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Ischemic Stroke cytokine

Hai Lu, Menghan Li, Bo Zhang, Xuesong Ren, Lina Meng, Weijing Bai, Li Wang, Zhenzhen Wang, Shaojie Ding, Yuanyuan Gan, Zhilong Zhang, Peifang Li, Linpeng Wang, Zhihong Meng, Hong Zhao, Fei Wang, Chunhong Zhang
INTRODUCTION: Poststroke depression is a serious and common complication of stroke, especially the ischemic poststroke depression. Antidepressants are used in poststroke depression, and acupuncture may be an alternative approach. However, the efficacy and mechanism of acupuncture for poststroke depression has not been confirmed. METHODS/DESIGN: This is a multicenter, central-randomized, single-blind, sham-controlled clinical trial. We will allocate 208 subjects aged between 40 and 80 years old, diagnosed with initial poststroke depression (PSD) within 6 months to 2 groups randomly in a ratio of 1:1...
February 2019: Medicine (Baltimore)
Hanna Markstad, Andreas Edsfeldt, Ingrid Yao Mattison, Eva Bengtsson, Pratibha Singh, Michele Cavalera, Giuseppe Asciutto, Harry Björkbacka, Gunilla Nordin Fredrikson, Nuno Dias, Petr Volkov, Marju Orho-Melander, Jan Nilsson, Gunnar Engström, Isabel Gonçalves
Background When the lectinlike oxidized low-density lipoprotein (ox LDL) receptor-1 ( LOX -1), a scavenger receptor for ox LDL , binds ox LDL , processes leading to endothelial dysfunction and inflammation are promoted. We aimed to study release mechanisms of LOX -1 and how circulating levels of soluble LOX -1 ( sLOX -1) relate to plaque inflammation and future risk for ischemic stroke. Methods and Results Endothelial cells and leukocytes were used to study release of sLOX -1. Plasma levels of sLOX -1 were determined in 4703 participants in the Malmö Diet and Cancer cohort...
February 19, 2019: Journal of the American Heart Association
Anne-Sophie Ernst, Laura-Inés Böhler, Anna M Hagenston, Angelika Hoffmann, Sabine Heiland, Carsten Sticht, Martin Bendszus, Markus Hecker, Hilmar Bading, Hugo H Marti, Thomas Korff, Reiner Kunze
Local cerebral hypoperfusion causes ischemic stroke while driving multiple cell-specific responses including inflammation, glutamate-induced neurotoxicity mediated via NMDAR, edema formation and angiogenesis. Despite the relevance of these pathophysiological mechanisms for disease progression and outcome, molecular determinants controlling the onset of these processes are only partially understood. In this context, our study intended to investigate the functional role of EphB2, a receptor tyrosine kinase that is crucial for synapse function and binds to membrane-associated ephrin-B ligands...
February 5, 2019: Acta Neuropathologica Communications
Jialin Duan, Jia Cui, Zhifu Yang, Chao Guo, Jinyi Cao, Miaomiao Xi, Yan Weng, Ying Yin, Yanhua Wang, Guo Wei, Boling Qiao, Aidong Wen
BACKGROUND: Previous studies had showed that Apelin 13 could protect against apoptosis induced by ischemic/reperfusion (I/R). However, the mechanisms whereby Apelin 13 protected brain I/R remained to be elucidated. The present study was designed to determine whether Apelin 13 provided protection through AMPK/GSK-3β/Nrf2 pathway. METHODS: In vivo, the I/R model was induced and Apelin 13 was given intracerebroventricularly 15 min before reperfusion. The neurobehavioral scores, infarction volumes, and some cytokines in the brain were measured...
February 1, 2019: Journal of Neuroinflammation
B I Geltser, I G Kurpatov, V N Kotelnikov, Yu V Zayats
Literature data of chronic obstructive pulmonary disease (COPD) and cerebrovascular diseases (CVD) comorbidity are represented in this review. Key aspects of this interaction and its importance for clinical medicine have been considered. CVD and COPD are the main mortality factors in adults, which contribute to great economic wastes. The incidence of chronic cerebral ischemia for COPD patients is almost three times as high as for general population. The incidence of ischemic stroke for COPD patients is 1,2 times higher than in general population...
April 19, 2018: Terapevticheskiĭ Arkhiv
Sha Tan, Yilong Shan, Yinyao Lin, Siyuan Liao, Bingjun Zhang, Qin Zeng, Yuge Wang, Zhezhi Deng, Chen Chen, Xueqiang Hu, Lisheng Peng, Wei Qiu, Zhengqi Lu
Astrocytes mediate the destruction of the blood-brain barrier (BBB) during ischemic stroke (IS). IL-9 is a pleiotropic cytokine that we previously found to be highly expressed in peripheral blood mononuclear cells from patients with IS, and the presence of IL-9 receptors on astrocytes has been reported in the literature. Here, we detected the effect of IL-9 on astrocytes using an anti-IL-9-neutralizing antibody to treat rats with experimental stroke. Supernatants from astrocytes treated with or without oxygen-glucose deprivation and/or IL-9 were incubated with bEnd...
January 29, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Awadhesh K Arya, Bingren Hu
Stroke leads to inflammatory and immune response in the brain and immune organs. The gut or gastrointestinal tract is a major immune organ equipped with the largest pool of immune cells representing more than 70% of the entire immune system and the largest population of macrophages in the human body. The bidirectional communication between the brain and the gut is commonly known as brain-gut or gut-brain axis. Stroke often leads to gut dysmotility, gut microbiota dysbiosis, "leaky" gut, gut hemorrhage, and even gut-origin sepsis, which is often associated with poor prognosis...
October 2018: Brain Circulation
Lara Buscemi, Melanie Price, Paola Bezzi, Lorenz Hirt
After ischemic stroke, in the lesion core as well as in the ischemic penumbra, evolution of tissue damage and repair is strongly affected by neuroinflammatory events that involve activation of local specialized glial cells, release of inflammatory mediators, recruiting of systemic cells and vascular remodelling. To take advantage of this intricate response in the quest to devise new protective therapeutic strategies we need a better understanding of the territorial and temporal interplay between stroke-triggered inflammatory and cell death-inducing processes in both parenchymal and vascular brain cells...
January 24, 2019: Scientific Reports
Xiang Yu, Kaiming Zeng, Xing Liu, Yi Peng, Chunhua Li, Ke Fu, Hui Liang
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine expressed in the skin, gut, lungs, and thymus. TSLP triggers dendritic cell-mediated T helper 2 inflammatory responses by formation of a ternary complex consisting of a heterodimer of interleukin-7 (IL-7) receptor α chain (IL-7Rα), TSLP, and the TSLP receptor chain (TSLPR). The present study aimed to investigate the expression of this ternary complex and its interaction with signal transducer and activator of transcription 5 (STAT5) in a ischemic stroke model using middle cerebral artery occlusion...
January 22, 2019: Neuroreport
Jiayi Zhu, Yan Wan, Hexiang Xu, Yulang Wu, Bo Hu, Huijuan Jin
Endogenous protease tissue-type plasminogen activator (tPA) has highly efficient fibrinolytic activity and its recombinant variants alteplase and tenecteplase are established as highly effective thrombolytic drugs for ischemic stroke. Endogenous tPA is constituted of five functional domains through which it interacts with a variety of substrates, binding proteins and receptors, thus having enzymatic and cytokine-like effects to act on all cell types of the brain. In the past 2 decades, numerous studies have explored the clinical relevance of endogenous tPA in neurological diseases, especially in ischemic stroke...
January 17, 2019: Cellular and Molecular Life Sciences: CMLS
Candela Diaz-Cañestro, Martin F Reiner, Nicole R Bonetti, Luca Liberale, Mario Merlini, Patricia Wüst, Heidi Amstalden, Sylvie Briand-Schumacher, Aurora Semerano, Giacomo Giacalone, Maria Sessa, Jürg H Beer, Alexander Akhmedov, Thomas F Lüscher, Giovanni G Camici
Background and Purpose- Inflammation is a major pathogenic component of ischemia/reperfusion brain injury, and as such, interventions aimed at inhibiting inflammatory mediators promise to be effective strategies in stroke therapy. JunD-a member of the AP-1 (activated protein-1) family of transcription factors-was recently shown to regulate inflammation by targeting IL (interleukin)-1β synthesis and macrophage activation. The purpose of the present study was to assess the role of JunD in ischemia/reperfusion-induced brain injury...
January 10, 2019: Stroke; a Journal of Cerebral Circulation
Fumiaki Shikata, Kenji Shimada, Hiroki Sato, Taichi Ikedo, Atsushi Kuwabara, Hajime Furukawa, Masaaki Korai, Masakazu Kotoda, Kimihiko Yokosuka, Hiroshi Makino, Emma A Ziegler, Daisuke Kudo, Michael T Lawton, Tomoki Hashimoto
Gut microbiota modulates metabolic and immunoregulatory axes and contributes to the pathophysiology of diseases with inflammatory components, such as atherosclerosis, diabetes mellitus, and ischemic stroke. Inflammation is emerging as a critical player in the pathophysiology of an intracranial aneurysm. Therefore, we hypothesized that the gut microbiota affects aneurysm formation by modulating inflammation. We induced intracranial aneurysms in mice by combining systemic hypertension and a single injection of elastase into the cerebrospinal fluid...
February 2019: Hypertension
Marios K Georgakis, Dipender Gill, Kristiina Rannikmae, Matthew Traylor, Christopher D Anderson, Jin-Moo Lee, Yoichiro Kamatani, Jemma C Hopewell, Bradford B Worrall, Jürgen Bernhagen, Cathie Lm Sudlow, Rainer Malik, Martin Dichgans
BACKGROUND: Cytokines and growth factors have been implicated in the initiation and propagation of vascular disease. Observational studies have shown associations of their circulating levels with stroke. Our objective was to explore whether genetically determined circulating levels of cytokines and growth factors are associated with stroke and its etiologic subtypes by conducting a two-sample Mendelian randomization (MR) study. METHODS: Genetic instruments for 41 cytokines and growth factors were obtained from a genome-wide association study (GWAS) of 8,293 healthy adults...
September 26, 2018: Circulation
Abdullah Al Mamun, Haifu Yu, Mehwish A Mirza, Sharmeen Romana, Louise D McCullough, Fudong Liu
Interferon regulatory factor 4 (IRF4), a transcription factor recognized as a key regulator of lymphoid and myeloid cell differentiation, has recently been recognized as a critical mediator of macrophage activation. Previously we have reported that IRF4 signaling is closely correlated with anti-inflammatory polarization of microglia in adult mice after stroke. However, IRF4's role in the inflammatory response in the immature brain is unknown. Using a model of neonatal hypoxic ischemic encephalopathy (HIE) we investigated the regulatory action of IRF4 signaling in the activation of microglia and monocytes after HIE...
December 23, 2018: Neurochemistry International
Di Wu, Xinglong Zhi, Yunxia Duan, Mo Zhang, Hong An, Wenjing Wei, Kai Dong, Ying Zhang, Jingfei Shi, Xiaoduo He, Jun Zhang, Chuanjie Wu, Ran Meng, Yuchuan Ding, Xunming Ji
OBJECTIVE: The combination of pharmacological hypothermia - dihydrocapsaicin (DHC) and intra-arterial regional cooling infusions (RCI) was found to enhance the efficiency of hypothermia and efficacy of hypothermia-induced neuroprotection in acute ischemic stroke. The aim of this study was to explore whether the combination could induce a long-term neuroprotective effects, as well as the underlying mechanism. METHODS: Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) for 2 h using intraluminal hollow filament...
December 22, 2018: Brain Research
C Widmann, C Gandin, A Petit-Paitel, M Lazdunski, C Heurteaux
Inflammation is considered as a major contributor to brain injury following cerebral ischemia. The therapeutic potential of both MLC601/MLC901, which are herbal extract preparations derived from Chinese Medicine, has been reported both in advanced stroke clinical trials and also in animal and cellular models. The aim of this study was to investigate the effects of MLC901 on the different steps of post-ischemic inflammation in focal ischemia in mice. In vivo injury was induced by 60 minutes of middle cerebral artery occlusion (MCAO) followed by reperfusion...
December 24, 2018: Scientific Reports
Guiqian Huang, Huijun Chen, Qiongzhang Wang, Xianchai Hong, Pinglang Hu, Meijuan Xiao, Meichun Shu, Jincai He
BACKGROUND: Post-stroke depression (PSD) is the most common psychological consequence among stroke patients, and inflammatory cytokines have cited as risk factors in PSD. We aimed to evaluate the predictive value of stratification of PLR (platelet-to-lymphocyte ratio), an inflammatory marker, in PSD patients. METHODS: A total of 363 acute ischemic stroke (AIS) patients were screened in the study and received 1-month follow-up. All of the patients were categorized into equal tertiles according to the number of patients and the distribution of PLR...
December 10, 2018: Journal of Affective Disorders
Qianyi Huang, Wei Zhong, Zhiping Hu, Xiangqi Tang
Ischemic stroke starts a series of pathophysiological processes that cause brain injury. Caveolin-1 (cav-1) is an integrated protein and locates at the caveolar membrane. It has been demonstrated that cav-1 can protect blood-brain barrier (BBB) integrity by inhibiting matrix metalloproteases (MMPs) which degrade tight junction proteins. This article reviews recent developments in understanding the mechanisms underlying BBB dysfunction, neuroinflammation, and oxidative stress after ischemic stroke, and focuses on how cav-1 modulates a series of activities after ischemic stroke...
December 20, 2018: Journal of Neuroinflammation
Yinghua Jiang, Ning Liu, Qingzhi Wang, Zhanyang Yu, Li Lin, Jing Yuan, Shuzhen Guo, Bum Ju Ahn, Xiao-Jie Wang, Xiaokun Li, Eng H Lo, Xiaochuan Sun, Xiaoying Wang
Background and Purpose- The complexity and heterogeneity of stroke, as well as the associated comorbidities, may render neuroprotective drugs less efficacious in clinical practice. Therefore, the development of targeted therapies to specific patient subsets has become a high priority in translational stroke research. Ischemic stroke with type 2 diabetes mellitus has a nearly double mortality rate and worse neurological outcomes. In the present study, we tested our hypothesis that rFGF21 (recombinant human fibroblast growth factor 21) administration is beneficial for improving neurological outcomes of ischemic stroke with type 2 diabetes mellitus...
December 2018: Stroke; a Journal of Cerebral Circulation
Adel Alhazzani, Prasanna Rajagopalan, Zaher Albarqi, Anantharam Devaraj, Mohamed Hessian Mohamed, Ahmed Al-Hakami, Harish C Chandramoorthy
Cell-therapy modalities using mesenchymal stem (MSCs) in experimental strokes are being investigated due to the role of MSCs in neuroprotection and regeneration. It is necessary to know the sequence of events that occur during stress and how MSCs complement the rescue of neuronal cell death mediated by [Ca2+ ]i and reactive oxygen species (ROS). In the current study, SH-SY5Y-differentiated neuronal cells were subjected to in vitro cerebral ischemia-like stress and were experimentally rescued from cell death using an MSCs/neuronal cell coculture model...
December 6, 2018: Cells
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