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psychopharmacological treatment of anxiety

Angelo G I Maremmani, Matteo Pacini, Icro Maremmani
Mental Disorders and Heroin Use Disorder (HUD) often co-occur and constitute correlated risk factors that the authors believe are best considered from a unitary perspective. In this article we review and discuss data collected by the V.P. Dole Research Group in Dual Disorder (V.P. Dole DD-RG) patients according to the following six discussion points: (1) Treatment of personality disorders during Methadone Maintenance Treatment (MMT); (2) Treatment of Mood Disorders during MMT; (3) Treatment of Anxiety Disorders during MMT; (4) Treatment of Psychotic Disorders during MMT; (5) Treatment of violence during MMT; (6) Treatment of Alcohol Use Disorder (AUD) during MMT...
February 3, 2019: International Journal of Environmental Research and Public Health
Mark B Hamner, Melba A Hernandez-Tejada, Zachary D Zuschlag, Deborah Agbor-Tabi, Michael Huber, Zhewu Wang
BACKGROUND: Posttraumatic stress disorder (PTSD) is often a chronic, disabling illness for which antidepressant medications (ie, SSRI) are considered the primary psychopharmacological treatment. However, many patients remain refractory to antidepressants alone or in combination with psychotherapy. Safe and effective treatments for individuals with refractory PTSD are needed. This study aimed to examine ziprasidone augmentation of SSRI treatment of PTSD. METHODS: This was a 2-phase study...
January 10, 2019: Journal of Clinical Psychopharmacology
Claudia Delgado-Acevedo, Sebastián F Estay, Anna Radke, Ayesha Sengupta, Angélica P Escobar, Francisca Henríquez-Belmar, Cristopher Reyes, Valentina Haro, Elías Utreras, Ramón Sotomayor-Zárate, Andrew Cho, Jens R Wendland, Ashok B Kulkarni, Andrew Holmes, Dennis L Murphy, Andrés E Chávez, Pablo R Moya
Obsessive-compulsive disorder (OCD) is a severe, chronic neuropsychiatric disorder with a strong genetic component. The SLC1A1 gene encoding the neuronal glutamate transporter EAAT3 has been proposed as a candidate gene for this disorder. Gene variants affecting SLC1A1 expression in human brain tissue have been associated with OCD. Several mouse models fully or partially lacking EAAT3 have shown no alterations in baseline anxiety-like or repetitive behaviors. We generated a transgenic mouse model (EAAT3glo ) to achieve conditional, Cre-dependent EAAT3 overexpression and evaluated the overall impact of increased EAAT3 expression at behavioral and synaptic levels...
December 26, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Dawson Church, Peta Stapleton, Phil Mollon, David Feinstein, Elizabeth Boath, David Mackay, Rebecca Sims
Clinical EFT (Emotional Freedom Techniques) is an evidence-based method that combines acupressure with elements drawn from cognitive and exposure therapies. The approach has been validated in more than 100 clinical trials. Its efficacy for post-traumatic stress disorder (PTSD) has been investigated in a variety of demographic groups including war veterans, victims of sexual violence, the spouses of PTSD sufferers, motor accident survivors, prisoners, hospital patients, adolescents, and survivors of natural and human-caused disasters...
December 12, 2018: Healthcare (Basel, Switzerland)
Ulrich Palm, Jérôme Brunelin, Linda Wulf, Marine Mondino, Andre R Brunoni, Frank Padberg
More than 40 % of patients with obsessive-compulsive disorder (OCD) do not respond to established treatments despite advances in psychopharmacology and psychotherapy. Since a couple of years, non-invasive brain stimulation techniques gain importance in the treatment of psychiatric disorders. Transcranial direct current stimulation (tDCS) uses weak constant direct current to modulate neuronal activation and changes the function of neuronal networks. This technique is recently investigated for the improvement of treatment resistant OCD symptoms...
December 11, 2018: Fortschritte der Neurologie-Psychiatrie
Amina K Kuby, Bernd Loewe, Alexandra B Fabisch, Katharina Piontek, Martin Haerter, Hans-Helmut Koenig, Meike C Shedden-Mora
Many primary care patients with high somatic symptom burden do not initiate mental health treatment. Using a cross-sectional design, this study aimed to identify predictors of psychotherapy seeking behavior for patients with high somatic symptom burden within the last 12 months. Data from 20 primary care practices were analyzed. Patients with high somatic symptom burden were identified using the Patient Health Questionnaire, structured interviews, and information from primary care physicians (PCPs). Within the final sample of 142 patients, 54 (38...
December 11, 2018: Behavioral Medicine
Ewa Kędzierska, Ferdinando Fiorino, Ewa Gibuła, Angela Corvino, Flavia Giordano, Mariola Herbet, Jarosław Dudka, Ewa Poleszak, Piort Wlaź, Jolanta H Kotlińska
Anxiety disorder is a great challenge for modern psychopharmacology. Although a variety of single drugs are used in the treatment of anxiety, it is important to search for new therapeutics with faster onset of action, fewer side effects and higher efficacy. In this work, we studied the possible anxiolytic action mechanism of two new arylpiperazine derivatives: compounds 4p N-(3-(4-(piperonyl)piperazin-1-yl)propyl)isonicotinamide and 3o N-(2-(4-(pyrimidin-2-yl)piperazin-1-yl)ethyl)picolinamide, focusing on their effects on the GABA-ergic and 5-HT systems...
December 2, 2018: Fundamental & Clinical Pharmacology
Aribert Rothenberger, Veit Roessner
While Behavioral Therapy (BT) should be recommended as the first step in the treatment of OCD as well as TS, medication can be added for augmentation and in certain situations (e.g. family preference, BT not available or feasible) the priority may even reverse. This narrative review is given on the complexity of drug treatment in patients comorbid for obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) and other tic problems. OCD with TS is a co-occuring combination of two generally delimitable, but in detail also overlapping disorders which wax and wane with time but have different courses and necessities and options of treatment...
August 27, 2018: Current Neuropharmacology
Wendy Spettigue, Mark L Norris, Alexandre Santos, Nicole Obeid
Background: To date, little research has examined the effectiveness of either modified Family-Based Therapy or psychopharmacological treatments for patients diagnosed with avoidant/restrictive food intake disorder (ARFID), and there is little evidence to guide clinicians treating children and adolescents with ARFID. This case series describes the clinical presentations, treatments and outcomes of six patient diagnosed with ARFID who were treated sequentially by a child psychiatrist and adolescent medicine physician in a hospital-based eating disorder program...
2018: Journal of Eating Disorders
Jeffrey R Strawn, Laura Geracioti, Neil Rajdev, Kelly Clemenza, Amir Levine
Generalized anxiety disorder (GAD) often begins during adolescence or early adulthood and persists throughout the lifespan. Randomized controlled trials support the efficacy of selective serotonin and selective serotonin norepinephrine reuptake inhibitors (SSRIs and SNRIs, respectively), as well as benzodiazepines, azapirones, anti-adrenergic medications, melatonin analogs, second-generation antipsychotics, kava, and lavender oil in GAD. However, psychopharmacologic treatment selection requires clinicians to consider multiple factors, including age, co-morbidity, and prior treatment...
July 2018: Expert Opinion on Pharmacotherapy
Sophie van Rijn
BACKGROUND: Approximately 1 in 650 boys are born with an extra X chromosome. Boys and men with 47,XXY (Klinefelter syndrome) are at risk for neurodevelopmental disorders and specific cognitive impairments. This study was focused on social anxiety and social cognition. The aim was to assess if these aspects of the phenotype are related to testosterone deficiency, which is typically seen in 47,XXY from puberty onwards. METHODS: In the study 20 boys with 47,XXY and 25 non-clinical controls between 8 and 19 years participated...
2018: PloS One
Kai G Kahl, Gabriel Eckermann, Helge Frieling, Thomas Hillemacher
Organ transplantation has become a well-established treatment option in patients with end-stage organ diseases. Although quality of life has markedly improved, psychiatric disorders before and after transplantation are more frequent compared to the general population. Psychopharmacological treatment is recommended for almost all mental disorders according to current guidelines, but may pose particular problems in organ transplant patients. Changes in the metabolism and elimination of drugs during organ insufficiency, drug interactions, and overlapping side effects between psychopharmacological and immunosuppressive drugs are challenging problems in clinical management...
January 10, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Filipe Silveira Duarte, Marcelo Duzzioni, Rafael Luiz Prim, Alcíbia Maia Cardozo, Claudia Regina Dos Santos, Maria Goretti da Silva, Maria Beatriz Cacese Shiozawa, Beatriz Garcia Mendes, Tiago Tizziani, Inês Maria Costa Brighente, Moacir Geraldo Pizzolatti, Thereza Christina Monteiro de Lima
OBJECTIVES: To investigate whether mice develop tolerance to the anxiolytic-like and anticonvulsant effects of subchronic treatment with EA (the styryl-2-pyrones and dihydrostyryl-2-pyrones-rich fraction of Polygala sabulosa), as well as any withdrawal symptoms after abrupt discontinuation; to compare the effects of EA with those of diazepam (DZP) on withdrawal-induced anxiety; and to evaluate the toxicity of EA according to OECD guidelines. METHODS: Male or female mice were acutely or subchronically treated with EA or DZP, and their tolerance to anxiolytic (evaluated in the elevated plus maze, EPM) and anticonvulsant effects (measured against pentylenetetrazole (PTZ)-induced convulsions) were investigated...
September 2018: Journal of Pharmacy and Pharmacology
Yael I Nillni, Aydan Mehralizade, Laura Mayer, Snezana Milanovic
Women with psychiatric disorders during pregnancy and the postpartum period (i.e., perinatal period) are at increased risk for adverse maternal and child outcomes. Effective treatment of psychiatric disorders during the perinatal period is imperative. This review summarizes the outcomes of 78 studies focused on the treatment of depression, anxiety, and trauma-related disorders during the perinatal period. The majority of studies focused on perinatal depression (n = 73). Of the five studies focused on anxiety or trauma-related disorders, only one was a randomized controlled trial (RCT)...
June 9, 2018: Clinical Psychology Review
Murad Atmaca, Hanefi Yildirim, Seda Yilmaz, Neslihan Caglar, Sema Baykara, Yasemin Kekilli, Filiz Koseoglu, Hakan Turkcapar
OBJECTIVE: The beneficial effects of psychopharmacological and cognitive behavioral therapy (CBT) on the brain are not well understood. In a previous study, we found smaller pituitary volumes in patients with obsessive-compulsive disorder (OCD). The purpose of this study was to examine the effect of CBT on pituitary gland volume. METHODS: A total of 81 patients with various anxiety disorders and the same number of healthy controls underwent magnetic resonance imaging, and their pituitary gland volumes were compared at baseline...
October 2018: Revista Brasileira de Psiquiatria
(no author information available yet)
Reports an error in "Initiation and retention in couples outpatient treatment for parents with drug and alcohol use disorders" by Abby L. Braitman and Michelle L. Kelley ( Experimental and Clinical Psychopharmacology , 2016[Jun], Vol 24[3], 174-184). In the article, there are errors in Table 2. In the corrected table, the impact of Men's perpetration of violence changes from a non-significant trend (p < .10) to a significant effect (p < .05). Also within Table 2, Women's dyadic cohesion effect changed from a significant finding to a non-significant trend (p ...
June 2018: Experimental and Clinical Psychopharmacology
N Hock, G Juckel
The application of homeopathic treatment quickly becomes a matter of ideological confrontation; however, homeopathy is steadily gaining in sympathy in the population. Although the possible effectiveness and the modes of action are currently not scientifically elucidated and the study situation regarding homeopathic treatment in psychiatry is still manageable, there is a whole series of positive evidence for the effects of homeopathic remedies for mental disorders, such as depression, anxiety disorders and addiction...
September 2018: Der Nervenarzt
Katie R Thorsness, Corey Watson, Elizabeth M LaRusso
Anxiety is common in women during the perinatal period, manifests with various symptoms and severity, and is associated with significant maternal morbidity and adverse obstetric and neonatal outcomes. Given the intimate relationship and frequency of contact, the obstetric provider is positioned optimally to create a therapeutic alliance and to treat perinatal anxiety. Time constraints, absence of randomized controlled trials, mixed quality of data, and concern for potential adverse reproductive outcomes all limit the clinician's ability to initiate informed risk-benefit discussions...
October 2018: American Journal of Obstetrics and Gynecology
Katharine Thomson, Kristine McKenna, Katherine Bedard-Thomas, Melisa Oliva, Patricia Ibeziako
This study examined the demographic, medical, and psychiatric characteristics of transplant patients across organ groups seen by transplant psychology/psychiatry clinicians at a pediatric institution between 2008 and 2014. Chart reviews were conducted to better understand the behavioral health care provided to SOT patients and the role of transplant-dedicated psychology and psychiatry clinicians. Transplant psychology/psychiatry was consulted a total of 1060 times on 399 unique SOT patients over a 6-year period...
August 2018: Pediatric Transplantation
Laura Cremaschi, Benedetta Grancini, Vera De Carlo, Sara Pozzoli, A Carlo Altamura, Bernardo Dell'Osso
Benzodiazepines (BDZs) are widespread psychotropic compounds, often prescribed as first-line symptomatic option by general practitioners in patients with different psychiatric disorders. Sometimes, however, they contribute to delay the administration of the first appropriate psychopharmacological treatment, thus leading to a longer duration of untreated illness in patients with depressive and anxiety disorders. The well-established pros of BDZs use in clinical practice include efficacy, rapidity of action, versatility, and safety...
May 5, 2018: Aging Clinical and Experimental Research
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