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JOURNAL ARTICLE
Mayumi Matsuda, Yu Funakubo Asanuma, Kyohei Emoto, Sakon Sakai, Nobuhito Okumura, Hiroaki Yazawa, Takashi Maruyama, Takuma Tsuzuki Wada, Kazuhiro Yokota, Yasuto Araki, Yuji Akiyama, Toshihide Mimura
Vaccines against coronavirus disease 2019 (COVID-19) have been distributed in most countries for the prevention of onset and aggravation of COVID-19. Recently, there have been increasing numbers of reports on new-onset autoimmune and autoinflammatory diseases following COVID-19 vaccination, however, only little information is available on the long-term safety of these vaccines. Here, we experienced three cases of new-onset rheumatic diseases following COVID-19 vaccination, one case each of rheumatoid arthritis (RA), anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and systemic lupus erythematosus (SLE)...
April 16, 2024: Immunological Medicine
#2
JOURNAL ARTICLE
Brendyn M St Louis, Sydney M Quagliato, Yu-Ting Su, Gregory Dyson, Pei-Chung Lee
UNLABELLED: The Hippo kinases MST1 and MST2 initiate a highly conserved signaling cascade called the Hippo pathway that limits organ size and tumor formation in animals. Intriguingly, pathogens hijack this host pathway during infection, but the role of MST1/2 in innate immune cells against pathogens is unclear. In this report, we generated Mst1/2 knockout macrophages to investigate the regulatory activities of the Hippo kinases in immunity. Transcriptomic analyses identified differentially expressed genes (DEGs) regulated by MST1/2 that are enriched in biological pathways, such as systemic lupus erythematosus, tuberculosis, and apoptosis...
April 16, 2024: MBio
#3
REVIEW
David S Pisetsky
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that primarily affects young women and causes a wide range of inflammatory manifestations. The hallmark of SLE is the production of antibodies to components of the cell nucleus (antinuclear antibodies or ANAs). These antibodies can bind to DNA, RNA and protein complexes with nucleic acids. Among ANAs, antibodies to DNA (anti-DNA) are markers for classification and disease activity, waxing and waning in many patients. In the blood, anti-DNA antibodies can bind DNA to form immune complexes with two distinct roles in pathogenesis: renal deposition to provoke nephritis and stimulation of cytokine production following uptake into innate immune cells and interaction with internal nucleic acid sensors...
April 15, 2024: Arthritis & Rheumatology
#4
JOURNAL ARTICLE
Dawn M E Bowdish, Vinod Chandran, Carol A Hitchon, Gilaad G Kaplan, J Antonio Avina-Zubieta, Paul R Fortin, Maggie J Larché, Gilles Boire, Anne-Claude Gingras, Roya M Dayam, Ines Colmegna, Luck Lukusa, Jennifer L F Lee, Dawn P Richards, Daniel Pereira, Tania H Watts, Mark S Silverberg, Charles N Bernstein, Diane Lacaille, Jenna Benoit, John Kim, Nadine Lalonde, Janet Gunderson, Hugues Allard-Chamard, Sophie Roux, Joshua Quan, Lindsay Hracs, Elizabeth Turnbull, Valeria Valerio, Sasha Bernatsky
OBJECTIVE: To determine how serologic responses to COVID vaccination/infection in immunemediated inflammatory disease (IMID) are affected by time since last vaccination and other factors. METHODS: Post-COVID-19 vaccination, data and dried blood spots/sera were collected from adults with rheumatoid arthritis, inflammatory bowel disease, systemic lupus, ankylosing spondylitis/spondylarthritis and psoriasis/psoriatic arthritis. First sample was at enrolment and then 2-4 weeks and 3, 6, and 12 months after latest vaccine dose...
April 15, 2024: Journal of Rheumatology
#5
JOURNAL ARTICLE
Julia Barbado
Systemic lupus erythematosus (SLE) is a common, potentially fatal autoimmune disease involving a significant inflammatory response. SLE is characterised by failure of self-tolerance and activation of autoreactive lymphocytes, leading to persistent disease. Although current treatments achieve some improvement in patients, some SLE patients are refractory and others relapse after drug withdrawal. The toxicity of current drug regimens, with recurrent infections, together with ongoing inflammation, contribute significantly to the progressive decline in organ function...
April 12, 2024: Biomedical Journal
#6
JOURNAL ARTICLE
Murugan Sudhakar, Anu P Kocheril, Anish S George, George I Vettiyil, Anitha Jasper, Sathish Kumar
Idiopathic intracranial hypertension (IIH) is a diagnosis of exclusion characterized by features of raised intracranial pressure (ICP) in the absence of brain parenchymal lesion, vascular malformations, hydrocephalus, or central nervous system (CNS) infection. Commonly used other terms for this entity include benign intracranial hypertension (BIH) or pseudotumor cerebri. Few case reports of systemic lupus erythematosus (SLE) presenting as IIH are available in the literature. We report a 12-year-old girl presented with chronic holocranial headache and occasional episodes of projectile vomiting for the last 6 months and then developed blurring of vision for the last month...
April 12, 2024: Lupus
#7
JOURNAL ARTICLE
Anita Wach, Joanna Kosałka-Węgiel, Katarzyna Wawrzycka-Adamczyk, Mariusz Korkosz
No abstract text is available yet for this article.
April 11, 2024: Polish Archives of Internal Medicine
#8
REVIEW
Naim Mahroum, Mona Habra, Mohamad Aosama Alrifaai, Yehuda Shoenfeld
In addition to the respiratory symptoms associated with COVID-19, the disease has consistently been linked to many autoimmune diseases such as systemic lupus erythematous and antiphospholipid syndrome (APS). APS in particular was of paramount significance due to its devastating clinical sequela. In fact, the hypercoagulable state seen in patients with acute COVID-19 and the critical role of anticoagulant treatment in affected individuals shed light on the possible relatedness between APS and COVID-19. Moreover, the role of autoimmunity in the assumed association is not less important especially with the accumulated data available regarding the autoimmunity-triggering effect of SARS-CoV-2 infection...
April 9, 2024: Autoimmunity Reviews
#9
Wei Zhang, Xingguo Zhang, Jinming Han, Wen Zhang, Jiarui Xu, Xin Zhang, Hongjun Bian, Chong Meng, Deya Shang, Yi Zhou, Dawei Wang, Baobao Feng
Patients with systemic autoimmune rheumatic diseases are at a high risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and effective antiviral treatments including nirmatrelvir/ritonavir can improve their outcomes. However, there might be potential drug-drug interactions when these patients take nirmatrelvir/ritonavir together with immunosuppressants with a narrow therapeutic window, such as tacrolimus and cyclosporine. We present a case of paralytic ileus resulting from tacrolimus toxicity mediated by the use of nirmatrelvir/ritonavir in a patient with systemic lupus erythematosus (SLE)...
2024: Frontiers in Pharmacology
#10
JOURNAL ARTICLE
Claudia Magaly Sandoval-Ramírez, Nathalia Ballesteros, Juan Carlos Pinilla, Carolina Hernández, Marina Muñoz, Juan David Ramírez
The global presence of SARS-CoV-2 in household pets is acknowledged, yet documentation remains scarce, leaving many regions unexplored. Thus, our study sought to fill this gap by investigating SARS-CoV-2 presence in dogs visiting veterinary clinics during the third pandemic peak in eastern Colombia. We collected and analyzed 43 oropharyngeal and rectal swabs using real-time PCR assays targeting the Envelope Gene of SARS-CoV-2. Out of these, two dogs tested positive, indicating an infection rate of 4.7%. Further examination through complete sequencing and phylogenetic analysis revealed the lineage B...
April 10, 2024: Veterinary Research Communications
#11
JOURNAL ARTICLE
Paloma Vela-Casasempere, Rocío Caño Alameda, Silvia Gómez Sabater, Silvia Cortell Aznar, Encarnación Pérez Pascual
OBJECTIVE: To share our experience with belimumab in lupus pregnant women and to review the relevant published literature on its use in this scenario. METHODS: A prospective observational study of pregnant patients with lupus was conducted. Additionally, MEDLINE and EMBASE databases were searched, and a secondary hand search of the literature was performed. Studies were evaluated and visualised descriptively. RESULTS: Sixteen pregnancies of 12 lupus women were included, six (involving eight pregnancies) received belimumab throughout their illness, five of them during some period of gestation...
April 9, 2024: Lupus
#12
REVIEW
Isa Seida, Maisam Al Shawaf, Naim Mahroum
The role of infections in the pathogenesis of autoimmune diseases has long been recognized and reported. In addition to infectious agents, the internal composition of the "friendly" living bacteria, (microbiome) and its correlation to immune balance and dysregulation have drawn the attention of researchers for decades. Nevertheless, only recently, scientific papers regarding the potential role of transferring microbiome from healthy donor subjects to patients with autoimmune diseases has been proposed. Fecal microbiota transplantation or FMT, carries the logic of transferring microorganisms responsible for immune balance from healthy donors to individuals with immune dysregulation or more accurately for our paper, autoimmune diseases...
April 7, 2024: Autoimmunity Reviews
#13
JOURNAL ARTICLE
Sofia Romero-Santos, Daniela Parra-Tanoux, Carlos Cifuentes-González, Juliana Muñoz-Ortiz, Germán Mejía-Salgado, Alejandra de-la-Torre
PURPOSE: To present an atypical case of severe bilateral ocular toxoplasmosis with systemic involvement that initially mimicked an autoimmune etiology, posing challenges to its diagnosis and treatment. CASE REPORT: A 39-year-old immunocompetent male was admitted to the hospital due to a presumed pulmonary thromboembolism concomitant with an abrupt onset of vision loss. Initial differential diagnoses included antiphospholipid syndrome and systemic lupus erythematosus, prompting the administration of corticosteroid pulses and rituximab...
April 9, 2024: Ocular Immunology and Inflammation
#14
JOURNAL ARTICLE
Je Hee Shin, Jung Yoon Pyo, Minkyung Han, Myeongjee Lee, Sung Min Lim, Jee Yeon Baek, Ji Young Lee, Ji-Man Kang, InKyung Jung, Jong Gyun Ahn
BACKGROUND: Infections are considered risk factors for autoimmune inflammatory rheumatic diseases (AIRDs), the incidence of which is considered to have been impacted by the COVID-19 pandemic. The impact of non-pharmaceutical interventions (NPIs) on the incidence of AIRDs and their associated health care services and medical expenses in Korea was investigated. METHODS: We included all AIRD cases reported between January 2016 and February 2021 based on the National Health Insurance Service data...
April 2024: International Journal of Rheumatic Diseases
#15
REVIEW
Iñigo Rua-Figueroa, M Jesus García de Yébenes, Julia Martinez-Barrio, Maria Galindo Izquierdo, Jaime Calvo Alén, Antonio Fernandez-Nebro, Raúl Menor-Almagro, Loreto Carmona, Beatriz Tejera Segura, Eva Tomero, Mercedes Freire-González, Clara Sangüesa, Loreto Horcada, Ricardo Blanco, Esther Uriarte Itzazelaia, Javier Narváez, José Carlos Rosas Gómez de Salazar, Silvia Gómez-Sabater, Claudia Moriano Morales, Jose L Andreu, Vicente Torrente Segarra, Elena Aurrecoechea, Ana Perez, Javier Nóvoa Medina, Eva Salgado, Nuria Lozano-Rivas, Carlos Montilla, Esther Ruiz-Lucea, Marta Arevalo, Carlota Iñiguez, María Jesús García-Villanueva, Lorena Exposito, Mónica Ibáñez-Barceló, Gema Bonilla, Irene Carrión-Barberà, Celia Erausquin, Jorge Juan Fragio Gil, Angela Pecondón, Francisco J Toyos, Tatiana Cobo, Alejandro Muñoz-Jiménez, Jose Oller, Joan M Nolla, J M Pego-Reigosa
OBJECTIVE: To develop an improved score for prediction of severe infection in patients with systemic lupus erythematosus (SLE), namely, the SLE Severe Infection Score-Revised (SLESIS-R) and to validate it in a large multicentre lupus cohort. METHODS: We used data from the prospective phase of RELESSER (RELESSER-PROS), the SLE register of the Spanish Society of Rheumatology. A multivariable logistic model was constructed taking into account the variables already forming the SLESIS score, plus all other potential predictors identified in a literature review...
April 8, 2024: Lupus Science & Medicine
#16
JOURNAL ARTICLE
Hui-Lan Li, Lan-Yi Zhong, Yin-Feng Kang, Yan-Lan Yang, Liang Shi, Ai-Xia Zhai, Chao Wu, Mu-Sheng Zeng, Qian-Ying Zhu
Systemic autoimmune diseases (SADs) are a growing spectrum of autoimmune disorders that commonly affect multiple organs. The role of Epstein-Barr virus (EBV) infection or reactivation as a trigger for the initiation and progression of SADs has been established, while the relationship between EBV envelope glycoproteins and SADs remains unclear. Here, we assessed the levels of IgG, IgA, and IgM against EBV glycoproteins (including gp350, gp42, gHgL, and gB) in serum samples obtained from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and found that RA and SLE patients exhibited a statistically significant increase in the levels of 8 and 11 glycoprotein antibodies, respectively, compared to healthy controls (p < 0...
April 2024: Journal of Medical Virology
#17
JOURNAL ARTICLE
Pooja Yedehalli Thimmappa, Aswathy S Nair, Sian D'silva, Anjana Aravind, Sandeep Mallya, Sreelakshmi Pathappillil Soman, Kanive Parashiva Guruprasad, Shamee Shastry, Rajesh Raju, Thottethodi Subrahmanya Keshava Prasad, Manjunath B Joshi
Neutrophils play a vital role in the innate immunity by perform effector functions through phagocytosis, degranulation, and forming extracellular traps. However, over-functioning of neutrophils has been associated with sterile inflammation such as Type 2 Diabetes, atherosclerosis, cancer and autoimmune disorders. Neutrophils exhibiting phenotypical and functional heterogeneity in both homeostatic and pathological conditions suggests distinct signaling pathways are activated in disease-specific stimuli and alter neutrophil functions...
April 3, 2024: International Immunopharmacology
#18
REVIEW
Bohdana Doskaliuk, Olena Zimba
The genus Borrelia encompasses a diverse group of spirochetes transmitted primarily by ticks, with Borrelia burgdorferi causing Lyme disease, which is prevalent in North America and Europe. Borrelia's structural adaptations and ability to persist in diverse host tissues underscore its pathogenic potential. Beyond traditional infectious responses, Borrelia engages in complex interactions with the host immune system, contributing to autoimmune mechanisms such as molecular mimicry and persistent infections. This intricate interplay manifests in symptoms resembling various autoimmune diseases, including systemic lupus erythematosus, dermatomyositis, local scleroderma, and systemic sclerosis...
April 5, 2024: Rheumatology International
#19
JOURNAL ARTICLE
Niloufar Ebrahimi, Sahibzadi Mahrukh Noor, Shahram Kordasti, Mojtaba Akhtari, Sayna Norouzi, Mehrbod Vakhshoori, Amir Abdipour
Macrophage activation syndrome (MAS) is a form of secondary hemophagocytic lymphohistiocytosis (HLH) when it occurs in the context of rheumatologic disorders. HLH is a rare and potentially life-threatening syndrome characterized by excessive immune system activation. It is mainly seen in children and can be genetic based or related to infections, malignancies, rheumatologic disorders, or immunodeficiency syndromes. MAS can present with nonspecific symptoms, leading to a delay in diagnosis. This report describes a case of a 64-year-old female with marginal zone lymphoma and systemic lupus erythematosus who presented with a purpuric rash and acute kidney injury...
2024: Journal of Investigative Medicine High Impact Case Reports
#20
JOURNAL ARTICLE
Nicole K Andeen, Jean Hou
Recent progress in glomerular immune complex and complement-mediated diseases have refined diagnostic categories and informed mechanistic understanding of disease development in pediatric patients. Herein, we discuss selected advances in 3 categories. First, membranous nephropathy antigens are increasingly utilized to characterize disease in pediatric patients and include phospholipase A2 receptor (PLA2R), Semaphorin 3B (Sema3B), neural epidermal growth factor-like 1 (NELL1), and protocadherin FAT1, as well as the lupus membranous-associated antigens exostosin 1/2 (EXT1/2), neural cell adhesion molecule 1 (NCAM1), and transforming growth factor beta receptor 3 (TGFBR3)...
April 5, 2024: Pediatric and Developmental Pathology
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