keyword
https://read.qxmd.com/read/38524641/remarkable-remission-of-symptomatic-dermatomyositis-after-curative-breast-cancer-surgery
#1
JOURNAL ARTICLE
Makoto Fujino, Masahiro Kawashima, Hajime Yoshifuji, Ran Nakashima, Yosuke Yamada, Yoshiaki Matsumoto, Nobuko Kawaguchi-Sakita, Yukiko Mori, Fengling Pu, Ayane Yamaguchi, Kosuke Kawaguchi, Masahiro Takada, Masakazu Toi
Dermatomyositis (DM) is an autoimmune disease that causes proximal muscle weakness in the extremities leading to severe immobility and dysphagia. Approximately 20% of patients with DM are positive for anti-TIF-1γ antibody and frequently accompanied by malignant tumors. Although DM remission after tumor resection has been reported, the indications for surgery in patients with severe DM are unknown. Herein, we report a case of a 79-year-old Japanese woman who presented with breast cancer and anti-TIF-1γ antibody-positive DM...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38414744/small-cell-lung-cancer-with-dermatomyositis-a-case-report
#2
Xiaomin Guan, Shi Qiu, Yinghui Xu, Jianjiao Zu, Chao Sun, Ye Guo, Xu Wang, Kewei Ma
Dermatomyositis represents an autoimmune disorder characterized by notable skin and muscular manifestations. The annual incidence of dermatomyositis stands at approximately (5~10)/1 million individuals. Notably, patients with malignant tumors exhibit an elevated risk of developing dermatomyositis compared to the general population. However, in cases where dermatomyositis co-occurs with malignancy, the efficacy of hormone therapy alone tends to be suboptimal. Moreover, reports addressing the correlation between tumor treatment and the management of dermatomyositis are scarce...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38410335/targeting-weakness-with-a-combination-of-isotonic-exercises-in-dermatomyositis-with-polyneuropathy-a-case-report
#3
Vaishnavi R Waghe, Anam R Sasun, Raghuveer Raghumahanti
Dermatomyositis, an autoimmune inflammatory myositis commonly linked to polymyositis, is marked by inflammatory and degenerative transformations impacting muscles, skin, limb girdles, the neck, and the pharynx. These changes result in symmetrical weakness and diverse levels of muscle atrophy. Uncommonly, the condition may impact the esophagus, lungs, and heart. While dermatomyositis is believed to involve genetic, immunological, and environmental factors, its precise etiology remains elusive. Typically, the classical presentation involves a symmetrical proximal myopathy alongside dermatological manifestations such as a purplish-red rash affecting the face, arms, hands, legs, and other areas...
January 2024: Curēus
https://read.qxmd.com/read/38410065/magnetic-resonance-imaging-patterns-revealing-muscle-pathology-and-clinical-features-in-idiopathic-inflammatory-myopathies
#4
JOURNAL ARTICLE
Takashi Shimoyama, Ken Yoshida, Yoshinao Muro, Haruyasu Ito, Takayuki Matsushita, Yohsuke Oto, Taro Ukichi, Kentaro Noda, Daitaro Kurosaka
OBJECTIVE: Idiopathic inflammatory myopathies (IIMs) are autoimmune disorders significantly impacting skeletal muscles; however, the precise correlation between muscle magnetic resonance imaging (MRI) findings, muscle pathology, disease subtypes, and clinical characteristics remains uncertain. Thus, we investigated the association of muscle MRI findings in IIMs with muscle pathology and clinical features. METHODS: New-onset IIM patients underwent proximal upper and/or lower limb muscle MRI...
February 26, 2024: Rheumatology
https://read.qxmd.com/read/38205150/a-case-of-dermatomyositis-with-coexistence-of-positive-anti-mda5-antibodies-and-anti-ssa-ro52-antibodies-combined-with-necrotic-skin-ulcers
#5
Tian Sun, Zhong Hao Hu, Jin Shi He, Yu Chi Chen, Yong Xiang Gao
BACKGROUND: Dermatomyositis (DM) is an idiopathic inflammatory myopathy that is clinically challenging to diagnose and has a poor prognosis. It is characterized by symmetric proximal muscle weakness, muscle tenderness, dysphagia, characteristic skin rash (heliotrope rash, Gottron's sign), elevated muscle enzyme levels, abnormal electromyography, and muscle biopsy findings. DM with positive anti-MDA5 antibodies is mainly characterized by Gottron's sign, skin ulcers, facial erythema, mechanic's hands, and V-sign...
2024: International Medical Case Reports Journal
https://read.qxmd.com/read/38163807/a-rare-case-of-primary-sjogren-s-syndrome-with-idiopathic-pulmonary-fibrosis-with-variable-presentations-a-case-report
#6
JOURNAL ARTICLE
A Yadav, R B Nepali, A M J Alam
We diagnosed and treated a case of Primary SjoGren's Syndrome with Idiopathic Pulmonary Fibrosis (IPF) in a 65 years old woman who presented with dyspnoea and multiple joint pains for 5 years and remained undiagnosed. She had variable presentation and was initially established as a case of mixed connective tissue disease which consists of Systemic Lupus Erythematosus (SLE), Systemic Sclerosis and Dermatomyositis. She complained of xerostomia, xerophthalmia, difficulty in opening mouth, progressive dysphagia with solid foods and raynaud's phenomenon...
January 2024: Mymensingh Medical Journal: MMJ
https://read.qxmd.com/read/38116495/a-case-report-of-anti-tif1-%C3%AE-antibody-positive-dermatomyositis-concomitant-with-small-cell-neuroendocrine-carcinoma-of-the-urinary-bladder
#7
Hiroyuki Hounoki, Takafumi Onose, Miho Yamazaki, Ryoko Asano, Satoshi Yamaguchi, Koichiro Shinoda, Kazuyuki Tobe, Akira Noguchi, Kenichi Hirabayashi
Small cell neuroendocrine carcinoma is rare among urinary bladder cancer types, and to date, there are no case reports of concurrent antitranscriptional intermediary factor 1- γ antibody-positive dermatomyositis. We describe the case of a 69-year-old Japanese man who presented with elevated creatine kinase levels and haematuria on medical examination. Approximately one month later, he developed dysphagia. Laryngoscopy confirmed laryngeal dysfunction. He also presented with muscle weakness and a skin rash...
2023: Case Reports in Rheumatology
https://read.qxmd.com/read/37926535/a-case-of-anti-nxp2-antibody-positive-juvenile-dermatomyositis-with-characteristic-fascial-thickening-on-muscle-ultrasound-and-improvement-with-immunotherapy
#8
JOURNAL ARTICLE
Koji Fukushima, Takeshi Yoshida, Hiroki Yamazaki, Naoko Takamatsu, Takashi Nagai, Yusuke Osaki, Masafumi Harada, Ichizo Nishino, Naoko Okiyama, Kazuma Sugie, Yuishin Izumi
We herein report a 12-year-old boy who presented with a fever, erythematous rash on the cheeks, back pain, and dysphagia. Blood tests revealed increased creatine kinase levels, and muscle ultrasonography (MUS) revealed characteristic fascial thickening in the lumbar paraspinal muscles, where myalgia was prominent. Sarcoplasmic expression of myxovirus-resistant protein A on a muscle biopsy and the presence of anti-nuclear matrix protein 2 (NXP2) antibodies confirmed the diagnosis of dermatomyositis. Prednisolone and intravenous immunoglobulin therapy improved the clinical and laboratory parameters as well as fascial thickening...
November 6, 2023: Internal Medicine
https://read.qxmd.com/read/37880118/-two-cases-of-anti-nuclear-matrix-protein-2-antibody-positive-dermatomyositis-sine-dermatitis-with-severe-diffuse-subcutaneous-edema-and-dysphagia
#9
JOURNAL ARTICLE
Yoshiaki Takahashi, Motonori Takamiya, Yuki Ichimura, Naoko Okiyama, Ichizo Nishino, Nobutoshi Morimoto
Case 1 involved a 68-year-old woman who was admitted to our hospital because of muscle weakness, diffuse subcutaneous edema, dysphagia, and an elevated serum creatine kinase level that had worsened within the previous month. Case 2 involved a 78-year-old woman who was admitted to our hospital because of muscle weakness, bilateral shoulder pain, diffuse subcutaneous edema, and dysphagia that had gradually worsened during the past 5 months. Both patients showed severe diffuse subcutaneous edema and dysphagia and underwent enteral tube feeding...
October 25, 2023: Rinshō Shinkeigaku, Clinical Neurology
https://read.qxmd.com/read/37863375/clinical-features-of-dermatomyositis-patients-with-anti-tif1-antibodies-a-case-based-comprehensive-review
#10
REVIEW
Ozgur C Kilinc, Serdal Ugurlu
BACKGROUND AND OBJECTIVES: Dermatomyositis is chronic autoimmune disease primarily affecting skin and muscles. Antibodies are key players of pathogenesis and are in strong correlation with distinct clinical phenotypes. We present a case and a comprehensive review of the literature on dermatomyositis patients with Anti TIF1 antibodies. METHODS: PubMed and Web of Science databases were reviewed. 166 articles were identified; 95 of them were evaluated; 79 of them included to the study...
December 2023: Autoimmunity Reviews
https://read.qxmd.com/read/37830399/a-case-of-anti-sae1-2-antibody-positive-dermatomyositis-with-extensive-panniculitis-a-possible-cutaneous-manifestation-of-treatment-resistance
#11
JOURNAL ARTICLE
Misako Fujisaki, Hiroshi Kasamatsu, Kentarou Nishimura, Yasuyuki Yoshida, Yoriko Muneishi, Tomohisa Yamaguchi, Ichizo Nishino, Risa Konishi, Yuki Ichimura, Naoko Okiyama, Noritaka Oyama, Minoru Hasegawa
Dermatomyositis constitutes a heterogeneous group of autoimmune inflammatory conditions with a wide variety of clinical outcomes. The symptomatic heterogeneity carries skin, muscle, and joint manifestations; pulmonary and cardiac involvements; and concomitant malignancy. Any of these symptoms often appear at different combinations and time courses, thus posing difficulty in early diagnosis and appropriate treatment choice. Recent progress in laboratory investigations explored the identification of several myositis-specific autoantibodies (MSAs) and myositis-associated autoantibodies, allowing precise characterization for a clinical perspective of the disease...
October 13, 2023: Journal of Dermatology
https://read.qxmd.com/read/37828536/nailfold-capillary-density-in-140-untreated-children-with-juvenile-dermatomyositis-an-indicator-of-disease-activity
#12
JOURNAL ARTICLE
Lauren M Pachman, Gabrielle Morgan, Marisa S Klein-Gitelman, Najah Ahsan, Amer Khojah
BACKGROUND: We lack a reliable indicator of disease activity in Juvenile Dermatomyositis (JDM), a rare disease. The goal of this study is to identify the association of nailfold capillary End Row Loop (ERL) loss with disease damage in children with newly diagnosed, untreated JDM. FINDINGS: We enrolled 140 untreated JDM and 46 age, race and sex matched healthy controls, ages 2-17. We selected items from the Juvenile Myositis Registry for analysis. Variables include average ERL density of 8 fingers, average capillary pattern, hemorrhages, and clinical and laboratory correlates...
October 13, 2023: Pediatric Rheumatology Online Journal
https://read.qxmd.com/read/37812480/characterising-oesophageal-motility-disorders-by-high-resolution-impedance-manometry-in-dermatomyositis-patients
#13
JOURNAL ARTICLE
Chiara Rizzo, Lidia La Barbera, Gabriele Barletta, Federica Camarda, Denise Donzella, Giorgio Romano, Antonino Agrusa, Sebastiano Bonventre, Giuliana Guggino
OBJECTIVES: We studied high-resolution impedance manometry (HRiM) findings in dermatomyositis (DM) to detect oesophageal dysmotility, even in asymptomatic patients, and correlated the alterations to clinical and serological disease domains. METHODS: We performed a cross-sectional study of DM patients, enrolled between December 2021 and December 2022. All patients underwent rheumatological, laboratory and HRiM assessment. HRiM findings were compared with different clinical and serological profiles...
September 19, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37805487/juvenile-dermatomyositis-in-afro-caribbean-children-a-cohort-study-in-the-french-west-indies
#14
JOURNAL ARTICLE
Arthur Felix, Frederique Delion, Fabienne Louis-Sidney, Lindsay Osei, Aurélie Armougon, Remi Bellance, Moustapha Dramé, Christophe Deligny, Benoit Suzon, Yves Hatchuel
INTRODUCTION: The epidemiology of Juvenile Dermatomyositis (JDM) in non-Caucasian population is poorly described. We performed a study of patients followed up in the French West Indies for JDM. We aimed to describe clinical and biological specificities during childhood. METHODS: Retrospective study covering the period from Januarys 2000-2023. Listings of patients were obtained from multiple sources, namely computerized hospital archives, registry of referent pediatricians and adult specialists in internal medicine and the French National Registry for rare diseases...
October 7, 2023: Pediatric Rheumatology Online Journal
https://read.qxmd.com/read/37801141/clinical-profile-of-anti-nxp-2-antibody-positive-inflammatory-myositis-and-outcome-in-an-indian-population
#15
JOURNAL ARTICLE
Abhilasha Manwatkar, Shivraj Padiyar, Aswin Nair, Avanish Jha, Sathish Kumar, Bijesh Yadav, John Antony Jude Prakash, John Kumar Das, John Mathew
INTRODUCTION: Myositis-specific antibodies (MSA) play an important role in the clinical presentation and prognosis of patients with idiopathic inflammatory myositis (IIM). Anti-NXP-2 is one of the newly described MSA. OBJECTIVE: We aimed to describe various clinical presentations associated with anti-NXP2 antibodies and assess response to treatment. METHODS: In this retrospective study, the electronic medical records of all patients who tested positive for anti-NXP2 during June 2019 to April 2022 were screened...
October 6, 2023: Clinical Rheumatology
https://read.qxmd.com/read/37748434/clinical-characteristics-and-prognostic-value-of-ro52-ssa-antibodies-in-idiopathic-inflammatory-myopathies
#16
JOURNAL ARTICLE
Elizabeth Pepper, Lilian Vilar, Ian M Ward
BACKGROUND/PURPOSE: Anti-Ro52 are myositis-associated antibodies found in idiopathic inflammatory myopathies (IIMs). This chart review aims to evaluate the frequency, significance, and associated clinical characteristics of Ro52/SSA positivity in IIM patients. METHODS: We performed a chart review of IIM patients diagnosed between January 2006 and December 2020. All patients met either the 1975 Bohan and Peter or the European League Against Rheumatism/American College of Rheumatology classification criteria for probable or definite myositis...
October 1, 2023: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://read.qxmd.com/read/37697781/an-overview-of-the-management-and-rehabilitation-of-dysphagia
#17
REVIEW
Mari Nakao-Kato, Farooq Azam Rathore
Dysphagia is a medical condition that makes it difficult for a person to eat or swallow. It is estimated that 590 million people worldwide have dysphagia. The causes are varied and include neurological disorders like stroke and motor neuron disease, head and neck cancer, neuromuscular diseases, inflammatory diseases such as dermatomyositis, dementia, cervical spinal cord injury, and anterior vertebral ossification. The assessment and screening of dysphagia consists of a questionnaire-based interview, mealtime observation, and, if deemed necessary by a screening test or instrumental examination by specialists...
August 2023: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/37666644/in-inflammatory-myopathies-dropped-head-bent-spine-syndrome-is-associated-with-scleromyositis-an-international-case-control-study
#18
JOURNAL ARTICLE
Luc Pijnenburg, Margherita Giannini, Maude Bouchard-Marmen, Laurent Arnaud, Simone Barsotti, Silvia Bellando-Randone, Livio Bernardi, Paola Bini, Jelena Blagojevic, Veronica Codullo, Marion Couderc, Claire De Moreuil, Emanuelle Dernis, Luca Diamanti, Jean Jacques Dubost, Fanny Duval, Giacomo Emmi, Jean-Marc Galempoix, Bernard Geny, Jacques-Eric Gottenberg, Monica Groza, Aurelien Guffroy, Isabelle Guichard, Philippe Guilpain, Baptiste Hervier, Marie Hudson, Luca Iaccarino, Florenzo Iannone, Delphine Lebrun, Enrico Marchioni, Kuberaka Mariampillai, Francois Maurier, Marta Mosca, Aleksandra Nadaj-Pakleza, Carlotta Nannini, Jean-Maxime Piot, Sergio Prieto-González, Nicolas Poursac, Eglantine Rouanet, Jérémie Sellam, Albert Selva-O'Callaghan, François Séverac, Jean Sibilia, Guilhem Sole, Antoine Soulages, Benjamin Terrier, Anne Tournadre, Yves Troyanov, Nathalie Vernier, Veronique Vesperini, Jean-François Viallard, Rahima Ziane, Lorenzo Cavagna, Alain Meyer
BACKGROUND: Some myopathies can lead to dropped head or bent spine syndrome (DH/BS). The significance of this symptom has not been studied in inflammatory myopathies (IM). OBJECTIVES: To assess the significance of DH/BS in patients with IM. METHODS: Practitioners from five IM networks were invited to report patients with IM suffering from DH/BS (without other known cause than IM). IM patients without DH/BS, randomly selected in each participating centre, were included as controls at a ratio of 2 to 1...
September 2023: RMD Open
https://read.qxmd.com/read/37591620/dermatomyositis-a-debilitating-paraneoplastic-phenomenon-following-a-diagnosis-of-localised-squamous-cell-carcinoma-of-the-cervix
#19
JOURNAL ARTICLE
Victoria Floyd-Ellis, Alexandra Taylor
This case report describes the management of a patient, recently diagnosed with Stage IIIC cervical cancer, presenting with significant proximal muscle weakness, dysphagia and cutaneous changes over the hands, knees and outer thighs bilaterally. Following multiple investigations, this clinical presentation was proven to be dermatomyositis as a paraneoplastic phenomenon, a rare diagnosis with cervical cancer.Improvement of the presenting symptoms followed commencement of radical chemoradiation to the primary tumour plus administration of high dose steroids and intravenous immunoglobulins...
August 17, 2023: BMJ Case Reports
https://read.qxmd.com/read/37405442/long-standing-and-poorly-controlled-disease-in-juvenile-dermatomyositis-is-associated-with-calcinosis-a-real-world-experience-from-a-low-middle-income-country
#20
JOURNAL ARTICLE
Pankti Mehta, Able Lawrence, Latika Gupta, Durga P Misra, Vikas Agarwal, Ramnath Misra, Amita Aggarwal
To study the prevalence and predictors of calcinosis in Juvenile Dermatomyositis (JDM). Medical records over 20 years at a tertiary care rheumatology center in Northern India were reviewed to identify patients with JDM and clinical details were recorded. The frequency of calcinosis, predictors, specific treatment, and its outcomes were studied. Data are expressed as median and interquartile range. In eighty-six patients (median age 10) of JDM, the frequency of calcinosis was 18.2% (8.5% at presentation)...
July 5, 2023: Rheumatology International
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