keyword
https://read.qxmd.com/read/38468482/the-economic-burden-of-systemic-lupus-erythematosus-in-united-arab-emirates
#21
JOURNAL ARTICLE
Atheer Alansari, Suad Hannawi, Afra Aldhaheri, Noura Zamani, Gihan Hamdy Elsisi, Sara Aldalal, Waiel Al Naeem, Mohamed Farghaly
AIMS: Our study aims to provide an enhanced comprehension of systemic lupus erythematosus (SLE) burden in United Arab Emirates (UAE), over a five-year period from payer and societal perspective. MATERIALS AND METHODS: A Markov model was established to simulate the economic consequences of SLE among UAE population. It included four health states: i) the three phenotypes of SLE, representing mild, moderate, and severe states, and ii) death. Clinical parameters were retrieved from previous literature and validated using the Delphi panel-the most common clinical practice within the Emirati healthcare system...
2024: Journal of Medical Economics
https://read.qxmd.com/read/38468480/the-economic-burden-of-systemic-lupus-erythematosus-in-taiwan
#22
REVIEW
Gihan Hamdy Elsisi, Song-Chou Hsieh, Der-Yuan Chen
BACKGROUND: Our cost-of-illness (COI) model adopted both payer and societal perspectives over a time horizon of 5 years to measure the economic burden of systemic lupus erythematosus (SLE) in Taiwan. METHODOLOGY: A prevalence-based model was established to estimate the economic consequences of SLE after diagnosis in Taiwan. The model included four health states: (i) the three phenotypes representing mild, moderate, and severe SLE, and (ii) death. The inputs were obtained from a literature review of all the clinical trials and validated using a Delphi panel...
2024: Journal of Medical Economics
https://read.qxmd.com/read/38468479/economic-burden-of-systemic-lupus-erythematosus-in-malaysia
#23
JOURNAL ARTICLE
Gihan Hamdy Elsisi, Ang Yu Joe, Mollyza Mohd Zain, Habibah Mohd Yusoof, Cheng Lay Teh, Asmah Binti Mohd, Xiang Ting Khor, Liza Binti Mohd Isa
INTRODUCTION: Our cost-of-illness (COI) model adopted the perspective of both payer and society over a time horizon of 5 years to measure the economic burden of systemic lupus erythematosus (SLE) in Malaysia. METHODOLOGY: Our COI model utilized a prevalence-based model to estimate the costs and economic consequences of SLE in Malaysia. The clinical parameters were obtained from published literature and validated using the Delphi panel. Direct and indirect medical costs were measured, including disease management, transient events, and indirect costs...
2024: Journal of Medical Economics
https://read.qxmd.com/read/38468478/clinical-and-economic-burden-of-systemic-lupus-erythematosus-in-colombia
#24
JOURNAL ARTICLE
Gihan Hamdy Elsisi, Gerardo Quintana, Diana Gil, Pedro Santos, Diana Fernandez
AIMS: Our cost-of-illness (COI) model adopted payer and societal perspectives over five years to measure the economic burden of Systemic Lupus Erythematosus (SLE) in Colombia. MATERIALS AND METHODS: A prevalence-based model was constructed to estimate costs and economic consequences for SLE patients in Colombia. The model included four health states: three phenotypes of SLE representing mild, moderate, and severe states and death. The clinical inputs were captured from the published literature and validated by the Delphi panel...
2024: Journal of Medical Economics
https://read.qxmd.com/read/38468477/the-economic-burden-of-systemic-lupus-erythematosus-in-mexico
#25
JOURNAL ARTICLE
Gihan Hamdy Elsisi, Lilia Andrade-Ortega, Margarita Portela, Gabriel Medrano Ramírez
AIMS: Our cost of illness study aimed to provide an estimate of the burden related to systemic lupus erythematosus (SLE) in the Mexican context. METHODS: Our model was used to simulate the resource utilization and economic consequences over a period of 5 years for patients with SLE in Mexico. The model simulated four health states-three phenotypes of SLE, including mild, moderate, and severe states, and death. Clinical parameters were retrieved from the literature...
2024: Journal of Medical Economics
https://read.qxmd.com/read/38465028/diffuse-alveolar-hemorrhage-caused-by-disseminated-cryptococcosis-in-a-patient-with-systemic-lupus-erythematosus
#26
Takao Nagashima, Hiroki Yabe, Toshiaki Ogishi, Tsuyoshi Kobashigawa
A teenage girl with systemic lupus erythematosus (SLE) was admitted with fever, dry cough, and dyspnea on exertion. Chest computed tomography revealed bilateral diffuse infiltration and swelling of the mediastinal lymph nodes. The bronchoalveolar lavage (BAL) fluid was light red, suggesting diffuse alveolar hemorrhage (DAH). Therefore, glucocorticoid pulse therapy was initiated. However, blood and BAL fluid cultures showed the growth of Cryptococcus neoformans . The patient was diagnosed with disseminated cryptococcosis...
February 2024: Curēus
https://read.qxmd.com/read/38463916/surgical-complications-of-bariatric-surgery-among-patients-with-rheumatic-diseases
#27
JOURNAL ARTICLE
Mohsen Soori, Seyed Hadi Mirhashemi, Fariborz Rashnoo, Gholamhosein Faghih, Fatemeh Ebrahimi, Amir Zamani, Azadeh Hakakzadeh
BACKGROUND: Obesity is one the most prevalent diseases all around the world. Some studies have shown a relationship between obesity and the worsening of rheumatic disorders. Higher rates of surgical complications might also be seen among these patients. METHODS: This retrospective-descriptive study was performed on 25 patients with rheumatic disease referred to Loghman Hakim Hospital (Tehran- Iran) and candidates for bariatric surgery (laparoscopic Roux-en-Y gastric and laparoscopic sleeve gastrectomy) from 2018 to 2020...
2024: Caspian Journal of Internal Medicine
https://read.qxmd.com/read/38461065/the-complement-system-in-the-pathogenesis-and-progression-of-kidney-diseases-what-doesn-t-kill-you-makes-you-older
#28
REVIEW
Emma Diletta Stea, Giuseppina D'Ettorre, Adele Mitrotti, Loreto Gesualdo
The Complement System is an evolutionarily conserved component of immunity that plays a key role in host defense against infections and tissue homeostasis. However, the dysfunction of the Complement System can result in tissue damage and inflammation, thereby contributing to the development and progression of various renal diseases, ranging from atypical Hemolytic Uremic Syndrome to glomerulonephritis. Therapeutic interventions targeting the complement system have demonstrated promising results in both preclinical and clinical studies...
March 8, 2024: European Journal of Internal Medicine
https://read.qxmd.com/read/38459356/clinical-characteristics-of-patients-with-connective-tissue-disease-related-interstitial-lung-disease-a-retrospective-analysis
#29
JOURNAL ARTICLE
Seda Colak, Emre Tekgoz, Ezgi Cimen Gunes, Nesrin Ocal, Deniz Dogan, Canturk Tasci, Muhammet Cinar, Sedat Yilmaz
INTRODUCTION: Interstitial lung disease is one of the most critical manifestations of connective tissue diseases that may cause morbidity and mortality. This study aimed to evaluate the clinical and demographic characteristics and treatment of the patients with connective tissue disease-related interstitial lung disease. METHOD: This retrospective observational study included patients from the Gulhane Rheumatology Interstitial Lung Disease cohort between October 2016 and June 2023...
March 9, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38458302/novel-therapeutic-strategies-targeting-abnormal-t-cell-signaling-in-systemic-lupus-erythematosus
#30
REVIEW
Masayuki Mizui, Michihito Kono
Therapeutic strategies for autoimmune diseases have been based on the use of glucocorticoids and immunosuppressive agents that broadly suppress immune responses. Therefore, organ damage from long-term use and infections due to immunocompromised status have been significant issues. Safer immunosuppressants and biological agents are now available, but there is still an urgent need to develop specific drugs to replace glucocorticoids. T-lymphocytes, central players in immune responses, could be crucial targets in the treatment of autoimmune diseases...
March 6, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38456915/assessment-of-south-asian-pediatric-acute-kidney-injury-epidemiology-and-risk-factors-aspire-a-prospective-study-on-severe-dialysis-dependent-pediatric-aki
#31
JOURNAL ARTICLE
Sidharth Kumar Sethi, Rupesh Raina, Ahmad Sawan, Sadaf Asim, Aye Kyawt Khant, Manoj Matnani, Kalaivani Ganesan, Shraddha Lohia, Rajiv Sinha, Jubaida Rumana, Syed Saimul Haque, Suprita Kalra, Rabia Safdar, Gopal Prasad, Iftikhar Ijaz, Omer S Ashruf, Aishwarya Nair, Savita S, Kritika Soni, Devendra Shrestha, Shankar Yadav, Asiri Abeyagunawardena, Valerie A Luyckx, Khalid A Alhasan, Azmeri Sultana
BACKGROUND: Pediatric acute kidney injury (AKI) is a global health concern with an associated mortality risk disproportionately pronounced in resource-limited settings. There is a pertinent need to understand the epidemiology of pediatric AKI in vulnerable populations. Here, we proposed a prospective study to investigate the epidemiology and associated risk factors of "severe dialysis dependent AKI" in children among South Asian nations which would be the first and largest of its kind...
March 8, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38455505/massive-hemoptysis-in-pregnancy-due-to-invasive-pulmonary-aspergillosis-with-pulmonary-tuberculosis-co-infection
#32
Nurul Aisyah Abd Rahman, Boon Hau Ng, Nik Nuratiqah Nik Abeed, Muhammad Ishamuddin Ismail, Mohamed Faisal Abdul Hamid, Andrea Ban Yu-Lin
A 37-year-old woman, 25 weeks pregnant, experienced sudden massive hemoptysis. She had a background history of systemic lupus erythematosus (SLE) and past pulmonary tuberculosis (PTB). Emergency intubation was necessary, and bronchoscopy revealed blood pooling in both main bronchi, with active bleeding from the right upper lobe bronchus. Urgent computed tomography (CT) angiography of the bronchial artery identified a bleeding source and was successfully embolized. Antifungal and anti-tuberculous therapy was initiated based on bronchoalveolar lavage results...
March 2024: Respirology Case Reports
https://read.qxmd.com/read/38443873/frosted-branch-angiitis-in-a-patient-with-systemic-juvenile-idiopathic-arthritis-a-case-report
#33
JOURNAL ARTICLE
Jarret L Garbrecht, Zachary R Powell, Cynthia K McClard, Jila Noori
BACKGROUND: Frosted branch angiitis is a retinal vascular condition that is associated with a viral infection or autoimmune disorders like Crohn's disease, systemic lupus erythematosus, and Behcet's disease. Frosted branch angiitis presents with vascular inflammation, retinal edema, and severe retinal vascular sheathing. We present a case of systemic juvenile idiopathic arthritis, an autoinflammatory disease, presenting with frosted branch angiitis. REPORT OF CASE: A 14-year-old female with systemic juvenile idiopathic arthritis and a history of bilateral anterior uveitis developed acute unilateral vision loss and was found to have frosted branch angiitis complicated by branch retinal vein occlusion...
March 5, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38440043/cardiac-tamponade-and-primary-biliary-cholangitis-an-unusual-presentation-and-a-rare-association-of-systemic-lupus-erythematosus
#34
Ana Carvoeiro, Rita Mota, Patrícia Sobrosa, Alexandra Esteves
Systemic lupus erythematosus (SLE) is a disease known for its multiple manifestations, including numerous cardiac complications. While pericardial effusions are common in patients with SLE, cardiac tamponade is rare, and it is even rarer as an initial and isolated clinical manifestation of SLE. We describe a case of a young adult woman who presented with a four-week history of shortness of breath, orthopnea, and paroxysmal nocturnal dyspnea. Chest radiography revealed a significant increase in the cardiothoracic index, and transthoracic echocardiography confirmed a life-threatening cardiac tamponade that necessitated emergency pericardiocentesis and high-dose corticosteroids...
February 2024: Curēus
https://read.qxmd.com/read/38436267/treatment-with-lysophosphatidic-acid-improves-glomerulonephritis-through-the-suppression-of-macrophage-activation-in-a-murine-model-of-systemic-lupus-erythematosus
#35
JOURNAL ARTICLE
Wataru Nagata, Eiji Takayama, Keiichi Nakagawa, Akiho Koizumi, Yukiko Ohsawa, Hiroyasu Goto, Aoi Yamashiro, Yuki Ishinoda, Keiko Tanoue, Hiroo Kumagai, Naoki Oshima, Toshiaki Ishizuka
OBJECTIVES: Several therapeutic agents have been developed and used for the clinical treatment of systemic lupus erythematosus (SLE). In cases where SLE is accompanied by severe organ failures, such as neuropsychiatric lupus erythematosus (NPSLE) and acute onset of lupus nephritis, the use of potent immunosuppressive drugs, such as cyclophosphamide, is necessary. However, potent immunosuppressive drugs are known to increase infection risks. Thus, the development of therapeutic agents with novel mechanisms is urgently required...
February 28, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38435371/seroprevalence-of-pathogenic-leptospira-serogroups-in-asymptomatic-domestic-dogs-and-cats-systematic-review-and-meta-analysis
#36
REVIEW
Tamara Ricardo, Lucía Isabel Azócar-Aedo, María Andrea Previtali, Gustavo Monti
Leptospirosis is a neglected zoonotic disease transmitted by contact with the urine of animals infected with pathogenic species of the bacteria Leptospira or by contact with environments contaminated with the bacteria. Domestic dogs and cats may act as reservoirs or as sentinels of environmental contamination with leptospires, posing a public health concern. There is a great diversity of leptospires, and one common way to classify them is into serogroups that provide some information on the host species they are associated with...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38427562/integrative-systems-biology-reveals-nkg2a-biased-immune-responses-correlate-with-protection-in-infectious-disease-autoimmune-disease-and-cancer
#37
JOURNAL ARTICLE
Daniel G Chen, Jingyi Xie, Jongchan Choi, Rachel H Ng, Rongyu Zhang, Sarah Li, Rick Edmark, Hong Zheng, Ben Solomon, Katie M Campbell, Egmidio Medina, Antoni Ribas, Purvesh Khatri, Lewis L Lanier, Philip J Mease, Jason D Goldman, Yapeng Su, James R Heath
Infection, autoimmunity, and cancer are principal human health challenges of the 21st century. Often regarded as distinct ends of the immunological spectrum, recent studies hint at potential overlap between these diseases. For example, inflammation can be pathogenic in infection and autoimmunity. T resident memory (TRM ) cells can be beneficial in infection and cancer. However, these findings are limited by size and scope; exact immunological factors shared across diseases remain elusive. Here, we integrate large-scale deeply clinically and biologically phenotyped human cohorts of 526 patients with infection, 162 with lupus, and 11,180 with cancer...
February 29, 2024: Cell Reports
https://read.qxmd.com/read/38426680/-examination-of-urinary-sediment-in-a-patient-with-lupus-like-hiv-associated-immune-complex-kidney-disease-hivick-case-report-and-review-of-the-literature
#38
Gianmarco Borriello, Michelangelo Nigro, Pierluigi D'Angiò, Simona Laurino, Andrea Gigliotti, Davide Viggiano, Giuseppe Gigliotti
Renal involvement is very common in patients with HIV infection. The phenotype varies from the most frequently "collapsing" variant of focal and segmental glomerulosclerosis (FSGS) to "lupus-like HIV-immune complex kidney disease" (HIVICK). The latter is characterized by a histological picture that recalls lupus nephropathy. Through a clinical case, we underline the importance of urinary sediment analysis in patients with suspected glomerulopathy. Findings such as the characteristic cells that show the typical appearance of Herpes virus (HSV) infection or LE cells have significantly supported the diagnosis of HIVICK...
February 28, 2024: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://read.qxmd.com/read/38420060/deciphering-the-neuropsychiatric-lupus-enigma-navigating-the-intersection-of-acute-inflammatory-demyelinating-polyneuropathy-aidp-infection-and-flare
#39
Jhasaketan Meher, Jivtesh Singh, Saroj Kumar Pati, Vinay R Pandit, Saurabh K Patel, Mallika Kapur, M S Nithin
A 17-year-old male diagnosed with systemic lupus erythematosus (SLE), showing poor compliance with medication, presented to our facility with a 20-day history of fever, polyarthritis, and cough. Additionally, he had experienced a seizure episode, followed by a one-day history of altered mentation. Subsequently, he developed pneumonia, respiratory distress, and shock, necessitating ventilator and inotropic support. Neuropsychiatric lupus (NP-lupus) was suspected, and hence high-dose steroids, hydroxychloroquine, and broad-spectrum antibiotics were initiated...
January 2024: Curēus
https://read.qxmd.com/read/38415936/potential-clinical-implications-of-molecular-mimicry-induced-autoimmunity
#40
REVIEW
Bandar A Suliman
BACKGROUND: Molecular mimicry is hypothesized to be a mechanism by which autoimmune diseases are triggered. It refers to sequence or structural homology between foreign antigens and self-antigens, which can activate cross-reactive lymphocytes that attack host tissues. Elucidating the role of molecular mimicry in human autoimmunity could have important clinical implications. OBJECTIVE: To review evidence for the role of molecular mimicry in major autoimmune diseases and discuss potential clinical implications...
February 2024: Immunity, Inflammation and Disease
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