keyword
https://read.qxmd.com/read/38499995/bone-endosteal-mimics-regulates-breast-cancer-development-and-phenotype
#21
JOURNAL ARTICLE
Noa Ben Ghedalia Peled, Dane K Hoffman, Livnat Barsky, Noy S Zer, Katya Amar, Hanna Rapaport, Levi A Gheber, Xiang H-F Zhang, Razi Vago
Bone is a frequent site for metastatic development in various cancer types, including breast cancer, with a grim prognosis due to the distinct bone environment. Despite considerable advances, our understanding of the underlying processes leading to bone metastasis progression remains elusive. Here, we applied a bioactive three-dimensional (3D) model capable of mimicking the endosteal bone microenvironment. MDA-MB-231 and MCF7 breast cancer cells were cultured on the scaffolds, and their behaviors and the effects of the biomaterial on the cells were examined over time...
March 18, 2024: Biomacromolecules
https://read.qxmd.com/read/38499398/covalent-adaptable-networks-with-tailorable-material-properties-based-on-divanillin-polyimines
#22
JOURNAL ARTICLE
Noé Fanjul-Mosteirín, Karin Odelius
Covalent adaptable networks (CANs) are being developed as future replacements for thermosets as they can retain the high mechanical and chemical robustness inherent to thermosets but also integrate the possibility of reprocessing after material use. Here, covalent adaptable polyimine-based networks were designed with methoxy and allyloxy-substituted divanillin as a core component together with long flexible aliphatic fatty acid-based amines and a short rigid chain triamine, yielding CANs with a high renewable content...
March 18, 2024: Biomacromolecules
https://read.qxmd.com/read/38492706/a-data-mining-approach-to-analyze-the-role-of-biomacromolecules-based-nanocomposites-in-sustainable-packaging
#23
JOURNAL ARTICLE
John Paul, Jeeja Jacob, Md Mahmud, Mahesh Vaka, Syam G Krishnan, A Arifutzzaman, Dignesh Thesiya, Teng Xiong, K Kadirgama, Jeyraj Selvaraj
Recent decades have witnessed a surge in research interest in bio-nanocomposite-based packaging materials, but still, a lack of systematic analysis exists in this domain. Bio-based packaging materials pose a sustainable alternative to petroleum-based packaging materials. The current work employs bibliometric analysis to deliver a comprehensive outline on the role of bio nanocomposites in packaging. India, Iran, and China were revealed to be the top three nations actively engaged in this domain in total publications...
March 14, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38490188/polysaccharide-aldehydes-and-ketones-synthesis-and-reactivity
#24
REVIEW
Zhenghao Zhai, Kevin J Edgar
Polysaccharides are biodegradable, abundant, sustainable, and often benign natural polymers. The achievement of selective modification of polysaccharides is important for targeting specific properties and structures and will benefit future development of highly functional, sustainable materials. The synthesis of polysaccharides containing aldehyde or ketone moieties is a promising tool for achieving this goal because of the rich chemistry of aldehyde or ketone groups, including Schiff base formation, nucleophilic addition, and reductive amination...
March 15, 2024: Biomacromolecules
https://read.qxmd.com/read/38485470/eumelanin-like-poly-levodopa-nanoscavengers-for-inflammation-disease-therapy
#25
JOURNAL ARTICLE
Xianheng Wang, Jianhua Zhang, Lei Yang, Tianyou Wang, Gaigai Duan, Zhipeng Gu, Yiwen Li
In the current years, polydopamine nanoparticles (PDA NPs) have been extensively investigated as an eumelanin mimic. However, unlike natural eumelanin, PDA NPs contain no 5,6-dihydroxyindole-2-carboxylic acid (DHICA)-derived units and may be limited in certain intrinsic properties; superior eumelanin-like nanomaterials are still actively being sought. Levodopa ( l -DOPA) is a natural eumelanin precursor and expected to convert into DHICA and further remain within the final product through covalent or physical interactions...
March 14, 2024: Biomacromolecules
https://read.qxmd.com/read/38484154/genetically-fused-resilin-like-polypeptide-coiled-coil-bundlemer-conjugates-exhibit-tunable-multistimuli-responsiveness-and-undergo-nanofibrillar-assembly
#26
JOURNAL ARTICLE
Sai S Patkar, Yao Tang, Tianren Zhang, Arriana M Bisram, Jeffery G Saven, Darrin J Pochan, Kristi L Kiick
Peptide-based materials are diverse candidates for self-assembly into modularly designed and stimuli-responsive nanostructures with precisely tunable compositions. Here, we genetically fused computationally designed coiled coil-forming peptides to the N- and C-termini of compositionally distinct multistimuli-responsive resilin-like polypeptides (RLPs) of various lengths. The successful expression of these hybrid polypeptides in bacterial hosts was confirmed through techniques such as gel electrophoresis, mass spectrometry, and amino acid analysis...
March 14, 2024: Biomacromolecules
https://read.qxmd.com/read/38483111/polydopamine-coated-silk-fiber-with-controllable-length-for-enhanced-hemostatic-application
#27
JOURNAL ARTICLE
Junha Hwang, Pilseon Im, Min Kyung Kim, Jaeyun Kim
The development of highly effective hemostatic materials with high biocompatibility and outstanding performance is vital to the field of biomaterials. In this study, we develop a hemostatic fiber material that exhibits high biocompatibility and excellent performance. By incorporating polydopamine (PDA) into the alkaline treatment of silk fibroin (SF), we achieve PDA-coated SF fibers with lengths that can be controlled by the alkaline concentration. The PDA coating significantly enhances the hemostatic ability of the silk fibers and exhibits superior performance in both in vitro and ex vivo experiments...
March 14, 2024: Biomacromolecules
https://read.qxmd.com/read/38478850/redox-regulated-in-situ-seed-induced-assembly-of-peptides
#28
JOURNAL ARTICLE
Xiaowei Mo, Jinyan Song, Xin Liu, Ruo-Chen Guo, Binbin Hu, Zhilin Yu
Morphology-transformational self-assembly of peptides allows for manipulation of the performance of nanostructures and thereby advancing the development of biomaterials. Acceleration of the morphological transformation process under a biological microenvironment is important to efficiently implement the tailored functions in living systems. Herein, we report redox-regulated in situ seed-induced assembly of peptides via design of two co-assembled bola-amphiphiles serving as a redox-resistant seed and a redox-responsive assembly monomer, respectively...
March 13, 2024: Biomacromolecules
https://read.qxmd.com/read/38478587/precision-loading-and-delivery-of-molecular-cargo-by-size-controlled-coacervation-of-gold-nanoparticles-functionalized-with-elastin-like-peptides
#29
JOURNAL ARTICLE
Yifeng Cai, Nada Y Naser, Jinrong Ma, François Baneyx
Thermoresponsive elastin-like peptides (ELPs) have been extensively investigated in biotechnology and medicine, but little attention has been paid to the process by which coacervation causes ELP-decorated particles to aggregate. Using gold nanoparticles (AuNPs) functionalized with a cysteine-terminated 96-repeat of the VPGVG sequence (V96-Cys), we show that the size of the clusters that reversibly form above the ELP transition temperature can be finely controlled in the 250 to 930 nm range by specifying the concentration of free V96-Cys in solution and using AuNPs of different sizes...
March 13, 2024: Biomacromolecules
https://read.qxmd.com/read/38478586/regulation-of-photophysical-behaviors-in-hyperbranched-aggregation-induced-emission-polymers-for-reactive-oxygen-species-scavenging
#30
JOURNAL ARTICLE
Yan Zhao, Lei Xu, Zhixuan Feng, Sha Yin, Weixu Feng, Hongxia Yan
Developing nonconjugated materials with large Stokes shifts is highly desired. In this work, three kinds of hyperbranched aggregation-induced emission (AIE) polymers with tunable n/π electronic effects were synthesized. HBPSi-CBD contains alkenyl groups in the backbone and possesses a promoted n-π* transition and red-shifted emission wavelength with a large Stokes shift of 186 nm. Experiments and theoretical simulations confirmed that the planar π electrons in the backbone are responsible for the red-shifted emission due to the strong through-space n···π interactions and restricted backbone motions...
March 13, 2024: Biomacromolecules
https://read.qxmd.com/read/38476284/polymersomes-for-therapeutic-protein-and-peptide-delivery-towards-better-loading-properties
#31
REVIEW
Chengxu Hua, Liyan Qiu
Therapeutics based on proteins and peptides have profoundly transformed the landscape of treatment for diseases, from diabetes mellitus to cancers, yet the short half-life and low bioavailability of therapeutic proteins and peptides hinder their wide applications. To break through this bottleneck, biomolecules-loaded polymersomes with strong adjustability and versatility have attracted more and more attentions recently. Loading proteins or peptides into polymersomes is the first but extremely important step towards developing high-quality formulation products...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38474451/volatile-compound-markers-in-beef-irradiated-with-accelerated-electrons
#32
JOURNAL ARTICLE
Ulyana Bliznyuk, Polina Borshchegovskaya, Timofey Bolotnik, Victoria Ipatova, Aleksandr Kozlov, Alexander Nikitchenko, Irina Mezhetova, Alexander Chernyaev, Igor Rodin, Elena Kozlova
This study focuses on the behavior of volatile organic compounds in beef after irradiation with 1 MeV accelerated electrons with doses ranging from 0.25 kGy to 5 kGy to find reliable dose-dependent markers that could be used for establishing an effective dose range for beef irradiation. GC/MS analysis revealed that immediately after irradiation, the chemical yield and accumulation rate of lipid oxidation-derived aldehydes was higher than that of protein oxidation-derived aldehydes. The nonlinear dose-dependent relationship of the concentration of volatile organic compounds was explained using a mathematical model based on the simultaneous occurrence of two competing processes: decomposition of volatile compounds due to direct and indirect action of accelerated electrons, and accumulation of volatile compounds due to decomposition of other compounds and biomacromolecules...
February 21, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38471518/smart-electrospun-nanofibers-from-short-peptidomimetics-based-on-pyrrolo-pyrazole-scaffold
#33
JOURNAL ARTICLE
Enrica Chiesa, Francesca Clerici, Raffaella Bucci, Francesco Anastasi, Matteo Bottiglieri, Maddalena Patrini, Ida Genta, Alexander M Bittner, M Luisa Gelmi
We prepared a small library of short peptidomimetics based on 3-pyrrolo-pyrazole carboxylate, a non-coded γ-amino acid, and glycine or alanine. The robust and eco-friendly synthetic approach adopted allows to obtain the dipeptides in two steps from commercial starting materials. This gives the possibility to shape these materials by electrospinning into micro- and nanofibers, in amounts required to be useful for coating surfaces of biomedical relevance. To promote high quality of electrospun fibers, different substitution patterns were evaluated, all for pure peptide fibers, free of any polymer or additive...
March 12, 2024: Biomacromolecules
https://read.qxmd.com/read/38460522/engineering-functional-materials-through-bacteria-assisted-living-grafting
#34
JOURNAL ARTICLE
Runtao Zhu, Jiao Zhang, Lin Wang, Yunfeng Zhang, Yang Zhao, Ying Han, Jing Sun, Xi Zhang, Ying Dou, Huaxiong Yao, Wei Yan, Xiaozhou Luo, Junbiao Dai, Zhuojun Dai
Functionalizing materials with biomacromolecules such as enzymes has broad applications in biotechnology and biomedicine. Here, we introduce a grafting method mediated by living cells to functionalize materials. We use polymeric scaffolds to trap engineered bacteria and micron-sized particles with chemical groups serving as active sites for grafting. The bacteria synthesize the desired protein for grafting and autonomously lyse to release it. The released functional moieties are locally grafted onto the active sites, generating the materials engineered by living grafting (MELGs)...
March 5, 2024: Cell Systems
https://read.qxmd.com/read/38457661/multifunctional-hydrogel-enhances-inflammatory-control-antimicrobial-activity-and-oxygenation-to-promote-healing-in-infectious-wounds
#35
JOURNAL ARTICLE
Yunfeng Tang, Renliang Zhao, Min Yi, Zilu Ge, Dong Wang, Guanglin Wang, Xiangtian Deng
Chronic infected wounds often fail to heal through normal repair mechanisms, and the persistent response of reactive oxygen species (ROS) and inflammation is a major contributing factor to the difficulty in their healing. In this context, we developed an ROS-responsive injectable hydrogel. This hydrogel is composed of ε-polylysine grafted (EPL) with caffeic acid (CA) and hyaluronic acid (HA) grafted with phenylboronic acid (PBA). Before the gelation process, a mixture CaO2 @Cur-PDA (CCP) consisting of calcium peroxide (CaO2 ) coated with polydopamine (PDA) and curcumin (Cur) is embedded into the hydrogel...
March 8, 2024: Biomacromolecules
https://read.qxmd.com/read/38457653/postpolymerization-modification-of-poly-2-vinyl-4-4-dimethyl-azlactone-as-a-versatile-strategy-for-drug-conjugation-and-stimuli-responsive-release
#36
JOURNAL ARTICLE
Sk Arif Mohammad, Veeresh B Toragall, Alex Fortenberry, Oluwaseyi Shofolawe-Bakare, Suresh Sulochana, Katie Heath, Iyanuoluwani Owolabi, Garrett Tassin, Alex S Flynt, Adam E Smith, Thomas Werfel
Postpolymerization modification of highly defined "scaffold" polymers is a promising approach for overcoming the existing limitations of controlled radical polymerization such as batch-to-batch inconsistencies, accessibility to different monomers, and compatibility with harsh synthesis conditions. Using multiple physicochemical characterization techniques, we demonstrate that poly(2-vinyl-4,4-dimethyl azlactone) (PVDMA) scaffolds can be efficiently modified with a coumarin derivative, doxorubicin, and camptothecin small molecule drugs...
March 8, 2024: Biomacromolecules
https://read.qxmd.com/read/38456841/benchmarking-the-humidity-dependent-mechanical-response-of-nano-fibrillated-cellulose-and-dissolved-polysaccharides-as-sustainable-sand-amendments
#37
JOURNAL ARTICLE
M-Haidar A Dali, Roozbeh Abidnejad, Mohamed Hamid Salim, Mamata Bhattarai, Monireh Imani, Orlando J Rojas, Luiz G Greca, Blaise L Tardy
Soil quality is one of the main limiting factor in the development of the food sector in arid areas, mainly due to its poor mechanics and lack of water retention. Soil's organic carbon is nearly absent in arid soils, though it is important for water and nutrient transport, to soil mechanics, to prevent erosion, and as a long-term carbon sink. In this study, we evaluate the potential benefits that are brought to inert sand by the incorporation of a range of, mainly, cellulosic networks in their polymeric or structured (fiber) forms, analogously to those found in healthy soils...
March 8, 2024: Biomacromolecules
https://read.qxmd.com/read/38456765/irradiation-behavior-of-analgesic-and-nonsteroidal-anti-inflammatory-drug-loaded-uhmwpe-for-joint-replacement
#38
JOURNAL ARTICLE
Sashank Lekkala, Nicoletta Inverardi, Scott C Grindy, Shannon Hugard, Orhun K Muratoglu, Ebru Oral
Local delivery of pain medication can be a beneficial strategy to address pain management after joint replacement, as it can decrease systemic opioid usage, leading to less side and long-term effects. In this study, we used ultrahigh molecular weight polyethylene (UHMWPE), commonly employed as a bearing material for joint implants, to deliver a wide set of analgesics and the nonsteroidal anti-inflammatory drug tolfenamic acid. We blended the drugs with UHMWPE and processed the blend by compression molding and sterilization by low-dose gamma irradiation...
March 8, 2024: Biomacromolecules
https://read.qxmd.com/read/38456398/dual-modified-hyaluronic-acid-for-tunable-double-cross-linked-hydrogel-adhesives
#39
JOURNAL ARTICLE
Cameron Milne, Rijian Song, Melissa Johnson, Chunyu Zhao, Francesca Santoro Ferrer, Sigen A, Jing Lyu, Wenxin Wang
Conventional techniques for the closure of wounds, such as sutures and staples, have significant drawbacks that can negatively impact wound healing. Tissue adhesives have emerged as promising alternatives, but poor adhesion, low mechanical properties, and toxicity have hindered their widespread clinical adoption. In this work, a dual modified, aldehyde and methacrylate hyaluronic acid (HA) biopolymer (HA-MA-CHO) has been synthesized through a simplified route for use as a double cross-linked network (DCN) hydrogel (HA-MA-CHO-DCN) adhesive for the effective closure and sealing of wounds...
March 8, 2024: Biomacromolecules
https://read.qxmd.com/read/38454747/sweet-janus-particles-multifunctional-inhibitors-of-carbohydrate-based-bacterial-adhesion
#40
JOURNAL ARTICLE
Serap Üclü, Claudia Marschelke, Felictas Drees, Markus Giesler, Dimitri Wilms, Thorben Köhler, Stephan Schmidt, Alla Synytska, Laura Hartmann
Escherichia coli and other bacteria use adhesion receptors, such as FimH, to attach to carbohydrates on the cell surface as the first step of colonization and infection. Efficient inhibitors that block these interactions for infection treatment are multivalent carbohydrate-functionalized scaffolds. However, these multivalent systems often lead to the formation of large clusters of bacteria, which may pose problems for clearing bacteria from the infected site. Here, we present Man-containing Janus particles (JPs) decorated on one side with glycomacromolecules to target Man-specific adhesion receptors of E...
March 7, 2024: Biomacromolecules
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