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apathy scale

LingYu Zhang, Bei Cao, Yutong Zou, Qian-Qian Wei, RuWei Ou, Bi Zhao, Jing Yang, Ying Wu, HuiFang Shang
BACKGROUND: Cognitive impairment is an important and common symptom in patients with multiple system atrophy (MSA). OBJECTIVE: The objective of the study was to explore the potential relationships among frontal lobe function, behavioral changes and quality of life (QoL) in patients with MSA. METHODS: A total of 203 MSA patients were enrolled and evaluated using the Frontal Assessment Battery (FAB), the Frontal Behavioral Inventory (FBI) and the Parkinson's disease Questionnaire-39 item version (PDQ-39)...
February 5, 2019: Restorative Neurology and Neuroscience
Jonathan Tay, Anil M Tuladhar, Matthew J Hollocks, Rebecca L Brookes, Daniel J Tozer, Thomas R Barrick, Masud Husain, Frank-Erik de Leeuw, Hugh S Markus
OBJECTIVE: To investigate whether white matter network disruption underlies the pathogenesis of apathy, but not depression, in cerebral small vessel disease (SVD). METHODS: Three hundred thirty-one patients with SVD from the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC) study completed measures of apathy and depression and underwent structural MRI. Streamlines reflecting underlying white matter fibers were reconstructed with diffusion tensor tractography...
February 8, 2019: Neurology
Sharmila Sagnier, Fanny Munsch, Antoine Bigourdan, Sabrina Debruxelles, Mathilde Poli, Pauline Renou, Stéphane Olindo, François Rouanet, Vincent Dousset, Thomas Tourdias, Igor Sibon
BACKGROUND AND PURPOSE: The role of stroke location as a determinant of mood and cognitive symptoms is still a matter of debate. The aim of this study was to identify the predictive value of ischemic stroke location, on a voxel basis, for mood and cognitive outcome. MATERIALS AND METHODS: A prospective monocentric study including patients with a supratentorial ischemic stroke was conducted. A 3 Tesla brain MRI was performed at baseline. Mood and cognition were assessed using Hospital Anxiety and Depression scale (HAD), apathy inventory (AI), and Montreal Cognitive Assessment scale subscores, performed at 3 months poststroke...
February 1, 2019: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Marinda Henskens, Ilse M Nauta, Katja T Drost, Maarten V Milders, Erik J A Scherder
BACKGROUND: Nursing home residents with dementia show a rapid decline in their ability to perform activities of daily living. This decline is linked to a greater care dependency, which is associated with a reduced quality of life. Care dependency is influenced by multiple predictors, yet current research often focuses on the contribution of a single or a small number of predictors of care dependency. OBJECTIVES: To examine the contribution of multiple predictors in predicting care dependency...
January 1, 2019: International Journal of Nursing Studies
Sara McGuigan, Shou-Han Zhou, Méadhbh B Brosnan, Dominic Thyagarajan, Mark A Bellgrove, Trevor T-J Chong
Disorders of motivation, such as apathy, are common in Parkinson's disease, and a key feature of such disorders is a greater aversion to effort. In humans, the experience of cognitive effort is ubiquitous, and cognitive apathy has traditionally been considered distinct and separable from other subtypes. Surprisingly, however, the neurobiology of cognitive motivation is poorly understood. In particular, although dopamine has a well-characterized role in incentivizing physically effortful behaviour, a critical, unresolved issue is whether its facilitatory role generalizes to other domains...
January 24, 2019: Brain: a Journal of Neurology
Gad A Marshall, Jennifer R Gatchel, Nancy J Donovan, Martha C Muniz, Aaron P Schultz, J Alex Becker, Jasmeer P Chhatwal, Bernard J Hanseeuw, Kathryn V Papp, Rebecca E Amariglio, Dorene M Rentz, Reisa A Sperling, Keith A Johnson
BACKGROUND: Instrumental activities of daily living (IADL) impairment and apathy occur in early-stage Alzheimer's disease (AD) and are associated with regional atrophy and hypometabolism in vivo and greater tau burden at autopsy. OBJECTIVE: To explore the association between IADL impairment, apathy, and in vivo regional tau in mild cognitive impairment (MCI) and AD dementia. METHODS: Forty participants (24 MCI, 16 AD dementia) underwent assessments of IADL (Functional Activities Questionnaire, FAQ) and apathy (Apathy Evaluation Scale Informant report, AES-I)...
2019: Journal of Alzheimer's Disease: JAD
Kei Funaki, Shinichiro Nakajima, Yoshihiro Noda, Taisei Wake, Daisuke Ito, Bun Yamagata, Takahito Yoshizaki, Masashi Kameyama, Tadaki Nakahara, Koji Murakami, Masahiro Jinzaki, Masaru Mimura, Hajime Tabuchi
BACKGROUND: Subjective cognitive decline (SCD) may herald the first symptoms of Alzheimer's disease (AD) whereas individuals with beta-amyloid (Aβ) deposition are regarded as a high-risk group for AD. Recently, amyloid positron emission tomography (PET) studies have demonstrated clinical and cognitive feature differences between Aβ-positive and negative SCD, but details of their differences remain unclear. We aimed to investigate the relationships among Aβ deposition, clinical, and cognitive features in patients with SCD...
January 27, 2019: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
Genoveva Montoya-Murillo, Naroa Ibarretxe-Bilbao, Javier Peña, Natalia Ojeda
OBJECTIVES: To examine the impact of apathy on cognitive performance in the elderly following the conceptual principles proposed by Marin1 and Stuss et al2 and to determine the role of the symptoms of apathy in different cognitive domains. METHODS: Cross-sectional study with a cohort of healthy elderly subjects over 55 years (n = 140). One hundred forty healthy elderly subjects (aged 79.24 ± 8.6 years) were recruited from twelve day centers in northern Spain. Participants underwent a neuropsychological battery which evaluated MMSE, attention, processing speed, verbal fluency, visual and verbal memory, working memory and executive functioning...
January 22, 2019: International Journal of Geriatric Psychiatry
Alana Rogers, Audrey McKinlay
PRIMARY OBJECTIVE: To investigated the long-term effect of childhood Traumatic Brain Injury (TBI) on adulthood Relationship Quality (RQ), examining injury severity, age of injury, and markers of prefrontal cortex (PFC) functioning, apathy, disinhibition, and executive dysfunction. RESEARCH DESIGN: Longitudinal, between-subjects, cross-sectional design using retrospective and current data. METHODS AND PROCEDURES: Participants (N = 169; 61 mild TBI (mTBI); 65 moderate to severe TBI (MSTBI); 43 orthopaedic injury (OI); Injury age: 1-17 years; Testing age: 18-31 years) completed a structured interview regarding their injury, demographic characteristics and RQ, the National Adults Reading Test, and Frontal Systems Behaviour Scale...
January 21, 2019: Brain Injury: [BI]
Paolo Solla, Lucia Cugusi, Matilde Bertoli, Andrea Cereatti, Ugo Della Croce, Danilo Pani, Laura Fadda, Antonino Cannas, Francesco Marrosu, Giovanni Defazio, Giuseppe Mercuro
OBJECTIVES: Among different exercise models proposed for individuals with Parkinson's disease (IwPD), the popularity of traditional forms of dance is increasing. The aim of this study was to evaluate the effects of Sardinian folk dance (Ballu Sardu, BS) on functional performance and motor and nonmotor symptoms in IwPD. DESIGN: Single-blind, randomized controlled pilot trial. SETTINGS: Outpatient health clinic. SUBJECTS AND INTERVENTIONS: Twenty IwPD (13M, 7F; 67...
January 9, 2019: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Ayşe İnel Manav, Nuray Simsek
This study was carried out to assess the effects of reminiscence therapy that was supported with internet-based videos on the cognitive condition and apathy levels of older people with mild dementia living in nursing homes. This randomized controlled experimental study was conducted between May 15, 2016, and August 25, 2016, in two nursing homes in Adana, Turkey. A total of 32 people participated in this study, 16 individuals were in the intervention group and 16 individuals were in the control group. The data were collected using a Personal Information Form, the Standardized Mini-Mental State Examination (SMMSE) test, and the Apathy Rating Scale (ARS) Self-assessment Form...
January 6, 2019: Journal of Geriatric Psychiatry and Neurology
Daniel S Brown, Matthew J Barrett, Joseph L Flanigan, Scott A Sperling
OBJECTIVE: To better understand the demographic, neuropsychiatric, cognitive, and motor predictors of apathy in Parkinson's disease (PD). METHOD: 112 participants (Mage = 68.53 years; Mdisease duration = 6.17 years) were administered the Apathy Scale (AS), Beck Depression Inventory-II (BDI-II), Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Trail Making Test (TMT), Wechsler Adult Intelligence Scale-IV Matrix Reasoning subtest, letter (F-A-S) and category (Animals) fluency, and Hopkins Verbal Learning Test-Revised...
January 2, 2019: Journal of Neurology
Marieke J Henstra, Didi Rhebergen, Max L Stek, Karin M A Swart, Suzanne C van Dijk, M Carola Zillikens, Sadaf Oliai Araghi, Lisette C M G M de Groot, Natasja M van Schoor, Nathalie van der Velde
BACKGROUND: Symptoms of apathy are common in older persons. Negative effects on physical performance and fall risk are plausible, considering the pathophysiology of apathy. However, literature is scarce. AIM: To longitudinally assess the association between apathy and (1) decline of physical performance and (2) the number of falls in older community-dwelling persons. METHODS: The 'B vitamins for the PRevention Of Osteoporotic Fractures' study provided data on 2919 older persons over a period of 2 years...
January 2, 2019: Aging Clinical and Experimental Research
Qiguang Li, Shaoling Zhong, Jiansong Zhou, Xiaoping Wang
Little is known about the risk factors for aggression in general clinical settings in China. The aim of this study is to explore potential risk factors for inpatients with serious mental illness. The study was conducted from 15 March to 14 April 2013 and involved 16 general psychiatric institutions in China. A standardized data collection form was used to collect demographic and clinical characteristics data, including information on current hallucinations, delusions, depression, excitement, aboulia, apathy, and adherence to treatment...
December 13, 2018: Psychiatry Research
Qiujin Yu, Peng Guo, Danning Li, Lijun Zuo, Tenghong Lian, Shuyang Yu, Yang Hu, Li Liu, Zhao Jin, Ruidan Wang, Yingshan Piao, Lixia Li, Xiaomin Wang, Wei Zhang
Our study aimed to analyse the olfactory dysfunction (OD) evaluations between self-report, the Hyposmia Rating Scale (HRS) and the Sniffin' Sticks test, and the relationship between OD and clinical features of AD. Sixty patients with AD dementia, 37 patients with mild cognitive impairment (MCI) due to AD and 30 healthy controls were consecutively recruited. Olfactory function was evaluated by self-report, HRS and Sniffin' Sticks test. Patients were divided into AD with OD (AD-OD) and AD with no OD (AD-NOD) groups based on the results of the Sniffin' Sticks test...
December 2018: Aging and Disease
Yasuyuki Ohta, Nozomi Hishikawa, Kota Sato, Mami Takemoto, Toru Yamashita, Shinji Doutare, Koji Abe
Objective We evaluated the clinical effects of a telephone call service for psychological symptoms such as anxiety, depression or apathy in subacute myelo-optico-neuropathy (SMON) patients living alone or with a single caregiver. Methods Up to 16 SMON patients (4 men, 12 women) and 32 control subjects were evaluated by the geriatric depression scale (GDS), apathy scale (AS) and state and trait anxiety inventory (STAI) forms X-I, including the P and A values for depression, apathy and state anxiety including disturbed peace of mind and enhanced anxiety, respectively, before (pre) and three months after (post) the telephone call service...
December 18, 2018: Internal Medicine
Thibaut Dondaine, Pierre Philippot, Jean-Marie Batail, Florence Le Jeune, Paul Sauleau, Sophie Drapier, Marc Vérin, Bruno Millet, Dominique Drapier, Gabriel Robert
Background: Within the heterogeneity of schizophrenia, apathy constitutes an independent cluster of negative symptoms associated with poor outcomes. Attempts to identify an emotional deficit in patients who have schizophrenia with negative symptoms have yielded mixed results, and studies that focus on the relationship between apathy and emotional disorders are lacking. Methods: We set out to remedy this shortcoming using a validated battery of film excerpts to induce positive and negative emotions in patients with chronic schizophrenia with (n = 20) or without (n = 20) apathy, and in controls (n = 20) comparable for age, sex and socioeconomic status...
January 1, 2019: Journal of Psychiatry & Neuroscience: JPN
Gurpreet Rekhi, Mei San Ang, Caryn Kai Yan Yuen, Wai Yee Ng, Jimmy Lee
This study aimed to examine the validity of the Clinical Assessment Interview for Negative Symptoms (CAINS) in Singapore. 274 participants with schizophrenia were assessed on the CAINS, Scale for the Assessment of Negative Symptoms (SANS), Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS), Social and Occupational Functioning Assessment Scale (SOFAS) and the Simpson-Angus Extrapyramidal Side Effects Scale (SES). Factor analyses were conducted and Cronbach's coefficient alpha was calculated...
December 14, 2018: Schizophrenia Research
Maud van Dorst, Kees Okkersen, Roy P C Kessels, Frederick J A Meijer, Darren G Monckton, Baziel G M van Engelen, Anil M Tuladhar, Joost Raaphorst
The myriad of neuropsychiatric manifestations reported in myotonic dystrophy type 1 may have its origin in alterations of complex brain network interactions at the structural level. In this study, we tested the hypothesis that altered white matter microstructural integrity and network organisation were present in a cohort of individuals with DM1 compared to unaffected controls, which was expected to be associated with CNS related disease manifestations of DM1. We performed a cross-sectional neuropsychological assessment and brain MRI in 25 myotonic dystrophy type 1 (DM1) patients and 26 age, sex and educational level matched unaffected controls...
November 28, 2018: NeuroImage: Clinical
Liping Chen, Siqing Xiong, Yi Liu, Meiqing Lin, Lu Zhu, Renjia Zhong, Jiuhan Zhao, Wenjing Liu, Jirui Wang, Xiuli Shang
BACKGROUND: Apathy is a multidimensional syndrome referring to a primary lack of motivation, frequent in survivors of stroke. And prior studies have demonstrated the negative effect of apathy on recovery from stroke. METHODS: A randomized controlled study of acute stroke patients. Four hundred and eighty-eight patients without evidence of apathy or depression at the initial visit were consecutively recruited, 258 males and 230 female. Patients were block randomized into 2 groups...
November 27, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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