Juliette Demortier, Mathieu Vautier, Olivier Chosidow, Laure Gallay, Didier Bessis, Alice Berezne, Nadège Cordel, Jean Schmidt, Amar Smail, Pierre Duffau, Marie Jachiet, Edouard Begon, Jeremy Gottlieb, François Chasset, Julie Graveleau, Myriam Marque, Elise Cesbron, Amandine Forestier, Séverine Josse, Nicolas Kluger, Caroline Beauchêne, Yannick Le Corre, Valentine Pagis, Aude Rigolet, Perrine Guillaume-Jugnot, François-Jérôme Authier, Nelly Guilain, Nathalie Streichenberger, Sarah Leonard-Louis, Samia Boussouar, Océane Landon-Cardinal, Olivier Benveniste, Yves Allenbach
OBJECTIVE: Among specific autoantibodies in DM, the anti-small ubiquitin-like modifier activating enzyme (SAE) antibody is rare. We aim to describe the clinical characteristics, cancer prevalence, and muscle pathology of anti-SAE-positive DM. METHODS: Patients with a diagnosis of DM and sera positive for the anti-SAE antibody were recruited from 19 centres in this retrospective observational study. The available muscular biopsies were reviewed. We conducted a comparison with anti-SAE-negative DM and a review of the literature...
December 1, 2023: Rheumatology