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Adv36 treatment

V Hainer, H Zamrazilová, M Kunešová, B Bendlová, I Aldhoon-Hainerová
Associations between different infectious agents and obesity have been reported in humans for over thirty years. In many cases, as in nosocomial infections, this relationship reflects the greater susceptibility of obese individuals to infection due to impaired immunity. In such cases, the infection is not related to obesity as a causal factor but represents a complication of obesity. In contrast, several infections have been suggested as potential causal factors in human obesity. However, evidence of a causal linkage to human obesity has only been provided for adenovirus 36 (Adv36)...
2015: Physiological Research
H Zamrazilová, I Aldhoon-Hainerová, R L Atkinson, L Dušátková, B Sedláčková, Z P Lee, M Kunešová, M Hill, V Hainer
Human adenovirus 36 (Adv36) increases adiposity and is more prevalent in overweight and obese children. Dietary intake in animal models is comparable regardless of Adv36 status. The effects of Adv36 on obesity treatment outcomes have not been clarified. The aim of this study is to investigate the pre-treatment dietary intake and the response to a 4-week inpatient weight management in 184 obese adolescent girls aged 13.0-17.9 years with respect to the presence of Adv36 antibodies. Evaluation of 3-day dietary records did not show any difference in daily intake of energy and essential nutrients between Adv36 antibody positive and negative girls...
December 2015: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Francesca M Trovato, Daniela Catalano, Adriana Garozzo, G Fabio Martines, Clara Pirri, Guglielmo M Trovato
Obesity and liver steatosis are usually described as related diseases. Obesity is regarded as exclusive consequence of an imbalance between food intake and physical exercise, modulated by endocrine and genetic factors. Non-alcoholic fatty liver disease (NAFLD), is a condition whose natural history is related to, but not completely explained by over-nutrition, obesity and insulin resistance. There is evidence that environmental infections, and notably adipogenic adenoviruses (ADV) infections in humans, are associated not only with obesity, which is sufficiently established, but also with allied conditions, such as fatty liver...
October 28, 2014: World Journal of Gastroenterology: WJG
Malin Almgren, Richard Atkinson, Jia He, Agneta Hilding, Emilia Hagman, Alicja Wolk, Anders Thorell, Claude Marcus, Erik Näslund, Claes-Göran Östenson, Martin Schalling, Catharina Lavebratt
BACKGROUND: Experimental and natural human adenovirus-36 (Adv36) infection of multiple animal species results in obesity through increasing adipogenesis and lipid accumulation in adipocytes. Presence of Adv36 antibodies detected by serum neutralization assay has previously been associated with obesity in children and adults living in the USA, South Korea and Italy, whereas no association with adult obesity was detected in Belgium/The Netherlands nor among USA military personnel. Adv36 infection has also been shown to reduce blood lipid levels, increase glucose uptake by adipose tissue and skeletal muscle biopsies, and to associate with improved glycemic control in non-diabetic individuals...
2012: PloS One
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