Bogdan Czerniak, Sangkyou Lee, Sung Yun Jung, Pawel Kus, Jolanta Bondaruk, June Lee, Roman Jaksik, Nagireddy Putluri, Khanh Dinh, David Cogdell, Huiqin Chen, Yishan Wang, Jiansong Chen, Neema Nevai, Colin Dinney, Cathy Mendelsohn, David McConkey, Richard Behringer, Charles Guo, Peng Wei, Marek Kimmel
Multi-platform mutational, proteomic, and metabolomic spatial mapping was used on the whole-organ scale to identify the molecular evolution of bladder cancer from mucosal field effects. We identified complex proteomic and metabolomic dysregulations in microscopically normal areas of bladder mucosa adjacent to dysplasia and carcinoma in situ . The mutational landscape developed in a background of complex defects of protein homeostasis which included dysregulated nucleocytoplasmic transport, splicesome, ribosome biogenesis, and peroxisome...
April 10, 2024: Research Square