Daina Martínez-Falguera, Júlia Aranyó, Albert Teis, Gemma Ferrer-Curriu, Marta Monguió-Tortajada, Edgar Fadeuilhe, Oriol Rodríguez-Leor, Idoia Díaz-Güemes, Santiago Roura, Roger Villuendas, Axel Sarrias, Victor Bazan, Victoria Delgado, Antoni Bayes-Genis, Felipe Bisbal, Carolina Gálvez-Montón
BACKGROUND: Sacubitril/valsartan (Sac/Val) is superior to angiotensin-converting enzyme inhibitors in reducing the risk of heart failure hospitalization and cardiovascular death, but its mechanistic data on myocardial scar after myocardial infarction (MI) are lacking. The objective of this work was to assess the effects of Sac/Val on inflammation, fibrosis, electrophysiological properties, and ventricular tachycardia inducibility in post-MI scar remodeling in swine. METHODS: After MI, 22 pigs were randomized to receive β-blocker (BB; control, n=8) or BB+Sac/Val (Sac/Val, n=9)...
April 26, 2024: Circulation. Arrhythmia and Electrophysiology