Cheryl van de Wetering, Allison M Manuel, Mona Sharafi, Reem Aboushousha, Xi Qian, Cuixia Erickson, Maximilian MacPherson, Garrett Chan, Ian M Adcock, Nazanin ZounematKermani, Florence Schleich, Renaud Louis, Eric Bohrnsen, Angelo D'Alessandro, Emiel F Wouters, Niki L Reynaert, Jianing Li, C Roland Wolf, Colin J Henderson, Lennart K A Lundblad, Matthew E Poynter, Anne E Dixon, Charles G Irvin, Albert van der Vliet, Jos L van der Velden, Yvonne M Janssen-Heininger
BACKGROUND: Interleukin-1-dependent increases in glycolysis promote allergic airways disease in mice and disruption of pyruvate kinase M2 (PKM2) activity is critical herein. Glutathione-S-transferase P (GSTP) has been implicated in asthma pathogenesis and regulates the oxidation state of proteins via S-glutathionylation. We addressed whether GSTP-dependent S-glutathionylation promotes allergic airways disease by promoting glycolytic reprogramming and whether it involves the disruption of PKM2...
November 2021: Redox Biology