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Degenerative joint disease

Sahil Mehta, Rajender Kumar, Vivek Lal
Background: Camptocormia is defined as forward flexion of the spine that manifests during walking and standing and disappears in recumbent position. The various etiologies include idiopathic Parkinson's disease, multiple system atrophy, myopathies, degenerative joint disease, and drugs. Case Report: A 67-year-old diabetic female presented with bradykinesia and camptocormia that started 1 year prior to presentation. Evaluation revealed levosulpiride, a dopamine receptor blocker commonly used for dyspepsia, to be the culprit...
2019: Tremor and Other Hyperkinetic Movements
Deborah Solomonow-Avnon, Amir Herman, Uriel Giwnewer, Nimrod Rozen, Avi Elbaz, Amit Mor, Alon Wolf
Footwear devices that shift foot center of pressure (COP), thereby impacting lower-limb biomechanics to produce clinical benefit, have been studied regarding degenerative diseases of knee and hip joints, exhibiting evidence of clinical success. Ability to purposefully affect trunk biomechanics has not been investigated for this type of footwear. Fifteen healthy young male subjects underwent gait and electromyography analysis using a biomechanical device that shifts COP via moveable convex elements attached to the shoe sole...
February 12, 2019: Journal of Biomechanics
Andrey Bokov, Anatoliy Bulkin, Alexander Aleynik, Marina Kutlaeva, Sergey Mlyavykh
Study Design: Retrospective cohort study. Objective: To determine risk factors that may affect the rate of pedicle screws loosening in patients with degenerative diseases of the lumbar spine. Methods: A total of 250 patients with a low-grade spondylolisthesis and lumbar instability associated with degenerative diseases were enrolled. Preoperatively patients underwent computed tomography (CT) and cancellous bone radiodensity of a vertebral body was measured in Hounsfield units (HU)...
February 2019: Global Spine Journal
Carlos Bagley, Matthew MacAllister, Luke Dosselman, Jessica Moreno, Salah Aoun, Tarek El Ahmadieh
Lumbar spinal stenosis is a degenerative process that is extremely frequent in today's aging population. It can result in impingement on the nerves of the cauda equina or on the thecal sac itself, and lead to debilitating symptoms such as severe leg pain, or restriction in the perimeter of ambulation, both resulting in dependency in daily activities. The impact of the disease is global and includes financial repercussions because of its involvement in the active work force group. Risk factors for the disease include some comorbidities such as obesity or smoking, daily habits such as an active lifestyle, but also genetic factors that are not completely elucidated yet...
2019: F1000Research
Federico Bruno, Francesco Arrigoni, Pierpaolo Palumbo, Raffaele Natella, Nicola Maggialetti, Alfonso Reginelli, Alessandra Splendiani, Ernesto Di Cesare, Luca Brunese, Giuseppe Guglielmi, Andrea Giovagnoni, Carlo Masciocchi, Antonio Barile
Degenerative osteoarthropathy is one of the leading causes of the pain and disability from musculoskeletal disease in the adult population. Magnetic resonance imaging (MRI) allows optimal visualization of all tissues involved in degenerative osteoarthritis disease process, mainly the articular cartilage. In addition to qualitative and semiquantitative morphologic assessment, several MRI-based advanced techniques have been developed to allow characterization and quantification of the biochemical cartilage composition...
February 15, 2019: La Radiologia Medica
Genjun Chen, Shengping Hu, Zhen Lai, Binsong Qiu
Osteoarthritis (OA) is a degenerative joint disease characterized by joint destruction with cartilage loss and occasional gross derangement of joint integrity. In recent years, several studies have reported the association between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and knee osteoarthritis (OA). However, the results were conflicting. To determine the association between ACE gene I/D polymorphism and knee OA, we conducted a hospital-based case-control study with 282 knee OA cases and 316 controls to investigate the association between ACE gene I/D polymorphism and knee OA susceptibility in a Chinese Han population...
February 14, 2019: Bioscience Reports
Brendan O'Connell, Nicholas Martin Wragg, Samantha Louise Wilson
Osteoarthritis (OA) is a degenerative disease involving joint damage, an inadequate healing response and progressive deterioration of the joint architecture that commonly affects the knee and/or hip joints. It is a major world public health problem and is predicted to increase rapidly with an ageing population and escalating rate of obesity. Autologous blood-derived products possess much promise in the repair and regeneration of tissue and have important roles in inflammation, angiogenesis, cell migration and metabolism in pathological conditions, including OA...
February 13, 2019: Cell and Tissue Research
Merit P George, Floranne C Ernste, Aaron Tande, Douglas Osmon, Tad Mabry, Elie F Berbari
Introduction: Calcium pyrophosphate deposition disease (CPPD), or pseudogout, is rare in prosthetic joints, but can mimic prosthetic joint infection (PJI) according to case reports. The purpose of this case series is to describe the demographics, presentation, management, and outcomes of a cohort of these patients seen at our academic medical center. Methods: Patients with post-implant pseudogout, who were evaluated at our medical center between January 1, 2000 and June 30, 2016, were identified from our EHR...
2019: Journal of Bone and Joint Infection
Chase Thorson, Kevin Galicia, Andrew Burleson, Olivia Bouchard, Debra Hoppensteadt, Jawed Fareed, William Hopkinson
Osteoarthritis, a degenerative disease of the joints, is the most common form of arthritis in the knee. Total joint arthoplasty is a commonly used treatment for joint degeneration and osteoarthritis, and due to these factors, TJA for hip and knee joints is projected to grow by 137% and 601% between 2005 and 2030. Matrix metalloproteases are enzymes found in the extracellular matrix that cleave matrix components. Normally MMPs are downregulated in tissues by Tissue Inhibitors of Metalloproteases, or TIMPs. The relative concentration of TIMPs also may denote some of the activity of the MMPs found in serum...
January 2019: Clinical and Applied Thrombosis/hemostasis
Herbert Stimmer, Lucas Ritschl, Carolin Goetz, Andreas Kolk, Benedikt Hofauer, Markus Wirth, Andreas Knopf, Armin Ott, Klaus-Dietrich Wolff
PURPOSE:  The purpose of the present study was to investigate the degree and clinical relevance of synovitis in craniomandibular dysfunction. MATERIALS AND METHODS:  In total, 140 temporomandibular joints were examined using a 3 T MRI scanner. Quantitative analysis of synovial enhancement was performed and interrelated with arthrosis deformans, degenerative disc disease, joint effusion, bone marrow edema and restriction of motion. RESULTS:  We found a statistically high and significant correlation between the degenerative changes as mentioned above and the intensity of synovial enhancement...
February 12, 2019: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Jason Wong, Taylor Murtaugh, Akshay Lakra, H John Cooper, Roshan P Shah, Jeffrey A Geller
PURPOSE: Unicompartmental knee arthroplasty (UKA) is effective for treating degenerative joint disease in a single compartment. Robotic-arm-assisted arthroplasty (RAA) has gained popularity and has theoretical benefits of improved outcomes over conventional (CONV) UKA due to the technical precision of bone preparation. This study compares the short-term clinical outcomes, including survivorship and patient-reported functional outcomes, for a series of medial UKAs performed with RAA and CONV...
February 12, 2019: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Vito Crincoli, Maria Grazia Anelli, Eleonora Quercia, Maria Grazia Piancino, Mariasevera Di Comite
Aims: Temporomandibular disorders (TMD) represent a heterogeneous group of inflammatory or degenerative diseases of the stomatognatic system, with algic and/or dysfunctional clinical features involving temporomandibular joint (TMJ) and related masticatory muscles. Rheumatoid Arthritis (RA) is an autoimmune polyarthritis characterized by the chronic inflammation of synovial joints and oral implications such as hyposalivation, difficulty in swallowing and phoning, feeling of burning mouth, increased thirst, loss of taste or unpleasant taste and smell, dental sensitivity...
2019: International Journal of Medical Sciences
Jung Hwan Kim, Alok Sharan, Woojin Cho, Mohammed Emam, Michael Hagen, Soo Yeon Kim
Study Design: Case control study. Purpose: To determine the prevalence and degree of asymptomatic cervical and lumbar facet joint arthritis. We retrospectively reviewed 500 computed tomography (CT) scans of cervical facet joints obtained from 50 subjects. Moreover, 500 lumbar facet joints obtained from an additional 50 subjects were reviewed. Overview of Literature: Numerous reports in the literature indicate that joint arthritis is a major source of axial neck and low back pain...
February 13, 2019: Asian Spine Journal
Robyn Thom, David A Silbersweig, Robert J Boland
Major Depression, as well as other depressive disorders, are commonly comorbid with other medical illnesses, particularly chronic and systemic medical illnesses. The cooccurrence of the disorders is so common that it challenges our notions of the meaning of comorbidity and our desire to neatly separate psychiatric and medical illnesses. The overlap between symptoms of physical illness and the neurovegetative symptoms of major depression and the initial normative emotional response to physical illness add to the challenge of accurate diagnosis and timely treatment of depression in the medically ill...
February 1, 2019: Psychosomatic Medicine
P Klemm, O Hudowenz, T Asendorf, U Müller-Ladner, U Lange, I H Tarner
BACKGROUND: Multimodal rheumatologic complex treatment (MRCT, operation and procedures classification system, OPS code 8‑983) is a specific concept of acute inpatient care (DRG I97Z) for treatment of patients with rheumatic diseases, degenerative diseases and/or chronic pain syndromes suffering from exacerbated pain and functional impairment. OBJECTIVE: A monocentric retrospective analysis of the effects of MRCT on pain and functional status in patients with rheumatoid arthritis (RA) was conducted...
February 4, 2019: Zeitschrift Für Rheumatologie
Elena Rezuș, Anca Cardoneanu, Alexandra Burlui, Andrei Luca, Cătălin Codreanu, Bogdan Ionel Tamba, Gabriela-Dumitrița Stanciu, Nicoleta Dima, Codruța Bădescu, Ciprian Rezuș
Aging is an inevitable process in the human body that is associated with a multitude of systemic and localized changes. All these conditions have a common pathogenic mechanism characterized by the presence of a low-grade proinflammatory status. Inflammaging refers to all the processes that contribute to the occurrence of various diseases associated with aging such as frailty, atherosclerosis, Alzheimer's disease, sarcopenia, type 2 diabetes, or osteoarthritis. Inflammaging is systemic, chronic, and asymptomatic...
January 31, 2019: International Journal of Molecular Sciences
Zhang Qi, Han Xiao-Guang, Xu Yun-Feng, Liu Ya-Jun, Liu Bo, He Da, Sun Yu-Qing, Tian Wei
OBJECTIVE: To compare the clinical accuracy and perioperative outcomes for pedicle screw placement in transforaminal lumbar interbody fusion (TLIF) between robot-assisted (RA) technique and fluoroscopy-guided (FG) technique. METHODS: 77 patients scheduled to undergo RA (43 patients) and FG (44 patients) TLIF surgery were included. Patient demographics, radiographic accuracy and perioperative outcomes were recorded and compared. The accuracy of pedicle screw placement was according to the Gertzbein and Robbins scale and facet joint violation...
January 29, 2019: World Neurosurgery
Janine McKay, Kristian Frantzen, Neeltje Vercruyssen, Kholoud Hafsi, Tyler Opitz, Amelia Davis, William Murrell
The purpose of this manuscript is to provide a current concept review for the rehabilitative management of knee osteoarthritis (KOA) following regenerative medicine intervention. A proposed comprehensive regenerative rehabilitative program has been created, based on a literature review of the current best practices of rehabilitative methods and non-operative management in KOA patients with an emphasis on the goals of regenerative medicine: to optimize self-healing and functional tissue recovery. Regenerative medicine promotes regeneration and joint restoration by using blood-based procedures such as platelet rich plasma, stem cell and cell-based or tissue engineering...
January 2019: Journal of Clinical Orthopaedics and Trauma
Diego Delgado, Ane Garate, Hunter Vincent, Ane Miren Bilbao, Rikin Patel, Nicolás Fiz, Steve Sampson, Mikel Sánchez
Knee osteoarthritis (OA) is a degenerative process that slowly destroys the joints producing pain and loss of function, and diminishes the quality of life. Current treatments alleviate this symptomatology but do not stop the disease, being total knee arthroplasty the only definitive solution. Among the emerging treatments, Platelet-Rich Plasma (PRP) has shown promising results in the treatment of OA. However, to improve its effectiveness, it is necessary to approach this pathology targeting the whole joint, not only the cartilage, but including other tissues such as subchondral bone...
January 2019: Journal of Clinical Orthopaedics and Trauma
Kholoud Hafsi, Janine McKay, Jinjie Li, José Fábio Lana, Alex Macedo, Gabriel Silva Santos, William D Murrell
Knee osteoarthritis (KOA) is a multifactorial degenerative disorder of joints, affecting the world's population over the age of 65 and with a higher prevalence in females. KOA is responsible for many age associated joint problems such as stiffness and pain. Conventional methods for managing KOA such as nonsteroidal anti-inflammatory drugs (NSAID) may not improve pain or alter the disease progression and may have adverse side effects. Non-pharmacological management of OA is fundamental to management of functional limitations and provides effective symptom relief but has not shown that disease progression can be altered...
January 2019: Journal of Clinical Orthopaedics and Trauma
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