keyword
https://read.qxmd.com/read/38505341/genetic-prediction-of-modifiable-lifestyle-factors-for-erectile-dysfunction
#21
JOURNAL ARTICLE
Yu-Jia Xi, Yi-Ge Feng, Ya-Qi Bai, Rui Wen, He-Yi Zhang, Qin-Yi Su, Qiang Guo, Cheng-Yong Li, Zhen-Xing Wang, Liang Pei, Sheng-Xiao Zhang, Jing-Qi Wang
BACKGROUND: The causal relationship between certain lifestyle factors and erectile dysfunction (ED) is still uncertain. AIM: The study sought to investigate the causal effect of 9 life factors on ED through 2-sample single-variable Mendelian randomization (SVMR) and multivariable Mendelian randomization (MVMR). METHODS: Genetic instruments to proxy 9 risk factors were identified by genome-wide association studies. The genome-wide association studies estimated the connection of these genetic variants with ED risk (n = 223 805)...
February 2024: Sexual Medicine
https://read.qxmd.com/read/38505155/redo-inferior-pubectomy-for-failed-anastomotic-urethroplasty-in-pelvic-fracture-urethral-injury
#22
JOURNAL ARTICLE
Lin Wang, Wenxiong Song, Xufeng Peng, Rong Lyu, Jijian Wang, Chongrui Jin, Chao Feng, Xiangguo Lyu, Yinglong Sa, Yidong Liu
OBJECTIVES: To assess the effect of redo inferior pubectomy on the management of complicated pelvic fracture urethral injury (PFUI) in patients with a history of failed anastomotic urethroplasty. MATERIALS AND METHODS: We retrospectively reviewed all patients receiving redo anastomotic urethroplasty with redo inferior pubectomy for failed PFUI between January 2010 and December 2021. Patients with incomplete data and those who were lost to follow-up were excluded...
March 2024: Current Urology
https://read.qxmd.com/read/38500665/the-value-of-audiovisual-sexual-stimulation-with-virtual-reality-in-diagnosing-erectile-dysfunction
#23
JOURNAL ARTICLE
Yan-Ping Huang, Tao Jing, Kai-Feng Liu, Wei Liu, Ming Zhang, Da-Chuan Zhong, Yi-Dong Liu, Shi-Ran Xu, Mu-Jun Lu
BACKGROUND: The traditional audiovisual sexual stimulation (AVSS) test may experience limitations including low erectile response rate and lack of unified diagnostic criteria. AIM: We aimed to explore the clinical value of AVSS with virtual reality (VR-AVSS) test in assessing erectile function and diagnosing erectile dysfunction (ED). METHODS: Participants 18 to 60 years of age were screened for analysis in 3 clinical centers from June 2020 to March 2022...
February 2024: Sexual Medicine
https://read.qxmd.com/read/38500286/choc-tadalafil-fusion-unlocking-solubility-and-taste-harmony-with-%C3%A3-cd-infused-medicated-chocolate
#24
JOURNAL ARTICLE
Chetna Modi, Manobika Sinha, Vaishali Thakkar, Hardik Rana, Dipika Chavda
OBJECTIVE: The primary limitations of tadalafil in treating erectile dysfunction are its low solubility and unpleasant bitter taste, which ultimately result in inadequate patient adherence. The present study aimed to develop and characterize a medicated chocolate formulation containing Tadalafil and ß-CD (solubility enhancer) employing the concept of Design of Experiment (DoE) using chocolate as a user-friendly excipient. METHODS: An inclusion complex was formulated by incorporating the drug into ß-CD using the kneading method for solubility improvement and also as a taste masker for Tadalafil...
March 18, 2024: Recent advances in drug delivery and formulation
https://read.qxmd.com/read/38498298/major-adverse-cardiovascular-events-related-to-phosphodiesterase-5-inhibitors-analysis-of-real-life-data-from-eudra-vigilance-database
#25
JOURNAL ARTICLE
Cosimo DE Nunzio, Antonio Nacchia, Maria C Grimaldi, Beatrice Turchi, Lorenzo Rovesti, Antonio Franco, Giorgio Guarnotta, Olivia Voglino, Elisa Mancini, Valeria Baldassarri, Riccardo Lombardo, Antonio Cicione, Andrea Tubaro
BACKGROUND: Phosphodiesterase 5 inhibitors (PDE5i) are the standard medical treatment for erectile dysfunction. Aim of our study was to evaluate the rate of major adverse cardiovascular events (MACE) reported during PDE5i treatment based on Eudra-Vigilance (EV) reports. METHODS: EV database is the system for managing and analyzing data on suspected adverse reactions to medicines which have been authorized or being studied in clinical trials in the European Economic Area...
March 18, 2024: Minerva urology and nephrology
https://read.qxmd.com/read/38495136/discovery-of-new-%C3%AE-glucosides-antiglycation-agent-and-in-silico-study-of-2-3-4-dihydroxyphenyl-7-8-dihydroxy-3-methoxy-4h-chromen-4-one-isolated-from-pistacia-chinensis
#26
JOURNAL ARTICLE
Tareq Abu-Izneid, Abdur Rauf, Zuneera Akram, Saima Naz, Abdul Wadood, Naveed Muhammad, Chandni Hayat, Yahya S Al-Awthan, Omar S Bahattab
Pistacia chinensis is locally practiced for treating diabetes, pain, inflammation, and erectile dysfunction. Therefore, the current studies subjected the crude extract/fractions and the isolated compound (2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-3-methoxy-4H-chromen-4-one) to α-glucosidase inhibitor and anti-glycation activities. The development of long-term complications associated with diabetes is primarily caused by chronic hyperglycemia. Regarding α-glucosidase, the most significant inhibitory effect was observed with compound 1 (93...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38494449/a-primer-on-the-restorative-therapies-for-erectile-dysfunction-a-narrative-review
#27
JOURNAL ARTICLE
Manish Narasimman, Max Sandler, Ari Bernstein, Justin Loloi, Russell G Saltzman, Helen Bernie, Ranjith Ramasamy
INTRODUCTION: Erectile dysfunction (ED) is a common condition that affects millions worldwide. Patients and urologists alike are seeking alternative therapies that can provide long-lasting results in the treatment of ED. This review provides a comprehensive overview of restorative treatments available for ED, such as platelet-rich plasma, stem cell therapy, and shockwave therapy. OBJECTIVE: The aim of this narrative review is to provide a primer for urologists and general practitioners on the basics of implementing ED restorative therapies in their practice...
March 17, 2024: Sexual Medicine Reviews
https://read.qxmd.com/read/38494081/experimental-testing-combined-with-inverse-fe-for-mechanical-characterisation-of-penile-tissues
#28
JOURNAL ARTICLE
Shirsha Bose, Majid Akbarzadeh Khorshidi, Robert D Johnston, Brian Watschke, Evania Mareena, Caitríona Lally
Erectile dysfunction (ED) predominantly affects men in their 40-70s and can lead to a poor quality of life. One option for ED treatment is surgical implantation of an inflatable penile prosthesis (IPP). However, they can be associated with negative outcomes including infection, migration or fibrosis. To improve outcomes, the interaction between the IPP device and surrounding tissues needs further investigation and this could be achieved using pre-clinical testbeds, but they need to be informed by extensive tissue testing...
March 15, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38492404/association-between-air-pollution-and-male-sexual-function-a-nationwide-observational-study-in-china
#29
JOURNAL ARTICLE
Ziyuan Shen, Feng Zhang, Zihan Guo, Rui Qu, Yiqiu Wei, Jingxuan Wang, Weiqian Zhang, Xing Xing, Yan Zhang, Jue Liu, Dongdong Tang
This study aimed to explore the associations between air pollution and male sexual function. A total of 5047 male subjects in China were included in this study. The average air pollution exposure (PM2.5 , PM10 , SO2 , CO, NO2 , and O3 ) for the preceding 1, 3, 6, and 12 months before the participants' response was assessed. Male sexual function was evaluated using the International Index of Erectile Function-5 (IIEF-5) and the Premature Ejaculation Diagnostic Tool (PEDT). Generalized linear models were utilized to explore the associations between air pollution and male sexual function...
March 13, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38492318/characteristics-and-predictors-of-sexual-dysfunction-in-men-with-multiple-sclerosis
#30
JOURNAL ARTICLE
Ivan Adamec, Tomislav Sambolić, Mihovil Santini, Antea Karić, Anamari Junaković, Barbara Barun, Tereza Gabelić, Luka Crnošija, Magdalena Krbot Skorić, Mario Habek
PURPOSE: To validate and culturally adapt the Sexual Health Inventory for Men (IIEF-5) and the Premature Ejaculation Diagnostic Tool (PEDT), to compare the frequency and severity of erectile dysfunction (ED) and premature ejaculation (PE) in male individuals with MS (mwMS) in comparison with healthy controls (HC) and to investigate predictors of the severity of ED and PE in mwMS. METHODS: 216 consecutive mwMS and 37 HC completed IIEF-5 and PEDT. Additionally, 114 mwMS completed the Modified Fatigue Impact Scale (MFIS), Beck Depression Inventory (BDI-2), Composite Autonomic System Score-31 (COMPASS-31), and the 5-level EQ-5D questionnaire...
March 5, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38490968/top-50-most-cited-articles-about-female-sexual-dysfunction-a-bibliometric-analysis
#31
JOURNAL ARTICLE
Susan Gong, Samuel Yim, Abdo Kabarriti
INTRODUCTION: Female sexual dysfunction (FSD) consists of low libido, sexual arousal problems, anorgasmia, and dyspareunia. Sexual function is an important aspect of life for many women and is closely correlated with overall well-being. FSD is often underrepresented in the academic space when compared with male sexual disorders, such as erectile dysfunction. As FSD spans many fields (eg, urology, gynecology, psychology), bibliometric analyses are an important resource to highlight landmark articles...
March 15, 2024: Sexual Medicine Reviews
https://read.qxmd.com/read/38490689/association-of-sildenafil-use-with-age-related-macular-degeneration-a-retrospective-cohort-study
#32
JOURNAL ARTICLE
Ji Eun Diana Han, Anuradhaa Subramanian, Wen Hwa Lee, Jesse Coker, Alastair K Denniston, Krishnarajah Nirantharakumar, Nicola Jaime Adderley
OBJECTIVE: Despite significant advances in clinical care and understanding of the underlying pathophysiology, age-related macular degeneration (AMD)-a major cause of global blindness-lacks effective treatment to prevent the irreversible degeneration of photoreceptors leading to central vision loss. Limited studies suggest phosphodiesterase type 5 (PDE5) inhibitors, such as sildenafil, may prevent AMD by increasing retinal blood flow. This study explores the potential association between sildenafil use and AMD risk in men with erectile dysfunction using UK data...
March 15, 2024: BMJ Open Ophthalmology
https://read.qxmd.com/read/38490276/algorithmic-midline-approach-to-perineal-urethrostomy-is-associated-with-long-term-success-and-high-patient-satisfaction
#33
JOURNAL ARTICLE
Eshan G Joshi, Maia E VanDyke, Brian T Langford, Bryce P Franzen, Allen F Morey
PURPOSE: To assess surgical success and patient-reported outcomes of perineal urethrostomy via midline approach. MATERIALS & METHODS: Charts of patients undergoing primary perineal urethrostomy between May 2008 and June 2022 were reviewed. Background characteristics were assessed; success was defined as freedom from re-intervention. Patient-reported outcome measures were assessed using a cross-sectional phone survey. Several validated questionnaires were used to assess lower urinary tract symptoms, quality of life, and erectile dysfunction...
March 13, 2024: Urology
https://read.qxmd.com/read/38488864/exploring-complex-links-inflammatory-rheumatic-diseases-and-men-s-health
#34
REVIEW
Burhan Fatih Kocyigit, Yuliya Fedorchenko, Kassymkhan Sultanbekov, Gulsah Yasa Ozturk, Marlen Yessirkepov
This article examines the complex interactions between inflammatory rheumatic diseases (IRDs) and men's health. It delves into the effects of IRDs on reproductive health, erectile dysfunction, prostate involvement, male osteoporosis, body composition, physical activity, and coping mechanisms. The findings show that the prevalence of sexual dysfunction varies among different diseases, underscoring the necessity for comprehensive counseling. The link between IRDs and prostate health, with a substantial rise in benign prostatic hyperplasia among IRD patients, demonstrates the condition's importance...
March 15, 2024: Rheumatology International
https://read.qxmd.com/read/38487305/safety-tolerability-and-pharmacokinetics-of-aildenafil-citrate-tablets-a-novel-oral-pde5-inhibitor-in-healthy-chinese-volunteers-after-multiple-dose-administration
#35
JOURNAL ARTICLE
Ran Xie, Bo Jia, Lu Cheng, Nan Zhao, Xu He, Xia Wang, Xia Zhao, Yimin Cui
BACKGROUND: Aildenafil citrate is a potent and selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase type 5, developed for the treatment of erectile dysfunction (ED). AIM: This study aimed to assess the pharmacokinetics, safety, and tolerability of aildenafil citrate tablets after multiple doses in healthy Chinese males. METHODS: Twenty participants were divided into 2 groups, 10 participants each. Participants were administered multiple doses of aildenafil citrate tablets at 30 and 60 mg...
February 2024: Sexual Medicine
https://read.qxmd.com/read/38486122/post-orgasmic-illness-syndrome-a-review
#36
REVIEW
Benjamin Olasunkanmi Odusanya, Ian Pearce, Vaibhav Modgil
POIS is a rare condition characterized by multisystem symptoms with unclear aetiology. Various attempts have been made to characterize this condition and knowledge is still evolving regarding its aetiology and effective treatment. We have summarized the findings in the English language literature for this rare condition. PubMed search was performed and over 300 English language articles which were screened for relevance. 34 articles were deemed suitable for inclusion. POIS occurs in age range of 21-61 years...
March 14, 2024: International Journal of Impotence Research
https://read.qxmd.com/read/38486121/the-impact-of-digital-media-on-sexuality-a-descriptive-and-qualitative-study
#37
JOURNAL ARTICLE
Ana Filipa Beato, Patrícia M Pascoal, Joana Rodrigues
The beliefs about Digital Information and Communication Media (DM) impact on sexuality by people from the community are an essential field to understanding people's sexual behaviours and their response to others' sexuality. This cross-sectional, online, descriptive, qualitative study, developed in the context of the celebration of National Sexual Health Day in Portugal, intended to identify the reasons and the activities using DM related to sexuality and explore participant's beliefs about the impact of DM on sexuality...
March 14, 2024: International Journal of Impotence Research
https://read.qxmd.com/read/38483941/date-phoenix-dactylifera-l-mill-fruit-enhances-sexual-performance-via-modulation-of-oxido-inflammatory-mediators-and-purinergic-signaling-in-hypertensive-male-rats
#38
JOURNAL ARTICLE
Adeniyi A Adebayo, Ayokunle O Ademosun, Ganiyu Oboh
Introduction: The present study aimed at investigating the effect of dietary supplementation of Phoenix dactylifera , an important component of aphrodisiac supplements, on sexual performance, oxido-inflammatory mediators and purinergic signaling system in hypertensive rats. Material and methods: Hypertension was induced via oral administration of 40 mg/kg L-NAME. Thereafter, the sexual performance of the experimental animals was determined and the hypertensive rats with impaired sexual activities were placed on P...
March 14, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38481874/addressing-the-need-for-preclinical-study-of-penile-prosthesis-infection-a-new-animal-model-and-narrative-review
#39
REVIEW
Yash B Shah, Ji-Bin Liu, Priscilla Machado, Andrew Denisenko, Corinne E Wessner, Kerith R Wang, Rishabh K Simhal, Selin Isguven, Lauren J Delaney, Noreen J Hickok, Flemming Forsberg, Paul H Chung
BACKGROUND AND OBJECTIVE: Erectile dysfunction (ED) is a common condition in men, and many patients refractory to conservative treatment may undergo penile prostheses (PPs) placement. The primary concern following PP implantation is device infection. Although antibiotic and hydrophilic coatings have reduced the incidence of inflatable PP (IPP) infections, there remains room for improvement. Optimization of PP outcomes requires a practical in vivo model to better understand mechanisms of infection and to test new infection control strategies...
February 29, 2024: Translational Andrology and Urology
https://read.qxmd.com/read/38481867/management-of-the-anatomically-complex-penile-implant-candidate-through-an-infrapubic-incision-a-review-of-surgical-techniques-and-benefits
#40
JOURNAL ARTICLE
Jeffrey Loh-Doyle
This article provides a comprehensive discussion of 3-piece inflatable penile implant surgery when performed through an infrapubic approach in patients presenting with challenging anatomy or corporal fibrosis. The infrapubic approach is one of the primary approaches for inflatable device placement with excellent long-term functional outcomes. While the literature is rich in descriptions of infrapubic placement in the primary, uncomplicated setting, its role in the management of complex patients presenting to centers of excellence is less elucidated...
February 29, 2024: Translational Andrology and Urology
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