Rosa Cortese, Marco Battaglini, Maria Laura Stromillo, Ludovico Luchetti, Matteo Leoncini, Giordano Gentile, Daniele Gasparini, Domenico Plantone, Manuela Altieri, Alessandro D'Ambrosio, Antonio Gallo, Costanza Giannì, Claudia Piervincenzi, Patrizia Pantano, Elisabetta Pagani, Paola Valsasina, Paolo Preziosa, Nicolo' Tedone, Maria Assunta Rocca, Massimo Filippi, Nicola De Stefano
BACKGROUND: Research work has shown that hippocampal subfields are atrophic to varying extents in multiple sclerosis (MS) patients. However, studies examining the functional implications of subfield-specific hippocampal damage in early MS are limited. We aim to gain insights into the relationship between hippocampal atrophy and memory function by investigating the correlation between global and regional hippocampal atrophy and memory performance in early MS patients. METHODS: From the Italian Neuroimaging Network Initiative (INNI) dataset, we selected 3D-T1-weighted brain MRIs of 219 early relapsing remitting (RR)MS and 246 healthy controls (HC) to identify hippocampal atrophic areas...
May 14, 2024: Journal of Neurology