Chia-Lin Lee, Yun-Lian Jhan, Hsiu-Mei Chiang, Chao-Jung Chen
Thirty-four phytochemicals were isolated from dry tubers of Bletilla striata Rchb.f. The compounds were classified as bibenzyls 1 - 14 , dihydrophenanthrenes 15 , 17 , 20 , 21 , phenanthrenes 16 , 18 , 19 , simple benzoids 22 - 24 , a fatty acid 25 , glucosyloxybenzyl 2-isobutylmalates 26 - 32 , and glucosyloxybenzyl cinnamates 33 , 34 . Compounds 1 - 4 , 7 , 8 , 11 , 12 , and 16 inhibited melanogenesis (17.96-55.27%) induced by α-MSH in B16F10 cells at 10-40 μM. However, compounds 9 , 10 , 17 , 18 , and 21 exhibited significant cytotoxicity against melanomas, with IC50 values of 12-34 μM...
September 23, 2023: Natural Product Research