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memory of pain

Antonio Giorgio, Chiara Lupi, Jian Zhang, Francesco De Cesaris, Mario Alessandri, Marzia Mortilla, Antonio Federico, Pierangelo Geppetti, Nicola De Stefano, Silvia Benemei
Cluster headache (CH) shows a more severe clinical picture than migraine (Mig). We tested whether brain changes can explain such difference. Multimodal MRI was acquired in attack-free patients with CH (n = 12), Mig (n = 13) and in normal controls (NC, n = 13). We used FSL for MRI data analysis and nonparametric permutation testing for voxelwise analyses (p < 0.01, corrected). CH showed lower grey matter (GM) volume, compared to Mig and NC, in frontal cortex regions (inferior frontal gyrus and frontal pole [FP], respectively) and, only compared to Mig, in lateral occipital cortex (LOC)...
February 14, 2019: Brain Imaging and Behavior
Stefanie Hardt, Caroline Fischer, Alexandra Vogel, Annett Wilken-Schmitz, Irmgard Tegeder
Inflammation or injuries of the trigeminal nerve are often associated with persistent facial pain and its sequelae. A number of models have been described to study trigeminal pain in rodents, but the long-lasting behavioral consequences are unknown. The present study characterizes the impact of a distal infraorbital nerve injury, called DIONI, which consists of ligature and transection of distal fibers of the infraorbital nerve. We assessed nociception using a conflict paradigm and optogenetics, and a set of reward, aversion, spatial, temporal and competition tasks in the IntelliCage to study multiple aspects of cognition, circadian rhythms and social interactions in groups of mice in home cage environments...
February 8, 2019: Pain
E Guedj, C Eldin, D Raoult, J M Azorin, R Belzeaux
Approximately 10% of patients presenting with Lyme disease experience fatigue, musculoskeletal pain, concentration disorders, or short-term memory deficits in the six months following treatment. This entity has been defined as post-Lyme disease syndrome or post-treatment Lyme disease syndrome. The pathophysiology of this syndrome is unknown, but neither persistence of the bacterium nor effectiveness of antibiotics are currently reported in the literature. The French High Council for Public Health (French acronym HCSP) has recently defined a new entity called "persistent polymorphic symptoms after a tick bite" allowing for designing studies to better understand these subjective presentations, for which objective biomarkers are currently lacking...
February 5, 2019: Médecine et Maladies Infectieuses
Rachel E Ward, Lien Quach, Sarah A Welch, Suzanne G Leveille, Elizabeth Leritz, Jonathan F Bean
Background: Neuromuscular and clinical factors contribute to falls among older adults, yet the interrelated nature of these factors is not well understood. We investigated the relationships between these factors and how they contribute to falls, which may help optimize fall risk assessment and prevention. Methods: 365 primary care patients (age=77±7, 67% female) were included from the Boston Rehabilitative Impairment Study of the Elderly. Neuromuscular measures included leg strength and leg velocity, trunk extensor endurance, and knee range of motion...
February 5, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Jie Gao, Chongfa Zhao, Wenchen Jiang, Baosen Zheng, Yongjin He
To estimate the effect of acupuncture on idiopathic trigeminal neuralgia (ITN), we recruited 116 patients with ITN from December 2016 to April 2018 and further divided into them into two groups: acupuncture intervention group (n = 62) and sham control group (n = 54). Clinical pain, cognitive function, and quality of life (QoL) assessed with the 36-Item Short Form Health Survey (SF-36) were evaluated at the initial time of treatment, at the end of treatment, and 6 weeks after the treatment. Pain intensity, headache, and generalized body pain showed significant decrease both at the end of treatment and after 6 weeks of treatment when compared with initial time...
January 31, 2019: Journal of Nervous and Mental Disease
Janna R Shapiro, Breanna Hodgins, Hilary E Hendin, Aakash Patel, Karim Menassa, Celine Menassa, Maurice Menassa, Jennifer A Pereira, Brian J Ward
BACKGROUND: Needle-free vaccine delivery systems have many potential advantages including increased vaccine compliance and decreased risk of needlestick injuries and syringe reuse. The Med-Jet® H4 is a gas-powered, auto-disabling disposable syringe jet injector. The Med-Jet family of products are currently being used in dermatology, podiatry, pain management and veterinary practices. The objectives of this study were to assess patient attitudes, time-efficiency, safety and immunogenicity of the seasonal influenza vaccine delivered by Med-Jet compared to the traditional needle-and-syringe...
January 29, 2019: Vaccine
Y Yuan, J Zhang, H L Yue, J Wang, Y H Pei, X J Qiu, Y L Wang, T Wang
Objective: This study aimed to explore a feasible method of anesthesia for painless bronchoscopy. Methods: A total of 120 patients receiving flexible bronchoscopy in Beijing Tiantan Hospital during the period from February, 8, 2018 to May, 4, 2018, were randomly divided into 3 groups, including group A (using lidocaine for local anesthesia), group B (using lidocaine + midazolam + fentanyl), and group C (using lidocaine + propofol + sufentanil). There were 41 patients in group A, 38 in group B and 41 in group C...
February 12, 2019: Chinese Journal of Tuberculosis and Respiratory Diseases
Ksenija Vucurovic, Clémentine Dupont-Gaudin, Delphine Raucher-Chéné, Arthur Kaladjian, Christine-Vanessa Cuervo-Lombard
OBJECTIVE: Self-defining memories (SDMs) are vivid, emotionally intense and well-rehearsed autobiographical memories that provide fundamental information about one's cognitive affective motivational representation of self. Exploring SDMs in fibromyalgia (FM) is of interest for understanding the psychopathology of this disorder and improving clinical interventions. Our aim was to compare patients and healthy controls (HC) on SDM characteristics. METHOD: We included 25 patients with FM and 24 HC matched for age, sex and education level...
January 7, 2019: Comprehensive Psychiatry
Helder Cardoso-Cruz, Pedro Paiva, Clara Monteiro, Vasco Galhardo
Stability of local medial prefrontal cortex (mPFC) network activity is believed to be critical for sustaining cognitive processes such as working memory (WM) and decision making. Dysfunction of the mPFC has been identified as a leading cause to WM deficits in several chronic pain conditions; however, the underlying mechanisms remain largely undetermined. Here, to address this issue, we implanted multichannel arrays of electrodes in the prelimbic region of the mPFC and recorded the neuronal activity during a food-reinforced delayed nonmatch to sample (DNMS) task of spatial WM...
December 3, 2018: Pain
Marta Szantroch, Aleksandra Bala, Andrzej Rysz, Jarosław Żyłkowski, Andrzej Marchel
The aim of this study was to assess the type and frequency of adverse events during the Wada test conducted with propofol as an anaesthetic agent. In total, 122 patients with temporal lobe epilepsy underwent the Wada test with propofol between 2006 and 2016 as part of presurgical evaluation at the Department of Neurosurgery of the Medical University of Warsaw. The Wada test was conducted bilaterally on 118 patients (236 cases). In four cases, due to complications, the test was conducted only unilaterally, which resulted in a total of 240 cases...
January 24, 2019: Scientific Reports
Ole Mikal Wormdal, Trond Flægstad, Tore Stokland
BACKGROUND: Two 14-year old boys with acute lymphocytic leukemia were treated according to the NOPHO-ALL-08 protocol with intrathecal methotrexate (MTX) on the same day. Due to a preparation error in the hospital pharmacy, they were both given 240 mg of MTX instead of the prescribed 12 mg. Treatment (or methods): Both patients developed acute neurotoxicity with confusion, pain and seizures. Intravenous dexamethasone and folinic acid (leucovorin) was given. Exchange of cerebrospinal fluid was performed...
January 23, 2019: Pediatric Hematology and Oncology
Daniel E Schoth, Rebecca Beaney, Philippa Broadbent, Jin Zhang, Christina Liossi
Introduction: Cognitive biases in attention, interpretation and less consistently memory have been observed in individuals with chronic pain and play a critical role in the onset and maintenance of chronic pain. Despite operating in combination cognitive biases are typically explored in isolation. Aim: The primary aim of this study was to explore attentional, interpretation and memory biases and their interrelationship in individuals with chronic headache. Methods: Twenty-eight participants with chronic headache and 34 healthy controls completed paradigms assessing attentional, interpretation and memory biases with ambiguous sensory-pain and neutral words...
February 2019: British Journal of Pain
Stephanie Shiers, Theodore J Price
Memories of painful events protect us from danger. A new study demonstrates that, in both mice and humans, pain memories elicited by place conditioning are driven by spinal mechanisms, involve stress circuits and are surprisingly only found in males.
January 21, 2019: Current Biology: CB
Mohaddeseh Hafez Yosephi, Fatemeh Ehsani, Maryam Daghiani, Maryam Zoghi, Shapour Jaberzadeh
Intensifying fear and fear of pain may lead to some diseases such as panic disorder, phobias, post-traumatic stress disorder (PTSD), anxiety disorders, depression, etc. A number of studies indicated positive effect of transcranial direct current stimulation (tDCS) on controlling fear and some studies did not observe any effect or even negative effect on decreasing fear. Due to lack of consensus in the findings of research, we aimed to systematically review studies, which investigated the effect of tDCS on fear...
January 16, 2019: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
A J M Boulton
A series of clinical research projects conducted over the past 40 years, all of which were informed by clinical observation or discussions with people with diabetes and staff colleagues are described in this review. A study of necrobiosis lipoidica iabeticorum confirmed that this rare skin complication occurs predominantly in young women with Type 1 diabetes and other microvascular complications. Biopsies of necrobiotic lesions showed destruction of superficial nerve fibres by inflammatory tissue, which likely causes the sensory loss in lesions that is pathognomonic of the condition...
January 19, 2019: Diabetic Medicine: a Journal of the British Diabetic Association
Michele Tsai Owens, Cynthia Harbeck-Weber, Alexandra Kirsch, Leslie Sim, Michael Zaccariello, Kendra Homan, Philip Fischer
Objective: Adolescents and young adults (AYAs) with postural orthostatic tachycardia syndrome (POTS) commonly report cognitive difficulties, though there is limited information regarding the objective measurement of neurocognitive deficits in this population. This study described the rates of subjectively experienced and objectively measured neurocognitive difficulties and explored effects of medications on neurocognitive functioning among AYAs with POTS admitted to an intensive outpatient pain rehabilitation program...
January 12, 2019: Journal of Pediatric Psychology
Ann Sophie Schröder, Hilke Andresen-Streichert, Sven Anders
Ecstasy (MDMA) is a mood-lifting drug with numerous somatic side effects, for example, dehydration or continuous chewing and biting. We describe the case of a young woman who underwent a forensic medical examination for suspected sexual assault. She claimed to have suffered from a memory lapse, and she had a painful swelling of her lips with a plaque-like coating on her lips and buccal mucosa. The attending physician suspected that these findings might have been caused by strong sucking pressure on her lips within the context of a sexual assault...
January 15, 2019: Journal of Forensic Sciences
Huahua Gu, Xianyu Deng, Yizheng Lv, Qian Chen, Weifeng Yu
Purpose: This study aimed to investigate the relationship of preoperative chronic pain and postoperative cognitive dysfunction (POCD) in non-elderly patients who underwent arthroscopic surgery. Materials and methods: The pain intensity was estimated using visual analog scale, and the cognitive function was assessed by Syndrom Kurz Test. The effects of preoperative chronic pain on the cognitive scales were comparatively studied between the patients of observational group (OG, with chronic pain) and control group (CG, without chronic pain) pre- and postoperatively, and followed up for 3 months...
2019: Journal of Pain Research
Yunlong Deng, Honggui Zhou
Mindfulness-based psychotherapy, known as the third-wave cognitive behavior therapy, showed a multi-cultural integration trend. As part of it, willing acceptance and commitment therapy not only took root in the discoveries in the fields of evolutionary psychology and cognitive psychology, but also absorbed the concepts of psychotherapy from Chinese traditional culture. As a result, it regards truth and harmony as the essence of health, proposes a triangle model (health/pain-willing acceptance-striving) to elucidate the mechanism of psychopathology and psychotherapy in theory...
November 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Caroline Blais, Daniel Fiset, Hana Furumoto-Deshaies, Miriam Kunz, Dominik Seuss, Stéphanie Cormier
Previous research has revealed that the face is a finely tuned medium for pain communication. Studies assessing the decoding of pain facial expressions have revealed an interesting discrepancy, namely that despite "eyes narrowing" being the most frequent facial expression accompanying pain, individuals mostly rely on "brow lowering", "nose wrinkling/upper lip raising" to evaluate pain. The present study verifies if this discrepancy may reflect an interaction between the features coding pain expressions and the features used by observers and stored in their mental representations...
January 8, 2019: Journal of Pain: Official Journal of the American Pain Society
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