Giorgia Coratti, Francesca Bovis, Maria Carmela Pera, Mariacristina Scoto, Jacqueline Montes, Amy Pasternak, Anna Mayhew, Robert Muni-Lofra, Tina Duong, Annemarie Rohwer, Sally Dunaway Young, Matthew Civitello, Francesca Salmin, Irene Mizzoni, Simone Morando, Marika Pane, Emilio Albamonte, Adele D'Amico, Noemi Brolatti, Maria Sframeli, Chiara Marini-Bettolo, Valeria Ada Sansone, Claudio Bruno, Sonia Messina, Enrico Bertini, Giovanni Baranello, John Day, Basil T Darras, Darryl C De Vivo, Michio Hirano, Francesco Muntoni, Richard Finkel, Eugenio Mercuri
BACKGROUND AND PURPOSE: Spinal muscular atrophy (SMA) is a rare and progressive neuromuscular disorder with varying severity levels. The aim of the study was to calculate minimal clinically important difference (MCID), minimal detectable change (MDC), and values for the Hammersmith Functional Motor Scale Expanded (HFMSE) in an untreated international SMA cohort. METHODS: The study employed two distinct methods. MDC was calculated using distribution-based approaches to consider standard error of measurement and effect size change in a population of 321 patients (176 SMA II and 145 SMA III), allowing for stratification based on age and function...
April 24, 2024: European Journal of Neurology