanna C Morrison, Dabeeru C Rao, Charles N Rotimi, L Adrienne Cupples
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings...
April 2019: Nature Genetics
https://read.qxmd.com/read/30923584/conditional-regression-based-on-a-multivariate-zero-inflated-logistic-normal-model-for-microbiome-relative-abundance-data
#12
Zhigang Li, Katherine Lee, Margaret R Karagas, Juliette C Madan, Anne G Hoen, A James O'Malley, Hongzhe Li
The human microbiome plays critical roles in human health and has been linked to many diseases. While advanced sequencing technologies can characterize the composition of the microbiome in unprecedented detail, it remains challenging to disentangle the complex interplay between human microbiome and disease risk factors due to the complicated nature of microbiome data. Excessive numbers e f zero values, high dimensionality, the hierarchical phylogenetic tree and compositional structure are compounded and consequently make existing methods inadequate to appropriately address these issues...
December 2018: Statistics in Biosciences
https://read.qxmd.com/read/30913959/patient-reported-reasons-for-declining-or-discontinuing-statin-therapy-insights-from-the-palm-registry
#13
Corey K Bradley, Tracy Y Wang, Shuang Li, Jennifer G Robinson, Veronique L Roger, Anne C Goldberg, Salim S Virani, Michael J Louie, L Veronica Lee, Eric D Peterson, Ann Marie Navar
Background Many adults eligible for statin therapy for cardiovascular disease prevention are untreated. Our objective was to investigate patient-reported reasons for statin underutilization, including noninitiation, refusal, and discontinuation. Methods and Results This study included the 5693 adults recommended for statin therapy in the PALM (Patient and Provider Assessment of Lipid Management) registry. Patient surveys evaluated statin experience, reasons for declining or discontinuing statins, and beliefs about statins and cardiovascular disease risk...
April 2, 2019: Journal of the American Heart Association
https://read.qxmd.com/read/30899092/the-bdnf-val66met-snp-modulates-the-association-between-beta-amyloid-and-hippocampal-disconnection-in-alzheimer-s-disease
#14
Nicolai Franzmeier, Jinyi Ren, Alexander Damm, Gemma Monté-Rubio, Mercè Boada, Agustín Ruiz, Alfredo Ramirez, Frank Jessen, Emrah Düzel, Octavio Rodríguez Gómez, Tammie Benzinger, Alison Goate, Celeste M Karch, Anne M Fagan, Eric McDade, Katharina Buerger, Johannes Levin, Marco Duering, Martin Dichgans, Marc Suárez-Calvet, Christian Haass, Brian A Gordon, Yen Ying Lim, Colin L Masters, Daniel Janowitz, Cihan Catak, Steffen Wolfsgruber, Michael Wagner, Esther Milz, Sonia Moreno-Grau, Stefan Teipel, Michel J Grothe, Ingo Kilimann, Martin Rossor, Nick Fox, Christoph Laske, Jasmeer Chhatwal, Peter Falkai, Robert Perneczky, Jae-Hong Lee, Annika Spottke, Henning Boecker, Frederic Brosseron, Klaus Fliessbach, Michael T Heneka, Peter Nestor, Oliver Peters, Manuel Fuentes, Felix Menne, Josef Priller, Eike J Spruth, Christiana Franke, Anja Schneider, Christine Westerteicher, Oliver Speck, Jens Wiltfang, Claudia Bartels, Miguel Ángel Araque Caballero, Coraline Metzger, Daniel Bittner, Stephen Salloway, Adrian Danek, Jason Hassenstab, Igor Yakushev, Peter R Schofield, John C Morris, Randall J Bateman, Michael Ewers
In Alzheimer's disease (AD), a single-nucleotide polymorphism in the gene encoding brain-derived neurotrophic factor (BDNFVal66Met ) is associated with worse impact of primary AD pathology (beta-amyloid, Aβ) on neurodegeneration and cognitive decline, rendering BDNFVal66Met an important modulating factor of cognitive impairment in AD. However, the effect of BDNFVal66Met on functional networks that may underlie cognitive impairment in AD is poorly understood. Using a cross-validation approach, we first explored in subjects with autosomal dominant AD (ADAD) from the Dominantly Inherited Alzheimer Network (DIAN) the effect of BDNFVal66Met on resting-state fMRI assessed functional networks...
March 21, 2019: Molecular Psychiatry
https://read.qxmd.com/read/30898840/extracellular-matrix-protein-tenascin-c-increases-phagocytosis-mediated-by-cd47-loss-of-function-in-glioblastoma
#15
Shuli Xia, Ding Ma, Senquan Liu, Bachchu Lal, Shuang Wei, Shuyan Wang, Daqian Zhan, Hao Zhang, Richard S Lee, Peisong Gao, Hernando Lopez-Bertoni, Mingyao Ying, Jian Jian Li, John Laterra, Mary Ann Wilson
Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME). CD47 has been shown to mediate immune evasion, as the CD47-SIRPα axis prevents phagocytosis of tumor cells by macrophages and other myeloid cells. In this study, we established CD47 homozygous deletion (CD47-/-) in human and mouse GBM cells and investigated the impact of eliminating the "don't eat me" signal on tumor growth and tumor-TME interactions...
March 21, 2019: Cancer Research
https://read.qxmd.com/read/30889217/diagnosing-cardiovascular-disease-in-western-lowland-gorillas-gorilla-gorilla-gorilla-with-brain-natriuretic-peptide
#16
Suzan Murray, Jennifer C Kishbaugh, Lee-Ann C Hayek, Ilana Kutinsky, Patricia M Dennis, William Devlin, Katharine L Hope, Marietta D Danforth, Hayley W Murphy
Cardiovascular disease is a leading cause of death in zoo-housed great apes, accounting for 41% of adult gorilla death in North American zoological institutions. Obtaining a timely and accurate diagnosis of cardiovascular disease in gorillas is challenging, relying on echocardiography which generally requires anesthetic medications that may confound findings and can cause severe side effects in cardiovascularly compromised animals. The measurement of brain natriuretic peptide (BNP) has emerged as a modality of interest in the diagnosis, prognosis and treatment of human patients with heart failure...
2019: PloS One
https://read.qxmd.com/read/30887517/targeted-therapy-of-the-akt-kinase-inhibits-esophageal-squamous-cell-carcinoma-growth-in-vitro-and-in-vivo
#17
Xuejiao Liu, Mengqiu Song, Penglei Wang, Ran Zhao, Hanyong Chen, Man Zhang, Yuanyuan Shi, Kangdong Liu, Fangfang Liu, Ran Yang, Enmin Li, Ann M Bode, Zigang Dong, Mee-Hyun Lee
Esophageal cancer, a leading cause of cancer death worldwide, is associated with abnormal activation of the AKT signaling pathway. Xanthohumol, a prenylated flavonoid tested in clinical trials, is reported to exert anti-diabetes, anti-inflammation and anticancer activities. However, the mechanisms underlying its chemopreventive or chemotherapeutic effects remain elusive. In the present study, we found that xanthohumol directly targeted AKT1/2 in esophageal squamous cell carcinoma (ESCC). Xanthohumol significantly inhibited the AKT kinase activity in an ATP competitive manner, which was confirmed in binding and kinetic studies and computational docking models...
March 18, 2019: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/30876714/prophylactic-versus-therapeutic-mastectomy-a-contemporary-analysis-of-the-acs-nsqip-database
#18
Ryan J Hendrix, Connie Lee, Ann-Kristin Friedrich, Eva Rouanet, Anne C Larkin, Jennifer LaFemina
INTRODUCTION: The objective of the study was to evaluate the morbidity, mortality, and postoperative outcomes associated with simple or subcutaneous mastectomy in the management of prophylactic versus therapeutic resection. In this study we aimed to assess if simple or subcutaneous mastectomy for prophylaxis affects perioperative outcomes compared with resection performed for biopsy proven malignancy. MATERIALS AND METHODS: The American College of Surgeons National Surgical Quality Improvement Program database was queried for subjects who underwent simple or subcutaneous mastectomy between 2007 and 2012...
January 31, 2019: Clinical Breast Cancer
https://read.qxmd.com/read/30867156/usability-testing-of-a-sick-day-protocol-in-chronic-kidney-disease
#19
Rebecca M Doerfler, Clarissa J Diamantidis, Lee-Ann Wagner, Beth M Scism, Monifa Vaughn-Cooke, Wanda J Fink, Thomas Blakeman, Jeffrey C Fink
No abstract text is available yet for this article.
March 13, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30846610/human-impact-erodes-chimpanzee-behavioral-diversity
#20
Hjalmar S Kühl, Christophe Boesch, Lars Kulik, Fabian Haas, Mimi Arandjelovic, Paula Dieguez, Gaëlle Bocksberger, Mary Brooke McElreath, Anthony Agbor, Samuel Angedakin, Emmanuel Ayuk Ayimisin, Emma Bailey, Donatienne Barubiyo, Mattia Bessone, Gregory Brazzola, Rebecca Chancellor, Heather Cohen, Charlotte Coupland, Emmanuel Danquah, Tobias Deschner, Orume Diotoh, Dervla Dowd, Andrew Dunn, Villard Ebot Egbe, Henk Eshuis, Rumen Fernandez, Yisa Ginath, Annemarie Goedmakers, Anne-Céline Granjon, Josephine Head, Daniela Hedwig, Veerle Hermans, Inaoyom Imong, Kathryn J Jeffery, Sorrel Jones, Jessica Junker, Parag Kadam, Mbangi Kambere, Mohamed Kambi, Ivonne Kienast, Deo Kujirakwinja, Kevin Langergraber, Juan Lapuente, Bradley Larson, Kevin Lee, Vera Leinert, Manuel Llana, Giovanna Maretti, Sergio Marrocoli, Tanyi Julius Mbi, Amelia C Meier, Bethan Morgan, David Morgan, Felix Mulindahabi, Mizuki Murai, Emily Neil, Protais Niyigaba, Lucy Jayne Ormsby, Liliana Pacheco, Alex Piel, Jodie Preece, Sebastien Regnaut, Aaron Rundus, Crickette Sanz, Joost van Schijndel, Volker Sommer, Fiona Stewart, Nikki Tagg, Elleni Vendras, Virginie Vergnes, Adam Welsh, Erin G Wessling, Jacob Willie, Roman M Wittig, Kyle Yurkiw, Klaus Zuberbuehler, Ammie K Kalan
Chimpanzees possess a large number of behavioral and cultural traits among non-human species. The 'disturbance hypothesis' predicts that human impact depletes resources and disrupts social learning processes necessary for behavioral and cultural transmission. We used an unprecedented data set of 144 chimpanzee communities, with information on 31 behaviors, to show that chimpanzees inhabiting areas with high human impact have a mean probability of occurrence reduced by 88%, across all behaviors, compared to low impact areas...
March 7, 2019: Science
keyword
keyword
108285
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"