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JOURNAL ARTICLE
Guner Kilic, Gulce Ecem Kilic, Adnan Özkahraman, Sevki Konur, Ramazan Dertli, Yusuf Kayar
Success in eradication of H. pylori is decreasing due to increasing resistant strains. In particular, side-effects due to 4-agent treatment multiple drug use are observed and treatment compliance decreases. The aim of this study was to evaluate the efficacy, reliability, and side-effect profile of the combination of amoxicillin and rabeprazole with gemifloxacin, which is a new generation quinolone, in the treatment of H. pylori infection. This study was conducted on 71 naive patients who received H. pylori eradication...
May 3, 2024: Medicine (Baltimore)
#2
JOURNAL ARTICLE
Yu-Ming Ding, Miao Duan, Zhong-Xue Han, Xiao-Hui Song, Feng-Lan Zhang, Zhi Wang, Zhang Ning, Shu-Yan Zeng, Qing-Zhou Kong, Wen-Lin Zhang, Jing Liu, Meng Wan, Min-Juan Lin, Bo-Shen Lin, Xue-Ping Nan, Hui Wang, Yue-Yue Li, Xiu-Li Zuo, Yan-Qing Li
BACKGROUND: Bismuth-containing quadruple therapy is the first-line treatment for eradicating Helicobacter pylori (H. pylori). The optimal duration for H. pylori eradication using bismuth-containing quadruple therapy remains controversial. Therefore, we aimed to compare the clinical effects of the 10- and 14-day bismuth-containing quadruple treatment regimen to eradicate H. pylori. METHODS: Treatment-naïve patients with H. pylori infection (n = 1300) were enrolled in this multicenter randomized controlled study across five hospitals in China...
May 3, 2024: Digestive Diseases and Sciences
#3
JOURNAL ARTICLE
Xiaolin Liu, Paphavee Lertsethtakarn, Vanessa T Mariscal, Fitnat Yildiz, Karen M Ottemann
UNLABELLED: Motility promotes biofilm initiation during the early steps of this process: microbial surface association and attachment. Motility is controlled in part by chemotaxis signaling, so it seems reasonable that chemotaxis may also affect biofilm formation. There is a gap, however, in our understanding of the interactions between chemotaxis and biofilm formation, partly because most studies analyzed the phenotype of only a single chemotaxis signaling mutant, e.g., cheA . Here, we addressed the role of chemotaxis in biofilm formation using a full set of chemotaxis signaling mutants in Helicobacter pylori , a class I carcinogen that infects more than half the world's population and forms biofilms...
May 3, 2024: MBio
#4
JOURNAL ARTICLE
Ying Chen, Siyu Li, Wenbin Li, Yiran Wang, Jihua Shi, Xue Xu, Pan Zhang, Dan Chen, Rui Gang, Qingfeng Luo
BACKGROUND: Rising clarithromycin resistance undermines Helicobacter pylori ( H. pylori ) treatment efficacy. We aimed to determine clarithromycin's minimum inhibitory concentration (MIC) levels and identify specific mutation sites in the 23S ribosomal subunit (23S rRNA) that predict treatment outcomes in a 14-day regimen of clarithromycin bismuth quadruple therapy (amoxicillin 1g, clarithromycin 500 mg, rabeprazole 10 mg, and colloidal bismuth pectin 200 mg). MATERIALS AND METHODS: We included adult H...
April 30, 2024: Heliyon
#5
JOURNAL ARTICLE
Qiyunna He, Yan Ou, Huili Zhu, Zhiqian Chen, Dailan Yang, Qian Cheng, Xia Yin, Lina Xiao, Lin Cai, Yan Ye, Xin Xu, Juan Liao
BACKGROUND AND AIM: To evaluate the efficacy and safety of minocycline, vonoprazan, amoxicillin, and bismuth quadruple therapy for Helicobacter pylori ( H. pylori ) treatment. METHODS: From August 2022 to May 2023, clinical data were collected from patients who received H. pylori eradication treatment at West China Fourth Hospital, Sichuan University. One group received the MVAB regimen (amoxicillin, minocycline, vonoprazan, and colloidal bismuth pectin), while another group received the FOAB regimen (amoxicillin, furazolidone, omeprazole, and colloidal bismuth pectin), both administered for 14 days...
May 2024: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
#6
REVIEW
Steffen Backert, Nicole Tegtmeyer, Anselm H C Horn, Heinrich Sticht, Bodo Linz
Single nucleotide polymorphisms (SNPs) account for significant genomic variability in microbes, including the highly diverse gastric pathogen Helicobacter pylori. However, data on the effects of specific SNPs in pathogen-host interactions are scarce. Recent functional studies unravelled how a serine/leucine polymorphism in serine protease HtrA affects the formation of proteolytically active trimers and modulates cleavage of host cell-to-cell junction proteins during infection. A similar serine/leucine mutation in the carbohydrate binding domain of the adhesin BabA controls binding of ABO blood group antigens, enabling binding of either only the short Lewis b/H antigens of blood group O or also the larger antigens of blood groups A and B...
May 2, 2024: Cell Communication and Signaling: CCS
#7
JOURNAL ARTICLE
Zihan Yang, Yueyang Zhou, Ziying Han, Kun He, Yuelun Zhang, Dong Wu, Hongda Chen
Helicobacter pylori infection, a worldwide health issue, is typically treated with standard antibiotic therapies. However, these treatments often face resistance and non-compliance due to side effects. In this umbrella review, we aimed to comprehensively assess the impact of probiotics supplementation in different preparations on Helicobacter pylori standard treatment. We searched PubMed, Embase and Cochrane Central Register of Controlled Trials in the Cochrane Library from inception to June 1, 2023, to identify systematic reviews with meta-analyses that focused on eradication rates, total side effects and other outcomes of interest...
May 2, 2024: Scientific Reports
#8
Yin Chen, Tao Teng, Yu Su, Wen-Zhong Chen
BACKGROUND AND OBJECTIVE: It remains uncertain if the addition of Saccharomyces boulardii ( S. boulardii ) to bismuth quadruple therapy (BQT) recommended in the current guidelines can enhance the Helicobacter pylori ( H. pylori ) eradication rate and decrease the incidence of adverse events. We therefore conducted a meta-analysis of randomized controlled trials (RCTs) to address this issue. METHODS: We performed comprehensive searches in PubMed, Embase, Web of Science, and Cochrane library databases from the inception of the databases through to November 1, 2023...
2024: Frontiers in Medicine
#9
Xinyu Jin, Xin Jin, Piao Guo, Linjuan Lu, Weisong Sheng, Danrong Zhu
INTRODUCTION AND IMPORTANCE: Extranodal marginal zone lymphoma (EMZL lymphoma), also known as mucosa-associated lymphoid tissue (MALT) lymphoma, is a rare B-cell lymphoma that rarely affects children. The involvement of infectious agents, especially H. pylori , has been observed in the formation and progression of MALT lymphoma in the stomach. Hematemesis as the primary clinical manifestation is uncommon, highlighting the need for case studies with this presentation. This article uses SCARE2023 criteria as a framework to sort out a case report in order...
May 2024: Annals of Medicine and Surgery
#10
JOURNAL ARTICLE
Jehad Zuhair Tayyeb, Shibam Mondal, Md Anisur Rahman, Swapon Kumar, Imren Bayıl, Shopnil Akash, Md Sarowar Hossain, Taha Alqahtani, Magdi E A Zaki, Jonas Ivan Nobre Oliveira
Gastric cancer is considered a class 1 carcinogen that is closely linked to infection with Helicobacter pylori (H. pylori), which affects over 1 million people each year. However, the major challenge to fight against H. pylori and its associated gastric cancer due to drug resistance. This research gap had led our research team to investigate a potential drug candidate targeting the Helicobacter pylori-carcinogenic TNF-alpha-inducing protein. In this study, a total of 45 daidzein derivatives were investigated and the best 10 molecules were comprehensively investigated using in silico approaches for drug development, namely pass prediction, quantum calculations, molecular docking, molecular dynamics simulations, Lipinski rule evaluation, and prediction of pharmacokinetics...
May 2024: Journal of Cellular and Molecular Medicine
#11
JOURNAL ARTICLE
Ruyi Peng, Canxia Xu, Linfang Zhang, Xiaoming Liu, Dongzi Peng, Xingcen Chen, Deliang Liu, Rong Li
Helicobacter pylori ( H. pylori ) causes a diversity of gastric diseases. The host immune response evoked by H. pylori infection is complicated and can influence the development and progression of diseases. We have reported that the Group 2 innate lymphocytes (ILC2) were promoted and took part in building type-2 immunity in H. pylori infection-related gastric diseases. Therefore, in the present study, we aim to clarify how H. pylori infection induces the activation of ILC2. It was found that macrophages were necessary for activating ILC2 in H...
2024: Gut Microbes
#12
JOURNAL ARTICLE
Noah A Siegel, Monica T Jimenez, Clarissa Santos Rocha, Matthew Rolston, Satya Dandekar, Jay V Solnick, Lisa A Miller
It is estimated that more than half of the world population has been infected with Helicobacter pylori. Most newly acquired H. pylori infections occur in children before 10 years of age. We hypothesized that early life H. pylori infection could influence the composition of the microbiome at mucosal sites distant to the stomach. To test this hypothesis, we utilized the infant rhesus macaque monkey as an animal model of natural H. pylori colonization to determine the impact of infection on the lung and oral microbiome during a window of postnatal development...
May 1, 2024: Scientific Reports
#13
JOURNAL ARTICLE
Choong-Kyun Noh, Gil Ho Lee, Eunyoung Lee, Bumhee Park, Sun Gyo Lim, Sung Jae Shin, Kee Myung Lee
BACKGROUND AND AIMS: The rapid urease test (RUT) is widely used to detect Helicobacter pylori (H. pylori) infection; however, it is not preferred as a monitoring strategy following eradication owing to its low sensitivity. In this study, we evaluated the diagnostic performance of RUT using the sweeping method, which overcomes the limitations of conventional tissue sampling methods following eradication. METHODS: Patients who received H. pylori eradication treatment were enrolled...
April 29, 2024: Gastrointestinal Endoscopy
#14
EDITORIAL
Ying Liu, Ding-Quan Yang, Jun-Nan Jiang, Yan Jiao
Helicobacter pylori ( H. pylori ) plays an important role in the development of gastric cancer, although its association to colorectal polyp (CP) or colorectal cancer (CRC) is unknown. In this issue of World Journal of Gastrointestinal Surgery , Zhang et al investigated the risk factors for H. pylori infection after colon polyp resection. Importantly, the researchers used R software to create a prediction model for H. pylori infection based on their findings. This editorial gives an overview of the association between H...
April 27, 2024: World Journal of Gastrointestinal Surgery
#15
JOURNAL ARTICLE
Ioana Alexandra Cardos, Catalina Danila, Timea Claudia Ghitea, Ovidiu Pop, Andrei Pascalau, Simona Cavalu
BACKGROUND/AIM: H. pylori infection can promote a systemic inflammatory syndrome, eventually leading to intestinal metaplasia and gastric cancer. The aim of our study was to investigate the possible association between dyslipidemia and histopathological features of H. pylori gastritis. PATIENTS AND METHODS: An observational, retrospective study was conducted over the period 2017-2022 on symptomatic patients with a positive rapid urease test. A total of 121 patients who underwent upper gastrointestinal endoscopy with stomach biopsy were enrolled in this study...
2024: In Vivo
#16
JOURNAL ARTICLE
Xin Guan, Jing Ning, Weiwei Fu, Ye Wang, Jing Zhang, Shigang Ding
BACKGROUND: Helicobacter pylori infection is one of the main causes of gastric cancer. thioredoxin-1 (Trx1) and arginase (RocF) expressed by H. pylori were found to be closely related to its pathogenicity. However, whether Trx1 and RocF can be used in clinical screening of highly pathogenic H. pylori and the pathogenesis of trx1 high expressing H. pylori remain still unknown. MATERIALS AND METHODS: We investigated the expression level of H. pylori trx1 and H. pylori rocF in human gastric antrum tissues using reverse transcription and quantitative real-time PCR (RT-qPCR) and clarified the clinical application value of trx1 and rocF for screening highly pathogenic H...
2024: Helicobacter
#17
JOURNAL ARTICLE
Jose M Huguet, Luis Ferrer-Barceló, Patrícia Suárez, Susana Barcelo-Cerda, Javier Sempere, Ilaria Maria Saracino, Giulia Fiorini, Dino Vaira, Ángeles Pérez-Aísa, Laimas Jonaitis, Bojan Tepes, M Castro-Fernandez, Manuel Pabón-Carrasco, Alma Keco-Huerga, Irina Voynovan, Alfredo J Lucendo, Ángel Lanas, Samuel J Martínez-Domínguez, Enrique Alfaro Almajano, Luis Rodrigo, Ludmila Vologzanina, Dmitry S Bordin, Antonio Gasbarrini, Gülüstan Babayeva, Frode Lerang, Mārcis Leja, Juozas Kupčinskas, Theodore Rokkas, Ricardo Marcos-Pinto, Antonio Meštrović, Oleksiy Gridnyev, Perminder S Phull, Sinead M Smith, Doron Boltin, György Miklós Buzás, Jan Kral, Halis Şimşek, Tamara Matysiak-Budnik, Vladimir Milivojevic, Wojciech Marlicz, Marino Venerito, Lyudmila Boyanova, Michael Doulberis, Lisette G Capelle, Anna Cano-Català, Leticia Moreira, Olga P Nyssen, Francis Mégraud, Colm O'Morain, Javier P Gisbert
BACKGROUND: Adherence to Helicobacter pylori (H. pylori) eradication treatment is a cornerstone for achieving adequate treatment efficacy. OBJECTIVE: To determine which factors influence compliance with treatment. METHODS: A systematic prospective non-interventional registry (Hp-EuReg) of the clinical practice of European gastroenterologists. Compliance was considered adequate if ≥90% drug intake. Data were collected until September 2021 using the AEG-REDCap e-CRF and were subjected to quality control...
April 29, 2024: United European Gastroenterology Journal
#18
JOURNAL ARTICLE
V Sánchez-Quezada, N Velázquez-Guadarrama, S Mendoza-Elizalde, M Hernandez-Iturriaga, P Vázquez Landaverde, G Loarca-Piña
ETHNOPHARMACOLOGICAL RELEVANCE: In ancient Mexican cultures, the Persea americana Mill seed has been used against gastrointestinal diseases, due to high concentrations of bioactive compounds. According to Traditional Mexican Medicine, P. americana seed aqueous infusion is used against roundworms, intestinal worms, parasites, and gastrointestinal problems, in a dose taken over three or four days. In addition, Mexican Society of Natural History indicates the traditional use of P. americana seed powder as an antiparasitic, and antibacterial (MTM, 2009)...
April 27, 2024: Journal of Ethnopharmacology
#19
JOURNAL ARTICLE
Lih-Lih Ong, Hau-Ming Jan, Hong-Hanh Thi Le, Tsai-Chen Yang, Chou-Yu Kuo, Ai-Feng Feng, Kwok-Kong Tony Mong, Chun-Hung Lin
BACKGROUND: Helicobacter pylori, the main cause of various gastric diseases, infects approximately half of the human population. This pathogen is auxotrophic for cholesterol which it converts to various cholesteryl α-glucoside derivatives, including cholesteryl 6'-acyl α-glucoside (CAG). Since the related biosynthetic enzymes can be translocated to the host cells, the acyl chain of CAG likely comes from its precursor phosphatidylethanolamine (PE) in the host membranes. This work aims at examining how the acyl chain of CAG and PE inhibits the membrane functions, especially bacterial adhesion...
April 29, 2024: Journal of Biomedical Science
#20
JOURNAL ARTICLE
Zhenyu Jiang, Boning Deng, Yaqi Zhang, Ye Li, Zhijun Yu, Haiying Deng, Yajun Chen
OBJECTIVES: To compare the efficacy and safety of seven Chinese patent medicines (CPMs) combined with conventional triple/quadruple therapy (T/Q) for Helicobacter pylori -positive peptic ulcers. DESIGN: A systematic review and network meta-analysis. DATA SOURCES: China National Knowledge Infrastructure, VIP database, Wanfang database, ScienceDirect, EBSCO, EMBASE, Web of Science, Cochrane Library and PubMed were searched through 1 June 2022...
April 29, 2024: BMJ Open
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