Daniel G Chen, Jingyi Xie, Jongchan Choi, Rachel H Ng, Rongyu Zhang, Sarah Li, Rick Edmark, Hong Zheng, Ben Solomon, Katie M Campbell, Egmidio Medina, Antoni Ribas, Purvesh Khatri, Lewis L Lanier, Philip J Mease, Jason D Goldman, Yapeng Su, James R Heath
Infection, autoimmunity, and cancer are principal human health challenges of the 21st century. Often regarded as distinct ends of the immunological spectrum, recent studies hint at potential overlap between these diseases. For example, inflammation can be pathogenic in infection and autoimmunity. T resident memory (TRM ) cells can be beneficial in infection and cancer. However, these findings are limited by size and scope; exact immunological factors shared across diseases remain elusive. Here, we integrate large-scale deeply clinically and biologically phenotyped human cohorts of 526 patients with infection, 162 with lupus, and 11,180 with cancer...
February 29, 2024: Cell Reports