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neonatal developmental care

S Pose, M J Zuluaga, M Ferreño, D Agrati, G Bedó, N Uriarte
The maternal behavior of a rat dynamically changes during the postpartum period, adjusting to the characteristics and physiological needs of the pups. This adaptation has been attributed to functional modifications in the maternal circuitry. Maternal behavior can also flexibly adapt according to different litter compositions. Thus, mothers with two overlapping litters can concurrently take care of neonate and juvenile pups; mostly directing their attention to the newborns. We hypothesized that the maternal circuitry of these mothers would show a differential activation pattern after interacting with pups depending on their offspring's developmental stage...
February 19, 2019: Journal of Neuroendocrinology
Mercedes García Reymundo, José Antonio Hurtado Suazo, M José Calvo Aguilar, Francisco Javier Soriano Faura, Gemma Ginovart Galiana, Yolanda Martín Peinador, Ana Jiménez Moya, Xavier Demestre Guasch
The population of late preterm infants (PT), those born between 34+0 and 36+6 weeks of gestation, accounts for 70-74% of all premature infants, and is not specifically included in most of the follow-up protocols for preterm infants. For many years, PTs have been handled as if they were term newborns, which has led to a limited knowledge of their outcome in the medium and long term. Their neonatal morbidity is associated with a higher incidence of postnatal complications, with an increased rate of hospital re-admissions due to malnutrition, hyperbilirubinaemia, and respiratory problems, when compared to term infants...
February 15, 2019: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Sachiko Iwata, Masahiro Kinoshita, Hisayoshi Okamura, Kennosuke Tsuda, Mamoru Saikusa, Eimei Harada, Shinji Saitoh, Osuke Iwata
Backgrounds: Environmental factors during early life alter the hypothalamus-pituitary-adrenal (HPA) axis regulation and increase the risk of diseases in later life. However, adrenal function at each developmental stage has not fully been investigated in relation to pathological antenatal conditions. Cortisol levels of newborns with intrauterine growth restriction (IUGR) are elevated during the neonatal period; however, when studied during early childhood, cortisol levels are reduced compared with their peers, suggesting that the HPA axis regulation might be altered from activation to suppression, the timing of which remains uncertain...
2019: PeerJ
Harish Chellani, Pratima Mittal, Sugandha Arya
Health facilities in India are faced with the challenge of providing quality newborn care in the face of major skilled human resource shortage. A possible solution is the concept of Mother-Neonatal ICU (M-NICU), where the mother has her bed inside the neonatal intensive care unit (NICU) by the side of baby's warmer. Our observations in M-NICU of a public sector hospital in New Delhi, India, indicate that mothers can be easily trained to follow asepsis routines and monitor the neonates, and are better prepared for their post-discharge care...
December 15, 2018: Indian Pediatrics
Yonghui Wu, Xinyi Lin, Ives Yubin Lim, Li Chen, Ai Ling Teh, Julia L MacIsaac, Kok Hian Tan, Michael S Kobor, Yap Seng Chong, Peter D Gluckman, Neerja Karnani
BACKGROUND: Preterm birth (PTB), defined as child birth before completion of 37 weeks of gestation, is a major challenge in perinatal health care and can bear long-term medical and financial burden. Over a million children die each year due to PTB complications, and those who survive can face developmental delays. Unfortunately, our understanding of the molecular pathways associated with PTB remains limited. There is a growing body of evidence suggesting the role of DNA methylation (DNAm) in mediating the effects of PTB on future health outcomes...
February 11, 2019: Clinical Epigenetics
Hannah C Glass, Donna M Ferriero, David H Rowitch, Thomas K Shimotake
PURPOSE OF REVIEW: With the advent of therapeutic hypothermia for treatment of hypoxic ischemic encephalopathy, and improvements in neuroimaging and bedside neuromonitoring, a new era of neonatal brain-focused care has emerged in recent years. We describe the development of the first neurointensive care nursery (NICN) as a model for comanagement of neonates with identified neurologic risk factors by a multidisciplinary team constituted of neurologists, neonatologists, specialized nurses, and others with the goal of optimizing management, preventing secondary injury and maximizing long-term outcomes...
January 31, 2019: Current Opinion in Pediatrics
Trassanee Chatmethakul, Robert D Roghair
Consistent with the paradigm shifting observations of David Barker and colleagues that revealed a powerful relationship between decreased weight through 2 years of age and adult disease, intrauterine growth restriction (IUGR) and preterm birth are independent risk factors for the development of subsequent hypertension. Animal models have been indispensable in defining the mechanisms responsible for these associations and the potential targets for therapeutic intervention. Among the modifiable risk factors, micronutrient deficiency, physical immobility, exaggerated stress hormone exposure and deficient trophic hormone production are leading candidates for targeted therapies...
January 1, 2019: Journal of Endocrinology
Eui Kyung Choi, Seung Han Shin, Ee-Kyung Kim, Han-Suk Kim
BACKGROUND: Owing to advances in the critical care of premature infants with bronchopulmonary dysplasia (BPD), BPD-associated pulmonary hypertension (PH) is becoming a growing concern. However, only few investigations were available on neurodevelopmental outcomes in preterm infants with PH. Therefore, this study aimed to identify the impact of PH on growth and neurodevelopment at 18-24 months of corrected age (CA). METHODS: We retrospectively analyzed the medical records of 394 infants (aged < 28 weeks of gestation) admitted to the neonatal intensive care unit between 2005 and 2014...
January 17, 2019: BMC Pediatrics
Jila Mirlashari, Fatemeh Khoshnavay Fomani, Helen Brown, Beheshteh Tabarsy
PURPOSE: The Newborn Individualized Developmental Care and Assessment Program (NIDCAP) provides comprehensive newborn focused family-centered care in the Neonatal Intensive Care Unit (NICU). The purpose of this study was to investigate nurses' and physicians' experiences of implementing the NIDCAP model to optimize its implementation for both caregivers, infants, and families in the NICU. DESIGN & METHODS: A purposes sample of 11 nurses and four physicians participated in this qualitative study...
January 7, 2019: Journal of Pediatric Nursing
Miho Nonomura, Sayaka Harada, Yuki Asada, Hisako Matsumura, Hiroko Iwami, Yuko Tanaka, Hiroyuki Ichiba
BACKGROUND: Although therapeutic hypothermia improves the outcome of neonatal hypoxic-ischemic encephalopathy (HIE), its efficacy is still limited. This preliminary study evaluates the safety and feasibility of the combination therapy with erythropoietin (Epo), magnesium sulfate and hypothermia in neonates with HIE. METHODS: A combination therapy with Epo (300 U/kg every other day for 2 weeks), magnesium sulfate (250 mg/kg for 3 days) and hypothermia was started within 6 h of birth in neonates who met the institutional criteria for hypothermia therapy...
January 8, 2019: BMC Pediatrics
Vanita Kumari, Poonam Joshi, Anjan Kumar Dhua, Savita Sapra, Maddur Srinivas, Sandeep Agarwala, Veereshwar Bhatnagar
INTRODUCTION:  Esophageal atresia with or without tracheoesophageal fistula (EA with or without TEF) is one of the neonatal surgical emergencies requiring surgical intervention in the early neonatal period, influencing the developmental outcome in the operated children. This study was aimed to assess the developmental status of children operated for EA with or without TEF along with maternal stress, their quality of life (QOL), and coping abilities. MATERIALS AND METHODS:  A descriptive cross-sectional survey was conducted on 51 children aged up to 5 years after EA with or without TEF repair and their mothers' in a tertiary care facility...
December 31, 2018: European Journal of Pediatric Surgery
Thomas A Imahiyerobo, Alexis L Johns, Eisha A Christian, Pedro A Sanchez-Lara, Mark D Krieger, J Gordon McComb, Mark M Urata
BACKGROUND: Some patients with isolated sagittal craniosynostosis have demonstrated mild neurodevelopmental delays. This study examined potential preoperative risk factors for developmental delay. METHODS: Patients completed preoperative Bayley Scales of Infant and Toddler Development, Third Edition, and medical records were reviewed. Multivariate analyses of covariance and correlations were calculated. RESULTS: Participants (n = 77) were predominantly male (77...
January 2019: Plastic and Reconstructive Surgery
Kelly M Boone, Mary Ann Nelin, Deena J Chisolm, Sarah A Keim
OBJECTIVE: To characterize gaps and factors related to receipt of care within a medical home for toddlers born preterm. STUDY DESIGN: Participants were 202 caregivers of children born at <35 weeks of gestation. At 10-16 months of corrected age, caregivers completed the National Survey of Children's Health (2011/2012) medical home module and a sociodemographic profile. Care within a medical home comprised having a personal doctor/nurse, a usual place for care, effective care coordination, family-centered care, and getting referrals when needed...
December 19, 2018: Journal of Pediatrics
Candy Bruton, Jennifer Meckley, Lori Nelson
The aim of this project was to determine how implementing neuroprotective, family-centered, developmental care interventions would impact the satisfaction of nurses and families compared with traditional care in a NICU. Neuroprotective, family-centered, developmental care is grounded in the principle that optimal health outcomes are accomplished when patients' family members play an active role in contributing emotional, social, and developmental support for their babies. To accomplish this, nurses needed an understanding of the developmental problems associated with high-risk premature infants, fundamentals of neurosensory growth, and how the intrauterine environment protects the infant from the fluctuation of an unstable extrauterine environment...
November 2018: Neonatal Network: NN
Maria Hafström, Øyvind Salvesen, Ingemar Kjellmer
AIM: To evaluate sex differences in infants born at term with metabolic acidosis with regard to perinatal health and symptomatology, and developmental outcome. METHODS: From a population-based cohort of infants born at term (n = 14 687), 78 were prospectively identified as having metabolic acidosis at birth. Two matched controls per case were selected. Sex differences in perinatal characteristics and in neurodevelopmental outcome at 6.5 years of age were analysed...
December 18, 2018: Acta Paediatrica
Jesse W Young, Kathryn Jankord, Marnie M Saunders, Timothy D Smith
Functional studies of skeletal anatomy are predicated on the fundamental assumption that form will follow function. For instance, previous studies have shown that the femora of specialized leaping primates are more robust than those of more generalized primate quadrupeds. Are such differences solely a plastic response to differential loading patterns during postnatal life, or might they also reflect more canalized developmental mechanisms present at birth? Here, we show that perinatal Lemur catta, an arboreal/terrestrial quadruped, have absolutely and relatively weaker femora than perinatal Propithecus coquereli, a closely-related species specialized for vertical clinging and leaping (a highly unusual locomotor mode in which the hindlimbs are used to launch the animal between vertical tree trunks)...
December 8, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Erika B Rosenzweig, Steven H Abman, Ian Adatia, Maurice Beghetti, Damien Bonnet, Sheila Haworth, D Dunbar Ivy, Rolf M F Berger
Paediatric pulmonary arterial hypertension (PAH) shares common features of adult disease, but is associated with several additional disorders and challenges that require unique approaches. This article discusses recent advances, ongoing challenges and distinct approaches for the care of children with PAH, as presented by the Paediatric Task Force of the 6th World Symposium on Pulmonary Hypertension. We provide updates of the current definition, epidemiology, classification, diagnostics and treatment of paediatric PAH, and identify critical knowledge gaps...
January 2019: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Bruna de Souza Lima Marski, Beatriz Castanheira Facio, Sueli Mutsumi Tsukuda Ichisato, Patricia Carla de Souza Della Barba, Monika Wernet
OBJECTIVE: to analyze the Developmental Care in nursing care for Newborns in critical Neonatal Intensive Care Units. METHOD: a qualitative study with 11 nurses from Neonatal Intensive Care Units of a city in the State of São Paulo countryside, based on the Developmental Care. Data collection was based on non-participant observation, documentary research in medical records and semi-structured interviews. The Symbolic Interactionism was adopted as theoretical framework, and the Bardin Content Analysis, as method of analysis...
2018: Revista Brasileira de Enfermagem
Andréa Araujo de Oliveira Cortines, Patrícia Corrêa-Faria, Liselotte Paulsson, Paulo Sucasas Costa, Luciane Rezende Costa
OBJECTIVE: Developmental defects of enamel (DDE) in preterm infants still require clarification and may favour dental caries, lower food intake, and greater difficulty with weight-height gain. We evaluated factors associated with DDE in preterm infants. SUBJECTS AND METHODS: In this prospective cohort study, we monitored 54 prematurely born infants from birth to 24 months of age. Trained and calibrated dentists examined the oral cavity of these children to identify and categorize DDE...
December 7, 2018: Oral Diseases
Arwin M Valencia, Maria A Abrantes, Jamal Hasan, Jacob V Aranda, Kay D Beharry
The lungs of extremely low gestational age neonates (ELGANs) are deficient in pulmonary surfactant and are incapable of efficient gas exchange necessary for successful transition from a hypoxic intrauterine environment to ambient air. To improve gas exchange and survival, ELGANs often receive supplemental oxygen with mechanical ventilation which disrupts normal lung developmental processes, including microvascular maturation and alveolarization. Factors that regulate these developmental processes include vascular endothelial growth factor and matrix metalloproteinases, both of which are influenced by generation of oxygen byproducts, or reactive oxygen species (ROS)...
November 2018: Reactive Oxygen Species (Apex, N.C.)
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