Arthur L Burnett, Natalie C Edwards, Tonya M Barrett, Krista D Nitschelm, Samir K Bhattacharyya
Erectile dysfunction (ED) is a common, burdensome, and costly urologic condition strongly related to all aspects of general health, from physical to mental. ED has profound consequences as it may interfere physical well-being, quality of life (QoL), self-esteem, relationships, self-worth, and productivity. It is therefore important to ensure that all types of effective ED treatments are consistently accessible to patients. While federal and state mandates ensure access to treatment for women's breast health, female-factor infertility, and gender affirmation to ensure that these individuals do not experience a diminished QoL, there are no comparable mandates for men's sexual and reproductive health...
September 2020: American Journal of Men's Health
Michael Pinkawa, Amr Gharib, Marsha Schlenter, Ludmila Timm, Michael J Eble
PURPOSE: Analysis of quality of life changes after radiotherapy with focus on the impact of time after treatment and prescription dose. METHODS: Consecutive patients were treated with doses from 70.2/1.8 Gy (n = 206) to 72/1.8-2.0 Gy (n = 176) in a single centre and surveyed using the Expanded Prostate Cancer Index Composite questionnaire. RESULTS: Urinary and bowel bother scores decreased 1 / 3 / 6 points and 7 / 7 / 9 points on average 1 / 5 / 10 years after RT in comparison to baseline scores...
October 9, 2020: Quality of Life Research
Caroline Hynes, Stephen McWilliams, Mark Clarke, Ita Fitzgerald, Larkin Feeney, Mark Taylor, Fiona Boland, Dolores Keating
Background: Antipsychotics are associated with a range of side-effects that can influence patients' subjective well-being negatively resulting in poor adherence. In order to limit the negative consequences of side-effects, they should be regularly systematically assessed. The aim of this study was to systematically assess antipsychotic side-effects in an inpatient cohort using validated rating scales. Methods: Eligible individuals prescribed an antipsychotic for at least 2 weeks were invited to have their side-effects assessed systematically...
2020: Therapeutic Advances in Psychopharmacology
Carolyn G Mazariego, Sam Egger, Madeleine T King, Ilona Juraskova, Henry Woo, Martin Berry, Bruce K Armstrong, David P Smith
OBJECTIVE: To assess treatment related changes in quality of life up to 15 years after diagnosis of localised prostate cancer. DESIGN: Population based, prospective cohort study with follow-up over 15 years. SETTING: New South Wales, Australia. PARTICIPANTS: 1642 men with localised prostate cancer, aged less than 70, and 786 controls randomly recruited from the New South Wales electoral roll into the New South Wales Prostate Cancer Care and Outcomes Study (PCOS)...
October 7, 2020: BMJ: British Medical Journal
Maurizio De Rocco Ponce, Andrea Garolla, Nicola Caretta, Luca De Toni, Angelo Avogaro, Carlo Foresta
AIMS: Erectile dysfunction (ED) is a frequent microvascular complication of type 2 diabetes mellitus (T2DM). Hormonal derangements such as hypogonadism and hyperestrogenism are common in T2DM. Our aim was to investigate the relationship between estrogens and ED in diabetic patients. METHODS: We performed a retrospective study on 57 patients with T2DM suffering from ED. ED was assessed with the International Index of Erectile Function questionnaire (IIEF-5) and penile color-doppler ultrasound (PCDU)...
September 6, 2020: Journal of Diabetes and its Complications
Jialiang Hui, Shisheng Chen, Haibo Zhang, Changmou Yang, Wei Anyang, Shuhua He
OBJECTIVE: This study was performed to explore the effects of metabolic memory on diabetic erectile dysfunction (ED), especially the severity and response to treatment. METHODS: Through medical records and follow-up by telephone, 67 patients meeting the criteria with a clinical diagnosis of ED and a diabetic history of more than 5 years were enrolled for erectile function analysis. They were divided into a glycemic control group, a glycemic non-control group and a metabolic memory group according to glycemic levels and treatments for diabetes in the past 5 years, and they were treated with phosphodiesterase type 5 (PDE5) inhibitors for 4 weeks...
October 6, 2020: Andrology
F L Malcolm, A Adiamah, A Banerjea, D Whitehead, A Gupta, J West, D J Humes
BACKGROUND: Remote follow-up (RFU) after colorectal cancer (CRC) surgery allows delivery of surveillance tests without the need for regular outpatient clinical appointments. However, little is known about health-related quality of life (HRQoL) in RFU patients. METHODS: EQ-5D, QLQ-C30 and QLQ-C29 questionnaires were distributed to CRC patients enrolled in a RFU programme. The primary outcome of HRQoL scores was analysed by year of RFU, demographics, operation-type, stoma and adherence to RFU protocols...
October 6, 2020: Colorectal Disease
Mahmoud A Bassiem, Iman Y Ismail, Tarek A Salem, Ahmed I El-Sakka
OBJECTIVE: To assess if the effect of intracavernosal injection (ICI) of prostaglandin E1 (PGE1) on duration and rigidity of erection is dose dependent in patients with different types of vasculogenic erectile dysfunction (ED)? METHODS: A hundred patients with ED were assigned into 4 groups (n=25/each); group (A) patients with arteriogenic ED, group (B) patients with veno-occlusive ED, group (C) patients with mixed (arteriogenic and veno-occlusive) ED and group (D) patients who have only psychogenic ED (control)...
October 2, 2020: Urology
Murad Asali, Muhammad Asali
OBJECTIVE: To assess the effectiveness of an intralesional injection of verapamil in men with Peyronie's disease (PD). MATERIALS AND METHODS: The data provided in the current review are based on a thorough review of the available original articles on PD retrieved with a systematic literature search using PubMed- Medline, and the Cochrane Central Register of Controlled Trials, up to December 2019, to identify studies dealing with Peyronie's disease and its treatment...
October 2, 2020: Archivio Italiano di Urologia, Andrologia
Zhonglin Cai, Xiaoqing Song, Jianzhong Zhang, Bin Yang, Hongjun Li
Erectile dysfunction (ED) is a common sexual disorder in adult males and one of the most important factors affecting their quality of life and that of their partners. Although PDE5 inhibitors (PDE5is) are the first choice for improving erectile function, there is a substantial proportion of ED patients, termed PDE5i nonresponders, who do not respond to PDE5is. Because of the lack of effective therapies, these patients always have serious social and psychological problems due to ED, which should be addressed...
October 2020: Aging and Disease
Sherry A Beaudreau, Katie Van Moorleghem, Stacy M Dodd, Victoria Liou-Johnson, Madhuvanthi Suresh, Christine E Gould
OBJECTIVES: To investigate satisfaction with a vacuum constriction device for middle-aged and older male Veterans with erectile dysfunction and their female partners. METHODS: Patients ( N = 57; mean age = 64.28 years; SD = 8.7) received comprehensive education and training and ongoing follow-up of device use, which included a semi-structured interview. Female partners ( n = 41) also rated their satisfaction with the device. RESULTS: Over 96% of patients ( n = 53/56 responses) endorsed the ability to maintain an erection with the device and 100% ( n = 56/56 responses) indicated they would recommend the device to others...
October 4, 2020: Clinical Gerontologist
Jingyu Song, Taotao Sun, Zhe Tang, Yajun Ruan, Kang Liu, Ke Rao, Ruzhu Lan, Shaogang Wang, Tao Wang, Jihong Liu
Erectile dysfunction (ED) is a major health issue among men with diabetes, and ED induced by diabetes mellitus (DMED) is particularly difficult to treat. Therefore, novel therapeutic approaches for the treatment of DMED are urgently needed. Exosomes, nanosized particles involved in many physiological and pathological processes, may become a promising tool for DMED treatment. In this study, we investigated the therapeutic effect of exosomes derived from corpus cavernosum smooth muscle cells (CCSMC-EXOs) on erectile function in a rat model of diabetes and compared their effect with that of exosomes derived from mesenchymal stem cells (MSC-EXOs)...
October 3, 2020: Journal of Cellular and Molecular Medicine
Hanin Assi, Anna Persson, Ingrid Palmquist, Martin Öberg, Pamela Buchwald, Marie-Louise Lydrup
INTRODUCTION: After extensive pelvic surgery for cancer two flap types are used at Skåne University Hospital (SUS), Sweden for perineal reconstruction: vertical rectus abdominis myocutaneous flap and gluteal flap with or without vaginal reconstruction. The objective was to study the long-term outcomes in patients treated for advanced pelvic cancer receiving a flap. METHOD: Patients with pelvic cancer subjected to surgery including perineal reconstruction between January 2010 and August 2016 at SUS were included retrospectively...
September 23, 2020: European Journal of Surgical Oncology
Paul Sargos, Sylvie Chabaud, Igor Latorzeff, Nicolas Magné, Ahmed Benyoucef, Stéphane Supiot, David Pasquier, Menouar Samir Abdiche, Olivier Gilliot, Pierre Graff-Cailleaud, Marlon Silva, Philippe Bergerot, Pierre Baumann, Yazid Belkacemi, David Azria, Meryem Brihoum, Michel Soulié, Pierre Richaud
BACKGROUND: Adjuvant radiotherapy reduces the risk of biochemical progression in prostate cancer patients after radical prostatectomy. We aimed to compare adjuvant versus early salvage radiotherapy after radical prostatectomy, combined with short-term hormonal therapy, in terms of oncological outcomes and tolerance. METHODS: GETUG-AFU 17 was a randomised, open-label, multicentre, phase 3 trial done at 46 French hospitals. Men aged at least 18 years who had an Eastern Cooperative Oncology Group performance status of 1 or less, localised adenocarcinoma of the prostate treated with radical prostatectomy, who had pathologically-staged pT3a, pT3b, or pT4a (with bladder neck invasion), pNx (without pelvic lymph nodes dissection), or pN0 (with negative lymph nodes dissection) disease, and who had positive surgical margins were eligible for inclusion in the study...
October 2020: Lancet Oncology
Hongguan Zhang, Yude Liu, Lian Rao, Yanyou Cen, Kaili Cheng
OBJECTIVE: To evaluate the effects of a combination of Yinyanghuo (Herba Epimedii Brevicornus) (HEB) and Cheqianzi (Semen Plantaginis) (SP) on erectile dysfunction caused by essential hypertension in spontaneously hypertensive rats (SHRs), and to elucidate the role of the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor (ACE2/Ang [1-7]/Mas receptor) axis in this process. METHODS: A total of 24 SHRs were randomly assigned to three groups: SHR-control, low-dose (12...
October 2020: Journal of Traditional Chinese Medicine
Nina U Robertson, Anel Schoonees, Amanda Brand, Janicke Visser
BACKGROUND: Pine bark (Pinus spp.) extract is rich in bioflavonoids, predominantly proanthocyanidins, which are antioxidants. Commercially-available extract supplements are marketed for preventing or treating various chronic conditions associated with oxidative stress. This is an update of a previously published review. OBJECTIVES: To assess the efficacy and safety of pine bark extract supplements for treating chronic disorders. SEARCH METHODS: We searched three databases and three trial registries; latest search: 30 September 2019...
September 29, 2020: Cochrane Database of Systematic Reviews
Radojica V Stolic, Zoran Bukumiric, Branislav Belic, Bozidar Odalovic, Goran Relic, Sasa Sovtic, Maja Sipic, Vekoslav Mitrovic, Biljana Krdzic
Background and objectives: In patients on hemodialysis, erectile dysfunction is an independent mortality factor. This study aimed to determine the risk factors that affect the survival of hemodialysis patients with erectile dysfunction. Materials and Methods: During a seven-year period, erectile dysfunction was identified among the fatalities reported in patients receiving chronic hemodialysis, on the basis of the International Index of Erectile Function questionnaire. The study covered 70 patients of mean age 57 ± 6...
September 24, 2020: Medicina
Olivier Picaud, Laura Beyer-Berjot, Yann Parc, Gilles Karsenty, Ben Creavin, Stéphane Berdah, Jérémie H Lefevre
AIM: Few studies have been published on erectile function after IPAA and, unlike in women, male fertility after IPAA has never been assessed. The primary objective was to assess the impact of ileal pouch-anal anastomosis (IPAA) on erectile function. The secondary objective was to assess the impact of IPAA on male fertility. METHODS: All of the male patients who underwent IPAA in two university care centres between 2003 and 2017, aged 70 years or less at the time of operation, were included...
September 28, 2020: Colorectal Disease
Soner Coban, Aygul Gunes, Abdullah Gul, Ali Riza Turkoglu, Muhammet Guzelsoy, Murat Ozturk, Osman Akyuz, Ozgur Ekici
PURPOSE: We aimed to investigate the effect of continuous positive airway pressure (CPAP) administered for the treatment of obstructive upper airway on lower urinary tract symptoms and erectile dysfunction in male patients. MATERIALS AND METHODS: A total of 626 male with suspected obstructive sleep apnea syndrome (OSAS) were evaluated prospectively. Nocturnal polysomnography tests were administered to the male. After application of the exclusion criteria, 54 patients with severe OSAS (Apnea-Hypopnea Index ≥30) were included in the study...
September 24, 2020: Investigative and Clinical Urology
Ming-Szu Hung, Yi-Chuan Chen, Tsung-Yu Huang, Dong-Ru Ho, Chuan-Pin Lee, Pau-Chung Chen, Yao-Hsu Yang
Background: Sexual problems are common in male lung cancer survivors. However, the development of erectile dysfunction (ED) in lung cancer patients after surgery has been rarely explored. In this study, we aimed to explore the incidence and risk factors of ED after lung cancer surgery. Methods: From 2000 to 2012, 6025 and 24,100 male patients were included in each matched cohort of lung cancer and non-lung cancer patients, respectively. Poisson regression analysis was used to calculate the incidence rate ratio (IRR) and 95% confidence interval (CI)...
2020: Clinical Epidemiology
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