Vladimir Lazarevic, Daniel Teta, Menno Pruijm, Catherine Stoermann, Nicola Marangon, Julie Mareschal, Raquel Solano, Arlene Wurzner-Ghajarzadeh, Nadia Gaïa, Patrice D Cani, Oğuzhan S Dizdar, François R Herrmann, Jacques Schrenzel, Laurence Genton
INTRODUCTION: The gut barrier, comprising gut microbiota, plays a pivotal role in chronic kidney disease (CKD) progression and nutritional status. This study aimed to explore gut barrier alterations in hemodialyzed (HD) patients, non-HD (NHD) CKD patients, and healthy volunteers. METHODS: Our cross-sectional study enrolled 22 HD patients, 11 NHD patients, and 11 healthy volunteers. We evaluated fecal microbiota composition (assessed via bacterial 16S rRNA gene sequencing), fecal IgA levels, surrogate markers of gut permeability, serum cytokines, appetite mediators, nutritional status, physical activity, and quality of life...
2024: Frontiers in Microbiology