Ana Paula Rennó Sierra, Giscard Humberto Oliveira Lima, Elton Dias da Silva, Jaqueline Fernanda de Souza Maciel, Marino Pereira Benetti, Rodrigo Assunção de Oliveira, Patrícia Fátima de Oliveira Martins, Maria Augusta Pedanti Kiss, Nabil Ghorayeb, Philip Newsholme, João Bosco Pesquero, Maria Fernanda Cury-Boaventura
Muscle damage is one of the most important factors that affect muscle fatigue during endurance exercise. Recent evidence suggests that the renin-angiotensin system impacts on skeletal muscle wasting. The aim of this study was to determine association between the AGT Met235Thr, ACE I/D and BDKRB2 -9/+9 polymorphisms with inflammation, myocardial and muscle injury induced by endurance exercise. Eighty-one Brazilian male runners participated in this study and completed the International Marathon of Sao Paulo. Muscle and myocardial damage markers (alanine transaminase, ALT, aspartate transaminase, AST, lactic dehydrogenase, LDH, creatine kinase, CK, Troponin, pro BNP, myoglobin, and CK-MB) and inflammatory mediators (IL-6, IL-8, IL-10, IL12p70, IL1β, and TNF-α) were determined one day before, immediately after, one day after, and three days after the event...
2019: Frontiers in Genetics