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hematological and neurological expressed 1

Lei Li, Yin-Li Zheng, Chen Jiang, Shuo Fang, Ting-Ting Zeng, Ying-Hui Zhu, Yan Li, Dan Xie, Xin-Yuan Guan
Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies and lacks targeted therapies. Here, we reported a novel potential therapeutic target hematological and neurological expressed 1 like (HN1L) in HCC. First, HCC tissue microarray analysis showed that HN1L was frequently up-regulated in cancer tissues than that in normal liver tissues, which significantly associated with tumor size, local invasion, distant metastases, and poor prognosis for HCC patients. Functional studies demonstrated that ectopic expression of HN1L could increase cell growth, foci formation in monolayer culture, colony formation in soft agar and tumorigenesis in nude mice...
February 18, 2019: Cell Death and Differentiation
Yi Liu, Dong Soon Choi, Jianting Sheng, Joe E Ensor, Diana Hwang Liang, Cristian Rodriguez-Aguayo, Amanda Polley, Steve Benz, Olivier Elemento, Akanksha Verma, Yang Cong, Helen Wong, Wei Qian, Zheng Li, Sergio Granados-Principal, Gabriel Lopez-Berestein, Melissa D Landis, Roberto R Rosato, Bhuvanesh Dave, Stephen Wong, Dario Marchetti, Anil K Sood, Jenny C Chang
Here, we show that HEMATOLOGICAL AND NEUROLOGICAL EXPRESSED 1-LIKE (HN1L) is a targetable breast cancer stem cell (BCSC) gene that is altered in 25% of whole breast cancer and significantly correlated with shorter overall or relapse-free survival in triple-negative breast cancer (TNBC) patients. HN1L silencing reduced the population of BCSCs, inhibited tumor initiation, resensitized chemoresistant tumors to docetaxel, and hindered cancer progression in multiple TNBC cell line-derived xenografts. Additionally, gene signatures associated with HN1L correlated with shorter disease-free survival of TNBC patients...
January 9, 2018: Stem Cell Reports
Galit Gincberg, Esther Shohami, Philip Lazarovici, Uriel Elchalal
Human umbilical cord blood (HUCB) transplantation has become an alternative cell therapy for hematological and oncological malignancies in the clinic and is considered for neurological disorders. The heterogeneity in the content of the different stem and progenitor cells composing HUCB mononuclear cells (MNC) may influence their engraftment and neurotherapeutic effect. We hypothesized that CD45 pan-hematopoietic marker expression is heterogeneous in MNC, and therefore, CD45+ subpopulation enrichment for neurotherapy may provide a tool to overcome cellular variance in different HUCB units...
February 2018: Journal of Molecular Neuroscience: MN
Chen Zhang, Bingfei Xu, Shi Lu, Ying Zhao, Pian Liu
BACKGROUND: Hematological and neurological expressed 1 (HN1) is upregulated in many tumors, but the role of HN1 in breast cancer progression and its regulatory mechanism have not been well understood. METHODS: To study the role of HN1 in the initiation and progression of breast cancer, we examined HN1 levels in breast cancer cells and tissues and analyzed the relationship between HN1 levels and patient survival. We used mammosphere formation assay, side population analysis, wound healing assay, transwell assay, soft agar formation assay, and xenografted tumor model to determine the effect of HN1 on the expansion of breast cancer stem cells, and the migration, invasion and tumorigenesis of breast cancer...
May 11, 2017: Molecular Cancer
Monika Burns, Aldo Amaya, Caroline Bodi, Zhongming Ge, Vasudevan Bakthavatchalu, Kathleen Ennis, Timothy C Wang, Michael Georgieff, James G Fox
Helicobacter pylori (H.pylori), a bacterial pathogen, is a causative agent of gastritis and peptic ulcer disease and is a strong risk factor for development of gastric cancer. Environmental conditions, such as poor dietary iron resulting in iron deficiency anemia (IDA), enhance H.pylori virulence and increases risk for gastric cancer. IDA affects billions of people worldwide, and there is considerable overlap between regions of high IDA and high H.pylori prevalence. The primary aims of our study were to evaluate the effect of H...
2017: PloS One
Thomas J Conlon, Cathryn S Mah, Christina A Pacak, Mary B Rucker Henninger, Kirsten E Erger, Marda L Jorgensen, C Chang I Lee, Alice F Tarantal, Barry J Byrne
Neuromuscular disorders such as Pompe disease (glycogen storage disease, type II), result in early and potentially irreversible cellular damage with a very limited opportunity for intervention in the newborn period. Pompe disease is due to deficiency in acid α-glucosidase (GAA) leading to lysosomal accumulation of glycogen in all cell types, abnormal myofibrillogenesis, respiratory insufficiency, neurological deficits, and reduced contractile function in striated muscle. Previous studies have shown that fetal delivery of recombinant adeno-associated virus (rAAV) encoding GAA to the peritoneal cavity of Gaa-/- mice resulted in high-level transduction of the diaphragm...
December 2016: Human Gene Therapy. Clinical Development
Mihaela Pupavac, David Watkins, Francis Petrella, Somayyeh Fahiminiya, Alexandre Janer, Warren Cheung, Anne-Claude Gingras, Tomi Pastinen, Joseph Muenzer, Jacek Majewski, Eric A Shoubridge, David S Rosenblatt
Vitamin B12 (cobalamin, Cbl) cofactors adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl) are required for the activity of the enzymes methylmalonyl-CoA mutase (MCM) and methionine synthase (MS). Inborn errors of Cbl metabolism are rare Mendelian disorders associated with hematological and neurological manifestations, and elevations of methylmalonic acid and/or homocysteine in the blood and urine. We describe a patient whose fibroblasts had decreased functional activity of MCM and MS and decreased synthesis of AdoCbl and MeCbl (3...
September 2016: Human Mutation
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
Alister P W Funnell, Paolo Prontera, Valentina Ottaviani, Maria Piccione, Antonino Giambona, Aurelio Maggio, Fiorella Ciaffoni, Sandra Stehling-Sun, Manuela Marra, Francesca Masiello, Lilian Varricchio, John A Stamatoyannopoulos, Anna R Migliaccio, Thalia Papayannopoulou
Elevated fetal hemoglobin (HbF) ameliorates the clinical severity of hemoglobinopathies such as β-thalassemia and sickle cell anemia. Currently, the only curative approach for individuals under chronic transfusion/chelation support therapy is allogeneic stem cell transplantation. However, recent analyses of heritable variations in HbF levels have provided a new therapeutic target for HbF reactivation: the transcriptional repressor BCL11A. Erythroid-specific BCL11A abrogation is now actively being sought as a therapeutic avenue, but the specific impact of such disruption in humans remains to be determined...
July 2, 2015: Blood
Leandro Maia, Fernanda da Cruz Landim-Alvarenga, Marilda Onghero Taffarel, Carolina Nogueira de Moraes, Gisele Fabrino Machado, Guilherme Dias Melo, Rogério Martins Amorim
BACKGROUND: Recent studies have demonstrated numerous biological properties of mesenchymal stem cells and their potential application in treating complex diseases or injuries to tissues that have difficulty regenerating, such as those affecting the central and peripheral nervous system. Thus, therapies that use mesenchymal stem cells are promising because of their high capacity for self-regeneration, their low immunogenicity, and their paracrine, anti-inflammatory, immunomodulatory, anti-apoptotic and neuroprotective effects...
2015: BMC Veterinary Research
Leandro Maia, Fernanda da Cruz Landim-Alvarenga, Marilda Onghero Taffarel, Carolina Nogueira de Moraes, Gisele Fabrino Machado, Guilherme Dias Melo, Rogério Martins Amorim
BACKGROUND: Recent studies have demonstrated numerous biological properties of mesenchymal stem cells and their potential application in treating complex diseases or injuries to tissues that have difficulty regenerating, such as those affecting the central and peripheral nervous system. Thus, therapies that use mesenchymal stem cells are promising because of their high capacity for self-regeneration, their low immunogenicity, and their paracrine, anti-inflammatory, immunomodulatory, anti-apoptotic and neuroprotective effects...
December 2015: BMC Veterinary Research
M Vázquez, D Vélez, V Devesa
The mercurial forms [inorganic divalent mercury, Hg(II) and methylmercury, CH3Hg] produce neurological and immune effects as well as hematological and renal alterations. The main route of exposure is through the diet. Consequently, the gastrointestinal mucosa is exposed to these mercurial forms, though the potential toxic effects upon the mucosa are not clear. The present study evaluates the toxicity of Hg(II) and CH3Hg (0.1-2 mg/L) in an intestinal epithelium model using the differentiated and undifferentiated human Caco-2 cell line...
December 2014: Food and Chemical Toxicology
Caterina Pipino, Sayandip Mukherjee, Anna L David, Michael P Blundell, Steven W Shaw, Peggy Sung, Panicos Shangaris, Jonathan J Waters, Drew Ellershaw, Marina Cavazzana, Gustavo Mostoslavsky, Assunta Pandolfi, Agostino Pierro, Pascale V Guillot, Adrian J Thrasher, Paolo De Coppi
Trisomy 21 is the most common chromosomal abnormality and is associated primarily with cardiovascular, hematological, and neurological complications. A robust patient-derived cellular model is necessary to investigate the pathophysiology of the syndrome because current animal models are limited and access to tissues from affected individuals is ethically challenging. We aimed to derive induced pluripotent stem cells (iPSCs) from trisomy 21 human mid-trimester amniotic fluid stem cells (AFSCs) and describe their hematopoietic and neurological characteristics...
October 2014: Cellular Reprogramming
Won-Tak Choi, Yilei Yang, Yan Xu, Jing An
The chemokine receptor CXCR4 is required for the entry of human immunodeficiency virus type 1 (HIV-1) into target cells and for the development and dissemination of various types of cancers, including gastrointestinal, cutaneous, head and neck, pulmonary, gynecological, genitourinary, neurological, and hematological malignancies. The T-cell (T)-tropic HIV-1 strains use CXCR4 as the entry coreceptor; consequently, multiple CXCR4 antagonistic inhibitors have been developed for the treatment of acquired immune deficiency syndrome (AIDS)...
2014: Current Topics in Medicinal Chemistry
Marinus R Heideman, Cesare Lancini, Natalie Proost, Eva Yanover, Heinz Jacobs, Jan-Hermen Dannenberg
Class I histone deacetylases are critical regulators of gene transcription by erasing lysine acetylation. Targeting histone deacetylases using relative non-specific small molecule inhibitors is of major interest in the treatment of cancer, neurological disorders and acquired immune deficiency syndrome. Harnessing the therapeutic potential of histone deacetylase inhibitors requires full knowledge of individual histone deacetylases in vivo. As hematologic malignancies show increased sensitivity towards histone deacetylase inhibitors we targeted deletion of class I Hdac1 and Hdac2 to hematopoietic cell lineages...
August 2014: Haematologica
Tatsushi Goto, Fumio Tokunaga, Osamu Hisatomi
Urodele amphibians such as Japanese common newts have a remarkable ability to regenerate their injured neural retina, even as adults. We found that hematological- and neurological-expressed sequence 1 (Hn1) gene was induced in depigmented retinal pigment epithelial (RPE) cells, and its expression was maintained at later stages of newt retinal regeneration. In this study, we investigated the distribution of the HN1 protein, the product of the Hn1 gene, in the developing retinas. Our immunohistochemical analyses suggested that the HN1 protein was highly expressed in an immature retina, and the subcellular localization changed during this retinogenesis as observed in newt retinal regeneration...
2012: Stem Cells International
Pilar Brito-Zerón, Soledad Retamozo, Myriam Gandía, Miriam Akasbi, Marta Pérez-De-Lis, Candido Diaz-Lagares, Xavier Bosch, Albert Bové, Roberto Pérez-Alvarez, María-José Soto-Cárdenas, Antoni Sisó, Manuel Ramos-Casals
OBJECTIVE: To analyze the monoclonal expression of SS through the detection of serum monoclonal immunoglobulins (mIgs) in a large series of patients with Sjögren syndrome (SS), focusing on the etiology, characterization and evolution of the monoclonal band and the association with SS clinical expression and outcomes. METHODS: Serum immunoelectrophoresis (IE) was performed to 408 consecutive patients who were evaluated by our unit between 1992 and 2011: 221 patients who fulfilled the 2002 American-European criteria for primary SS, 122 primary SS patients who fulfilled exclusively the 1993 European criteria and 65 patients with SS-associated hepatitis C virus infection...
August 2012: Journal of Autoimmunity
Lokman Varisli, Ceren Gonen-Korkmaz, Hamid Muhammad Syed, Nuray Bogurcu, Bilge Debelec-Butuner, Burcu Erbaykent-Tepedelen, Kemal Sami Korkmaz
We recently reported that hematological and neurological expressed 1 (HN1) is a ubiquitously expressed, EGF-regulated gene. Expression of HN1 in prostate cell lines down-regulates PI3K-dependent Akt activation. Here, we investigate whether HN1 is regulated by androgens through the putative androgen response elements (AREs) found in its promoter. Knockdown of HN1 expression by siRNA silencing leads to an increase in Akt((S473)) phosphorylation, resulting in the translocation of androgen receptor (AR) to the nucleus; these effects can be abrogated by the non-specific Akt inhibitor LY294002 but not by the ERK inhibitor PD98059...
March 5, 2012: Molecular and Cellular Endocrinology
Romain Micol, Lilia Ben Slama, Felipe Suarez, Loïc Le Mignot, Julien Beauté, Nizar Mahlaoui, Catherine Dubois d'Enghien, Anthony Laugé, Janet Hall, Jérôme Couturier, Louis Vallée, Bruno Delobel, François Rivier, Karine Nguyen, Thierry Billette de Villemeur, Jean-Louis Stephan, Pierre Bordigoni, Yves Bertrand, Nathalie Aladjidi, Jean-Michel Pedespan, Caroline Thomas, Isabelle Pellier, Michel Koenig, Olivier Hermine, Capucine Picard, Despina Moshous, Bénédicte Neven, Fanny Lanternier, Stéphane Blanche, Marc Tardieu, Marianne Debré, Alain Fischer, Dominique Stoppa-Lyonnet et al.
BACKGROUND: Ataxia-telangiectasia (A-T) is a rare genetic disease caused by germline biallelic mutations in the ataxia-telangiectasia mutated gene (ATM) that result in partial or complete loss of ATM expression or activity. The course of the disease is characterized by neurologic manifestations, infections, and cancers. OBJECTIVE: We studied A-T progression and investigated whether manifestations were associated with the ATM genotype. METHODS: We performed a retrospective cohort study in France of 240 patients with A-T born from 1954 to 2005 and analyzed ATM mutations in 184 patients, along with neurologic manifestations, infections, and cancers...
August 2011: Journal of Allergy and Clinical Immunology
Lokman Varisli, Ceren Gonen-Korkmaz, Bilge Debelec-Butuner, Burcu Erbaykent-Tepedelen, Hamid Syed Muhammed, Nuray Bogurcu, Fahri Saatcioglu, Kemal Sami Korkmaz
As the molecular mechanism of β-catenin deregulation is not well understood, and stabilized β-catenin is known to translocate into the nucleus and activate genes for proliferation, a novel regulatory factor, hematological and neurological expressed 1 (HN1), for Akt-GSK3β-β-catenin axis is reported here. In our studies, HN1 gene structure was characterized. HN1 expression was found to be epidermal growth factor-responsive in PC-3 cells, and protein expression was also upregulated in PC-3 and LNCaP but not in DU145 cells...
June 2011: DNA and Cell Biology
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