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meropenem use evaluation

Ibukun M Adesiyan, Mary A Bisi-Johnson, Aderemi O Ogunfowokan, Anthony I Okoh
Plesiomonas shigelloides, is an emerging and significant enteric pathogen in water having implication in both localised and gastrointestinal infections with characteristic of displaying high resistance against commonly used antibiotics. This study evaluated the prevalence of Plesiomonas shigelloides and their antibiogram fingerprints in water sample collected from four rivers in South-western Nigeria. In all, 148 presumptive Plesiomonas shigelloides isolates was recovered from the rivers out of which 66 (44...
February 5, 2019: Science of the Total Environment
Yao Wang, Xin-Fei Chen, Xiu-Li Xie, Meng Xiao, Yang Yang, Ge Zhang, Jing-Jia Zhang, Si-Meng Duan, Qian Zhang, Peng Zhang, Clement Tsui, Ying-Chun Xu
BACKGROUND AND PURPOSE: Bacteroides fragilis group isolates are most frequently isolated anaerobic pathogens. This study aimed to evaluate the accuracy of VITEK MS, Clin-ToF-II MS, Autof MS 1000 and VITEK 2 ANC card on the identification of clinical B. fragilis group isolates, as well as to determine their antimicrobial susceptibilities. METHODS: A total of 138 isolates of B. fragilis group isolates were identified with the three MALDI-TOF MS systems and VITEK 2 ANC cards...
January 4, 2019: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
Fatma Eser, Gül Ruhsar Yılmaz, Rahmet Güner, İmran Hasanoğlu, Fatma Yekta Ürkmez Korkmaz, Ziya Cibali Açıkgöz, Mehmet Akın Taşyaran
Background/aim: This study aimed to evaluate the risk factors of patients colonized with carbapenem-resistant Enterobacteriaceae (CRE). Materials and methods: The study was conducted between January 2010 and March 2016. The colonized group consisted of patients who had a CRE strain in their rectal swab cultures, whereas patients with negative rectal surveillance cultures for CRE who were concurrently hospitalized in the same units with the colonized group patients were included in the control group...
February 11, 2019: Turkish Journal of Medical Sciences
H V Dodou, A H M Batista, S C Medeiros, G W P Sales, M L Rodrigues, P I O Pereira, P C N Nogueira, E R Silveira, T B Grangeiro, N A P Nogueira
The aim of this study was to evaluate the antimicrobial potential of violacein (VIO) on Staphylococcus epidermidis biofilm. The minimum biofilm inhibition concentration (MBIC) and minimum biofilm eradication concentration (MBEC) were determined, as well as the effect of VIO exposure time on microbial viability in mature biofilm. Violacein showed good antibiofilm action, inhibiting biofilm formation and eradicating mature biofilm of S. epidermidis at concentrations of 20 μg.mL-1 and 160 μg.mL-1 , respectively...
February 13, 2019: Natural Product Research
Acar Ali, Karaahmetoğlu Gökhan, Akalın Halis, Altay F Aybala
OBJECTIVES: This meta-analysis aimed to evaluate the current prevalence and trends over the past 10-years of antimicrobial resistance of Pseudomonas aeruginosa. Two researches independently searched two national (ULAKBİM, Türk Medline) and two international databases (PubMed, Web of Science) to identify studies on P. aeruginosa resistance to antimicrobials from 2007 to 2017. METHODS: Homogeneity across studies was assessed using a Cochrane's and total variability due to between study variations was reflected in the I2 index...
February 9, 2019: Journal of Global Antimicrobial Resistance
Xingchen Bian, Xiaofen Liu, Yuancheng Chen, Daijie Chen, Jian Li, Jing Zhang
Background: Colistin-based combination therapy has become an important strategy to combat the carbapenem-resistant Acinetobacter baumannii (CRAB). However, the optimal dosage regimen selection for the combination with the maximum efficacy is challenging. Method: Checkerboard assay was employed to evaluate the synergy of colistin in combination with meropenem, rifampicin, fosfomycin and minocycline against nine carbapenem-resistant A. baumannii (Minimum inhibitory concentration of meropenem [MICMEM ]≥32 mg/L) isolated from Chinese hospital-acquired pneumonia (HAP) patients...
February 11, 2019: Antimicrobial Agents and Chemotherapy
Samuel T Cahill, Jonathan M Tyrrell, Iva Hopkins Navratilova, Karina Calvopiña, Sean W Robinson, Christopher T Lohans, Michael A McDonough, Ricky Cain, Colin W G Fishwick, Matthew B Avison, Timothy R Walsh, Christopher J Schofield, Jürgen Brem
BACKGROUND: The β-lactam antibiotics represent the most successful drug class for treatment of bacterial infections. Resistance to them, importantly via production of β-lactamases, which collectively are able to hydrolyse all classes of β-lactams, threatens their continued widespread use. Bicyclic boronates show potential as broad spectrum inhibitors of the mechanistically distinct serine- (SBL) and metallo- (MBL) β-lactamase families. METHODS: Using biophysical methods, including crystallographic analysis, we have investigated the binding mode of bicyclic boronates to clinically important β-lactamases...
February 7, 2019: Biochimica et biophysica acta. General subjects
George G Zhanel, Alyssa R Golden, Sheryl Zelenitsky, Karyn Wiebe, Courtney K Lawrence, Heather J Adam, Temilolu Idowu, Ronald Domalaon, Frank Schweizer, Michael A Zhanel, Philippe R S Lagacé-Wiens, Andrew J Walkty, Ayman Noreddin, Joseph P Lynch Iii, James A Karlowsky
Cefiderocol is an injectable siderophore cephalosporin discovered and being developed by Shionogi & Co., Ltd., Japan. As with other β-lactam antibiotics, the principal antibacterial/bactericidal activity of cefiderocol occurs by inhibition of Gram-negative bacterial cell wall synthesis by binding to penicillin binding proteins; however, it is unique in that it enters the bacterial periplasmic space as a result of its siderophore-like property and has enhanced stability to β-lactamases. The chemical structure of cefiderocol is similar to both ceftazidime and cefepime, which are third- and fourth-generation cephalosporins, respectively, but with high stability to a variety of β-lactamases, including AmpC and extended-spectrum β-lactamases (ESBLs)...
February 2, 2019: Drugs
Yuliya Bocharova, Tatiana Savinova, Dmitriy A Shagin, Andrey A Shelenkov, Nikolay A Mayanskiy, Igor V Chebotar
OBJECTIVES: Alteration of the porin-coding oprD gene by insertion sequences (ISs) is one of the mechanisms conferring carbapenem resistance in Pseudomonas aeruginosa. In this study, we described a carbapenem resistant clinical isolate P. aeruginosa 36-989 harboring a novel IS (ISPa195) in oprD. METHODS: Minimal inhibitory concentration (MIC) values were determined by broth microdilution. Carbapenemase activity was assessed using a MALDI-TOF MS-based assay of meropenem hydrolysis...
January 22, 2019: Journal of Global Antimicrobial Resistance
Özlem Akışoğlu, Doruk Engin, Seyyide Sarıçam, Hamit Kaan Müştak, Burçin Şener, Gülşen Hasçelik
Burkholderia spp. emerged as important pathogens in the airways of immunocompromised humans, especially those with cystic fibrosis (CF). Failure of identification with conventional techniques, high intrinsic resistance to most antibiotics and biofilm formation can cause difficulties in the treatment of these infections. The aim of this study was to identify Burkholderia spp. strains isolated from CF and non-CF patients with with routine microbiological methods, matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and multilocus sequence analysis (MLSA), to determine of the antibiotic susceptibility and synergies, and to evaluate biofilm formation of these isolates...
January 2019: Mikrobiyoloji Bülteni
Joan Gomez-Junyent, Eva Benavent, Yanik Sierra, Cristina El Haj, Laura Soldevila, Benjamin Torrejon, Raul Rigo-Bonnin, Fe Tubau, Javier Ariza, Oscar Murillo
Ceftolozane/tazobactam is a potential tool for infections by MDR Pseudomonas aeruginosa, but its efficacy against some difficult-to-treat infections has not been well defined. Using an in vitro pharmacodynamic biofilm model, we evaluated the comparative efficacy of ceftolozane/tazobactam against MDR/XDR P. aeruginosa strains, alone and in combination with colistin. Simulated regimens of ceftolozane/tazobactam (2g/1g every 8h), meropenem (2g every 8h) and ceftazidime (2g every 8h), alone and in combination with colistin (continuous infusion) were evaluated against three colistin-susceptible and ceftazidime-resistant strains: MDR-HUB1, ceftolozane/tazobactam- and meropenem-susceptible; XDR-HUB2, ceftolozane/tazobactam-susceptible and meropenem-resistant; MDR-HUB3, ceftolozane/tazobactam-resistant and meropenem-susceptible...
January 22, 2019: International Journal of Antimicrobial Agents
Xavier Mulet, Rafaela García, María Gayá, Antonio Oliver
The increasing prevalence of extensively drug-resistant (XDR) Pseudomonas aeruginosa infections is due to the global spread of defined high-risk clones (HRC). Among them, ST175 is particularly frequent in Spain and France. Here, we evaluated O-antigen serotyping and MALDI-TOF as typing methods for the early identification of ST175. O-antigen (O4) serotyping and MALDI-TOF biomarker peak-based recognition models were tested in several strain collections, including 206 non-duplicated P. aeruginosa clinical isolates collected in 2016...
January 24, 2019: European Journal of Clinical Microbiology & Infectious Diseases
Yoshiki Hiyama, Satoshi Takahashi, Toyotaka Sato, Masaaki Shinagawa, Yukari Fukushima, Chie Nakajima, Yasuhiko Suzuki, Naoya Masumori, Shin-Ichi Yokota
Neisseria gonorrhoeae is a principal pathogen for sexually transmitted infections, especially for male urethritis. Currently, the prevalence of multidrug resistance is increasing. Carbapenems are broad-spectrum antimicrobials that are widely used in the clinical setting, especially for multidrug-resistant Gram-negative bacteria. However, susceptibility to carbapenems has not been well evaluated for cephalosporin-resistant N. gonorrhoeae isolates. In this study, we determined the susceptibility to a series of carbapenems (meropenem, imipenem, doripenem, and biapenem) and faropenem against cephalosporin-resistant (resistant to cefixime, but susceptible to ceftriaxone) and cephalosporin-susceptible N...
January 24, 2019: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
Shoroq M Altawalbeh, Rawan Abu-Su'ud, Qais Alefan, Suleiman Mohammad Momany, Sandra L Kane-Gill
BACKGROUND: Intensive Care Unit (ICU) medication costs contribute to a large portion of the total ICU costs. Evaluating ICU drug expenditures is essential for optimal resource use especially in countries with limited resources. Considering the dearth of data regarding ICU medication expenses in the Middle East, we sought to evaluate ICU medication charges at a large academic hospital in Jordan. METHODS: ICU drug charges were extracted from the hospital administration database at King Abdullah University Hospital for 2014-2015 fiscal years (FYs)...
January 21, 2019: Expert Review of Pharmacoeconomics & Outcomes Research
Vittorio Magri, Matteo Boltri, Tommaso Cai, Roberto Colombo, Salvatore Cuzzocrea, Pieter De Visschere, Rosanna Giuberti, Clara Maria Granatieri, Maria Agnese Latino, Gaetano Larganà, Christian Leli, Giorgio Maierna, Valentina Marchese, Elisabetta Massa, Alberto Matteelli, Emanuele Montanari, Giuseppe Morgia, Kurt G Naber, Vaia Papadouli, Gianpaolo Perletti, Nektaria Rekleiti, Giorgio I Russo, Alessandra Sensini, Konstantinos Stamatiou, Alberto Trinchieri, Florian M E Wagenlehner
The modern clinical research on prostatitis started with the work of Stamey and coworkers who developed the basic principles we are still using. They established the segmented culture technique for localizing the infections in the males to the urethra, the bladder, or the prostate and to differentiate the main categories of prostatitis. Such categories with slight modifications are still used according to the NIH classification: acute bacterial prostatitis, chronic bacterial prostatitis, Chronic Pelvic Pain Syndrome (CPPS) and asymptomatic prostatitis...
January 18, 2019: Archivio Italiano di Urologia, Andrologia
Raziyeh Kheshti, Bahman Pourabbas, Maryam Mosayebi, Afsaneh Vazin
Introduction: Acinetobacter baumannii is a gram-negative,opportunistic pathogen responsible for resistant nosocomial infections especially in the intensive care units (ICUS).One reason for the failure in the treatment of A. baumannii is its ability of develop resistance against several antimicrobials. combination of different antimicrobials can be used to overcome such a resistance. This study was done to evaluate the in vitro synergistic activity of colistin in combination with six different antimicrobials, including ciprofloxacin, levofloxacin, imipenem, meropenem, ampicillin-sulbactam, and rifampin against A...
2019: Infection and Drug Resistance
Xingang Li, Xiaoping Wang, Yuanxing Wu, Shusen Sun, Kai Chen, Yanxia Lu, Qiang Wang, Zhigang Zhao
Combined intravenous and local intrathecal administration of meropenem in patients after craniotomy is widely used to treat intracranial infections. However, the optimal dosing regimen of meropenem has not been investigated, posing a risk to treatment efficacy. We aimed to identify significant factors associated with inter-individual variability in cerebrospinal fluid (CSF) pharmacokinetics of meropenem and to evaluate potential intravenous and intrathecal meropenem dosing regimens for the treatment of patients with intracranial infections...
August 17, 2018: Diagnostic Microbiology and Infectious Disease
Paola Hoff Alves, Roberta Taufer Boff, Afonso Luis Barth, Andreza Francisco Martins
Here, we evaluated the combinations of antibiotics polymyxin B (PMB), tigecycline (TGC) and meropenem (MEM) by time-kill curves (TKC) against carbapenem-resistant Enterobacter cloacae isolates. Combination of PMB/TGC and PMB/MEM showed promising results in sub-inhibitory concentration of PMB indicating the possibility of reducing the dose of PMB used in the treatment.
November 22, 2018: Diagnostic Microbiology and Infectious Disease
Hiromi Yamakawa, Kosuke Kosai, Norihiko Akamatsu, Junichi Matsuda, Norihito Kaku, Naoki Uno, Yoshitomo Morinaga, Hiroo Hasegawa, Taishi Tsubouchi, Yukihiro Kaneko, Taiga Miyazaki, Koichi Izumikawa, Hiroshi Mukae, Katsunori Yanagihara
This study investigated the molecular and phenotypic characteristics of carbapenemase-producing Klebsiella pneumoniae, and identified the risk factors underlying its acquisition. We evaluated K. pneumoniae isolated in Nagasaki University Hospital between January 2009 and June 2015. The presence of carbapenemase genes and plasmid characteristics were investigated. We performed multilocus sequence typing (MLST), and generated a dendrogram based on the results of pulsed-field gel electrophoresis (PFGE) for carbapenemase-producing strains...
January 2, 2019: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Myra E Durham, Johanna R Elfenbein
OBJECTIVE To evaluate the effects of vaporized hydrogen peroxide (VHP) sterilization on the in vitro antimicrobial efficacy of meropenem-impregnated polymethyl methacrylate (M-PMMA) beads. SAMPLE 6-mm-diameter polymethyl methacrylate beads that were or were not impregnated with meropenem. PROCEDURES Meropenem-free polymethyl methacrylate and M-PMMA beads were sterilized by use of an autoclave or VHP or remained unsterilized. To determine the antimicrobial efficacy of each bead-sterilization combination (treatment), Mueller-Hinton agar plates were inoculated with 1 of 6 common equine pathogens, and 1 bead from each treatment was applied to a sixth of each plate...
January 2019: American Journal of Veterinary Research
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