keyword
https://read.qxmd.com/read/38305691/impaired-value-based-decision-making-in-parkinson-s-disease-apathy
#1
JOURNAL ARTICLE
William Gilmour, Graeme Mackenzie, Mathias Feile, Louise Tayler-Grint, Szabolcs Suveges, Jennifer A Macfarlane, Angus D Macleod, Vicky Marshall, Iris Q Grunwald, J Douglas Steele, Tom Gilbertson
Apathy is a common and disabling complication of Parkinson's disease characterised by reduced goal-directed behaviour. Several studies have reported dysfunction within prefrontal cortical regions and projections from brainstem nuclei whose neuromodulators include dopamine, serotonin and noradrenaline. Work in animal and human neuroscience have confirmed contributions of these neuromodulators on aspects of motivated decision making. Specifically, these neuromodulators have overlapping contributions to encoding the value of decisions, and influence whether to explore alternative courses of action, or persist in an existing strategy to achieve a rewarding goal...
February 2, 2024: Brain
https://read.qxmd.com/read/37787488/motivational-and-cognitive-predictors-of-apathy-after-subthalamic-nucleus-stimulation-in-parkinson-s-disease
#2
JOURNAL ARTICLE
Matthieu Béreau, Astrid Kibleur, Mathieu Servant, Gautier Clément, Kathy Dujardin, Anne-Sophie Rolland, Thomas Wirth, Ouhaid Lagha-Boukbiza, Jimmy Voirin, Marie des Neiges Santin, Elodie Hainque, David Grabli, Alexandre Comte, Sophie Drapier, Franck Durif, Ana Marques, Alexandre Eusebio, Jean-Philippe Azulay, Caroline Giordana, Jean-Luc Houeto, Béchir Jarraya, David Maltete, Olivier Rascol, Tiphaine Rouaud, Mélissa Tir, Caroline Moreau, Teodor Danaila, Stéphane Prange, Laurent Tatu, Christine Tranchant, Jean-Christophe Corvol, David Devos, Stephane Thobois, Maxime Desmarets, Mathieu Anheim
Postoperative apathy is a frequent symptom in Parkinson's disease patients who have undergone bilateral deep brain stimulation of the subthalamic nucleus. Two main hypotheses for postoperative apathy have been suggested: i) dopaminergic withdrawal syndrome relative to postoperative dopaminergic drug tapering and ii) direct effect of chronic stimulation of the subthalamic nucleus. The primary objective of our study was to describe preoperative and one-year postoperative apathy in Parkinson's disease patients who underwent chronic bilateral deep brain stimulation of the subthalamic nucleus...
October 3, 2023: Brain
https://read.qxmd.com/read/37287548/neuropsychiatric-effects-of-bilateral-subthalamic-nucleus-deep-brain-stimulation-in-parkinson-s-disease-results-at-the-12-month-follow-up
#3
JOURNAL ARTICLE
Nazan Şimşek Erdem, Gökçe Yağmur Güneş Gencer, Sehur Sibel Özkaynak, Tanju Uçar, Özge Doğanavşargil Baysal
INTRODUCTION: It is aimed to report the effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on motor symptoms, neuropsychiatric symptoms, and quality of life in Parkinson's Disease (PD) patients. METHODS: The results of 22 patients with PD, who had undergone bilateral STN-DBS, were analyzed. The Unified Parkinson's Disease Rating Scale (UPDRS) was applied to assess the patients' clinical characteristics before surgery and 6-, and 12-month follow-up after surgery...
2023: Noro Psikiyatri Arsivi
https://read.qxmd.com/read/36395542/delineating-apathy-profiles-in-huntington-s-disease-with-the-short-lille-apathy-rating-scale
#4
JOURNAL ARTICLE
Audrey E De Paepe, Clara Garcia-Gorro, Saül Martinez-Horta, Jesus Perez Perez, Jaime Kulisevsky, Nadia Rodriguez-Dechicha, Irene Vaquer, Susana Subira, Matilde Calopa, Pilar Santacruz, Esteban Muñoz, Celia Mareca, Jesus Ruiz-Idiago, Ruth de Diego-Balaguer, Estela Camara
INTRODUCTION: Apathy, a prevalent feature in neurological disorders including Huntington's disease (HD), is characterized by a reduction in goal-directed behavior across cognitive, auto-activation (i.e., self-activating thoughts/behavior), and emotional domains. Nonetheless, current diagnostic criteria are incapable of distinguishing multidimensional apathy profiles. Meanwhile, the short-Lille Apathy Rating Scale (LARS-s) bears potential as an operative diagnostic tool to disentangle apathy dimensions in clinical practice...
October 28, 2022: Parkinsonism & related Disorders
https://read.qxmd.com/read/36189712/on-the-association-between-apathy-and-deficits-of-social-cognition-and-executive-functions-in-huntington-s-disease
#5
JOURNAL ARTICLE
Rebecca K Hendel, Marie N N Hellem, Lena E Hjermind, Jørgen E Nielsen, Asmus Vogel
OBJECTIVE: To investigate if executive and social cognitive dysfunction was associated with apathy in a large cohort of Huntington's disease gene expansion carriers. METHOD: Eighty premanifest and motor-manifest Huntington's disease gene expansion carriers (Mini-Mental State Examination score ≥ 24 and Montreal Cognitive Assessment score ≥ 19) and thirty-two controls were examined with the Lille Apathy Rating Scale (LARS), a tailored and quantitative measure of apathy, and a comprehensive cognitive battery on executive functions and social cognition (emotion recognition, theory of mind and sarcasm detection), as well as general correlates like demographic variables, and neuropsychiatric and cognitive screening tests...
October 3, 2022: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/35074744/psychometric-properties-of-the-birt-motivation-questionnaire-bmq-a-self-measure-of-avolition-in-individuals-with-schizophrenia
#6
JOURNAL ARTICLE
Stéphane Raffard, Joanna Norton, Martial Van der Linden, Christophe Lançon, Michel Benoit, Delphine Capdevielle
AIMS: Avolition defined as a lack of interest or engagement in goal-directed behavior plays a key role in everyday functioning in schizophrenia and is considered as one of the main contributors to the burden of disease. The aim of this study was to 1) validate the self-report BIRT Motivation Questionnaire (BMQ-S) seldom used before in schizophrenia 2) examine the degree of agreement between the BMQ-S and its informant-report version 3) to assess its ability to predict real-world outcome at 12 month follow-up...
March 2022: Journal of Psychiatric Research
https://read.qxmd.com/read/34851867/intellectual-curiosity-and-action-initiation-are-subtypes-of-apathy-affected-in-huntington-disease-gene-expansion-carriers
#7
JOURNAL ARTICLE
Rebecca K Hendel, Marie N N Hellem, Lena E Hjermind, Jørgen E Nielsen, Asmus Vogel
BACKGROUND: Apathy is a prevalent behavioral syndrome of Huntington disease (HD) that can result in severe loss of function for the individual with HD and substantial caregiver distress. Research-based evidence of apathy is characterized by methodological differences, and there is a deficiency in the evidence concerning the subtypes of apathy. OBJECTIVE: To characterize apathy in premanifest and motor-manifest HD gene expansion carriers and controls using the Short Problem Behaviors Assessment for Huntington's Disease (PBA-s) and the Lille Apathy Rating Scale (LARS)...
December 2, 2021: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://read.qxmd.com/read/34298224/the-use-of-the-french-dimensional-apathy-scale-f-das-to-assess-apathy-in-schizophrenia-properties-and-profiles
#8
JOURNAL ARTICLE
Lise M' Barek, Guillaume Mercy, Caroline Gautier, Malika Noquet, Emilie Legros-Lafarge, Lucia Fiegl, Dominique Fiard, Philippe Allain
BACKGROUND: Apathy can be defined as a quantitative reduction of self-generated voluntary and purposeful (or goal-directed) behaviour. The literature underlines the triadic dimensional nature of apathy, but in schizophrenia there are inconsistencies due to difficulty in assessment. The Dimensional Apathy Scale (DAS) and its validation into French (f-DAS) provide measurement of three neurobehavioral apathy subtypes: Executive, Emotional and Initiation, but these subtypes have never been explored in schizophrenia...
November 1, 2021: Journal of Affective Disorders
https://read.qxmd.com/read/34125323/clinical-significance-of-self-descriptive-apathy-assessment-in-patients-with-neurological-form-of-wilson-s-disease
#9
JOURNAL ARTICLE
Marcin Leśniak, Magdalena Roessler-Górecka, Anna Członkowska, Joanna Seniów
BACKGROUND AND AIM: Apathy is one of the neuropsychiatric symptoms of Wilson's disease (WD) which typically affects the brain's fronto-basal circuits. Lack of agreed diagnostic criteria and common use of self-description assessment tools lead to underestimation of this clinical phenomenon. The aim of this study was to investigate whether subjective and informant-based clinical features of apathy in patients with WD enable clinicians to make a valid diagnosis. METHODS: Multiple aspects of goal-oriented behavior were assessed in 30 patients with the neurological form of WD and 30 age-matched healthy participants using two questionnaires, the Lille Apathy Rating Scale (LARS) and the Dysexecutive Questionnaire (DEX)...
June 14, 2021: Neurological Sciences
https://read.qxmd.com/read/34072624/apathy-and-anhedonia-clinical-and-neurophysiological-assessment-of-a-romanian-cohort
#10
JOURNAL ARTICLE
Diana Sipos-Lascu, Ștefan-Cristian Vesa, Lăcrămioara Perju-Dumbravă
BACKGROUND: Patients with Parkinson's disease (PD) often have, besides the characteristic motor manifestations, a wide variety of non-motor symptoms. These include apathy and anhedonia, common issues in PD, which can be quantified with the help of evaluation scales recommended by the literature. There are sensory non-motor manifestations of PD, some of which are easy to detect through electrophysiological studies. Our aim was to investigate the possible association of apathy and anhedonia with the severity of the motor status in a sample of PD patients in Romania...
May 31, 2021: Brain Sciences
https://read.qxmd.com/read/33975314/apathy-measures-in-older-adults-and-people-with-dementia-a-systematic-review-of-measurement-properties-using-the-cosmin-methodology
#11
Clare Burgon, Sarah Elizabeth Goldberg, Veronika van der Wardt, Catherine Brewin, Rowan H Harwood
BACKGROUND: Apathy is highly prevalent in dementia and is also seen in mild cognitive impairment and the general population. Apathy contributes to failure to undertake daily activities and can lead to health problems or crises. It is therefore important to assess apathy. However, there is currently no gold standard measure of apathy. A comprehensive systematic review of the measurement properties of apathy scales is required. METHODS: A systematic review was registered with PROSPERO (ID: CRD42018094390)...
2021: Dementia and Geriatric Cognitive Disorders
https://read.qxmd.com/read/33331023/apathy-induced-by-subthalamic-nucleus-deep-brain-stimulation-in-parkinson-s-disease-a-meta-analysis
#12
REVIEW
Thomas J C Zoon, Geeske van Rooijen, Georgina M F C Balm, Isidoor O Bergfeld, Joost G Daams, Paul Krack, Damiaan A J P Denys, Rob M A de Bie
Apathy, the loss of motivation, is a common problem in Parkinson's disease (PD) and often observed following deep brain stimulation (DBS) of the subthalamic nucleus (STN). The aim of this meta-analysis was to determine the occurrence of apathy following STN DBS in literature. Relevant articles were searched in PubMed/Medline, SCOPUS, EMBASE, and Web of Sciences electronic databases. Studies were included if they reported apathy scores pre- and post-DBS or the cross-sectional difference between PD patients receiving STN DBS and patients receiving medication only...
February 2021: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/33268471/late-onset-depression-dopaminergic-deficit-and-clinical-features-of-prodromal-parkinson-s-disease-a-cross-sectional-study
#13
JOURNAL ARTICLE
Hiba Kazmi, Zuzana Walker, Jan Booij, Faraan Khan, Sachit Shah, Carole H Sudre, Joshua E J Buckman, Anette-Eleonore Schrag
BACKGROUND: Late onset depression (LOD) may precede the diagnosis of Parkinson's disease (PD) or dementia with Lewy bodies (DLB). We aimed to determine the rate of clinical and imaging features associated with prodromal PD/DLB in patients with LOD. METHODS: In a cross-sectional design, 36 patients with first onset of a depressive disorder (Diagnostic and Statistical Manual of Mental Disorders IV criteria) diagnosed after the age of 55 (LOD group) and 30 healthy controls (HC) underwent a detailed clinical assessment...
February 2021: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/32977165/dimensions-of-leadership-in-undergraduate-nursing-students-validation-of-a-tool
#14
JOURNAL ARTICLE
Pilar Fuster Linares, Encarna Rodriguez Higueras, M Luisa Martin-Ferreres, María Ángeles Cerezuela Torre, Laia Wennberg Capellades, Alberto Gallart Fernández-Puebla
BACKGROUND: Nurses require leadership skills in order to fulfil their clinical role in an ever-changing healthcare environment. The acquisition of such skills should therefore begin during their professional training. OBJECTIVES: To identify the dimensions of leadership present among nursing undergraduates in the original Self-Assessment Leadership Instrument (SALI). DESIGN: This was a validation study involving the translation and cultural adaptation of the Self-Assessment Leadership Instrument (SALI) for use with nursing undergraduates in the Spanish context...
September 3, 2020: Nurse Education Today
https://read.qxmd.com/read/32431630/cortical-thickness-in-alcohol-dependent-patients-with-apathy
#15
JOURNAL ARTICLE
Kebing Yang, Qingyan Yang, Yajuan Niu, Fengmei Fan, Song Chen, Xingguang Luo, Shuping Tan, Zhiren Wang, Jinghui Tong, Fude Yang, Thang M Le, Chiang-Shan R Li, Yunlong Tan
OBJECTIVES: Many studies reported structural brain changes in patients with alcohol dependence (PADs). However, no studies identified structural correlates of apathy that might aggravate alcohol misuse. Here, we explored regional differences in cortical thickness in PADs relative to healthy controls (HCs), and examined the potential correlation of regional thickness with the severity of apathy. METHODS: Magnetic resonance imaging data were collected from 33 male PADs and 35 male age- and education-matched HCs...
2020: Frontiers in Psychiatry
https://read.qxmd.com/read/31951481/impaired-option-generation-underpins-deficient-reasoning-in-parkinson-s-disease-patients-with-apathy
#16
JOURNAL ARTICLE
Joseph A Mole, Laurie Josephs, Simon J Prangnell
Apathy is a debilitating neurological syndrome known to be associated with executive dysfunction, particularly affecting abstract reasoning. However, the underlying cognitive mechanism remains unclear. Recently, it has been proposed that one cognitive process disrupted in apathy is option generation. We investigated whether impaired option generation could explain deficient reasoning in apathy. Data was retrospectively analyzed from patients with Parkinson's disease ( n  = 51) who had completed the Lille Apathy Rating Scale and the Brixton Spatial Anticipation Task (Brixton), a measure of inductive reasoning...
January 2022: Applied Neuropsychology. Adult
https://read.qxmd.com/read/31672088/decision-making-of-patients-with-major-depressive-disorder-in-the-framework-of-action-control
#17
JOURNAL ARTICLE
Romina Rinaldi, Laurent Lefebvre, Audrey Joachim, Mandy Rossignol
Introduction: Patients with major depressive disorder (MDD) experience dysfunctional emotional states and cognitive impairments, leading to behavioural, social, and functional issues. Neurocognitive theory proposes that the initiation and maintenance of MDD is primarily the result of a deficit of action control which in turn would lead to decision-making impairments. Methods: We assessed 27 medicated outpatients with MDD who were demographically matched with 16 healthy participants on decision-making (DM) processes (Iowa Gambling Task (IGT) and Reversal Learning Task (RLT)), clinical variables (depressive symptoms and self-efficacy), and volition (Lille Apathy Rating Scale)...
October 31, 2019: Cognitive Neuropsychiatry
https://read.qxmd.com/read/31424418/detecting-apathy-in-individuals-with-parkinson-s-disease-a-systematic-review
#18
JOURNAL ARTICLE
Bria Mele, Daria Merrikh, Zahinoor Ismail, Zahra Goodarzi
BACKGROUND: Individuals experiencing apathy in Parkinson's disease (PD) have a lack of emotion and motivation. Apathy often overlaps with comorbidities such as depression, and is sometimes difficult to detect. OBJECTIVE: To examine diagnostic accuracy of apathy-screening tools compared with a gold standard (clinician diagnosis) among adult outpatients with PD. METHODS: A systematic review was conducted. Six research databases were searched to May 23, 2018...
2019: Journal of Parkinson's Disease
https://read.qxmd.com/read/31401404/white-matter-cortico-striatal-tracts-predict-apathy-subtypes-in-huntington-s-disease
#19
JOURNAL ARTICLE
Audrey E De Paepe, Joanna Sierpowska, Clara Garcia-Gorro, Saül Martinez-Horta, Jesus Perez-Perez, Jaime Kulisevsky, Nadia Rodriguez-Dechicha, Irene Vaquer, Susana Subira, Matilde Calopa, Esteban Muñoz, Pilar Santacruz, Jesus Ruiz-Idiago, Celia Mareca, Ruth de Diego-Balaguer, Estela Camara
BACKGROUND: Apathy is the neuropsychiatric syndrome that correlates most highly with Huntington's disease progression, and, like early patterns of neurodegeneration, is associated with lesions to cortico-striatal connections. However, due to its multidimensional nature and elusive etiology, treatment options are limited. OBJECTIVES: To disentangle underlying white matter microstructural correlates across the apathy spectrum in Huntington's disease. METHODS: Forty-six Huntington's disease individuals (premanifest (N = 22) and manifest (N = 24)) and 35 healthy controls were scanned at 3-tesla and underwent apathy evaluation using the short-Problem Behavior Assessment and short-Lille Apathy Rating Scale, with the latter being characterized into three apathy domains, namely emotional, cognitive, and auto-activation deficit...
July 30, 2019: NeuroImage: Clinical
https://read.qxmd.com/read/31266408/apathy-in-obsessive-compulsive-disorder-and-its-psychological-correlates-comparison-with-individuals-with-schizophrenia
#20
COMPARATIVE STUDY
Stéphane Raffard, Delphine Capdevielle, Jérôme Attal, Caroline Novara, Catherine Bortolon
OBJECTIVE: Apathy, defined as reduced goal-directed behavior, is a frequent symptom in mental and neurological disorders but has been poorly studied in individuals with obsessive-compulsive disorder (OCD). The primary aim of this study was to examine levels of apathy between individuals with OCD, healthy control subjects, and individuals with schizophrenia, a mental disorder with high levels of apathy. The second aim was to assess whether the psychological factors that have been previously shown as underlying apathy in other mental disorders were associated with apathy in patients with OCD...
2020: Journal of Neuropsychiatry and Clinical Neurosciences
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