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Cervical intraepithelial lesions

Pascal van der Weele, Audrey J King, Chris J L M Meijer, Renske D M Steenbergen
INTRODUCTION: Recurrent cervical intraepithelial lesions (rCIN2/3) after treatment of CIN2/3 occur in 5-15% of cases. rCIN2/3 can result from incomplete resection of CIN2/3, where the same HPV type and variant remains present. rCIN2/3 could also occur following a new infection with a different HPV variant of the same HPV type as the initial lesion. This study investigates HPV16 consensus variants in paired HPV16 positive scrapes from baseline CIN2/3 and rCIN2/3 lesions. METHODS: Paired HPV16 positive cervical scrapes of women with CIN2/3 at baseline and rCIN2/3 6 or 12 months after treatment were selected for whole-genome amplification and Illumina sequencing...
April 13, 2019: Papillomavirus Research
Taylor M Jenkins, Hadi Shojaei, Sharon J Song, Lauren E Schwartz
The Papanicolaou (PAP) test is widely used to screen for cervical cancer. All high-grade lesions such as atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H), and high-grade squamous intraepithelial lesion, identified on a PAP test should be followed-up by a confirmatory cervical biopsy. In this review, we discuss the challenges in interpreting cervical tissue specimens and the various ancillary techniques used in the evaluation of cervical dysplasia. Ancillary studies include deeper levels, p16 immunohistochemistry (IHC), human papillomavirus (HPV) testing, and, importantly, cyto-histologic correlation...
April 12, 2019: Acta Cytologica
Angela Ahlquist Cleveland, Julia W Gargano, Ina U Park, Marie R Griffin, Linda M Niccolai, Melissa Powell, Nancy M Bennett, Kayla Saadeh, Manideepthi Pemmaraju, Kyle Higgins, Sara Ehlers, Mary Scahill, Michelle L Johnson Jones, Troy Querec, Lauri E Markowitz, Elizabeth R Unger
Primary prevention through the use of human papillomavirus (HPV) vaccination is expected to impact both cervical intraepithelial neoplasia (CIN) and adenocarcinoma in situ (AIS). While CIN is well described, less is known about the epidemiology of AIS, a rare cervical precancer. We identified AIS and CIN grade 3 (CIN3) cases through population-based surveillance, and analyzed data on HPV types and incidence trends overall, and among women screened for cervical cancer. From 2008-2015, 470 AIS and 6,587 CIN3 cases were identified...
April 13, 2019: International Journal of Cancer. Journal International du Cancer
Yutaka Ueda, Kei Kawana, Nozomu Yanaihara, Kouji Banno, Maryan Chhit, Kyna Uy, Leangsim Kruy, Chan S Sann, Miwa Ishioka-Kanda, Hiroki Akaba, Yasuyo Matsumoto, Noriko Fujita, Testu Yano, Kanal Koum, Aikou Okamoto, Tadashi Kimura
AIM: In Cambodia, the Japan Society of Obstetrics and Gynecology and the Cambodian Society of Gynecology and Obstetrics have an on-going project, started in 2015, for cervical cancer prevention and treatment. The project, currently aimed at factory workers, includes a women's health education program that leads into cervical cancer prevention by establishment of a system for early detection and treatment. It begins by health education, screening for human papillomavirus (HPV), followed by colposcopy and quicker treatment of earlier precursor lesions...
April 11, 2019: Journal of Obstetrics and Gynaecology Research
Sunyoung Park, Suji Lee, Jungho Kim, Geehyuk Kim, Kwang Hwa Park, Tae Ue Kim, Dawn Chung, Hyeyoung Lee
p63 is a transcription factor p53 family. Two major isoforms of p63, TAp63 with transactivation (TA) domain and ΔNp63 with truncated TA domain, have been reported to play opposing roles either in tumor suppression or oncogenic function. Little is known about the association of these two isoforms of p63 in the carcinogenesis of cervical cancer. In this study, the mRNA expression levels of TAp63 and ΔNp63 in 40 normal, 30 low-grade squamous intraepithelial lesions (LSIL), 38 high-grade squamous intraepithelial lesions (HSIL), and 52 cervical cancer formalin-fixed paraffin-embedded tissues were examined using quantitative reverse transcription polymerase chain reaction (RT-qPCR)...
2019: PloS One
Iris Babion, Lise M A De Strooper, Roosmarijn Luttmer, Maaike C G Bleeker, Chris J L M Meijer, Daniëlle A M Heideman, Saskia M Wilting, Renske D M Steenbergen
Cervical screening by high-risk HPV (hrHPV) testing requires additional risk stratification (triage), as most infections are transient and only a subset of hrHPV-positive women harbours clinically relevant disease. Molecular triage markers such as microRNAs (miRNAs) and DNA methylation markers are particularly promising, as they can be objectively tested directly on hrHPV-positive scrapes and cervicovaginal self-samples. Here, we evaluated the marker potential of 10 candidate miRNAs in 209 hrHPV-positive scrapes of women with underlying precancer (cervical intraepithelial neoplasia, grade 2-3 (CIN2-3)), cancer, or without disease (CIN0/1)...
April 8, 2019: Epigenetics: Official Journal of the DNA Methylation Society
Nina Karia, Alison Van Loon, Cindy Simoens, Ina Benoy, Johannes Bogers
Cervical cancer is a major worldwide health problem. Therefore, regular cervical screening in order to make an early diagnosis can help to prevent cervical cancer, through identifying and treating preinvasive cervical lesions. The aim of this review is to evaluate the correlation between the cytological screening result and the final gold standard histological outcome in the diagnosis of cervical lesions. More specifically, the correlation between high-grade intraepithelial lesion (HSIL) on cytology and histological cervical intraepithelial neoplasia grade 2 or higher (CIN2+) was intended, by calculating the positive predictive value (PPV)...
April 4, 2019: Acta Cytologica
Mahira Jahic
Introduction: Cervical erosion and squamouse intraepithelial lesion of low grade are most common gynecological problems of women. These changes on cervix are cause of painful coitus and enhanced vaginal secretion. Cryotherapy is widely accepted method in treating these changes and sympthoms. Aim: The aim of this study is to examine the efficiency of cryotherapy in eliminating erosion of cervics and LSIL, as well as conditions following these states. Patients and methods: Cryotherapy was performed in 124 women with cervical erosion (N-74) and LSIL (N-50)...
December 2018: Materia Socio-medica
Akira Shimizu, Yuko Kuriyama, Michiko Hasegawa, Atsushi Tamura, Osamu Ishikawa
Human papillomavirus (HPV) causes cervical cancer, anal cancer, vulvar cancer, vaginal cancer, penile cancer and oropharyngeal cancer. SCC in the genital region in particular is recognized to be caused by HPV infection, and intraepithelial lesions of the penis and vulva are termed penile intraepithelial neoplasia (PIN) and vulvar intraepithelial neoplasia (VIN), respectively. Although SCC of the nail apparatus is recognized as being associated with high-risk HPVs, it is not well-known in general medicine, and its analysis has been insufficient...
March 28, 2019: Journal of the American Academy of Dermatology
Fengxiang Xie, Zaibo Li, Liran Zhang, Huina Zhang, Debo Qi, Dongman Zhao, Xin Zhang, Xinguo Wang, Chengquan Zhao
INTRODUCTION: There is no national cervical screening program or national standards for cervical cytology quality control in China. Since 2013, systematic training and quality control programs were implemented in the Papanicolaou testing process at Jinan KingMed Diagnostics. Pathologists were required to complete 1 year of cytology study in the KingMed Diagnostics Cytology School, including 6 months of a diagnostic course and 6 months of practical training in the clinical laboratory. In this study, we compared the Papanicolaou abnormal reporting rates before and after the implementation systematic training and quality control programs...
January 2019: Journal of the American Society of Cytopathology
Gloria Maimela, Xolisile Nene, Nontuthuko Mvundla, Shobna Sawry, Trudy Smith, Helen Rees, Elizabeth Kachingwe, Matthew Chersich
OBJECTIVE: To assess whether decentralising colposcopy services to a primary care facility in inner-city Johannesburg, South Africa raises access to colposcopy. DESIGN: Before-after study comparing 2 years before and 2 years after decentralisation, using clinical records and laboratory data on cervical cytology and histology. PRIMARY OUTCOME: The proportion of all women attending Hillbrow Community Health Centre (HCHC) with an abnormal Papanikolaou (Pap) smear who had a colposcopy post-decentralisation...
March 30, 2019: BMJ Open
Sigrid Regauer, Olaf Reich, Karl Kashofer
AIM: To further characterize the thin variant of high grade squamous intraepithelial lesion (HSIL) of the cervix defined by the WHO as full thickness HSIL <9 cell layers. METHODS: We examined 31 excisional cervical specimens featuring exclusively p16ink4a over-expressing thin HSIL with respect to size, location at squamo-columnar junction or endocervical mucosa, human papilloma virus (HPV) subtypes (pre-therapeutic clinical HVP-tests and HPV-genotyping on lesional tissue after excision) and somatic mutations in 50 cancer genes...
March 30, 2019: Histopathology
Elizabeth Faris Crowell, Cyril Bazin, François Saunier, Romain Brixtel, Yann Caillot, Boris Lesner, Matthieu Toutain, Carole Ferreri, Incarnation Garcia, Marie-Claire Mathieu, Jérôme Vaussanvin, Joëlle Depardon, Arnaud Renouf
BACKGROUND: Current automated cervical cytology screening systems still heavily depend on manipulation of glass slides. We developed a new system called CytoProcessorTM (DATEXIM, Caen, France), which increases sensitivity and takes advantage of virtual slide technology to simplify the workflow and save worker time. We used an approach based on artificial intelligence to identify abnormal cells among the tens of thousands in a cervical preparation. OBJECTIVES: We set out to compare the diagnostic sensitivity and specificity of CytoProcessorTM and the ThinPrep Imaging System (HOLOGIC, Marlborough, MA, USA)...
March 28, 2019: Acta Cytologica
Emmanuel Timmy Donkoh, Francis Agyemang-Yeboah, Richard Harry Asmah, Edwin K Wiredu
Ghana does not have a universal population-based cervical cancer screening program and there is very limited information about the distribution of cervical epithelial cell lesions. This study provides evidence that a moderately high prevalence of cervical cancer and precancerous lesions exists among unscreened women in Kumasi.The prevalence of cervical epithelial cell abnormalities among a cross-section of women attending cervical cancer screening for the first time in a suburb of Ghana from 2011 to 2014 was studied...
March 2019: Medicine (Baltimore)
Yue-Jie Li, Xin Qing, Qing-Xu Tao, Li Xiang, Li Gong, Tie-Jun Zhou
Background: Vasculogenic mimicry (VM), as an endothelium-independent cancer microcirculation, has been observed in many malignancies including cervical cancer. Erythropoietin (EPO) and erythropoietin receptor (EPO-R) could produce an angiogenic effect to promote cervical squamous cell carcinoma (CSCC) progression. However, the association between VM formation and EPO/EPO-R expression in CSCC is poorly explored. Methods: Seventy-six paraffin-embedded CSCC samples, 25 high-grade squamous intraepithelial lesion (HSIL) samples, 20 low-grade squamous intraepithelial lesion (LSIL) samples, and 20 normal cervix samples were collected...
2019: BioMed Research International
Anna-Barbara Moscicki, Lisa Flowers, Megan J Huchko, Margaret E Long, Kathy L MacLaughlin, Jeanne Murphy, Lisa Beth Spiryda, Michael A Gold
EXECUTIVE SUMMARY: The risk of cervical cancer (CC) among women immunosuppressed for a variety of reasons is well documented in the literature. Although there is improved organ function, quality of life and life expectancy gained through use of immunosuppressant therapy, there may be increased long-term risk of cervical neoplasia and cancer and the need for more intense screening, surveillance, and management. Although guidance for CC screening among HIV-infected women (see Table 1) has been supported by evidence from retrospective and prospective studies, recommendations for CC screening among non-HIV immunosuppressed women remains limited because quality evidence is lacking...
April 2019: Journal of Lower Genital Tract Disease
José Eleutério, Liana R Cavalcante, Ana K S Gonçalves, Renata M N Eleutério, Paulo C Giraldo
BACKGROUND: There is a high frequency of human papillomavirus (HPV)-induced lesions in cervix and anus of immunosuppressed patients. However, few studies have evaluated these lesions in kidney-transplanted women. METHODS: This cross-sectional study examined 31 kidney-transplanted women receiving immunosuppressive therapy at the General Hospital of Fortaleza in Brazil. Cervical and anal samples were collected and preserved in order to perform liquid-based cytology and a real-time polymerase chain reaction assay detecting high-risk HPV...
March 21, 2019: Diagnostic Cytopathology
Xiang Tao, Huina Zhang, Hao Zhang, Jianan Xiao, Juan Li, Xianrong Zhou, Li Wang, Chengquan Zhao
BACKGROUND: Cervical cancer remains a major health problem in China. To provide baseline data for establishing the appropriate screening strategy, the authors investigated the histopathologic follow-up and human papillomavirus (HPV) testing results of low-grade squamous intraepithelial lesion (LSIL) cytology in the Chinese Largest Women Hospital. METHODS: Women with LSIL cytology, human papillomavirus (HPV) testing, and immediate histopathologic follow-up between 2011 and 2016 were analyzed...
March 20, 2019: Cancer Cytopathology
Freija Verdoodt, Christian Dehlendorff, Susanne K Kjaer
BACKGROUND: A reduced, two-dose schedule of human papillomavirus (HPV) vaccination has been endorsed for preadolescent women on the basis of immunogenicity data from randomised trials, and limited data suggest even one dose may provide sufficient protection. Surveillance of the impact of fewer than three vaccine doses on clinical endpoints in the targeted age group is warranted. METHODS: We conducted a nationwide cohort study of all women between 17-25 years, living in Denmark between 2006 and 2016...
March 20, 2019: Clinical Infectious Diseases
Feng Qiu, Chunlei Yuan, Jianhua Xu, Junai Zhang, Fu Chen, Dongdong Liu, Biying Zheng, Ruixi Li, Xianzhang Huang, Junfa Xu
The immune checkpoint molecule B7-H4 is highly expressed in various types of cancer, but little is known about its role in the development of cervical lesions associated with human papilloma virus (HPV). This study aimed to investigate the role of B7-H4 in cervical lesion progression and the relationship between B7-H4 and HPV infection. This was a retrospective study of tissue samples from 30 patients with cervical cancer, 28 with cervical intraepithelial neoplasia (CIN), and 75 with cervical inflammatory lesions...
May 1, 2019: Journal of Biomedical Nanotechnology
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