Giuseppe Ciliberti, Monica Verdoia, Marco Merlo, Filippo Zilio, Marco Vatrano, Francesco Bianco, Massimo Mancone, Denise Zaffalon, Alessia Bonci, Andrea Boscutti, Fabio Infusino, Stefano Coiro, Giulia Stronati, Isabella Tritto, Rocco Gioscia, Dello Russo Antonio, Francesco Fedele, Sabina Gallina, Francesco Cassadonte, Giuseppe Ambrosio, Roberto Bonmassari, Giuseppe De Luca, Gianfranco Sinagra, Alessandro Capucci, Juan Carlos Kaski, Federico Guerra
AIMS: To assess the effect of pharmacological therapy on long-term prognosis of patients with MINOCA. METHODS AND RESULTS: In this retrospective multicentre cohort study involving 9 Hub Hospitals across Italy we enrolled consecutive patients 18 years and older with diagnosis of MINOCA discharged from 1st March 2012 to 31st March 2018. Data on baseline characteristics and pharmacological therapy at discharge (ACEI/ARB, angiotensin-converting enzyme inhibitors/angiotensin receptor antagonists; ASA, acetylsalicylic acid; beta-blockers; CCB, calcium-channel blockers; DAPT, dual anti-platelet therapy; statins), were collected systematically...
November 23, 2020: International Journal of Cardiology
Shehnaz Hussain, Asieh Golozar, Daniel P Widney, Giovanna Rappocciolo, Sudhir Penugonda, Jay H Bream, Otoniel Martinez-Maza, Lisa Jacobson
BACKGROUND: Immune activation and inflammation are hallmarks of chronic HIV infection and are etiologically linked to major causes of morbidity and mortality among HIV-infected persons, including coronary artery disease and cancer. Systemic immune activation is dampened, but not resolved, with use of combination antiretroviral therapy (cART). Statins are cardioprotective drugs that also appear to have immunomodulatory and anti-inflammatory properties. We sought to understand the association between statin use, cART, and levels of circulating immune markers in a longitudinal cohort study...
November 25, 2020: AIDS Research and Human Retroviruses
Himesh B Zaver, Hassan Ghoz, Balkishan J Malviya, Bhaumik Brahmbhatt, William C Palmer, Brian E Lacy, Kenneth R DeVault, Murli Krishna, Yan Bi
BACKGROUND: Lymphocytic esophagitis is a rare esophageal condition. Our knowledge of potential risk factors and treatment outcomes of lymphocytic esophagitis is limited. AIM: To investigate potential risk factors associated with the development of lymphocytic esophagitis and compare clinical characteristics and treatment outcomes of patients diagnosed with lymphocytic esophagitis to patients diagnosed with eosinophilic esophagitis. METHODS: This is a multicenter retrospective study...
November 20, 2020: Digestive Diseases and Sciences
Paul Moayyedi, Hashem B El-Serag
Candidates for chemoprevention in Barrett's esophagus have long been suggested and there has been observational data to support many drugs, including statins, hormone replacement therapy, metformin, proton pump inhibitor therapy, and aspirin. Proton pump inhibitor therapy and aspirin are the most promising agents. Data suggest that aspirin and proton pump inhibitor therapy can decrease the risk of neoplastic progression in Barrett's esophagus. Further, the combination of aspirin and proton pump inhibitor therapy decrease all-cause mortality by approximately 33%...
January 2021: Gastrointestinal Endoscopy Clinics of North America
Nathan A Brooks, Andrea Kokorovic, Lianchen Xiao, Justin T Matulay, Roger Li, Weranja K B Ranisinghe, Supriya Nagaraju, Yu Shen, Jianjun Gao, Neema Navai, Colin P N Dinney, H Barton Grossman, Ashish M Kamat
OBJECTIVES: To evaluate if the obesity-paradox - wherein obesity portends worse overall prognosis for a disease but improved outcomes for patients receiving immunotherapy - exists for patients receiving Bacillus-Calmette Guerin (BCG) in a contemporary cohort. SUBJECTS AND METHODS: We performed an IRB approved database review to identify patients with NMIBC completing at least an induction course of BCG. Clinicopathological variables collected included: body mass index (BMI), medications, and diabetes...
November 14, 2020: BJU International
F Bonnet, F Le Marec, O Leleux, Y Gerard, D Neau, E Lazaro, P Duffau, O Caubet, M A Vandenhende, P Mercie, C Cazanave, F Dabis
BACKGROUND: The objective of the study was to describe the evolution of chronic non-AIDS related diseases and their risk factors, in patients living with HIV (PLHIV) in the French ANRS CO3 Aquitaine prospective cohort, observed both in 2004 and in 2014 in order to improve long-term healthcare management. METHODS: The ANRS CO3 Aquitaine cohort prospectively collects epidemiological, clinical, biological and therapeutic data on PLHIV in the French Aquitaine region...
November 16, 2020: BMC Infectious Diseases
Salim Yusuf, Philip Joseph, Antonio Dans, Peggy Gao, Koon Teo, Denis Xavier, Patricio López-Jaramillo, Khalid Yusoff, Anwar Santoso, Habib Gamra, Shamim Talukder, Courtney Christou, Preeti Girish, Karen Yeates, Freeda Xavier, Gilles Dagenais, Catalina Rocha, Tara McCready, Jessica Tyrwhitt, Jackie Bosch, Prem Pais
BACKGROUND: A polypill comprising statins, multiple blood-pressure-lowering drugs, and aspirin has been proposed to reduce the risk of cardiovascular disease. METHODS: Using a 2-by-2-by-2 factorial design, we randomly assigned participants without cardiovascular disease who had an elevated INTERHEART Risk Score to receive a polypill (containing 40 mg of simvastatin, 100 mg of atenolol, 25 mg of hydrochlorothiazide, and 10 mg of ramipril) or placebo daily, aspirin (75 mg) or placebo daily, and vitamin D or placebo monthly...
November 13, 2020: New England Journal of Medicine
Alessio Cortellini, Marco Tucci, Vincenzo Adamo, Luigia Stefania Stucci, Alessandro Russo, Enrica Teresa Tanda, Francesco Spagnolo, Francesca Rastelli, Renato Bisonni, Daniele Santini, Marco Russano, Cecilia Anesi, Raffaele Giusti, Marco Filetti, Paolo Marchetti, Andrea Botticelli, Alain Gelibter, Mario Alberto Occhipinti, Riccardo Marconcini, Maria Giuseppa Vitale, Linda Nicolardi, Rita Chiari, Claudia Bareggi, Olga Nigro, Alessandro Tuzi, Michele De Tursi, Nicola Petragnani, Laura Pala, Sergio Bracarda, Serena Macrini, Alessandro Inno, Federica Zoratto, Enzo Veltri, Barbara Di Cocco, Domenico Mallardo, Maria Grazia Vitale, David James Pinato, Giampiero Porzio, Corrado Ficorella, Paolo Antonio Ascierto
BACKGROUND: Concomitant medications, such as steroids, proton pump inhibitors (PPI) and antibiotics, might affect clinical outcomes with immune checkpoint inhibitors. METHODS: We conducted a multicenter observational retrospective study aimed at evaluating the impact of concomitant medications on clinical outcomes, by weighing their associations with baseline clinical characteristics (including performance status, burden of disease and body mass index) and the underlying causes for their prescription...
November 2020: Journal for Immunotherapy of Cancer
Yochai Schonmann, Hanny Yeshua, Itay Bentov, Shira Zelber-Sagi
BACKGROUND: A growing body of evidence suggests that Non-alcoholic fatty liver disease (NAFLD) and liver fibrosis are associated with cardiovascular disease (CVD). However, the independent role of liver fibrosis markers in the prediction of CVD in the general population is seldom tested. AIMS: To assess whether a marker of liver fibrosis predicts the first occurrence of a CVD event in a large sample of community-based general population. METHODS: Historical cohort using data from a large health provider that operates a centralized computerized medical record...
October 31, 2020: Digestive and Liver Disease
Raymond Fisher, Anthony Vandehei, Charles Haller, Joshua Boster, Brian Shipley, Christopher Kaatz, Jaclyn Harris, Satoshi R Shin, Lisa Townsend, Jessica Rouse, Sarah Davis, James Aden, Dustin Thomas
Background Coronary artery calcium (CAC) scoring based on gated non-contrast cardiac computed tomography (CT) is a validated risk marker of major adverse cardiovascular events (MACE). Reporting of CAC on non-gated CT chest (NGCT) scans and the impact on medical therapy is not well studied. Methods A retrospective cohort of 5,043 NGCT scans was reviewed for the presence of CAC. The radiology report was reviewed to determine whether CAC was mentioned in either the body of the report or the final impression. Electronic medical records (EMR) were abstracted for baseline demographics, cardiovascular (CV) risk factors, lipid-lowering agents, and aspirin (ASA) prior to and after NGCT...
September 21, 2020: Curēus
Madeline R MacDonald, Sydney Zarriello, Justin Swanson, Noura Ayoubi, Rahul Mhaskar, Abu-Sayeef Mirza
Objectives: Free clinics manage a diversity of diseases among the uninsured. We sought to assess the medical management of stroke in a population of uninsured patients. Methods: A retrospective chart review was conducted to collect chronic disease statistics from 6558 electronic medical records and paper charts at nine free clinics in Tampa, Florida, from January 2016 to December 2017. Demographics and risk factors were compared between stroke patients and non-stroke patients...
2020: SAGE Open Medicine
Duangjai Duangrithi, Ruja Wattanasermkit, Sudarat Rungwijee, Natthanicha Khunsom
Background: Impaired fasting plasma glucose (IFG) as well as diabetes mellitus (DM) may influence the presence of another metabolic syndrome (MetS) components resulting in the different risk of cardiovascular (CV) morbidity and mortality. This study aimed to determine the impact of IFG as well as DM on the 10-year CV risk using Thai CV risk score and primary prevention in complying with CV risk score in these patients. Methods: This cross-sectional study was conducted at the internal medicine clinic, Pathum Thani Hospital, Thailand...
2020: International Journal of Preventive Medicine
Pieter Vynckier, Giulia Ferrannini, Lars Rydén, Lale Tokgözoğlu, Jan Bruthans, Kornelia Kotseva, David Wood, Tine De Backer, Sofie Gevaert, Dirk De Bacquer, Delphine De Smedt
PURPOSE: This study is aimed at investigating gender differences in the medical management of patients with coronary heart disease (CHD). METHODS: Analyses were based on the ESC EORP EUROASPIRE V (European Survey Of Cardiovascular Disease Prevention And Diabetes) survey. Consecutive patients between 18 and 80 years, hospitalized for a coronary event, were included in the study. Information on cardiovascular medication intake at hospital discharge and at follow-up (≥ 6 months to < 2 years after hospitalization) was collected...
October 17, 2020: Cardiovascular Drugs and Therapy
Sadanori Okada, Takeshi Morimoto, Hisao Ogawa, Hirofumi Soejima, Chisa Matsumoto, Mio Sakuma, Masafumi Nakayama, Naofumi Doi, Hideaki Jinnouchi, Masako Waki, Izuru Masuda, Yoshihiko Saito
BACKGROUND: The antitumor effect of statins has been highlighted, but clinical study results remain inconclusive. While patients with diabetes are at high risk of cancer, it is uncertain whether statins are effective for cancer chemoprevention in this population. OBJECTIVE: This study evaluated the association between statins and cancer incidence/mortality in patients with type 2 diabetes. DESIGN: This study was a follow-up observational study of the Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes (JPAD) trial, which was a randomized controlled trial of low-dose aspirin in Japanese patients with type 2 diabetes...
October 15, 2020: Journal of General Internal Medicine
Roberto Ferrari, S Censi, P Cimaglia
In subjects with cardiovascular risk factors or in patients in need of secondary prevention, hypertriglyceridemia is a well-defined risk factor for adverse cardiac events. Drugs containing n-3 polyunsaturated fatty acids ( n-3 PUFAs ) are approved for treatment of hypertriglyceridemia. In 1999, a cardioprotective effect in post infarct patients was suggested by a large multicentre study, the GISSI prevention trial. The hypothesized mechanism of action was an antiarrhythmic action leading to reduction of the sudden death...
October 2020: European Heart Journal Supplements: Journal of the European Society of Cardiology
Ersilia M DeFilippis, Bradley L Collins, Avinainder Singh, David W Biery, Amber Fatima, Arman Qamar, Adam N Berman, Ankur Gupta, Mary Cawley, Malissa J Wood, Josh Klein, Jon Hainer, Martha Gulati, Viviany R Taqueti, Marcelo F Di Carli, Khurram Nasir, Deepak L Bhatt, Ron Blankstein
AIMS: There are sex differences in presentation, treatment, and outcomes of myocardial infarction (MI) but less is known about these differences in a younger patient population. The objective of this study was to investigate sex differences among individuals who experience their first MI at a young age. METHODS AND RESULTS: Consecutive patients presenting to two large academic medical centres with a Type 1 MI at ≤50 years of age between 2000 and 2016 were included...
October 13, 2020: European Heart Journal
Tyler B Moran, Juan Carlos Plana
Cancer patients with acute coronary syndrome (ACS) have significantly greater mortality compared with non-cancer patients. This risk is partly directly attributable to the malignancy; however these patients are frequently undertreated with respect to guideline recommended treatments for ACS due to higher bleeding risks from anemia and thrombocytopenia. Due to exclusion from large clinical trials, there is a paucity of data regarding how to best treat these complex and high-risk patients. PURPOSE OF REVIEW: To review the literature and identify risk factors among cancer patients associated with poor outcomes, pathophysiology of chemotherapy and radiation therapy contributing to accelerated coronary artery disease and ACS, and data regarding outcomes with medical therapy and invasive management...
October 10, 2020: Current Cardiology Reports
Belayneh Kefale, Gobezie T Tegegne, Yitayih Kefale, Mulugeta Molla, Amien Ewunetei, Amsalu Degu
Introduction: Type 2 diabetes mellitus patients with hypertension are at high risk of drug therapy problems since they are subject to receive multiple drug therapies due to comorbidities. Objectives: To determine the magnitude of drug therapy problems and its determinants among Type 2 diabetes mellitus patients with hypertension. Methods: A cross-sectional study was employed among 423 randomly selected participants based on the inclusion criteria...
2020: SAGE Open Medicine
Francisco Kleyton Zacarias Florêncio, Maiza de Oliveira Tenório, Aluísio Roberto Andrade Macedo Júnior, Sandro Gonçalves de Lima
INTRODUCTION: In the genesis of coronavirus disease (COVID-19), there is a process of endotheliitis associated with thrombotic changes, no studies have reported the use of acetylsalicylic acid (ASA) as a possible therapeutic approach. Statins could potentiate the ASA therapy. METHODS: This is a series of 14 cases with a laboratory-confirmed diagnosis of COVID-19. All patients underwent the ASA therapy. Those who had risk factors for vascular disease also underwent the high-potency statin therapy...
2020: Revista da Sociedade Brasileira de Medicina Tropical
S Michael Gharacholou, Zhuo Li, Jonathan J Uy, Lee H Eckstein, Carolyn R Flock, Joshua L Senger, Jorge F Trejo Gutierrez, Scott C Chapman
BACKGROUND: There are limited data on outcomes for patients with peripheral artery disease undergoing endovascular revascularization by multi-disciplinary teams in a community hospital setting. METHODS: From January 2015 through December 2015, we assembled a multi-disciplinary program comprised of cardiologists, surgeons, radiologists, nurses, and administrative staff for managing patients with peripheral artery disease undergoing endovascular revascularization...
September 21, 2020: Vascular
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