George A Ward, Zhiqiang Zhang, Simone Jueliger, Ilya S Potapov, Matthew P Davis, Adam R Boxall, Jason Taylor, Harold Keer, Andrea Biondo, John F Lyons, Martin Sims, Tomoko Smyth
Programmed cell death mechanisms are important for the regulation of tumor development and progression. Evasion of and resistance to apoptosis are significant factors in tumorigenesis and drug resistance. Bypassing apoptotic pathways and eliciting another form of regulated cell death, namely necroptosis, an immunogenic cell death (ICD), may override apoptotic resistance. Here, we present the mechanistic rationale for combining tolinapant, an antagonist of the inhibitor of apoptosis proteins (IAP), with decitabine, a hypomethylating agent (HMA), in T-cell lymphoma (TCL)...
May 10, 2024: Cancer Res Commun