Camila Albo, Sanjiv Kumar, Michael Pope, Kyle Michael Kidwell, Hongyan Xu, Latanya Bowman, Leigh Wells, Nadine Barrett, Sabine Fields, Pritam Bora, Niren Patel, Abdullah Kutlar
OBJECTIVES: In this study, we investigated the evolution of chronic pain in sickle cell patients (SCD) as an age-dependent phenomenon and studied the frequency of vaso-occlusive episode frequency, opioid use, quantitative sensory testing (QST), and biomarkers of chronic pain (CP). METHODS: We undertook a cross-sectional study of the evolution of CP in SCD. A total of 72 subjects (age 15-66) were enrolled. VOE frequency, presence of CP hydroxyurea (HU) therapy, opioid use, and laboratory parameters were collected...
June 4, 2020: European Journal of Haematology
Anthony Villani, Rebecca McClure, Michelle Barrett, David Scott
AIM: We aimed to compare diagnostic differences for identification of sarcopenia using the original operational definition developed by the European Working Group on Sarcopenia in Older People (EWGSOP1) and the most recently revised EWGSOP2 definition in community dwelling older adults with type 2 diabetes mellitus (T2DM). METHODS: Appendicular Lean Mass (ALM) corrected for height (ALM/m2 ) was assessed by dual energy X-ray absorptiometry. Muscle strength was assessed using hand-grip strength (HGS) or chair stands, and the Short Physical Performance Battery (SPPB) and gait speed were used to evaluate lower extremity physical function...
April 21, 2020: Archives of Gerontology and Geriatrics
Matthew Barrett Innes, Amber Reck Atwater
Orthopedic implant hypersensitivity reactions (IHRs) are known to occur but are uncommon. Clinical presentations include local and generalized cutaneous reactions and noncutaneous complications. Pathogenesis traditionally was believed a type IV delayed hypersensitivity reaction, but there is evidence that innate immunity plays a role. Orthopedic implants are made predominantly of metals, and nonmetal components, such as bone cement, plastics, and ceramics, also may be utilized. Several diagnostic tests are available, and patch testing is considered the gold standard...
July 2020: Dermatologic Clinics
Bridget M Crawford, Hsin-Neng Wang, Christina Stolarchuk, Richard J von Furstenberg, Pietro Strobbia, Dadong Zhang, Xiaodi Qin, Kouros Owzar, Katherine S Garman, Tuan Vo-Dinh
MicroRNAs (miRNAs) play an important role in the regulation of biological processes and have demonstrated great potential as biomarkers for the early detection of various diseases, including esophageal adenocarcinoma (EAC) and Barrett's esophagus (BE), the premalignant metaplasia associated with EAC. Herein, we demonstrate the direct detection of the esophageal cancer biomarker, miR-21, in RNA extracted from 17 endoscopic tissue biopsies using the nanophotonics technology our group has developed, termed the inverse molecular sentinel (iMS) nanobiosensor, with surface-enhanced Raman scattering (SERS) detection...
May 21, 2020: Analyst
Barrett Boody, Jesse Caballero, Caleb Macadaeg, Robert Funk, Kevin Macadaeg
Sacroiliac (SI) joint pathology has been an increasingly discussed pathology as a potential etiology for significant low back and lower extremity pain. While patient history and examination maneuvers can assist with identifying the SI joint as a potential cause of pain, an intra-articular SI joint injection is critical to properly diagnose the SI joint as a clinically relevant pain generator. In addition to the diagnostic information from the injection, SI joint intra-articular injections can be performed for therapeutic benefit as part of a multi-modal, conservative treatment approach for SI joint pathology...
May 19, 2020: Clinical Spine Surgery
Maarten de Rooij, Bas Israël, Marcia Tummers, Hashim U Ahmed, Tristan Barrett, Francesco Giganti, Bernd Hamm, Vibeke Løgager, Anwar Padhani, Valeria Panebianco, Philippe Puech, Jonathan Richenberg, Olivier Rouvière, Georg Salomon, Ivo Schoots, Jeroen Veltman, Geert Villeirs, Jochen Walz, Jelle O Barentsz
OBJECTIVES: This study aims to define consensus-based criteria for acquiring and reporting prostate MRI and establishing prerequisites for image quality. METHODS: A total of 44 leading urologists and urogenital radiologists who are experts in prostate cancer imaging from the European Society of Urogenital Radiology (ESUR) and EAU Section of Urologic Imaging (ESUI) participated in a Delphi consensus process. Panellists completed two rounds of questionnaires with 55 items under three headings: image quality assessment, interpretation and reporting, and radiologists' experience plus training centres...
May 19, 2020: European Radiology
Kali S Thomas, Margot L Schwartz, Eric Boyd, Dolly P White, Angela B Mariotto, Michael J Barrett, Joan L Warren
BACKGROUND: This article describes characteristics of patients receiving home health following an initial cancer diagnosis, comparing those enrolled in Medicare Advantage (MA) and Traditional Medicare (TM), using the newly linked 2010-2014 National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER)-Medicare and home health Outcome and Assessment Information Set (OASIS) data. METHODS: We identified SEER-Medicare beneficiaries with at least one OASIS assessment within 3 months of cancer diagnosis in 2010-2014, and summarized their demographic and clinical characteristics...
May 1, 2020: Journal of the National Cancer Institute. Monographs
Mazen R Al-Mansour, Antonio Caycedo-Marulanda, Brian R Davis, Abdulrahim Alawashez, Salvatore Docimo, Alia Qureshi, Shawn Tsuda
BACKGROUND: Confocal laser endomicroscopy (CLE) is a novel endoscopic adjunct that allows real-time in vivo histological examination of mucosal surfaces. By using intravenous or topical fluorescent agents, CLE highlights certain mucosal elements that facilitate an optical biopsy in real time. CLE technology has been used in different organ systems including the gastrointestinal tract. There has been numerous studies evaluating this technology in gastrointestinal endoscopy, our aim was to evaluate the safety, value, and efficacy of this technology in the gastrointestinal tract...
May 13, 2020: Surgical Endoscopy
Jared Radbel, Sugeet Jagpal, Jason Roy, Andrew Brooks, Jay Tischfield, Michael Sheldon, Christian Bixby, Dana Witt, Maria Laura Gennaro, Daniel B Horton, Emily S Barrett, Jeffrey L Carson, Reynold A Panettieri, Martin J Blaser
As the COVID-19 pandemic sweeps across the world, the availability of viral transport media (VTM) has become severely limited, contributing to delays in diagnosis and rationing of diagnostic testing. Given that SARS-CoV-2 viral RNA has demonstrated stability, we posited that phosphate buffered saline (PBS) may be a viable transport medium, as an alternative to VTM), for clinical qPCR testing. We assessed the intra- and inter-individual reliability of SARS-CoV-2 qPCR in clinical endotracheal secretion samples transported in VTM or PBS, evaluating the stability of the RT-qPCR signal for three viral targets ( N gene , ORF1ab , and S gene ) when samples were stored in these media at room temperature for up to 18 hours...
May 13, 2020: Journal of Molecular Diagnostics: JMD
Emma L Hartley, Barnaby Sanderson, Francesco Vasques, Kathleen Jr Daly, Maria Lozinski, Nicholas A Barrett, Luigi Camporota
OBJECTIVE: The criteria and process for liberation from extracorporeal membrane oxygenation in patients with severe acute respiratory distress syndrome are not standardized. The predictive accuracy of the oxygen challenge test as a diagnostic test in determining weaning and decannulation from venovenous extracorporeal membrane oxygenation was tested. DESIGN: A single-centre, retrospective, observational cohort study. SETTING: Tertiary referral severe respiratory failure centre in a university hospital in the United Kingdom...
May 2020: Perfusion
Mohammad Karimian, Majid Salamati, Milad Azami
BACKGROUND: The relationship between metabolic syndrome (MetS) and Barrett's esophagus (BE) is still a challenging issue, and inconsistent results have been reported in different studies. Therefore, this study was conducted to determine the relationship between MetS and BE. METHODS: In this study, we followed the MOOSE protocol and results were reported according to the PRISMA guidelines. All study steps were performed independently by two authors. If necessary, the dispute was resolved by consultation with a third author...
May 6, 2020: BMC Gastroenterology
Loris Riccardo Lopetuso, Marco Severgnini, Silvia Pecere, Francesca Romana Ponziani, Ivo Boskoski, Alberto Larghi, Gianluca Quaranta, Luca Masucci, Gianluca Ianiro, Tania Camboni, Antonio Gasbarrini, Guido Costamagna, Clarissa Consolandi, Giovanni Cammarota
Preliminary studies suggested a possible correlation of microbiota with Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC), where the need for tools to ameliorate its poor prognosis is mandatory. We explored the potential signature of esophageal microbiota and its predicted functional profile along the continuous spectrum from BE to EAC. We analyzed through 16S-based amplicon sequencing the mucosal microbiota and the microbiota-related functional predictions in 10 BE and 6 EAC patients compared with 10 controls, exploring also potential differences between the metaplastic mucosa (BEM) and the adjacent normal areas of BE patients (BEU)...
2020: PloS One
Jens Krugmann, Corinna Lang Schwarz, Balint Melcher, William Sterlacci, Michael Vieth, Sophia Rösch, Johannes Lermann
BACKGROUND: Cytological analysis of ascitic fluid is an important tool for diagnosis, staging, and prognostic assessment in patients with cancer, but more detailed information is needed regarding malignancy rates and the time sequence in which ascites develops for different sites of cancer origin. Especially, an increased early tumor diagnosis may improve the acceptance for cytological examinations for the tumor patients in oncological practice. METHODS: Ascites specimens from patients who were treated at Bayreuth Hospital from 2006 to 2015 were reevaluated retrospectively and correlated with clinical reports...
April 28, 2020: Archives of Gynecology and Obstetrics
Sara L Rassoulian Barrett, Elizabeth A Holmes, Dustin R Long, Ryan C Shean, Gilbert E Bautista, Sumedha Ravishankar, Vikas Peddu, Brad T Cookson, Pradeep K Singh, Alexander L Greninger, Stephen J Salipante
Diagnostically informative microbial cell-free DNA (cfDNA) can be detected from blood plasma during fulminant infections such as sepsis. However, the potential for DNA from airway pathogens to enter the circulation of cystic fibrosis (CF) patients during chronic infective states has not yet been evaluated. We assessed whether patient blood contained measurable quantities of cfDNA from CF respiratory microorganisms by sequencing plasma from 21 individuals with CF recruited from outpatient clinics and 12 healthy controls...
April 23, 2020: Scientific Reports
Josef Weismüller, René Thieme, Albrecht Hoffmeister, Tobias Weismüller, Ines Gockel
Though showing an increasing incidence over the past 20 years, esophageal adenocarcinoma (EAC) remains a rather uncommon cancer (i. e., compared to colorectal and gastric cancer). Once detected, the prognosis of this cancer entity is still very poor. Hence, in spite of some unfavorable prerequisites to systematic screening, the development of a screening concept for Barrett's esophagus (BE) and EAC seems worthwhile. Nowadays, screening for BE and EAC is based on conventional endoscopy, mostly conducted individually in patients with reflux complaints (gastroesophageal reflux disease-GERD)...
April 2020: Laryngo- Rhino- Otologie
Keng Hoong Chiam, Seon Ho Shin, Kun Cheong Choi, Florencia Leiria, Mariana Militz, Rajvinder Singh
Recent advances in endoscopic imaging of the esophagus have revolutionized the diagnostic capability for detecting premalignant changes and early esophageal malignancy. In this article, we review the practical application of narrow-band imaging focusing on diseases of the esophagus, including Barrett's esophagus, adenocarcinoma, and squamous cell carcinoma.
April 22, 2020: Gut and Liver
Qiuyang Zhang, Ajay Bansal
Esophageal adenocarcinoma (EAC) continues to be a significant public health problem with survival rates that have remained stagnant. Although the population at the highest risk for EAC, i.e., patients with Barrett's esophagus (BE) has been clearly defined, patients with EAC continue to do poorly due to advanced stage at diagnosis. The field of extracellular vesicles (EV) could have huge application for the management of patients with BE and EAC by allowing timely diagnosis, serial monitoring, and improved understanding of disease biology...
April 10, 2020: Digestive Diseases and Sciences
Trevor Houston, Prateek Sharma
Barrett's esophagus (BE) is the condition where intestinal metaplastic changes are found in the normal stratified squamous epithelium of the esophagus predisposing an individual to dysplasia and esophageal adenocarcinoma (EAC). It tends to affect males and is often the result of chronic gastroesophageal reflux disease (GERD). The current standard of therapy for diagnosing Barrett's is white light endoscopy (WLE) with biopsies obtained using the Seattle protocol. Multiple newer advanced modalities have been developed to improve diagnostic abilities, including volumetric laser endomicroscopy (VLE)...
2020: Translational Gastroenterology and Hepatology
D W Koch, M F Barrett, B R Jackman, D MacDonald, L R Goodrich
AIMS: To compare the outcome, in terms of lameness score or return to athletic function, of horses with acute vs. chronic digital lameness that underwent magnetic resonance imaging (MRI) of the distal limb and to compare the proportion of horses that received intra-articular therapy of the distal interphalangeal (DIP) joint and pattern of diagnostic analgesia in these groups. METHODS: This is a retrospective study of horses (n=95) with acute (≤12 weeks; n=46) or chronic (>12 weeks; n=49) digital lameness that underwent MRI of the distal limb from 2009-2016, at two equine referral centres in the USA...
April 5, 2020: New Zealand Veterinary Journal
Michael Quante, Julia Slotta Huspenina, Mohamed Abdelhafez
PATHOGENESIS:  Adenocarcinomas of the esophagus are very similar to those of the stomach and most likely develop in the gastric cardia, from where proliferating cells expand into the esophagus and form benign Barrett's mucosa. An additional genomic instability leads to the clonal evolution of certain cells, which can lead to the development of adenocarcinoma. RISK FACTORS:  A clear definition of factors is urgently needed for better risk stratification and the establishment of preventive strategies...
April 2020: Deutsche Medizinische Wochenschrift
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