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lupus tuberculosis

Ou Jun Kwon, Suk Woo Lee, Mun Sun Jang, Sang Chul Kim, Ji Han Lee, Hoon Kim
Perihepatic capsulitis is associated with various diseases, such as Fitz-Hugh-Curtis syndrome, systemic lupus erythematosus, perforated cholecystitis, perforated hepatic abscess, and tuberculous peritonitis. Miliary tuberculosis is present in about 2% of all reported cases of tuberculosis and is characterized by the widespread millet-like hematogenous dissemination of Mycobacterium tuberculosis. We describe a 24-year-old virgin patient presenting with right upper quadrant and costovertebral angle pain. Diffuse perihepatic capsular enhancement was observed in abdominal computed tomography scans...
February 12, 2019: Clinical and Experimental Emergency Medicine
Yudan Lv, Xiangyu Zheng, Xiao Zhang, Danyang Zhao, Li Cui
The diagnosis of autoimmune epilepsy is often challenging, and may be misdiagnosed as epileptic disorders or viral encephalitis. Autoimmune epilepsy has a strong association with other autoimmune diseases, especially systemic lupus erythematosus (SLE). In addition, autoimmune epilepsy was reported to present with complex partial seizure (CPS), simple partial seizure (SPS), and secondarily generalized tonic-clonic seizure (sGTCS). In our case, we present a different seizure type of tonic seizure in autoimmune epilepsy caused by SLE, which has not been reported, and it will provide with a new understanding of autoimmune epilepsy...
February 6, 2019: Journal of Nervous and Mental Disease
Lynnette R L Tan, Ho Yee Tiong
BACKGROUND: In patients with bladder augmentation undergoing kidney transplantation, conventional technique recommends anastomosing the transplanted ureter to the bladder. We report our technique of ureteric implantation into the bowel portion of the enterocystoplasty, and review the urological outcomes of transplantation in these patients. METHODS: Seven patients (mean age: 26 years (range 24-54 years), two females, five deceased donors) with augmented cystoplasty and subsequent kidney transplantation by a single surgeon from 2011 to 2015 were reviewed...
January 26, 2019: ANZ Journal of Surgery
S Chandrashekara, Vineeta Shobha, Vijay Rao, Anu Desai, Ramesh Jois, B G Dharmanand, Sharath Kumar, Pradeep Kumar, Chethana Dharmapalaiah, Kurugodu Mathada Mahendranath, Shiva Prasad, Manisha Ashwin Daware, Yogesh Singh, Uma Karjigi, S Nagaraj, K R Anupama
Biologic disease-modifying anti-rheumatic drugs (bDMARD) have transformed the treatment paradigm of chronic autoimmune rheumatic diseases (ARDs), but they are often associated with adverse drug reactions. The present study evaluated the frequency, characteristics and type of infections, other than tuberculosis (TB), in ARD patients receiving bDMARDs. The multicentre, cross-sectional, retrospective, observational study was conducted across 12 centers in Karnataka, India, between January to August 2016. The study included patients receiving bDMARD therapy for various ARDs...
March 2019: Rheumatology International
Justin Lee Loy, Gajapathiraju Chamarthi, Abhilash Koratala
Optic neuropathy is an uncommon finding in dialysis patients and has been associated with uremia, ischemia (arteritic and nonarteritic), drugs (isoniazid, ethambutol), infections (tuberculosis), and intracranial hypertension. Inflammatory optic neuritis associated with lupus is relatively rare, but clinicians need to be aware of this condition and obtain urgent ophthalmology consultation.
January 2019: Clinical Case Reports
Wonchibeni T Murry, Sonal Sharma, Vinod Kumar Arora, Sambit Nath Bhattacharya, Archana Singal
OBJECTIVES: The diagnosis of cutaneous tuberculosis is challenging due to its diverse clinical manifestations, paucibacillary state and lack of proper diagnostic tests. Clinico-pathological correlation is still frequently used for diagnosis. There is paucity of literature on cytomorphological features. Immunochemistry can help as an ancillary test. METHODS: Clinical diagnosis was made after thorough history and physical examination. Modified Fine Needle Aspiration technique was used to collect cytology samples and 3 mm punch biopsy for histological examination...
December 24, 2018: Diagnostic Cytopathology
J Yang, H H Yao, X D Mo, Z Luo, Yangjin Baima
OBJECTIVE: To describe the clinical, immunological characteristics and organ involvement of patients with systemic lupus erythematosus (SLE) in Tibet plateau, China. METHODS: We retrospectively investigated 70 patients admitted in the Tibet Autonomous Region People's Hospital between May 2014 and April 2016. In the study, 120 hospitalized patients with SLE from the Department of Rheumatology and Immunology of the Peking University People's Hospital were randomly selected as the control (plain) group...
December 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Carmen Maldonado-Bernal, Alberto Ramos-Garibay, Nora Rios-Sarabia, Héctor Serrano, Manuel Carrera, Gisela Navarrete-Franco, Fermín Jurado-Santacruz, Armando Isibasi
The role of Mycobacterium tuberculosis in the etiology and pathogenesis of cutaneous tuberculosis is controversial because of the difficulties associated with demonstrating the presence of these mycobacteria in tuberculid cutaneous lesions by routinely available microbiological and histological techniques. In this study, we aimed to demonstrate the presence of M. tuberculosis in cutaneous tuberculosis. Multiple polymerase chain reaction (PCR) followed by nested PCR was used to amplify genomic fragments from 3 different mycobacteria species...
November 27, 2018: American Journal of Dermatopathology
Xiaojing Zheng, Catherine M O'Connell, Wujuan Zhong, Taylor B Poston, Harold C Wiesenfeld, Sharon L Hillier, Maria Trent, Charlotte Gaydos, George Tseng, Brandie D Taylor, Toni Darville
Sexually transmitted infection (STI) of the upper reproductive tract can result in inflammation and infertility. A biomarker of STI-induced upper tract inflammation would be significant as many women are asymptomatic and delayed treatment increases risk of sequelae. Blood mRNA from 111 women from three cohorts was profiled using microarray. Unsupervised analysis revealed a transcriptional profile that distinguished 9 cases of STI-induced endometritis from 18 with cervical STI or uninfected controls. Using a hybrid feature selection algorithm we identified 21 genes that yielded maximal classification accuracy within our training dataset...
2018: Frontiers in Cellular and Infection Microbiology
Avneesh Gupta, Jaclyn Furman, Kilak Kesha, Francisco Diaz, Carl J Schmidt
Classic "bread-and-butter" appearance of fibrinous pericarditis had been described in rheumatic disease and other immunologic diseases such as systemic lupus erythematosus, post-myocardial infarct, uremia, tuberculosis, radiation effects, bacterial, and viral etiology. In most of the described cases, pericarditis occurs as a delayed complication. We present a case of a 21-year-old white woman who was seen in the emergency department to rule out pulmonary embolism for shortness of breath, chest pain, and lightheadedness...
October 2, 2018: American Journal of Forensic Medicine and Pathology
Ronald F van Vollenhoven, Bevra H Hahn, George C Tsokos, Carrie L Wagner, Peter Lipsky, Zahi Touma, Victoria P Werth, Robert M Gordon, Bei Zhou, Benjamin Hsu, Marc Chevrier, Manon Triebel, Jarrat L Jordan, Shawn Rose
BACKGROUND: Ustekinumab is a monoclonal antibody targeting interleukin (IL)-12 and IL-23 and is approved for the treatment of plaque psoriasis, psoriatic arthritis, and Crohn's disease. IL-12 and IL-23 have been implicated in systemic lupus erythematosus. We aimed to assess the efficacy and safety of ustekinumab for the treatment of systemic lupus erythematosus in patients with moderate-to-severe disease activity despite conventional treatment. METHODS: This was a multicentre, double-blind, phase 2, randomised, controlled trial of adult patients with active, seropositive systemic lupus erythematosus, done at 44 private practices and academic centres in Argentina, Australia, Germany, Hungary, Mexico, Poland, Spain, Taiwan, and the USA...
October 13, 2018: Lancet
Minxi Lao, Dongying Chen, Xiangni Wu, Haihong Chen, Qian Qiu, Xiuyan Yang, Zhongping Zhan
To investigate the characteristics and associated factors for Mycobacterium tuberculosis (TB) infection in patients with systemic lupus erythematosus (SLE) from Southern China. A retrospective study of 1108 patients admitted to the First Affiliated Hospital of Sun Yat-Sen University from January 2007 to December 2017 was performed. Demographic and clinical characteristics, laboratory data, and radiographic manifestations were recorded. A total of 59 (5.3%) lupus patients with active TB were included. Pulmonary TB occurred in 41 (69...
September 23, 2018: Clinical Rheumatology
Fatehi Elzein, Ahmed Elzein, Nazik Mohammed, Ramiz Alswailem
A 26-year-old woman was diagnosed with and treated for systemic lupus erythematosus (SLE) in 2002. She was admitted 11 years later with nephrotic-range proteinuria and lupus nephritis and received two doses of rituximab after failing on steroids and mycophenolate mofetil. Four months later, she presented with fever and joint pain/swelling. Gram stains, joint aspirates, and blood culture all yielded negative results for bacteria. She was discharged after treatment for a possible flare of lupus, but two weeks later, she presented again with a cough and shortness of breath in addition to the flare symptoms...
2018: Respiratory Medicine Case Reports
Ángel H Álvarez, Moisés Martínez Velázquez, Ernesto Prado Montes de Oca
Human β-defensin 1 (hBD-1) is a multifaceted antimicrobial peptide being a tumour suppressor and, depending on call of duty, capable of inducing self-nets and neutrophil extracellular traps (NETs) to capture and/or kill bacteria, participates in inflammatory responses in chronic diseases including hBD-3 upregulation and also capable of up/downregulation in the presence of certain species of Lactobacillus sp. Thus, is regulated by host microbiota. Alleles, genotypes and/or altered gene expression of its coding gene, DEFB1, have been associated with several human diseases/conditions ranging from metabolic/chronic (e...
November 2018: International Journal of Biochemistry & Cell Biology
Samuel Cohen-Tanugi, Margart L Wright, R Kumar Kadiyala
Infectious tenosynovitis of the hand is a serious condition with a high risk of morbidity. Mycobacterium tuberculosis is a rare cause of tenosynovitis, especially in regions where tuberculosis is no longer endemic, and presents significant diagnostic challenges. We present the case of a 42-year-old woman with no known history of or exposure to tuberculosis and a medical history of systemic lupus erythematosus on chronic immunosuppressive therapy who presented with swelling and erythema in the fifth finger of the left hand of 1-month duration...
April 2018: Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
Hendra Gunawan, Pati Aji Achdiat, Reti Hindritiani, Erika Dewi Essary, Lulu Dwiarti Ningtias, Elfrida Putri Siregar, Putri Reno Sori, Dia Febrina
Cutaneous tuberculosis (TB) has several clinical manifestations. The most common forms include cervical scrofuloderma and plaque type of lupus vulgaris (LV), otherwise the rare cases including inguinal scrofuloderma, ulcerative LV, and acute miliary TB. The highlight of this case series was to report various rare clinical manifestations of cutaneous TB.
July 2018: International Journal of Mycobacteriology
Giovanni Genovese, Gianluca Nazzaro, Antonella Coggi, Raffaele Gianotti, Stefano Ramoni, Marco Cusini
We report a case of secondary syphilis mimicking lupus vulgaris in an HIV-infected patient. A 21-year-old Brazilian man presented with a two-month history of asymptomatic cutaneous lesions accompanied by fever and fatigue. Dermatological evaluation revealed an erythematous, crusted, large plaque on the neck with the 'apple jelly' sign on diascopy and two smaller scaly elements on the trunk and left palm. Bacteriological examinations for bacteria and mycobacteria gave negative results. Histology revealed psoriasiform epidermal hyperplasia and dermal lymphoplasmacytic infiltrate...
December 2018: International Journal of STD & AIDS
Abhijit Chougule, Debajyoti Chatterjee, Rakesh Yadav, Sunil Sethi, Dipankar De, Uma Nahar Saikia
Granulomatous rosacea (GR) and lupus miliaris disseminatus faciei (LMDF) are 2 forms of facial granulomatous diseases. Although they show some morphological overlap, they have distinct clinical presentation. This study was performed to demonstrate the clinical and histological features of GR and LMDF and to establish their relationship to tuberculous etiology by molecular technique. All the cases of GR (n = 20) and LMDF (n = 10) diagnosed on skin biopsy over the past 6 years were reviewed along with their clinical detail...
November 2018: American Journal of Dermatopathology
Heda Melinda Nataprawira, Gartika Sapartini, Ketut Indriani
Tuberculoma is one of the manifestations of tuberculosis infection in the central nervous system. Even though its prevalence is only 1%, the mortality rate is high. Clinical presentation in immunocompromised patients with tuberculoma maybe different, thus making the diagnosis difficult. We present the case of a 13-year-old girl who was admitted for routine intravenous administration of cyclophosphamide and steroid therapy for nephritis due to systemic lupus erythematosus. She experienced severe headache and focal seizure on the second day of hospitalization...
July 2018: Turkish Thoracic Journal
Fabian Leo, Christian Grohé, Michael Tronnier
No abstract text is available yet for this article.
June 22, 2018: Deutsches Ärzteblatt International
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