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Statin aspirin

Matti Marklund, Jason H Y Wu, Fumiaki Imamura, Liana C Del Gobbo, Amanda Fretts, Janette de Goede, Peilin Shi, Nathan Tintle, Maria Wennberg, Stella Aslibekyan, Tzu-An Chen, Marcia C de Oliveira Otto, Yoichiro Hirakawa, Helle Højmark Eriksen, Janine Kröger, Federica Laguzzi, Maria Lankinen, Rachel A Murphy, Kiesha Prem, Cécilia Samieri, Jyrki Virtanen, Alexis C Wood, Kerry Wong, Wei-Sin Yang, Xia Zhou, Ana Baylin, Jolanda M A Boer, Ingeborg A Brouwer, Hannia Campos, Paulo H M Chaves, Kuo-Liong Chien, Ulf de Faire, Luc Djoussé, Gudny Eiriksdottir, Naglaa El-Abbadi, Nita G Forouhi, J Michael Gaziano, Johanna M Geleijnse, Bruna Gigante, Graham Giles, Eliseo Guallar, Vilmundur Gudnason, Tamara Harris, William S Harris, Catherine Helmer, Mai-Lis Hellénius, Allison Hodge, Frank B Hu, Paul F Jacques, Jan-Håkan Jansson, Anya Kalsbeek, Kay-Tee Khaw, Woon-Puay Koh, Markku Laakso, Karin Leander, Hung-Ju Lin, Lars Lind, Robert Luben, Juhua Luo, Barbara McKnight, Jaakko Mursu, Toshiharu Ninomiya, Kim Overvad, Bruce M Psaty, Eric Rimm, Matthias B Schulze, David Siscovick, Michael Skjelbo Nielsen, Albert V Smith, Brian T Steffen, Lyn Steffen, Qi Sun, Johan Sundström, Michael Y Tsai, Hugh Tunstall-Pedoe, Matti I J Uusitupa, Rob M van Dam, Jenna Veenstra, W M Monique Verschuren, Nicholas Wareham, Walter Willett, Mark Woodward, Jian-Min Yuan, Renata Micha, Rozenn N Lemaitre, Dariush Mozaffarian, Ulf Risérus
BACKGROUND: Global dietary recommendations for and cardiovascular effects of linoleic acid, the major dietary omega-6 fatty acid, and its major metabolite, arachidonic acid, remain controversial. To address this uncertainty and inform international recommendations, we evaluated how in vivo circulating and tissue levels of linoleic acid (LA) and arachidonic acid (AA) relate to incident cardiovascular disease (CVD) across multiple international studies. METHODS: We performed harmonized, de novo, individual-level analyses in a global consortium of 30 prospective observational studies from 13 countries...
April 11, 2019: Circulation
Jan Bornschein, Elizabeth L Bird-Lieberman, Peter Malfertheiner
While the primary risk factor for oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO) is gastro-oesophageal reflux, the infection with Helicobacter pylori (H. pylori) is the dominant risk factor for gastric cancer. Reduction of reflux by dietary measures and proton pump inhibitors has some merits in OAC prevention, and the chemopreventive effect of Aspirin and statins is being widely investigated; however, improved outcome in OAC occurs primarily as the result of secondary prevention...
April 10, 2019: Digestive Diseases
Huinan Yang, Chengfang Luo, Chengxing Shen, Huirong Ding, Bo Wu, Xiaoshu Cai
The morbidity of coronary heart disease (CHD) with high risks has been rising in recent years. A novel and noninvasive method based on surface-enhanced Raman spectroscopy (SERS) was proposed by Yang et al. (Analyst 143: 2235, 2018) to prospectively diagnose the arterial blockage by detecting platelet-derived growth factor-BB (PDGF-BB) in urine. Clinically, anti-platelet drugs (such as aspirin, statins and clopidogrel) are often used for ordinary CHD patients or patients with percutaneous coronary intervention (PCI)...
March 26, 2019: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Muhammad Waqas, Lilian L Bizzocchi, Mark A Menegus, Robert T Faillace
Coronary artery ectasia (CAE) can present as an acute coronary syndrome (ACS) with a high clot burden in ectatic coronary arteries. Thrombectomy with intracoronary thrombolysis often does not ensure immediate blood flow. Also, there have not been clear guidelines regarding long-term management in such cases. A 40-year-old male presented with anginal chest discomfort and a working diagnosis of non-ST elevation myocardial infarction (NSTEMI) was made. The initial angiography showed thrombotic occlusion of several large and ectatic coronary arteries with visibly swirling blood flow...
January 21, 2019: Curēus
Bala Ramanan, Haekyung Jeon-Slaughter, Xiaofei Chen, J Gregory Modrall, Shirling Tsai
OBJECTIVE: Peripheral artery disease is a common comorbidity in patients with end-stage renal disease (ESRD), but there is a paucity of data comparing outcomes of different interventions in this group of patients. In this study, we examined perioperative outcomes of lower extremity endovascular revascularization (ER) and open revascularization (OR) in dialysis patients with critical limb ischemia (CLI). METHODS: Patients on dialysis and undergoing ER and OR for CLI from 2011 to 2015 were identified in the American College of Surgeons National Surgical Quality Improvement Program dataset...
March 25, 2019: Journal of Vascular Surgery
Manuel Rivera, Leonardo Tamariz, Maritza Suarez, Gabriel Contreras
BACKGROUND: Management of chronic kidney disease (CKD) patients includes efforts directed toward modifying traditional cardiovascular risk factors. Such efforts include optimal management of hypertension together with the initiation of statin therapy. METHODS: In this observational study, we determine the modifying effect of statins on the relationship of systolic blood pressure (SBP) goal with mortality and other outcomes in patients with CKD participating in a clinical trial...
2019: American Journal of Nephrology
Christina Coroyannakis, Asma Khalil
PURPOSE OF REVIEW: To evaluate recent developments in the management of hypertension in obese pregnant women. RECENT FINDINGS: The mainstay of management targets prevention of hypertension with preconception counselling, entering pregnancy with a lower BMI, limiting weight gain, and taking low-dose aspirin to prevent pre-eclampsia from before 16 weeks' gestation. There are conflicting results regarding the use of metformin in reducing hypertensive disease, but there is a high probability that it has a role to play...
March 26, 2019: Current Hypertension Reports
Mohammad K Khan, Tahseen H Nasti, Zachary S Buchwald, Ralph R Weichselbaum, Stephen J Kron
It has long been recognized that combining radiotherapy with cytotoxic drugs such as cisplatin can improve efficacy. However, while concurrent chemoradiotherapy improves patient outcomes, it comes at costs of increased toxicity. A tremendous opportunity remains to investigate drug combinations in the clinical setting that might increase the benefits of radiation without additional toxicity. This chapter highlights opportunities to apply repurposing of drugs along with a mechanistic understanding of radiation effects on cancer and normal tissue to discover new therapy-modifying drugs and help rapidly translate them to the clinic...
March 2019: Cancer Journal
Ka Shing Cheung, Wai K Leung
Gastric cancer remains one of the leading cancers in the world with a high mortality, particularly in East Asia. Helicobacter pylori infection accounts for the majority of the noncardia gastric cancers by triggering gastric inflammation and subsequent neoplastic progression. Eradication of H. pylori can reduce, but not totally eliminate, subsequent risk of developing gastric cancer. Proton-pump inhibitors (PPIs) are one of the most widely prescribed medications worldwide. With their profound gastric-acid suppression, there are concerns about a possible carcinogenic role in gastric cancer, due to induced hypergastrinemia, gastric atrophy and bacterial overgrowth in the stomach...
2019: Therapeutic Advances in Gastroenterology
Cécile Droz-Perroteau, Patrick Blin, Caroline Dureau-Pournin, Daniel Thomas, Nicolas Danchin, Jacques Tricoire, François Paillard, Serge Hercberg, Louis Guize, Estelle Guiard, Hélène Maïzi, Marie-Agnès Bernard, Jacques Bénichou, Nicholas Moore
BACKGROUND: Studies of survival after myocardial infarction (MI) are often based on intention to treat analyses of controlled trials. OBJECTIVES: Describe long-term survival after MI in France. METHODS: Six-year cohort study of patients recruited within 3 months after MI. Primary outcome was all-cause death. Vital status was verified in the national death registry. Analysis used Cox models with time-dependent variables and propensity scores...
February 25, 2019: Thérapie
Lars Vedel Kessing, Helene Charlotte Rytgaard, Thomas Alexander Gerds, Michael Berk, Claus Thorn Ekstrøm, Per Kragh Andersen
OBJECTIVE: Drug repurposing is an increasingly promising idea in many fields of medicine. We systematically used Danish nation-wide population-based registers to investigate whether continued use of non-aspirin NSAIDs, low dose aspirin, high dose aspirin, statins, allopurinol, and angiotensin agents decrease the rate of incident mania/bipolar disorder. METHODS: A nation-wide population-based longitudinal study using Poisson regression analyses including all persons in Denmark who purchased the exposure medication of interest and a random sample of 30% of the Danish population...
March 14, 2019: Bipolar Disorders
Arim Kwak, Jae Hyun Kim, Cheol Ung Choi, In-Wha Kim, Jung Mi Oh, Kyungim Kim
Background While there is clear evidence for the benefit of statins in the secondary prevention of cardiovascular and cerebrovascular events, there is a lack of research on the effects of statin regimens in older patients aged 75 years and over. Objectives To compare the effectiveness of statin regimens in the secondary prevention of ischemic cardiovascular and cerebrovascular events among patients aged 75 years and over. Setting Claims data from the South Korean National Health Insurance Database from 2006 to 2014...
March 12, 2019: International Journal of Clinical Pharmacy
Lisanne A Gitsels, Elena Kulinskaya, Ilyas Bakbergenuly, Nicholas Steel
OBJECTIVE: Compare outcomes of intensive treatment of SBP to less than 120 mmHg versus standard treatment to less than 140 mmHg in the US clinical Systolic Blood Pressure Intervention Trial (SPRINT) with similar hypertensive patients managed in routine primary care in the United Kingdom. METHODS: Hypertensive patients aged 50-90 without diabetes or chronic kidney disease (CKD) were selected in SPRINT and The Health Improvement Network (THIN) database. Patients were enrolled in 2010-2013 and followed-up to 2015 (SPRINT N = 4112; THIN N = 8631)...
April 2019: Journal of Hypertension
Michael H C Pham, Christian Ballegaard, Martina C de Knegt, Per E Sigvardsen, Mathias H Sørgaard, Andreas Fuchs, Jørgen T Kühl, Mikkel Taudorf, Børge G Nordestgaard, Lars V Køber, Klaus F Kofoed
AIMS: Accurate assessment of aortic dimensions can be achieved using contrast-enhanced computed tomography. The aim of this study was to define normal values and determinants of aortic dimensions throughout multiple key anatomical landmarks of the aorta in healthy individuals from the Copenhagen General Population Study. METHODS AND RESULTS: The study group consisted of 902 healthy subjects selected from 3000 adults undergoing cardiovascular thoracic and abdominal computed tomography-angiography (CTA), where systematic measurements of aortic dimensions were performed retrospectively...
February 26, 2019: European Heart Journal Cardiovascular Imaging
Arshag D Mooradian
Multipronged risk management in diabetes has contributed to the recent decline in cardiovascular mortality. Few antihyperglycemic drugs have been conclusively shown to have cardioprotective effects. These include metformin, liraglutide, semaglutide, dulaglutide, and sodium-glucose cotransporter-2 inhibitors. Statins are the cornerstone of treatment for people with established coronary artery disease (CAD) or at risk of CAD. In patients with persistent low-density lipoprotein cholesterol (LDL-C) levels > 70 mg/dL, the addition of ezetimibe or proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors is recommended...
February 22, 2019: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
Li Li, Shuang Wang, Huilian Huang, Yi Cai, Yutao Xi, Ying Bai, Changsheng Ma
INTRODUCTION: Atherosclerosis erodes large elastic arteries and damages peripheral small vessels. Evaluating retinal vessel caliber enables exploration of the effect of improving microcirculation with statins. OBJECTIVE: We investigated whether rosuvastatin therapy improves retinal vasculature in hypercholesterolemic patients with a low-to-moderate risk of coronary artery disease (CAD). METHODS: This was a prospective, open-label, randomized study in which 127 patients were enrolled and randomized (ratio 1:1) into rosuvastatin and control groups...
February 22, 2019: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
Miodrag N Krstic, Dragana D Mijac, Dusan D Popovic, Aleksandra Pavlovic Markovic, Tomica Milosavljević
BACKGROUND: Cancer is the second leading cause of death worldwide next to cardiovascular diseases. Despite the advancement in screening, early diagnosis, and development in treatment technology in last several decades, cancer incidence overall, particularly that of gastrointestinal (GI) cancers, is far from being controlled, and is expected to increase worldwide. SUMMARY: Although numerous preclinical and population-based clinical studies have already made important progress in restraining the overall cancer incidence and mortality, the full potential of preventive strategy is still far from being realized, and remains at an early stage...
February 15, 2019: Digestive Diseases
Jiapeng Lu, Yuan Lu, Hao Yang, Wuhan Bilige, Yetong Li, Wade Schulz, Frederick A Masoudi, Harlan M Krumholz
Background: As cardiovascular risk increases in China, interest in strategies to mitigate it is growing. However, national information about the prevalence and treatment of high cardiovascular disease (CVD) risk is limited. Objective: To assess the prevalence and treatment of high CVD risk as well as variations in risk across population subgroups. Design: National project of CVD screening and management. Setting: 141 county-level regions in all 31 provinces of China...
February 19, 2019: Annals of Internal Medicine
Arthelma C Tyson, Shailraj Parikh, Kuldeep Singh, Saqib Zia, Jonathan S Deitch, Jonathan A Schor
BACKGROUND: Routine laboratory testing to rule out myocardial infarction (MI) after carotid endarterectomy (CEA) is common in many centers. Its utility in this patient population has not been thoroughly investigated. We hypothesize that routine testing for MI in post-CEA patients is of low-yield and not cost-effective. METHODS: A retrospective review of 291 consecutive CEAs from February, 2011 to July, 2015 was performed. Two patients were excluded: one for postoperative non-cardiac death and one for preoperative MI...
February 12, 2019: Annals of Vascular Surgery
Bo-Lin Ho, Ya-Ju Lin, Sheng-Feng Lin, Ping-Song Chou, Chien-Fu Chen, Ruey-Tay Lin, Han-Hwa Hu, A-Ching Chao
OBJECTIVES: Dabigatran etexilate is a direct thrombin inhibitor that clinicians increasingly prescribe to prevent stroke in patients with nonvalvular atrial fibrillation (NVAF). Clinicians also commonly prescribe statins for primary and secondary prevention of cardiovascular diseases. Little is known about the bleeding risk in patients taking a statin and dabigatran together. The aim of this study was to evaluate the safety and persistence of dabigatran after co-medication with statins...
February 11, 2019: Acta Neurologica Scandinavica
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