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lille apathy rating scale

Genoveva Montoya-Murillo, Naroa Ibarretxe-Bilbao, Javier Peña, Natalia Ojeda
OBJECTIVES: To examine the impact of apathy on cognitive performance in the elderly following the conceptual principles proposed by Marin1 and Stuss et al2 and to determine the role of the symptoms of apathy in different cognitive domains. METHODS: Cross-sectional study with a cohort of healthy elderly subjects over 55 years (n = 140). One hundred forty healthy elderly subjects (aged 79.24 ± 8.6 years) were recruited from twelve day centers in northern Spain. Participants underwent a neuropsychological battery which evaluated MMSE, attention, processing speed, verbal fluency, visual and verbal memory, working memory and executive functioning...
January 22, 2019: International Journal of Geriatric Psychiatry
Thomas R Barber, Ludovica Griffanti, Kinan Muhammed, Daniel S Drew, Kevin M Bradley, Daniel R McGowan, Marie Crabbe, Christine Lo, Clare E Mackay, Masud Husain, Michele T Hu, Johannes C Klein
Apathy is a common and under-recognized disorder that often emerges in the prodromal phase of Parkinsonian diseases. The mechanism by which this occurs is not known, but recent evidence from patients with established Parkinson's disease suggests that serotonergic dysfunction may play a role. The integrity of the raphe serotonergic system can be assessed alongside dopaminergic basal ganglia imaging using the radioligand 123I-ioflupane, which binds both serotonin and dopamine transporters. To investigate the relative roles of these neurotransmitters in prodromal parkinsonism, we imaged patients with idiopathic rapid eye movement sleep behaviour disorder, the majority of whom will develop a parkinsonian disorder in future...
October 1, 2018: Brain: a Journal of Neurology
Dana Mohammad, Courtney Ellis, Allison Rau, Myuri Ruthirakuhan, Krista L Lanctôt, Nathan Herrmann
Apathy is among the most prevalent neuropsychiatric symptom experienced in Parkinson's disease (PD) and can be assessed with a variety of scales. To identify which scale is most suitable for apathy assessment in PD, the psychometric properties of each scale and its sensitivity to change were analyzed. The methodological quality of the studies ranged from adequate to excellent. The Lille Apathy Rating Scale demonstrated consistently favorable psychometric properties and was used in two of four clinical trials found...
August 2018: Neurodegenerative Disease Management
Olaia Lucas-Jiménez, Natalia Ojeda, Javier Peña, Alberto Cabrera-Zubizarreta, María Díez-Cirarda, Juan Carlos Gómez-Esteban, María Ángeles Gómez-Beldarrain, Naroa Ibarretxe-Bilbao
Objective: Apathy is a common nonmotor symptom in Parkinson's disease (PD) affecting 40% of patients. The aim of the study was to investigate brain changes and correlates of frontal, striatal, and limbic pathways related to subclinical symptoms of apathy in PD patients. Methods: Thirty-two PD patients divided into low-subclinical symptoms of apathy (LSA) ( n = 18) and high-subclinical symptoms of apathy (HSA) ( n = 14) and 25 healthy controls (HC) underwent a T1-weighted, diffusion-weighted, and resting-state functional MRI...
July 2018: Annals of Clinical and Translational Neurology
Stéphane Raffard, Catherine Bortolon, Hanan Yazbek, Christophe Lançon, Michel Benoit, Joanna Norton, Delphine Capdevielle
Apathy is a frequent and debilitating condition with few treatment options available in schizophrenia patients. Despite evidence of its multidimensional structure, most of past studies have explored apathy through a categorical approach. The main objective of this study was to identify the cognitive, emotional, motivational, and clinical factors at baseline that best predicted the three subtypes of apathy dimensions at follow-up. In a longitudinal study, 137 participants diagnosed with schizophrenia underwent different assessments including clinical, motivational, affective and cognitive measurements, at 1-month (referred to as baseline) and 12-month follow-ups...
June 8, 2018: European Archives of Psychiatry and Clinical Neuroscience
Campbell Le Heron, Olivia Plant, Sanjay Manohar, Yuen-Siang Ang, Matthew Jackson, Graham Lennox, Michele T Hu, Masud Husain
Effort-based decision-making is a cognitive process crucial to normal motivated behaviour. Apathy is a common and disabling complication of Parkinson's disease, but its aetiology remains unclear. Intriguingly, the neural substrates associated with apathy also subserve effort-based decision-making in animal models and humans. Furthermore, the dopaminergic system plays a core role in motivating effortful behaviour for reward, and its dysfunction has been proposed to play a crucial role in the aetiology of apathy in Parkinson's disease...
May 1, 2018: Brain: a Journal of Neurology
T R Barber, K Muhammed, D Drew, M Lawton, M Crabbe, M Rolinski, T Quinnell, Z Zaiwalla, Y Ben-Shlomo, M Husain, M T M Hu
BACKGROUND AND PURPOSE: Apathy is an important neuropsychiatric feature of Parkinson's disease (PD), which often emerges before the onset of motor symptoms. Patients with rapid eye movement sleep behaviour disorder (RBD) have a high probability of developing PD in future. Neuropsychiatric problems are common in RBD, but apathy has not previously been detailed in this key prodromal population. METHODS: Eighty-eight patients with polysomnographically proven RBD, 65 patients with PD and 33 controls were assessed for apathy using the Lille Apathy Rating Scale...
March 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Hui Liu, Ruwei Ou, Qianqian Wei, Yanbing Hou, Lingyu Zhang, Bei Cao, Bi Zhao, Wei Song, Huifang Shang
OBJECTIVE: The aim of this study is to explore the prevalence and clinical correlates of apathy in early-stage Parkinson's disease (PD) from a cohort of Chinese patients. METHODS: A cross-sectional analysis of 133 treatment-naive PD patients was conducted. Each subject was categorized as PD with or without apathy using the Lille Apathy Rating Scale (LARS). RESULTS: Of 133 patients, 30 PD patients (22.56%) reported apathy, of whom 23 (17.29%) did not have concomitant depression...
November 2017: Parkinsonism & related Disorders
U Hidding, A Gulberti, A Horn, C Buhmann, W Hamel, J A Koeppen, M Westphal, A K Engel, C Gerloff, D Weiss, C K E Moll, M Pötter-Nerger
The goal of the study was to compare the tolerability and the effects of conventional subthalamic nucleus (STN) and combined subthalamic nucleus and substantia nigra (STN+SNr) high-frequency stimulation in regard to neuropsychiatric symptoms in Parkinson's disease patients. In this single center, randomized, double-blind, cross-over clinical trial, twelve patients with advanced Parkinson's disease (1 female; age: 61.3 ± 7.3 years; disease duration: 12.3 ± 5.4 years; Hoehn and Yahr stage: 2.2 ± 0.39) were included...
2017: Parkinson's Disease
Marta Fernández-Matarrubia, Jordi A Matías-Guiu, María Nieves Cabrera-Martín, Teresa Moreno-Ramos, María Valles-Salgado, José Luis Carreras, Jorge Matías-Guiu
OBJECTIVES: Apathy is one of the most common and disabling syndromes of dementia. Clinical apathy expression and neuroanatomical basis of apathy seem to differ between behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD), although evidence is scarce and poorly understood. Our main purposes were to compare the clinical apathy profile from patients with bvFTD and AD and analyze the relationship between apathy and brain metabolism measured using positron emission tomography imaging with 18 F fluorodeoxyglucose (FDG-PET)...
January 2018: International Journal of Geriatric Psychiatry
Audrey Maillet, Paul Krack, Eugénie Lhommée, Elise Météreau, Hélène Klinger, Emilie Favre, Didier Le Bars, Emmanuelle Schmitt, Amélie Bichon, Pierre Pelissier, Valérie Fraix, Anna Castrioto, Véronique Sgambato-Faure, Emmanuel Broussolle, Léon Tremblay, Stéphane Thobois
SEE SCHRAG AND POLITIS DOI101093/AWW190 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Apathy, which can occur separately or in combination with depression and anxiety, is one of the most frequently encountered neuropsychiatric symptoms in Parkinson's disease. Pathophysiological evidence suggests that parkinsonian apathy is primarily due to a mesolimbic dopaminergic denervation, but the role of the serotonergic alteration has never been examined, despite its well-known involvement in the pathogenesis of depression and anxiety...
September 2016: Brain: a Journal of Neurology
Márton Kovács, Attila Makkos, Zsuzsanna Aschermann, József Janszky, Sámuel Komoly, Rita Weintraut, Kázmér Karádi, Norbert Kovács
Background. Female Parkinson's disease (PD) patients seem to experience not only more severe motor complications and postural instability but also more pronounced depression, anxiety, pain, and sleep disturbances. Objective. The aim of the present study was to evaluate the role of sex as a possible independent predictor of HRQoL in PD. Methods. In this cross-sectional study, 621 consecutive patients treated at the University of Pécs were enrolled. Severity of PD symptoms was assessed by MDS-UPDRS, UDysRS, Non-Motor Symptoms Scale, PDSS-2, Hamilton Anxiety Scale, Montgomery-Asberg Depression Rating Scale, Lille Apathy Rating Scale, and Addenbrooke Cognitive Examination...
2016: Parkinson's Disease
Isabel Hindle Fisher, Hardev S Pall, Rosalind D Mitchell, Jamilla Kausar, Andrea E Cavanna
OBJECTIVE: Apathy has been reported as a possible adverse effect of deep brain stimulation of the subthalamic nucleus (STN-DBS). We investigated the prevalence and severity of apathy in 22 patients with Parkinson's disease (PD) who underwent STN-DBS, as well as the effects of apathy on quality of life (QOL). METHODS: All patients were assessed with the Lille Apathy Rating Scale (LARS), the Apathy Scale (AS), and the Parkinson's Disease Questionnaire and were compared to a control group of 38 patients on pharmacotherapy alone...
June 2016: CNS Spectrums
Rita Weintraut, Kázmér Karádi, Tivadar Lucza, Márton Kovács, Attila Makkos, József Janszky, Norbert Kovács
BACKGROUND: Apathy is a syndrome characterized primarily by lack of motivation which may be associated with cognitive, affective and behavioral changes. Although the Lille Apathy Scale (LARS) has been extensively utilized in PD for detecting apathy and testing the effectiveness of specific therapeutic interventions, the highly variable cut-off values (between -11 and -22 points) ensures the applicability of the LARS degree of difficulty as a superb screening tool. OBJECTIVE: The aim of this study is to determine more reliable threshold values based on the neuropsychiatric status of patients...
2016: Journal of Parkinson's Disease
Stéphane Raffard, Laure-Anne Gutierrez, Hanan Yazbek, Aurore Larue, Jean-Philippe Boulenger, Christophe Lançon, Michel Benoit, Catherine Faget, Joanna Norton, Delphine Capdevielle
Apathy, described as impaired motivation and goal-directed behavior, is a common yet often overlooked multidimensional psychopathological state in schizophrenia. Its underlying cognitive processes remain largely unexplored. Data was drawn from a longitudinal hospital study of patients with a DSM-IV diagnosis of schizophrenia; 137 (82.5%) participated at the 1-month follow-up and 81 (59.1%) at the 1-year follow-up. Apathy was assessed with the Lille Apathy Rating Scale, validated in French and in schizophrenia...
May 2016: Schizophrenia Bulletin
Marta Fernández-Matarrubia, Jordi A Matías-Guiu, Teresa Moreno-Ramos, María Valles-Salgado, Alberto Marcos-Dolado, Rocío García-Ramos, Jorge Matías-Guiu
OBJECTIVE: Apathy is one of the most common and disabling syndromes of dementia and presents at all stages of the disease. Comprehensive and structured methods to assess apathy in dementia are still needed. Lille's Apathy Rating Scale (LARS) has shown good psychometric properties for apathy evaluation in Parkinson disease but has not been validated in dementia. The aim of this study was to validate the LARS in a cohort of patients with very mild to moderate dementia. METHODS: 101 patients with cognitive impairment (Clinical Dementia Rating ≤ 2) and 50 healthy subjects were recruited...
July 2016: American Journal of Geriatric Psychiatry
Pablo Martinez-Martin, Albert F G Leentjens, Jesus de Pedro-Cuesta, Kallol Ray Chaudhuri, Anette E Schrag, Daniel Weintraub
Parkinson's disease includes neuropsychiatric manifestations, such as depression, anxiety, apathy, psychosis, and impulse control disorders, which often are unreported by patients and caregivers or undetected by doctors. Given their substantial impact on patients and caregivers as well as the existence of effective therapies for some of these disorders, screening for neuropsychiatric symptoms is important. Instruments for screening have a particular methodology for validation, and their performance is expressed in terms of accuracy compared with formal diagnostic criteria...
March 2016: Movement Disorders: Official Journal of the Movement Disorder Society
Kinan Muhammed, Sanjay Manohar, Masud Husain
BACKGROUND: Apathy is a common syndrome observed in many neurological conditions, including in up to 70% of patients with Parkinson's disease. Mechanisms underlying apathy are poorly understood and clinically we lack robust, objective detection methods. We aimed to address this using novel objective measures of motivation and reward sensitivity in relation to apathy in patients with Parkinson's disease. METHODS: Saccadic velocity and pupil modulation by reward were used as objective metrics of motivation in patients with Parkinson's disease...
February 26, 2015: Lancet
Trevor T-J Chong, Valerie Bonnelle, Sanjay Manohar, Kai-Riin Veromann, Kinan Muhammed, George K Tofaris, Michele Hu, Masud Husain
Parkinson's disease (PD) is traditionally conceptualised as a disorder of movement, but recent data suggest that motivational deficits may be more pervasive than previously thought. Here, we ask whether subclinical deficits in incentivised decision-making are present in PD and, if so, whether dopaminergic therapy ameliorates such deficits. We devised a novel paradigm in which participants decided whether they were willing to squeeze a hand-held dynamometer at varying levels of force for different magnitudes of reward...
August 2015: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Isabelle Rieu, Pablo Martinez-Martin, Bruno Pereira, Ingrid De Chazeron, Leo Verhagen Metman, Marjan Jahanshahi, Claire Ardouin, Isabelle Chéreau, Christine Brefel-Courbon, Fabienne Ory-Magne, Helene Klinger, Fleur Peyrol, Michael Schupbach, Kathy Dujardin, François Tison, Jean Luc Houeto, Paul Krack, Franck Durif
The "Ardouin Scale of Behavior in Parkinson's Disease" is a new instrument specifically designed for assessing mood and behavior with a view to quantifying changes related to Parkinson's disease, to dopaminergic medication, and to non-motor fluctuations. This study was aimed at analyzing the psychometric attributes of this scale in patients with Parkinson's disease without dementia. In addition to this scale, the following measures were applied: the Unified Parkinson's Disease Rating Scale, the Montgomery and Asberg Depression Rating Scale, the Lille Apathy Rating Scale, the Bech and Rafaelsen Mania Scale, the Positive and Negative Syndrome Scale, the MacElroy Criteria, the Patrick Carnes criteria, the Hospital Anxiety and Depression Scale, and the Mini-International Neuropsychiatric Interview...
April 15, 2015: Movement Disorders: Official Journal of the Movement Disorder Society
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