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dermatomyositis dysphagia

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https://read.qxmd.com/read/30767866/clinical-features-of-thirty-two-patients-with-anti-melanoma-differentiation-associated-gene-5-antibodies
#1
Wenhan Huang, Feifeng Ren, Qian Wang, Lei Luo, Jun Zhou, Dongmei Huang, Zhuma Pan, Lin Tang
OBJECTIVES: To investigate the clinical characteristics of patients positive for anti-melanoma differentiation-associated gene 5 (MDA5) antibodies, and to analyse the potential pathogenesis of anti-MDA5 antibodies. METHODS: The clinical manifestations, serological tests, imaging features, treatments, and prognoses of 32 anti-MDA5 antibody-positive patients diagnosed in the Rheumatology and Immunology Department of the Second Affiliated Hospital of Chongqing Medical University from September 2015 to August 2018 were analysed...
February 11, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30766682/lung-adenocarcinoma-and-anti-transcriptional-intermediary-factor-1-gamma-positive-dermatomyositis-complicated-with-spontaneous-oesophageal-rupture
#2
Takeshi Saraya, Masaki Tamura, Keisuke Kasuga, Masachika Fujiwara, Hajime Takizawa
A 58-year-old man presented with a two-month history of facial erythema and dry cough. Physical examination revealed typical cutaneous manifestations of dermatomyositis (DM), including heliotrope rash and shawl sign. A chest X-ray revealed a 4-cm mass in the right middle lung. After bronchoscopy and investigation of auto-antibodies, he was diagnosed with co-occurring transcriptional intermediary factor 1-gamma (TIF1-γ) positive DM and lung adenocarcinoma. He was administered oral prednisolone for subsequent muscle weakness, but developed TIF1-γ positive DM-associated oropharyngeal dysphagia complicated by spontaneous oesophageal rupture and died from progression of chemoresistant lung cancer...
April 2019: Respirology Case Reports
https://read.qxmd.com/read/30657080/favorable-rituximab-response-in-patients-with-refractory-idiopathic-inflammatory-myopathies
#3
Fernando Henrique Carlos de Souza, Renata Miossi, Júlio Cesar Bertacini de Moraes, Eloisa Bonfá, Samuel Katsuyuki Shinjo
BACKGROUND: Interpretation of rituximab efficacy for refractory idiopathic inflammatory myopathies (IIM) is hampered by the absence of a uniform definition of refractory myositis and clinical response. Therefore, rigorous criteria of refractoriness, together with a homogenous definition of clinical improvement, were used to evaluate rituximab one-year response. METHODS: A retrospective cohort study including 43 IIM (15 antisynthetase syndrome, 16 dermatomyositis, 12 polymyositis) was conducted...
September 18, 2018: Advances in rheumatology
https://read.qxmd.com/read/30645753/serum-soluble-trail-a-potential-biomarker-for-disease-activity-in-myositis-patients
#4
Hang Zhou, Yunchao Wang, Kuo Bi, Haiyu Qi, Shuju Song, Mingzhu Zhou, Letian Chen, Guochun Wang, Ting Duan
OBJECTIVES: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF super-family, which is involved in the regulation of immune response and pathogenesis of autoimmune diseases, including polymyositis (PM) and dermatomyositis (DM). In this study, we examined the level and origin of serum-soluble TRAIL (sTRAIL) in patients with PM and DM and analyzed its association with disease activity and clinical features. METHOD: 11 PM patients, 33 DM patients, and 20 healthy controls were enrolled in this study...
January 15, 2019: Clinical Rheumatology
https://read.qxmd.com/read/30458207/association-of-antinuclear-antibody-status-with-clinical-features-and-malignancy-risk-in-adult-onset-dermatomyositis
#5
Paul M Hoesly, Jason C Sluzevich, Anokhi Jambusaria-Pahlajani, Elizabeth R Lesser, Michael G Heckman, Andy Abril
BACKGROUND: The clinical significance of antinuclear antibody (ANA) status in adults with dermatomyositis (DM) has yet to be fully defined. OBJECTIVE: We compared the incidence of amyopathic disease, risk of malignancy, and clinical findings in ANA-positive and ANA-negative patients with adult-onset DM. METHODS: This was a retrospective cohort study of patients with ANA-positive or ANA-negative adult-onset DM determined by enzyme-linked immunosorbent assay...
November 17, 2018: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/30146744/long-term-follow-up-of-76-iranian-patients-with-idiopathic-inflammatory-myopathies
#6
Mehrzad Hajialilo, Amir Ghorbanihaghjo, Alireza Khabbazi, Sousan Kolahi, Mohammad Reza Jafari Nakhjavani, Ali Asghar Ebrahimi, Hamid Zareh, Aida Malek Mahdavi
AIM: This study aimed to follow up patients with polymyositis (PM) and/or dermatomyositis (DM) to determine survival rate, pattern of disease, response to treatment, malignancy incidence and poor prognostic factors (PPFs). METHOD: A total of 76 patients with PM (n = 47) and/or DM (n = 29) based on Bohan and Peter diagnostic criteria referred to the Imam-Reza Hospital were followed up from 2004 to 2016. The follow-up period was considered from diagnosis to patient's death or last visit...
August 2018: International Journal of Rheumatic Diseases
https://read.qxmd.com/read/30016492/features-distinguishing-clinically-amyopathic-juvenile-dermatomyositis-from-juvenile-dermatomyositis
#7
Gulnara Mamyrova, Takayuki Kishi, Ira N Targoff, Alison Ehrlich, Rodolfo V Curiel, Lisa G Rider
Objective: We examined features of clinically amyopathic JDM (CAJDM), in which patients have characteristic rashes with little to no evidence of muscle involvement, to determine whether this is a distinct phenotype from JDM. Methods: Demographic, clinical, laboratory and treatment data from 12 (9 hypomyopathic, 3 amyopathic) patients meeting modified Sontheimer criteria for CAJDM and from 60 matched JDM patients meeting Bohan and Peter criteria were examined. Differences were evaluated by Fisher's exact and Mann-Whitney tests, random forests and logistic regression analysis...
November 1, 2018: Rheumatology
https://read.qxmd.com/read/29848519/subcutaneous-oedema-of-upper-limbs-heralding-an-aggressive-form-of-dermatomyositis
#8
Mohit Shukla, Rishi Patel, Halyna Kuzyshyn, David Feinstein
Subcutaneous oedema is a rare presenting clinical manifestation of dermatomyositis. In this case, we report a 44-year-old man presenting with bilateral upper extremity predominant swelling and weakness. The proximal muscle weakness, dysphagia and presence of Gottron's papules as well poikiloderma like skin changes led to the clinical diagnosis of dermatomyositis. He received aggressive treatment with high-dose glucocorticoids and required intravenous immunoglobulin with improvement in his symptoms.
May 30, 2018: BMJ Case Reports
https://read.qxmd.com/read/29703016/a-case-report-of-life-threatening-acute-dysphagia-in-dermatomyositis-challenges-in-diagnosis-and-treatment
#9
Kyoung Min Kwon, Jung Soo Lee, Yeo Hyung Kim
RATIONALE: Although dysphagia is a known complication of dermatomyositis, sudden onset of dysphagia without the notable aggravation of other symptoms can make the diagnosis and treatment challenging. PATIENT CONCERNS: A 53-year-old male diagnosed as dermatomyositis 1 month ago came to our emergency department complaining of a sudden inability to swallow solid foods and liquids. The patient showed generalized edema, but the muscle power was not different compared with 1 month ago...
April 2018: Medicine (Baltimore)
https://read.qxmd.com/read/29665800/mda-5-associated-rapidly-progressive-interstitial-lung-disease-with-recurrent-pneumothoraces-a-case-report
#10
Safi Alqatari, Peter Riddell, Sinead Harney, Michael Henry, Grainne Murphy
BACKGROUND: Clinically hypomyopathic dermatomyositis is a rare disease that is important to recognize, investigate and treat early as it is associated with poor prognosis. In a proportion of patients, myositis specific antibodies could be negative, but with high clinical suspicion, myositis associated antibodies should be ordered. Anti-MDA-5 antibodies was reported in literature to be associated with severe and rapidly progressive interstitial lung disease, with few case reports of pneumothorax and/or pneumomediastinum...
April 17, 2018: BMC Pulmonary Medicine
https://read.qxmd.com/read/29507032/following-leads-connecting-dysphagia-to-mixed-connective-tissue-disease
#11
Rita de Sousa Gameiro, Ana Isabel Alves Reis, Ana Cristina Grilo, Carla Noronha
Mixed connective tissue disease (MCDT) is a rare condition characterised by the presence of high titres of anti-U1 ribonucleoprotein antibodies and selected clinical features of systemic lupus erythematosus, systemic sclerosis and polymyositis/dermatomyositis. Early symptoms are non-specific, including easy fatigability, myalgia, arthralgia and Raynaud's phenomenon. Some reports emphasised the favourable outcome and excellent response to glucocorticoids, but there are contradictory studies reporting worse prognosis...
March 5, 2018: BMJ Case Reports
https://read.qxmd.com/read/29170979/predictors-of-changes-in-disease-activity-among-children-with-juvenile-dermatomyositis-enrolled-in-the-childhood-arthritis-and-rheumatology-research-alliance-carra-legacy-registry
#12
Divya Challa, Cynthia S Crowson, Timothy B Niewold, Ann M Reed
Determinants of changes in disease activity among patients with juvenile dermatomyositis (JDM) are unknown. Our objective was to develop predictive models to predict changes in disease activity using the CARRA Legacy Registry. The CARRA Legacy Registry included 658 subjects with definite or probably JDM with 297 subjects with a one follow-up visit after baseline, and we studied the 65 subjects with active disease at baseline. Linear regression models were used to build risk scores for changes in disease activity adjusted for baseline disease activity, age, sex, and disease duration...
April 2018: Clinical Rheumatology
https://read.qxmd.com/read/29089813/breast-cancer-and-dermatomyositis-a-case-study-and-literature-review
#13
E Hendren, O Vinik, H Faragalla, R Haq
A 49-year-old woman presents with an extensive violaceous rash, rapidly progressive proximal muscle weakness, and dysphagia to solids, consistent with a diagnosis of dermatomyositis. Two weeks later, she palpates a mass in her left breast and is diagnosed with her2-positive metastatic invasive ductal carcinoma of the breast. There is a well-established association between dermatomyositis and malignancy. However, the specific association between breast cancer and dermatomyositis has not been well characterized...
October 2017: Current Oncology
https://read.qxmd.com/read/28943591/anti-transcription-intermediary-factor1%C3%AE-antibody-positive-dermatomyositis-complicated-by-dysphagia
#14
Shota Kurushima, Yoshiro Horai, Masataka Umeda, Atsushi Kawakami
No abstract text is available yet for this article.
November 1, 2017: Internal Medicine
https://read.qxmd.com/read/28912913/paraneoplastic-dermatomyositis-syndrome-presenting-as-dysphagia
#15
Emmanuel Ofori, Daryl Ramai, Mel Ona, Madhavi Reddy
Dermatomyositis (DM) is a rare autoimmune condition which predominantly affects females in the fifth and sixth decades of life. DM presents acutely or progressively as painless proximal skeletal muscle weakness and can be associated with a heliotropic rash around the eyes, and Gottron's papules on extensor surfaces of the hands. While the pathophysiology of DM is still unclear, abnormal T- and B-cell immune activity has been reported. DM has been associated with malignancy and has been shown to appear before, concurrently with, or after diagnosis of cancer...
August 2017: Gastroenterology Research
https://read.qxmd.com/read/28855174/the-euromyositis-registry-an-international-collaborative-tool-to-facilitate-myositis-research
#16
MULTICENTER STUDY
James B Lilleker, Jiri Vencovsky, Guochun Wang, Lucy R Wedderburn, Louise Pyndt Diederichsen, Jens Schmidt, Paula Oakley, Olivier Benveniste, Maria Giovanna Danieli, Katalin Danko, Nguyen Thi Phuong Thuy, Monica Vazquez-Del Mercado, Helena Andersson, Boel De Paepe, Jan L deBleecker, Britta Maurer, Liza J McCann, Nicolo Pipitone, Neil McHugh, Zoe E Betteridge, Paul New, Robert G Cooper, William E Ollier, Janine A Lamb, Niels Steen Krogh, Ingrid E Lundberg, Hector Chinoy
AIMS: The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled Registry data. METHODS: Cross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated. RESULTS: Of 3067 IIM cases, 69% were female. The most common IIM subtype was dermatomyositis (DM) (31%)...
January 2018: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/28717078/dermatomyositis-induced-by-hepatitis-b-virus-related-hepatocellular-carcinoma-a-case-report-and-review-of-the-literature
#17
REVIEW
Jen-Wei Chou, Yin-Lan Lin, Ken-Sheng Cheng, Po-Yuan Wu, Teressa Reanne Ju
Dermatomyositis or polymyositis as a paraneoplastic syndrome of hepatocellular carcinoma (HCC) is an uncommon event. Few cases have been reported in the literature. We herein report the case of a 55-year-old man with chronic hepatitis B and alcoholism who presented with skin rash. Abdominal computed tomography revealed multiple hypervascular liver tumors consistent with HCC. He subsequently developed dysphagia with proximal limb weakness. Laboratory tests and electromyography demonstrated inflammatory myopathy...
2017: Internal Medicine
https://read.qxmd.com/read/28685324/phenotypic-characteristics-and-outcome-of-juvenile-dermatomyositis-in-arab-children
#18
MULTICENTER STUDY
Sulaiman M Al-Mayouf, Nora AlMutiari, Mohammed Muzaffer, Rawiah Shehata, Adel Al-Wahadneh, Reem Abdwani, Safia Al-Abrawi, Mohammed Abu-Shukair, Zeyad El-Habahbeh, Abdullah Alsonbul
This study describes the disease characteristics and outcome of Arab children with juvenile dermatomyositis (JDM) and compares the findings with other ethnicities. We retrospectively reviewed the hospital registries of the participating hospitals for children with JDM seen between 1990 and 2016 in three Arab countries. All patients fulfilled Bohan and Peter criteria for JDM, diagnosed before 14 years of age and were of Arab ethnicity. Clinical and laboratory features as well as the long-term outcomes including accrual disease damage were collected at the last follow-up visit...
September 2017: Rheumatology International
https://read.qxmd.com/read/28660085/dermatomyositis-associated-with-myelofibrosis-following-polycythemia-vera
#19
Naomi Fei, Sarah Sofka
Dermatomyositis (DM) is a unique inflammatory myopathy with clinical findings of proximal muscle weakness, characteristic rash, and elevated muscle enzymes. The association of DM and malignancy, most commonly adenocarcinoma, is well known. There have been few case reports of primary myelofibrosis associated with DM. We present the case of a 69-year-old male with a history of polycythemia vera (PV) who developed proximal muscle weakness, dysphagia, and rash. He was found to have elevated creatinine kinase and skin biopsy was consistent with DM...
2017: Case Reports in Hematology
https://read.qxmd.com/read/28298642/clinical-characteristics-of-anti-sae-antibodies-in-chinese-patients-with-dermatomyositis-in-comparison-with-different-patient-cohorts
#20
COMPARATIVE STUDY
Yongpeng Ge, Xin Lu, Xiaoming Shu, Qinglin Peng, Guochun Wang
This study aimed to analyze the clinical features of anti-SAE antibodies in Chinese myositis patients in comparison with different cohorts. The anti-SAE antibodies were tested in myositis patients and in control subjects. Long-term follow-up was conducted on the antibody-positive patients. Anti-SAE antibodies were exclusively present in 12 out of 394 (3.0%) adult dermatomyositis (DM) patients. Of the anti-SAE-positive DM patients, 75% had distinctive diffuse dark-red or pigment-like skin rashes, and 67% of these patients experienced mild muscle weakness...
March 15, 2017: Scientific Reports
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