R Bole, M Ziegelmann, A Gopalakrishna, C S Collins, M Alom, L Trost, S Helo, T S Köhler
OBJECTIVES: To identify factors associated with patient willingness to consider surgical treatment for erectile dysfunction (ED) prior to urologic consultation. METHODS: A prospective database of patients presenting to the sexual health clinic at our institution was created from 2014-2018, consisting of pre-visit patient questionnaires and clinical information. Univariable and multivariable logistic regression analysis was performed to determine factors associated with consideration of surgery and decision to undergo surgery...
September 14, 2020: Urology
Mehmet Yilmaz, Mustafa Karaaslan, Senol Tonyali, Mecit Celik, Tuncay Toprak, Oner Odabas
BACKGROUND: Erectile dysfunction (ED) is often associated with endocrine metabolic diseases such as metabolic syndrome (MetS) and diabetes mellitus (DM), in which insulin resistance (IR) plays a decisive role in pathology. Triglyceride-glucose index (TyG), a simple, inexpensive and easily accessible IR marker, is calculated by fasting serum glucose and triglyceride values. OBJECTIVES: We aimed to reveal the relationship between TyG index and ED. MATERIALS AND METHODS: 152 male patients, aged between 24-80 years, admitted to the urology outpatient clinic with complaining erectile insufficiency were evaluated...
September 16, 2020: Andrology
Jerel P Calzo, S Bryn Austin, Brittany M Charlton, Stacey Missmer, Martin Kathrins, Audrey Gaskins, Jorge E Chavarro
PURPOSE: Little is understood about physiologic and psychologic correlates of erectile dysfunction (ED) among younger men. This study examined prevalence and correlates of ED in a large US sample of 18-31 year old men. MATERIALS AND METHODS: ED prevalence and severity (defined using the International Index of Erectile Function-5 scale) were examined in cross-sectional survey data from 2,660 sexually active men, aged 18-31 years, from the 2013 Growing Up Today Study...
September 16, 2020: Journal of Urology
Giorgio Bozzini, Lorenzo Berti, Matteo Maltagliati, Umberto Besana, Alberto Calori, Alexander Müller, Maria Chiara Sighinolfi, Salvatore Micali, Antonio Luigi Pastore, Rodrigo Ledezma, Paolo Broggini, Bernardo Rocco, Carlo Buizza
PURPOSE: To assess the effects of a new ejaculation-sparing thulium laser enucleation of the prostate (ES-ThuLEP) technique on sexual functions and micturition, in patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH) and to evaluate how the surgical technique of ES-ThuLEP can lead to ejaculation preservation. METHODS: A prospective study was carried out between January 2015 and January 2018 on patients with surgical indication for BPH, who wished to preserve ejaculation...
September 14, 2020: World Journal of Urology
Wang Zhou, Yuyang Zhang, Liang Li, Jingjing Gao, Hui Zheng, Meng Huang, Sheng Zhao, Xinxin Xie, Chaoxue Zhang, Xiansheng Zhang
OBJECTIVES: To explore the feasibility of shear wave elastography (SWE) in the evaluation of arterial erectile dysfunction (ED). METHODS: From November 2018 to November 2019, 26 patients with arterial ED and 30 patients with non-vascular ED were prospectively included. SWE values of corpus cavernosum penis (CCP) and the flow velocity of cavernous artery for all patients in both before intracavernous injection (ICI) (flaccid state) and after ICI (erectile state) were measured...
September 14, 2020: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Tongyan Liu, Zhihe Xu, Yong Guan, Mingzhen Yuan
BACKGROUND: Whether RigiScan could distinguish psychogenic from organic erectile dysfunction (ED) is still a matter of controversy. So this study was aimed to investigate the function of RigiScan in the diagnosis of ED, and compare it with that of pharmacopenile color doppler ultrasonography (PCDU). METHODS: This is a retrospective cohort study. All patients should be performed IIEF-5 questionnaire, blood test, RigiScan, PCDU, Neurophysiological tests. Golden standard: one patient was diagnosed as organic ED when any of the following tests was abnormal, including sex hormone, PCDU and neurological tests...
September 7, 2020: Annals of Palliative Medicine
Amjad Alwaal, Mohannad Awad, Nathan Boggs, Jake Kuzbel, Brian Snoad
INTRODUCTION: Sexual Health Inventory for Men (SHIM) is a validated questionnaire that is widely used in urology clinics to evaluate and assess treatment efficacy for erectile dysfunction (ED). AIM: In this study, we evaluated the benefit of using the SHIM questionnaire as a screening tool for ED in a general urology clinic MATERIAL AND METHODS: We retrospectively reviewed records of patients presenting to our general urology clinic from October 2018 to June 2019...
September 9, 2020: Sexual Medicine
Wanwan Zhang, Yifang Wei, Xiaoxiao Cao, Kaixin Guo, Qiangqiang Wang, Xiaochun Xiao, Xufeng Zhai, Dingding Wang, Zebo Huang
ETHNOPHARMACOLOGICAL RELEVANCE: Crassostrea gigas Thunberg and other oysters have been traditionally used in China as folk remedies to invigorate the kidney and as natural aphrodisiacs to combat male impotence. AIM OF THE STUDY: Erectile dysfunction (ED) has become a major health problem for the global ageing population. The aim of this study is therefore to evaluate the effect of peptide-rich preparations from C. gigas oysters on ED and related conditions as increasing evidence suggests that peptides are important bioactive components of marine remedies and seafood...
September 9, 2020: Journal of Ethnopharmacology
Martin Nyberg, Daniel D Sjoberg, Sigrid V Carlsson, Ulrica Wilderäng, Stefan Carlsson, Johan Stranne, Peter Wiklund, Gunnar Steineck, Eva Haglind, Jonas Hugosson, Anders Bjartell
OBJECTIVES: To evaluate how surgeon heterogeneity - the variation in outcomes between individual surgeons - influenced functional and oncologic outcomes after robot assisted radical prostatectomy (RALP) and retropubic radical prostatectomy (RRP), and to assess whether surgeon heterogeneity affected the comparison between RALP and RRP. PATIENTS AND METHODS: Laparoscopic Prostatectomy Robot Open (LAPPRO) is a prospective, controlled, non-randomized trial performed at 14 Swedish centers with 68 operating surgeons...
September 11, 2020: BJU International
Penghui Yuan, Delin Ma, Xintao Gao, Jiaxing Wang, Rui Li, Zhuo Liu, Tao Wang, Shaogang Wang, Jihong Liu, Xiaming Liu
Background: Erectile dysfunction (ED) occurs more frequently and causes a worse response to the first-line therapies in diabetics compared with nondiabetic men. Corpus cavernosum vascular dysfunction plays a pivotal role in the occurrence of diabetes mellitus ED (DMED). The aim of this study was to investigate the protective effects of glucagon-like peptide-1 (GLP-1) analog liraglutide on ED and explore the underlying mechanisms in vivo and in vitro . Methods: Type 1 diabetes was induced in rats by streptozotocin, and the apomorphine test was for screening the DMED model in diabetic rats...
2020: Frontiers in Pharmacology
Sandro La Vignera, Antonio Aversa, Rossella Cannarella, Rosita A Condorelli, Ylenia Duca, Giorgio I Russo, Aldo E Calogero
INTRODUCTION: Benign prostate hyperplasia (BPH) is one of the most prevalent diseases in aging men. It may adversely affect quality-of-life due to the presence of low urinary tract symptoms (LUTS) and its effects on sexuality. AREAS COVERED: The impact of α1-blockers, 5α-reductase inhibitors (5-ARI), and phosphodiesterase 5 inhibitors (PDE-5i) on erectile and ejaculatory functions in men with BPH are covered. Endocrinological aspects have also been addressed, including the management of hypogonadism, which affects many patients with BPH, and the impact of the use of 5-ARI use on bone health...
September 9, 2020: Expert Opinion on Pharmacotherapy
Shi-Chen Ou, Mei-Chen Lin, Hung-Jen Lin, Chi-Ping Huang, Sheng-Teng Huang
OBJECTIVES: To investigate the association between erectile dysfunction and fibromyalgia, and to clarify related comorbidities and treatment modalities. METHODS: This retrospective cohort study was carried out using 1 million records in the National Health Insurance Research Database. From 2001 to 2012, a total of 53 678 male patients newly diagnosed with fibromyalgia were recruited as the fibromyalgia cohort, and the same number of the non-fibromyalgia cohort was enrolled and matched with propensity score with age, income, comorbidities, and prescribed medications...
September 9, 2020: International Journal of Urology: Official Journal of the Japanese Urological Association
Uldouz Kharazi, Reza Badalzadeh
Stem cell therapy and exosome therapy are the two experimental methods that are now at the center of attention. Various types of stem cells, especially mesenchymal stem cells and spermatogonial stem cells have been widely administrated in reproductive medicine. However, due to the limitation of injecting living cells, using their paracrine secretions such as exosomes seems to be a better option. Exosomes show regenerative, pro-angiogenic, anti-apoptotic, anti-inflammatory, anti-hypoxic, and anti-fibrotic characteristics...
September 5, 2020: Reproductive Biology
Jiawei Cai, Junmin Chen, Qianqian Zeng, Jie Liu, Yanli Zhang, Haiping Cheng, Shasha Yao, Qiu Chen
BACKGROUND: Diabetes mellitus with erectile dysfunction (DMED) is one of the most common causes of disability in diabetic population, and its pathogenesis is related to a variety of factors. Because its pathogenesis is complex and the existing treatment methods have limitations, DMED is difficult to treat in clinical. Recently, some studies have shown that α-lipoic acid (ALA) is associated with DMED, but there is no systematic review and meta-analysis on the relationship between ALA and DMED...
September 4, 2020: Medicine (Baltimore)
Allen D Seftel
No abstract text is available yet for this article.
September 8, 2020: Journal of Urology
Allen D Seftel
No abstract text is available yet for this article.
September 8, 2020: Journal of Urology
Allen D Seftel
No abstract text is available yet for this article.
September 8, 2020: Journal of Urology
M I Kogan, Ig V Popov, Il V Popov, S S Todorov
Despite significant advances in andrology, the problem of penile cavernous fibrosis remains not fully understood. Many studies on the epidemiology of erectile dysfunction have been published, but consensus on the place and role of this pathology in the structure of sexual disorders has not yet been reached. The data obtained at different time intervals and in different geographical areas are strikingly different. Also, the role of organic disorders in the penis, including fibroplastic changes, in certain etiological factors has not been determined...
September 2020: Urologii︠a︡
Jian Xiong Ma, Bin Wang, Hai Song Li, Jia Yu, Hui Min Hu, Cai Fei Ding, Wang Qiang Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetes mellitus-induced erectile dysfunction (DMED) is one of the most common complications of diabetes mellitus. Leech and centipede granules (LCG) have traditionally been used as blood-activating agents in various ethnomedicinal systems of East Asia, especially in China. It is often used to regulate bodily functions and considered as adjuvant therapy for promoting blood circulation, alleviating blood coagulation, activating meridians, and relieving stasis...
September 4, 2020: Journal of Ethnopharmacology
Natsumi Tomita, Yuji Hotta, Aya Naiki-Ito, Kana Hirano, Tomoya Kataoka, Yasuhiro Maeda, Satoru Takahashi, Kazunori Kimura
Phosphodiesterase 5 inhibitors are widely used to treat erectile dysfunction and lower urinary tract symptoms with benign prostatic hyperplasia. Recent studies have indicated the renoprotective effects of this class of compounds. Whether renoprotection depends on blood pressure reduction remains controversial. In this study, we investigated the renoprotective effects of the phosphodiesterase 5 inhibitor, tadalafil, in a rat model of high-salt induced kidney injury with hypertension. Dahl salt-sensitive rats were fed a normal diet, high-salt (8% sodium chloride) diet, or high-salt diet with oral administration of either low- or high-dose tadalafil (1 and 10 mg kg-1  day-1 , respectively)...
September 2020: Physiological Reports
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