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JOURNAL ARTICLE
Eri Otaka, Aiko Osawa, Kenji Kato, Yota Obayashi, Shintaro Uehara, Masaki Kamiya, Katsuhiro Mizuno, Shusei Hashide, Izumi Kondo
BACKGROUND: Interventions and care that can evoke positive emotions and reduce apathy or agitation are important for people with dementia. In recent years, socially assistive robots used for better dementia care have been found to be feasible. However, the immediate responses of people with dementia when they are given multiple sensory modalities from socially assistive robots have not yet been sufficiently elucidated. OBJECTIVE: This study aimed to quantitatively examine the immediate emotional responses of people with dementia to stimuli presented by socially assistive robots using facial expression analysis in order to determine whether they elicited positive emotions...
April 11, 2024: JMIR aging
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JOURNAL ARTICLE
Jean-Charles Roy, Renaud Hédouin, Thomas Desmidt, Sébastien Dam, Iris Mirea-Grivel, Weyl Louise, Elise Bannier, Laurent Barantin, Dominique Drapier, Jean-Marie Batail, Renaud David, Julie Coloigner, Gabriel H Robert
BACKGROUND: Better understanding apathy in late-life depression (LLD) would help predicting poor prognosis of the disease such as dementia. Actimetry provides an objective and ecological measure of apathy from patients' daily motor activity. We aimed to determine if patterns of motor activity were associated with apathy and brain connectivity in networks underlying goal-directed behaviors. METHODS: Resting-state functional MRI and diffusion MRI were collected from 38 non-demented LLD subjects...
April 12, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
#3
REVIEW
Tuba Tanveer, Nixon Mathur, Rakesh Sarwal
INTRODUCTION: The partition of India on the dissolution of British Raj into two dominions is known to have been violent, polarizing and caused large-scale loss of life (about two million) and an unprecedented migration of 14 million people between the two dominions, India and Pakistan. It is not known how well the then scientific community covered this man-made disaster, and the response of the international community with aid. METHODOLOGY: A systematic review was conducted using different electronic databases of PubMed, Econlit, United Nations resolutions, Government of India websites, and Google Scholar for the period January 1947 to December 1951 on the impact of the partition of the Indian sub-continent, and to identify the international response toward this humanitarian crisis...
February 2024: Journal of Family Medicine and Primary Care
#4
JOURNAL ARTICLE
Baraka Alphonce, John Meda, Azan Nyundo
INTRODUCTION: Stroke survivors develop cognitive impairment, which significantly impacts their quality of life, their families, and the community as a whole but not given attention. This study aims to determine the incidence and predictors of post-stroke cognitive impairment (PSCI) among adult stroke patients admitted to a tertiary hospital in Dodoma, Tanzania. METHODOLOGY: A prospective cohort study was conducted at tertiary hospitals in the Dodoma region, central Tanzania...
2024: PloS One
#5
JOURNAL ARTICLE
Kanishk Kaushik, Anna M de Kort, Rosemarie van Dort, Reinier G J van der Zwet, Bob Siegerink, Sabine Voigt, Erik W van Zwet, Maaike C van der Plas, Emma A Koemans, Ingeborg Rasing, Roy P C Kessels, Huub A M Middelkoop, Floris H B M Schreuder, Catharina J M Klijn, Marcel M Verbeek, Gisela M Terwindt, Ellis S van Etten, Marieke J H Wermer
BACKGROUND: Neuropsychiatric symptoms (NPS) may affect cognition, but their burden in cerebral amyloid angiopathy (CAA), one of the main causes of intracerebral hemorrhage (ICH) and dementia in the elderly, remains unclear. We investigated NPS, with emphasis on apathy and irritability in sporadic (sCAA) and Dutch-type hereditary (D-)CAA. METHODS: We included patients with sCAA and (pre)symptomatic D-CAA, and controls from four prospective cohort studies. We assessed NPS per group, stratified for history of ICH, using the informant-based Neuropsychiatric Inventory (NPI-Q), Starkstein Apathy scale (SAS), and Irritability Scale...
April 6, 2024: Alzheimer's Research & Therapy
#6
JOURNAL ARTICLE
Rishabh Gupta, Jeffrey W Chen, Natasha C Hughes, Mohammad Hamo, Samuel Jean-Baptiste, Danika L Paulo, Hani Chanbour, Run Fan, Fei Ye, Abhiram Vadali, Anthony Cmelak, Sarah K Bick
OBJECTIVE: Anterior capsulotomy (AC) is a therapeutic option for patients with severe, treatment-resistant obsessive-compulsive disorder (OCD). The procedure can be performed via multiple techniques, with stereotactic radiosurgery (SRS) gaining popularity because of its minimally invasive nature. The risk-benefit profile of AC performed specifically with SRS has not been well characterized. Therefore, the primary objective of this study was to characterize outcomes following stereotactic radiosurgical AC in OCD patients...
March 29, 2024: Journal of Neurosurgery
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JOURNAL ARTICLE
Eva Q Gontrum, Emily W Paolillo, Shannon Lee, Valentina Diaz, Alexander Ehrenberg, Rowan Saloner, Nidhi S Mundada, Renaud La Joie, Gil Rabinovici, Joel H Kramer, Kaitlin Casaletto
INTRODUCTION: We comprehensively evaluated how self- and informant-reported neuropsychiatric symptoms (NPS) differentially associated with cerebral amyloid-beta (Aβ) PET levels in older adults without dementia. METHODS: 221 participants (48% female, age=73.4y±8.4, CDR=0 [n=184] or 0.5 [n=37]) underwent an Aβ-PET scan (Florbetapir or PIB), comprehensive neuropsychological testing, and self-reported (Geriatric Depression Scale- 30 item), and informant-reported interview (Neuropsychiatric Inventory Questionnaire) of NPS...
March 21, 2024: Dementia and Geriatric Cognitive Disorders
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JOURNAL ARTICLE
Sumiyo Umeda, Hideki Kanemoto, Maki Suzuki, Tamiki Wada, Takashi Suehiro, Kyosuke Kakeda, Yoshitaka Nakatani, Yuto Satake, Maki Yamakawa, Fuyuki Koizumi, Daiki Taomoto, Sakura Hikida, Natsuho Hirakawa, Andrew Sommerlad, Gill Livingston, Mamoru Hashimoto, Kenji Yoshiyama, Manabu Ikeda
OBJECTIVES: We aimed to psychometrically evaluate and validate a Japanese version of the Social Functioning in Dementia scale (SF-DEM-J) and investigate changes in social function in people with dementia during the coronavirus disease-19 (COVID-19) pandemic. DESIGN: We interviewed people with mild cognitive impairment (MCI) and mild dementia and their caregivers during June 2020-March 2021 to validate patient- and caregiver-rated SF-DEM-J and compared their scores at baseline (April 2020 to May 2020) and at 6-8 months (January 2021 to March 2021) during a time of tighter COVID-19 restrictions...
March 11, 2024: International Psychogeriatrics
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JOURNAL ARTICLE
Jessa E Burling, Zoe Katz, Ziwen Yuan, Catherine Munro, Kayden Mimmack, Grace Ma, Bernard J Hanseeuw, Kathryn V Papp, Rebecca E Amariglio, Patrizia Vannini, Dorene M Rentz, Yakeel T Quiroz, Keith A Johnson, Reisa A Sperling, Deborah Blacker, Gad A Marshall, Hyun-Sik Yang, Jennifer R Gatchel
OBJECTIVES: We examined relationships between apathy (self and study-partner-reported) and markers of Alzheimer's disease (AD) in older adults. DESIGN: The study utilized a well-characterized sample of participants from the Harvard Aging Brain Study (HABS), a longitudinal cohort study. Participants were cognitively unimpaired without clinically significant neuropsychiatric symptoms at HABS baseline. The dependent variables, apathy evaluation scale-self (AES-S) and informant (AES-I), were administered cross-sectionally between years 6-9 and compared to the independent variables, amyloid and tau PET neuroimaging, from the same year...
January 28, 2024: American Journal of Geriatric Psychiatry
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JOURNAL ARTICLE
Progress Njomboro, Tlholego Lekhutlile
BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia. Its initially characterized by progressive short-term memory loss followed by cross-domain cognitive decline in later stages resulting in significant functional deficits and loss of activities of daily living (ADLs) independence. Apathy and depression are frequent neuropsychiatric sequelae in AD, but their contribution to functional deficits is poorly understood. OBJECTIVE: We aimed to quantitatively investigate if apathy and depressive symptoms predict ADLs in AD...
February 26, 2024: Journal of Alzheimer's Disease: JAD
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Shannon B Juengst, Brittany Wright, Leia Vos, Gabriel Rodriguez, Michael Conley, Lauren Terhorst
The Behavioral Assessment Screening Tool (BAST) measures self-reported neurobehavioral symptoms commonly experienced by adults with traumatic brain injury (TBI). To assess the convergent, discriminant, and known-groups validity of the BAST among community-dwelling adults with chronic traumatic brain injury (TBI), we conducted correlation analyses and tests of group differences with previously validated symptom measures in two samples (n = 111, n = 134). Measures used for comparison were: Patient Health Questionnaire (depression), Generalized Anxiety Disorder-7 (anxiety), Positive and Negative Affect Schedule, Frontal Systems Behavior Scale (Executive Dysfunction, Apathy, Disinhibition), Modified Fatigue Impact Scale, PROMIS Fatigue, Aggression Questionnaire (anger, hostility, physical and verbal aggression), and Alcohol Use Disorders Test (alcohol misuse)...
February 15, 2024: Research Square
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JOURNAL ARTICLE
Impact of Pain and Neuropsychiatric Symptoms on Activities in Nursing Home Residents (COSMOS Trial).
Sifra H van de Beek, Ane Erdal, Bettina S Husebø, Maarja Vislapuu, Wilco P Achterberg, Monique A A Caljouw
OBJECTIVE: This study aims to identify whether pain and dementia-related behavior are associated with different types of activities in nursing home residents, controlled for dementia severity. DESIGN: Cross-sectional baseline data from the multicomponent cluster randomized controlled COSMOS trial (acronym for Communication, Systematic pain treatment, Medication review, Organization of activities, and Safety). SETTING AND PARTICIPANTS: A total of 723 patients from 33 Norwegian nursing homes with 67 units (clusters)...
February 22, 2024: Journal of the American Medical Directors Association
#13
JOURNAL ARTICLE
Catherine J Wedderburn, Tatum Sevenoaks, Jean-Paul Fouche, Nicole J Phillips, Stephen D Lawn, Dan J Stein, Jacqueline Hoare
Central nervous system involvement in HIV infection leads to neurobehavioural sequelae. Although apathy is a well-recognised symptom in adults living with HIV linked to alterations in brain structure, there is scarce research examining motivation in children living with HIV (CLWH). We used the Children's Motivation Scale (CMS; normative mean = 50, SD = 10) to assess motivation levels in 76 CLWH aged 6-16 years (63 on antiretroviral therapy [ART]; 13 ART-naïve slow progressors) in South Africa...
February 23, 2024: Scientific Reports
#14
JOURNAL ARTICLE
Emma Segura, Adrià Vilà-Balló, Aida Mallorquí, María F Porto, Esther Duarte, Jennifer Grau-Sánchez, Antoni Rodríguez-Fornells
BACKGROUND: Anhedonia refers to the diminished capacity to experience pleasure. It has been described both as a symptom of depression and an enduring behavioral trait that contributes its development. Specifically, in stroke patients, anhedonia has been closely linked to depression, resulting in reduced sensitivity to everyday pleasures and intrinsic motivation to engage in rehabilitation programs and maintain a healthy active lifestyle. This condition may hinder patients' recovery, diminishing their autonomy, functioning, and quality of life...
2024: Frontiers in Aging Neuroscience
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JOURNAL ARTICLE
A Padovani, S Caratozzolo, A Benussi, A Galli, L Rozzini, M Cosseddu, R Turrone, A Pilotto
BACKGROUND: Depressive symptoms are common in Alzheimer disease (AD) from the prodromal stage. The benefits of antidepressants have been investigated in patients with AD dementia with mixed results. OBJECTIVES: This study aimed to compare the efficacy of vortioxetine in prodromal and mild-to-moderate AD patients with depression, and to assess the comparative effect on secondary measures, including behavioral disturbances, cognitive function, and activities of daily living...
2024: Journal of Prevention of Alzheimer's Disease
#16
JOURNAL ARTICLE
Isolde L Maas, Marc M Bohlken, Shiral S Gangadin, Bram-Sieben Rosema, Wim Veling, Nynke Boonstra, Lieuwe de Haan, Marieke J H Begemann, Sanne Koops
BACKGROUND: The concept of personal recovery after psychotic illness focuses more on patients' social and existential needs compared to traditional outcome measures including clinical and functional recovery. This research aims to contribute to a broad framework on (personal) recovery and associated factors. METHODS: Data from 203 persons with symptomatic remission of their first-episode psychosis from the ongoing HAMLETT study were analyzed. To determine the relative importance of several biological, clinical, psychological, and social factors in explaining personal recovery as measured by the Recovery Assessment Scale (RAS), partial Spearman correlations (controlling for clinical recovery (PANSS) and functional recovery (WHODAS 2...
April 2024: Schizophrenia Research
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JOURNAL ARTICLE
Ella Burchill, Cameron James Watson, Jack B Fanshawe, James Brunton Badenoch, Emma Rengasamy, Dory Anthony Ghanem, Constantine Holle, Isabella Conti, Mohammed Ahmed Sadeq, Aman Saini, Abdelilah Lahmar, Ben Cross, Gareth McGuigan, Amar Nandrha, Edward J Kane, Julia Wozniak, Reem Mohamed Farouk Ghorab, Jia Song, Andrew Sommerlad, Andrew Lees, Michael S Zandi, Anthony S David, Glyn Lewis, Ben Carter, Jonathan P Rogers
BACKGROUND: The burden of psychiatric symptoms in Parkinson's disease includes depression, anxiety, apathy, psychosis, and impulse control disorders. However, the relationship between psychiatric comorbidities and subsequent prognosis and neurological outcomes is not yet well understood. In this systematic review and meta-analysis, in individuals with Parkinson's disease, we aimed to characterise the association between specific psychiatric comorbidities and subsequent prognosis and neurological outcomes: cognitive impairment, death, disability, disease progression, falls or fractures and care home admission...
April 2024: The Lancet regional health. Europe
#18
JOURNAL ARTICLE
Magali Payne, Kevin Galery, Alexandra Plonka, Justine Lemaire, Alexandre Derreumaux, Roxane Fabre, Aurélie Mouton, Guillaume Sacco, Olivier Guerin, Valeria Manera, Philippe Robert, Olivier Beauchet, Auriane Gros
INTRODUCTION: Previous studies have shown benefits of productive art-activity on frail older adults' mental and physical health. In this study, we investigated the effects of art-producing activities in a hybrid format (in-person and online) in a context of lockdown compared with previous studies taking place in museums and their effects on wellbeing, quality of life, physical frailty, and apathy in older adults. METHODS: We conducted a randomized unicentric control trial on a sample of 126 seniors older than 65 years (mean age 71...
2024: Frontiers in Public Health
#19
JOURNAL ARTICLE
Shaoyun Ge, Jun Liu, Yongfeng Jia, Zihan Li, Jianwei Wang, Min Wang
BACKGROUD: Apathy is a common neuropsychiatric manifestations in Parkinson's disease (PD), but neural network mechanisms still remain elusive. We aim to investigate the topological alteration of the brain structural network in PD with apathy. METHOD: In the present study, a total of 47 apathetic PD (aPD) patients, 37 non-apathetic PD (naPD) patients, and 40 healthy controls (HCs) were enrolled. Diffusion tensor imaging (DTI) in conjunction with graph-theoretic approaches were used to explore the alterations of topological properties of the WM structural network arising from apathy in PD...
February 8, 2024: Brain Research Bulletin
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JOURNAL ARTICLE
Tomás Caycho-Rodríguez, Jonatan Baños-Chaparro, José Ventura-León, Sherman A Lee, Lindsey W Vilca, Carlos Carbajal-León, Daniel E Yupanqui-Lorenzo, Pablo D Valencia, Mario Reyes-Bossio, Nicol Oré-Kovacs, Claudio Rojas-Jara, Miguel Gallegos, Roberto Polanco-Carrasco, Mauricio Cervigni, Pablo Martino, Marlon Elías Lobos-Rivera, Rodrigo Moreta-Herrera, Diego Alejandro Palacios Segura, Antonio Samaniego-Pinho, Andrés Buschiazzo Figares, Diana Ximena Puerta-Cortés, Andrés Camargo, Julio Torales, José Arkangel Monge Blanco, Pedronel González, Vanessa Smith-Castro, Olimpia Petzold-Rodriguez, Raymundo Calderón, Wendy Yamilet Matute Rivera, Daniela Ferrufino-Borja, Agueda Muñoz-Del-Carpio-Toia, Jorge Palacios, Carmen Burgos-Videla, Ana María Eduviges Florez León, Ibeth Vergara, Diego Vega, Marion K Schulmeyer, Hassell Tatiana Urrutia Rios, Arelly Esther Lira Lira, Nicol A Barria-Asenjo, Jesús Ayala-Colqui, Luis Hualparuca-Olivera
This study aimed to characterize the network structure of pandemic grief symptoms and suicidal ideation in 2174 people from eight Latin American countries. Pandemic grief and suicidal ideation were measured using the Pandemic Grief Scale and a single item, respectively. Network analysis provides an in-depth characterization of symptom-symptom interactions within mental disorders. The results indicated that, "desire to die," "apathy" and "absence of sense of life" are the most central symptoms in a pandemic grief symptom network; therefore, these symptoms could be focal elements for preventive and treatment efforts...
February 6, 2024: Psychological Reports
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