Aline Raulino Dutra, Daiana Cristina Salm, Rafaela Hardt da Silva, Fernanda Tanaka, Daniela Dero Lutdke, Bruna Hoffmann de Oliveira, Rose Lampert, Edsel B Bittencourt, Gianluca Bianco, Vinícius M Gadotti, William R Reed, Josiel Mileno Mack, Franciane Bobinski, Ari O O Moré, Daniel Fernandes Martins
OBJECTIVE: This study evaluated the antihyperalgesic and anti-inflammatory effects of percutaneous vagus nerve electrical stimulation (pVNS) associated with physical exercise, i.e., swimming, in mice with peripheral inflammation. METHODS: The pain model was induced by intraplantar (i.pl.) injection of Freund's complete adjuvant (CFA). Sixty-four male Swiss mice (35-40 g) received an i.pl. of CFA and underwent behavioral tests, i.e., mechanical hyperalgesia, edema, and paw temperature tests...
2023: Frontiers in Integrative Neuroscience