Brittney S Zimmerman, Danielle Seidman, Krystal P Cascetta, Meng Ru, Erin Moshier, Amy Tiersten
INTRODUCTION: The aim of this study was to assess for clinicopathologic and socioeconomic features that predict improved survival for patients with advanced breast cancer with synchronous brain metastases at diagnosis. METHODS: We utilized the National Cancer Database (NCDB) to identify all patients with brain metastases present at diagnosis, with adequate information on receptor status (ER, PR, Her2), clinical T stage of cT1-4, clinical M1, with 3,943 patients available for analysis...
March 2, 2021: Oncology
André den Exter
Recently, the Dutch Medical Doctors Association (Federatie Medisch Specialisten en de Koninklijke Nederlandsche Maatschappij tot bevordering der Geneeskunst) drafted the 'Covid-19 triage guideline ICU admission' that has age cut-offs that deprioritise or exclude the elderly. Such an age limit for intensive care unit (ICU) admission in case of a national emergency seems discriminatory, and thus, is it inappropriate to use, or not? The question is whether age in itself can be considered as an acceptable selection criterion...
September 21, 2020: European Journal of Health Law
Erika S Trapl, Brenna VanFrank, Christine M Kava, Vinh Trinh, Stephanie R Land, Rebecca S Williams, Elizabeth Frost, Stephen Babb
BACKGROUND: Federally funded health centers (HCs) provide care to the most vulnerable populations in the U.S., including populations with disproportionately higher smoking prevalence such as those with lower incomes. METHODS: This study compared characteristics of adult HC patients, by cigarette smoking status, and assessed smoking cessation-related behaviors using 2014 Health Center Patient Survey data; analysis was restricted to adults with data on cigarette smoking status (n = 5583)...
February 15, 2021: Drug and Alcohol Dependence
Susan Timpani, Linda Sweet, Nina Sivertsen
Storytelling is one method of arts-based learning. The pedagogy of arts-based learning integrates the arts into another topic to enhance learning. Nursing students' experiences of clinical placement are often complex. Students may benefit not only from cognitive thinking, but also creative reflection. This integrative literature review explores storytelling as an arts-based approach to learning during clinical placements. A search of electronic databases focused on articles published in English during 2010-2020...
February 24, 2021: Nurse Education in Practice
Sukriti Srivastava, Razi Ahmad, Sunil Kumar Khare
Alzheimer's disease (AD) is a neurodegenerative disorder that impairs mental ability development and interrupts neurocognitive function. This neuropathological condition is depicted by neurodegeneration, neural loss, and development of neurofibrillary tangles and Aβ plaques. There is also a greater risk of developing AD at a later age for people with cardiovascular diseases, hypertension and diabetes. In the biomedical sciences, effective treatment for Alzheimer's disease is a severe obstacle. There is no such treatment to cure Alzheimer's disease...
February 23, 2021: European Journal of Medicinal Chemistry
Ching-Jen Chang, Chih-Hsueh Lin, Hui-Min Hsieh, Wen-Yann Lo, Yen-Hsun Lai, Li-Ning Peng, Liang-Kung Chen
BACKGROUND: The association between type 2 diabetes mellitus (T2DM) and sarcopenia has been reported before, but little was known regarding associations between albuminuria status in the development of sarcopenia. This study aimed to explore the associations between albuminuria status and sarcopenia among older patients with T2DM. METHODS: This cross-sectional study recruited T2DM patients aged 65 years and older from the DM shared care center in a regional hospital who were grossly absent from functional impairment...
February 5, 2021: Archives of Gerontology and Geriatrics
Roger Erivan, Thomas Hacquart, Guillaume Villatte, Aurélien Mulliez, Stéphane Descamps, Stéphane Boisgard
BACKGROUND: Femoral neck fractures constitute a major public health challenge. The risk of death after surgery depends chiefly on the patient's general health and comorbidities. No studies assessing place of residence are available. The objectives of this study were to determine whether mortality differed according to the patient's previous place of residence and to the place of discharge, and to describe the complications occurring after femoral neck fracture surgery. HYPOTHESIS: After femoral neck fracture surgery, the place of discharge is associated with the risk of death, and the complication rate is high...
February 27, 2021: Orthopaedics & Traumatology, Surgery & Research: OTSR
Paul-Henri Bauwens, Matthieu Malatray, Gaspard Fournier, Frédéric Rongieras, Antoine Bertani
BACKGROUND: Intramedullary nailing is the standard of care for tibial shaft fractures. The risk factors for infectious and/or mechanical complications, notably non-union, remain incompletely understood. The objective of this study was to evaluate risk factors for complications, notably non-union. HYPOTHESIS: Active smoking and an initial open wound are independent risk factors for complications. MATERIALS AND METHODS: We retrospectively included consecutive patients managed for open or closed tibial shaft fractures by primary intramedullary nailing between 2013 and 2018...
February 27, 2021: Orthopaedics & Traumatology, Surgery & Research: OTSR
Charles H Bombardier, Robert W Motl, Ralph H B Benedict, Nancy Temkin, Peiqing Qian, Katharine Alexander, Annabeth Evans, Andrea Thomas, Kristin Toms, Cathea M Carey, George H Kraft
BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS) causes cognitive impairment in approximately 50% of cases. Disease modifying medications and cognitive rehabilitation produce only small positive effects on cognition in MS. Converging animal and human research suggests that aerobic exercise may improve cognition in people with MS, but definitive trials are lacking. We describe the design of the GET Smart study, a randomized controlled trial comparing the effects of aerobic exercise versus stretching and toning on cognition in MS...
February 27, 2021: Contemporary Clinical Trials
Kelcey A Bland, Meg Harrison, Eva M Zopf, Mariana S Sousa, David C Currow, Matthew Ely, Meera Agar, Belinda E Butcher, Vanessa Vaughan, Anna Dowd, Peter Martin
BACKGROUND: Cancer cachexia negatively affects quality of life (QoL) and increases symptom burden. A multimodal treatment approach may optimise cachexia outcomes, including QoL. We evaluated QoL and symptoms over time among patients attending a multidisciplinary clinical service for cancer cachexia. METHODS: Adults with cancer who attended the clinical service three times between 2017-2020 were included. Quality of life and symptoms were assessed using the European Organization for Research and Treatment of Cancer-Quality of life Questionnaire Core 15 Palliative (EORTC QLQ-C15-PAL) and Functional Assessment Anorexia/Cachexia Treatment (FAACT)...
February 27, 2021: Journal of Pain and Symptom Management
Lara Dhingra, Kin Lam, William Cheung, Gavin Hynes, Colleen Fleming-Damon, Stephanie Hicks, Philip Huang, Jack Chen, Victor Chang, Russell Portenoy
BACKGROUND: First-generation Chinese American patients have low engagement in advance care planning (ACP). Among the causes may be clinician uncertainty about traditional cultural values. AIM: Based on a survey identifying barriers to ACP among older ethnic Chinese American patients, we created a toolkit to support clinicians in culturally relevant ACP practices and conducted a pilot test to evaluate usability, acceptability, and preliminary outcomes. DESIGN/SETTING/PARTICIPANTS: The toolkit includes culturally relevant information and an ACP guideline with a prompt list of questions...
February 27, 2021: Journal of Pain and Symptom Management
Ahmed Osman, Mujahid Ibrahim, Jean Saunders, Roula Merheb, Michele Moscorelli, Vanessa Caretto, Sharon Groh-Wargo
OBJECTIVE: This study examines the hypothesis that infant-driven oral feeding leads to earlier achievement of oral feeding and reduces the length of hospital stay compared with provider-driven oral feeding in premature infants METHODS: We used a retrospective chart review to compare 2 groups of premature infants born at ≤35 weeks of gestation. The control group (CG) received the Provider-Driven Oral Feeding model and the intervention group (IG) received the Infant-Driven Oral Feeding model...
March 2, 2021: Nutrition in Clinical Practice
Kyriaki Karavanaki, Lydia Kossiva, Rigina Sklavou, Kostas Kakleas, Charalambos Tsentidis, Dimitris Gourgiotis, Antonis Marmarinos, Triantafyllia Sdogou, Maria Tsolia, Sophia Polychronopoulou
BACKGROUND: Infections in patients with cancer are a major cause of morbidity and mortality. In most cases, the presence of neutropenia renders them prone to infections to either common or opportunistic pathogens. A wide spectrum of bacterial, viral, or fungal agents is encountered in these patients. AIM: The aim of this study was to evaluate infection types and pathogens in pediatric patients with cancer with and without neutropenia. METHODS: A total of 37 pediatric patients with cancer (median age ± 25% quartile, 6...
March 1, 2021: Pediatric Emergency Care
Cecily L Betz, Jennifer E Mannino, Kristin Cleverley, Cara C Young, Monique Ridosh, Lynn Kysh, Sharon M Hudson
OBJECTIVE: The purpose of this scoping review is to explore the extent to which self-management of youth and young adults with special health care needs is reported in the health care transition literature. INTRODUCTION: It is essential for youth and young adults with special health care needs to learn the self-management skills, to the extent possible, that are essential in maintaining the stability of their chronic condition to seamlessly transfer to adult care and live independently...
March 2, 2021: JBI evidence synthesis
Jolandi Jacobs, Benita Olivier, Muhammad Dawood, Nirmala Kanthi Panagodage Perera
OBJECTIVE: The objective of this systematic review is to describe the incidence and prevalence of injuries in female cricket players participating in recreational, school, club, and elite level cricket. INTRODUCTION: Recent investments in women's cricket, stand-alone tournaments, and increased visibility through new broadcasting milestones has increased participation in many countries. With increased participation of women in cricket comes increased risk of injury...
March 2, 2021: JBI evidence synthesis
Maria M Martínez-Madrid, José Arnau-Sánchez, Ana M González-Cuello
OBJECTIVE: This study evaluated sexual function, the influence of the relationship with the intimate partner, and the factors related to sexual function in middle-aged Spanish women. METHODS: The methodology entailed a cross-sectional study of 187 sexually active women aged 40-59 years. The participants were randomly recruited from primary public health care. They completed the 6-item Female Sexual Function Index (FSFI-6), the short-form Woman Abuse Screening Tool (WAST), and a sociodemographic questionnaire...
March 1, 2021: Menopause: the Journal of the North American Menopause Society
J W L Cals, R Derckx, M H Blanker
METHOD: Registration system initiated by General Practice Research Consortium Netherlands (GPRC-NL). AIM: To obtain national estimates on clinically suspected Covid-19 mortality in general practice and on intensive and palliative covid-19 care provided by general practitioners (GPs) outside hospital, including palliative medication, availability of personal protective equipment, and reasons for not referring to hospital of vulnerable patients during the first three months of the Covid-19 pandemic in The Netherlands...
January 4, 2021: Nederlands Tijdschrift Voor Geneeskunde
Liza Hamstra, Martine Hollander, Rogier Jaspers, Marlies Garritsen, Ceciel Segers, Jeroen van Dillen
OBJECTIVE: To explore the experiences of women and health care professionals with misoprostol as a first line treatment for non-viable pregnancy. Additionally, we investigated to what extent adding this treatment to primary care will prevent a referral to secondary care. DESIGN: Retrospective mixed methods study METHOD: Pregnant women with a non-viable pregnancy with a gestational age shorter than 12 weeks treated by community midwives in Nijmegen Lent as part of an on-going pilot project were included...
February 18, 2021: Nederlands Tijdschrift Voor Geneeskunde
Marcel J H Ariës, Joop P van den Bergh, Martijn Beudel, Wim Boersma, Tom Dormans, Renee Douma, Annet Eerens, Paul W G Elbers, Lucas M Fleuren, Niels C Gritters van den Oever, Lianne de Haan, Iwan J C C van der Horst, Shi Hu, Deborah Hubers, Marcus L F Janssen, Martijn de Kruif, Pieter L Kubben, Sander M J van Kuijk, Peter G Noordzij, Maarten Ottenhoff, Dan A I Piña-Fuentes, Wouter V Potters, Auke C Reidinga, Roos S C Renckens, Sander Rigter, Daisy Rusch, Michiel Schinkel, Kim C E Sigaloff, Suat Simsek, Patricia Stassen, Robert Stassen, Rajat M Thomas, Guido A van Wingen, Anton Vonk Noordegraaf, Max Welling, W Joost Wiersinga, Marije D J Wolvers, Caroline E Wyers
OBJECTIVE: To systematically collect clinical data from patients with a proven COVID-19 infection in the Netherlands. DESIGN: Data from 2579 patients with COVID-19 admitted to 10 Dutch centers in the period February to July 2020 are described. The clinical data are based on the WHO COVID case record form (CRF) and supplemented with patient characteristics of which recently an association disease severity has been reported. METHODS: Survival analyses were performed as primary statistical analysis...
January 11, 2021: Nederlands Tijdschrift Voor Geneeskunde
Joanna Z J Ling, Olga Montvida, Kamlesh Khunti, Anthony L Zhang, Charlie C Xue, Sanjoy K Paul
OBJECTIVE: The trends in prevalence of hypertension and dyslipidaemia in incident type 2 diabetes (T2DM), time to antihypertensive (AHT) and lipid lowering (LLT) therapy, and the association with SBP/lipid control, are not known. RESEARCH DESIGN AND METHODS: Using THIN UK primary care database, 254,925 people with incident T2DM and existing dyslipidaemia/hypertension were identified. Among those without atherosclerotic cardiovascular disease (ASCVD) history and not on AHT/LLT at diagnosis, adjusted median months to initiating an AHT/LLT, and the probabilities of high SBP/lipids over 2-years in people initiating therapy within/after 1-year were evaluated by high and low ASCVD risk status...
March 2, 2021: Diabetes, Obesity & Metabolism
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