keyword
https://read.qxmd.com/read/38547378/a-biodegradable-janus-sponge-for-negative-pressure-wound-therapy
#1
JOURNAL ARTICLE
Lei Tang, Zhaoyuan Guo, Quan Zhao, Xi Fan, Yuji Pu, Bin He, Jianlin Chen
Negative pressure wound therapy (NPWT) is effective in repairing serious skin injury. The dressing used in the NPWT is important for wound healing. In this paper, we develop biodegradable amphiphilic polyurethanes (PUs) and fabricate the PUs into sponges as wound dressings (Bi@e ) with Janus pore architectures for NPWT. The Bi@e is adaptive to all the stages of the wound healing process. The Janus Bi@e sponge consists of two layers: the dense hydrophobic upper layer with small pores provides protection and support during negative pressure drainage, and the loose hydrophilic lower layer with large pores absorbs large amounts of wound exudate and maintains a moist environment...
March 28, 2024: Biomacromolecules
https://read.qxmd.com/read/38546162/controlled-release-of-drugs-from-extracellular-matrix-derived-peptide-based-nanovesicles-through-tailored-noncovalent-interactions
#2
JOURNAL ARTICLE
Haofu Huang, Jeongmin Hwang, Sudha Anilkumar, Kristi L Kiick
Elastin-collagen nanovesicles (ECnV) have emerged as a promising platform for drug delivery due to their tunable physicochemical properties and biocompatibility. The potential of nine distinct ECnVs to serve as drug-delivery vehicles was investigated in this study, and it was demonstrated that various small-molecule cargo (e.g., dexamethasone, methotrexate, doxorubicin) can be encapsulated in and released from a set of ECnVs, with extents of loading and rates of release dictated by the composition of the elastin domain of the ECnV and the type of cargo...
March 28, 2024: Biomacromolecules
https://read.qxmd.com/read/38542191/intradermal-injection-of-hybrid-complexes-of-high-and-low-molecular-weight-hyaluronan-where-do-we-stand-and-where-are-we-headed-in-regenerative-medicine
#3
REVIEW
Dalvi Humzah, Beatriz Molina, Giovanni Salti, Clara Cigni, Gilberto Bellia, Franco Grimolizzi
Hyaluronic acid (HA) is a remarkably multifaceted biomacromolecule, playing a role in regulating myriad biological processes such as wound healing, tissue regeneration, anti-inflammation, and immunomodulation. Crosslinked high- and low-molecular-weight hyaluronic acid hydrogels achieve higher molar concentrations, display slower degradation, and allow optimal tissue product diffusion, while harnessing the synergistic contribution of different-molecular-weight hyaluronans. A recent innovation in the world of hyaluronic acid synthesis is represented by NAHYCO® Hybrid Technology, a thermal process leading to hybrid cooperative hyaluronic acid complexes (HCC)...
March 12, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38533630/strongly-adhesive-self-healing-hemostatic-hydrogel-for-the-repair-of-traumatic-brain-injury
#4
JOURNAL ARTICLE
Zuoxiang Dong, Jihu Zhao, Jian Xu, Wenshuai Deng, Peng Sun
With wide clinical demands, therapies for traumatic brain injury (TBI) are a major problem in surgical procedures and after major trauma. Due to the difficulty in regeneration of neurons or axons after injury, as well as the inhibition of blood vessel growth by the formation of neural scars, existing treatment measures have limited effectiveness in repairing brain tissue. Herein, the biomultifunctional hydrogels are developed for TBI treatment based on the Schiff base reaction of calcium ion (Ca2+ )-cross-linked oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS)...
March 27, 2024: Biomacromolecules
https://read.qxmd.com/read/38531529/molecularly-imprinted-polymers-for-sensing-depleting-human-serum-albumin-hsa-a-critical-review-of-recent-advances-and-current-challenges
#5
REVIEW
Ali Jahanban-Esfahlan, Ryszard Amarowicz
Human serum albumin (HSA) is an essential biomacromolecule in the blood circulatory system because it carries numerous molecules, including fatty acids (FAs), bilirubin, metal ions, hormones, and different pharmaceuticals, and plays a significant role in regulating blood osmotic pressure. Fluctuations in HSA levels in human biofluids, particularly urine and serum, are associated with several disorders, such as elevated blood pressure, diabetes mellitus (DM), liver dysfunction, and a wide range of renal diseases...
March 24, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38530873/functional-polyphenol-based-nanoparticles-boosted-the-neuroprotective-effect-of-riluzole-for-acute-spinal-cord-injury
#6
JOURNAL ARTICLE
Taoyang Yuan, Tianyou Wang, Jianhua Zhang, Feng Ye, Zhipeng Gu, Yiwen Li, Jianguo Xu
Riluzole is commonly used as a neuroprotective agent for treating traumatic spinal cord injury (SCI), which works by blocking the influx of sodium and calcium ions and reducing glutamate activity. However, its clinical application is limited because of its poor solubility, short half-life, potential organ toxicity, and insufficient bioabilities toward upregulated inflammation and oxidative stress levels. To address this issue, epigallocatechin gallate (EGCG), a natural polyphenol, was employed to fabricate nanoparticles (NPs) with riluzole to enhance the neuroprotective effects...
March 26, 2024: Biomacromolecules
https://read.qxmd.com/read/38529803/releasing-free-radicals-in-precursor-triggers-the-formation-of-closed-pores-in-hard-carbon-for-sodium-ion-batteries
#7
JOURNAL ARTICLE
Yilin Wang, Zonglin Yi, Lijing Xie, Yixuan Mao, Wenjun Ji, Zhanjun Liu, Xianxian Wei, Fangyuan Su, Cheng-Meng Chen
Increasing closed pore volume in hard carbon is considered to be the most effective way to enhance the electrochemical performance in sodium-ion batteries. However, there lack of systematic insights into the formation mechanisms of closed pores at molecular level. In this study, a regulation strategy of closed pores via adjustment of the content of free radicals is reported. Sufficient free radicals are exposed by part delignification of bamboo, which is related to the formation of well-developed carbon layers and rich closed pores...
March 26, 2024: Advanced Materials
https://read.qxmd.com/read/38527924/photopolymerizable-and-antibacterial-hydrogels-loaded-with-metabolites-from-lacticaseibacillus-rhamnosus-gg-for-infected-wound-healing
#8
JOURNAL ARTICLE
Yanting Han, Zhe Yin, Yilin Wang, Yuanzhang Jiang, Jianming Chen, Zhonghua Miao, Fang He, Ruyue Cheng, Lin Tan, Ka Li
In response to increasing antibiotic resistance and the pressing demand for safer infected wound care, probiotics have emerged as promising bioactive agents. To address the challenges associated with the safe and efficient application of probiotics, this study successfully loaded metabolites from Lacticaseibacillus rhamnosus GG (LGG) into a gelatin cross-linked macromolecular network by an in situ blending and photopolymerization method. The obtained LM-GelMA possesses injectability and autonomous healing capabilities...
March 25, 2024: Biomacromolecules
https://read.qxmd.com/read/38527723/anaerobic-membrane-bioreactor-coupled-with-polyaluminum-chloride-for-high-strength-phenolic-wastewater-treatment-robust-performance-and-potential-mechanisms
#9
JOURNAL ARTICLE
Chao Pang, Shun Wang, Chunhua He, Mengqi Zheng, Wei Wang
Anaerobic digestion of phenolic wastewater by anaerobic membrane bioreactor (AnMBR) has revealed increasing attractiveness, but the application of AnMBRs for treating high-strength phenolic wastewater faces challenges related to elevated phenol stress and membrane fouling. In this study, the coupling of AnMBR and polyaluminum chloride (PAC) was developed for efficient treatment of high-strength phenolic wastewater. The system achieved robust removal efficiencies of phenol (99%) and quinoline (98%) at a gradual increase of phenol concentration from 1000 to 5000 mg/L and a constant quinoline concentration of 100 mg/L...
March 23, 2024: Environmental Research
https://read.qxmd.com/read/38525818/naturally-derived-injectable-dual-cross-linked-adhesive-hydrogel-for-acute-hemorrhage-control-and-wound-healing
#10
JOURNAL ARTICLE
Ziran Zhu, Huijun Ye, Kaiwen Zhang, Gang He, Zheng Pan, Yiwen Xian, Yu Yang, Chong Zhang, Decheng Wu
Developing biocompatible injectable hydrogels with high mechanical strength and rapid strong tissue adhesion for hemostatic sealing of uncontrolled bleeding remains a prevailing challenge. Herein, we engineer an injectable and photo-cross-linkable hydrogel based on naturally derived gelatin methacrylate (GelMA) and N -hydroxysuccinimide-modified poly(γ-glutamic acid) (γPGA-NHS). The chemically dual-cross-linked hydrogel rapidly forms after UV light irradiation and covalently bonds to the underlying tissue to provide robust adhesion...
March 25, 2024: Biomacromolecules
https://read.qxmd.com/read/38525550/versatile-triblock-peptide-self-assembly-system-to-mimic-collagen-structure-and-function
#11
JOURNAL ARTICLE
Linyan Yao, Biyang Ling, Wenjie Huang, Shuangni Shi, Jianxi Xiao
The construction of collagen mimetic peptides has been a hot topic in tissue engineering due to their attractive advantages, such as virus-free nature and low immunogenicity. However, all of the reported self-assembled peptides rely on the inclusion of risky elements of potential safety concerns or lack the capability of incorporating critical functional motifs. A versatile self-assembly design of pure synthetic peptides that can mimic the collagen structure and function remains an insurmountably challenging target...
March 25, 2024: Biomacromolecules
https://read.qxmd.com/read/38525496/correction-to-fibrin-dextran-hydrogels-with-tunable-porosity-and-mechanical-properties
#12
Shannon Anna Jung, Hanna Malyaran, Dan Eugen Demco, Anna Manukanc, Leonie Sophie Häser, Vytautas Kučikas, Marc van Zandvoort, Sabine Neuss, Andrij Pich
No abstract text is available yet for this article.
March 25, 2024: Biomacromolecules
https://read.qxmd.com/read/38523444/advances-in-polysaccharides-for-cartilage-tissue-engineering-repair-a-review
#13
REVIEW
Heng An, Meng Zhang, Zhen Gu, Xiangyu Jiao, Yinglei Ma, Zhe Huang, Yongqiang Wen, Yaozhong Dong, Peixun Zhang
Cartilage repair has been a significant challenge in orthopedics that has not yet been fully resolved. Due to the absence of blood vessels and the almost cell-free nature of mature cartilage tissue, the limited ability to repair cartilage has resulted in significant socioeconomic pressures. Polysaccharide materials have recently been widely used for cartilage tissue repair due to their excellent cell loading, biocompatibility, and chemical modifiability. They also provide a suitable microenvironment for cartilage repair and regeneration...
March 24, 2024: Biomacromolecules
https://read.qxmd.com/read/38522209/formation-of-sb-2-o-3-microcrystals-by-rhodotorula-mucilaginosa
#14
JOURNAL ARTICLE
Linping Yang, Aijiang Yang, Liyan Song, Wen Cui, Wanping Bian, Aping Niu, Peng Xu, Shouyang He, Shixue Mei, Xianrong Shi
Antimony (Sb) pollution seriously endangers ecological environment and human health. Microbial induced mineralization can effectively convert metal ions into more stable and less soluble crystalline minerals by extracellular polymeric substance (EPS). In this study, an efficient Sb-resistant Rhodotorula mucilaginosa (R. mucilaginosa) was screened, which can resist 41 mM Sb(III) and directly transform Sb(III) into Sb2 O3 microcrystals by EPS. The removal efficiency of R. mucilaginosa for 22 mM Sb(III) reached 70% by converting Sb(III) to Sb2 O3 ...
March 20, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38518950/a-comprehensive-review-on-the-inherent-and-enhanced-antifouling-mechanisms-of-hydrogels-and-their-applications
#15
REVIEW
Junting Cui, Lan Liu, Beiyue Chen, Jiayi Hu, Mengyao Song, Hongliang Dai, Xingang Wang, Hongya Geng
Biofouling remains a persistent challenge within the domains of biomedicine, tissue engineering, marine industry, and membrane separation processes. Multifunctional hydrogels have garnered substantial attention due to their complex three-dimensional architecture, hydrophilicity, biocompatibility, and flexibility. These hydrogels have shown notable advances across various engineering disciplines. The antifouling efficacy of hydrogels typically covers a range of strategies to mitigate or inhibit the adhesion of particulate matter, biological entities, or extraneous pollutants onto their external or internal surfaces...
March 20, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38514378/producing-cellulose-microfibrils-at-a-high-solid-content-with-and-without-mechanical-or-enzymatic-pretreatment
#16
JOURNAL ARTICLE
Xiaoxue Zhang, Daniel J Yelle, Peter Kitin, Guolin Tong, J Y Zhu
This study conducted a detailed evaluation of the feasibility of producing cellulose microfibrils (CMF) from a kraft-bleached hardwood pulp at high solid contents with and without pretreatments. CMFs produced by planetary ball milling at solid contents 17 and 28% were compared with those from 1 to 5% under the same milling conditions. Fiber pretreatments using a commercial endoglucanase and mechanical refining using a laboratory PFI mill were also applied before ball milling at a solid content of 28%. Two mechanisms of fiber fibrillation were identified from the results obtained: (i) ball and fiber/fibril interactions─the primary mechanism and (ii) interfiber/fibril frictional and tensional interactions─the secondary mechanism...
March 21, 2024: Biomacromolecules
https://read.qxmd.com/read/38511068/rationalized-landscape-on-protein-based-cancer-nanomedicine-recent-progress-and-challenges
#17
REVIEW
Zhechen Fan, Haroon Iqbal, Jiang Ni, Naveed Ullah Khan, Shahla Irshad, Anam Razzaq, Mohammad Y Alfaifi, Serag Eldin I Elbehairi, Ali A Shati, Jianping Zhou, Hao Cheng
The clinical advancement of protein-based nanomedicine has revolutionized medical professionals' perspectives on cancer therapy. Protein-based nanoparticles have been exploited as attractive vehicles for cancer nanomedicine due to their unique properties derived from naturally biomacromolecules with superior biocompatibility and pharmaceutical features. Furthermore, the successful translation of Abraxane™ (paclitaxel-based albumin nanoparticles) into clinical application opened a new avenue for protein-based cancer nanomedicine...
June 2024: International journal of pharmaceutics: X
https://read.qxmd.com/read/38508219/tuning-molecular-motion-enhances-intrinsic-fluorescence-in-peptide-amphiphile-nanofibers
#18
JOURNAL ARTICLE
Natchayaporn Sindhurattavej, Shreya Jampana, Mai Phuong Pham, Leonardo C Romero, Anna Grace Rogers, Griffin A Stevens, Whitney C Fowler
Peptide amphiphiles (PAs) are highly tunable molecules that were recently found to exhibit aggregation-induced emission (AIE) when they self-assemble into nanofibers. Here, we leverage decades of molecular design and self-assembly study of PAs to strategically tune their molecular motion within nanofibers to enhance AIE, making them a highly useful platform for applications such as sensing, bioimaging, or materials property characterization. Since AIE increases when aggregated molecules are rigidly and closely packed, we altered the four most closely packed amino acids nearest to the hydrophobic core by varying the order and composition of glycine, alanine, and valine pairs...
March 20, 2024: Biomacromolecules
https://read.qxmd.com/read/38507816/gelatin-methacryloyl-gelma-based-biomaterial-inks-process-science-for-3d-4d-printing-and-current-status
#19
REVIEW
Soumitra Das, Jeyapriya Thimukonda Jegadeesan, Bikramjit Basu
Tissue engineering for injured tissue replacement and regeneration has been a subject of investigation over the last 30 years, and there has been considerable interest in using additive manufacturing to achieve these goals. Despite such efforts, many key questions remain unanswered, particularly in the area of biomaterial selection for these applications as well as quantitative understanding of the process science. The strategic utilization of biological macromolecules provides a versatile approach to meet diverse requirements in 3D printing, such as printability, buildability, and biocompatibility...
March 20, 2024: Biomacromolecules
https://read.qxmd.com/read/38507559/controlling-the-nematic-liquid-crystallinity-of-cellulose-nanocrystals-with-an-alcohol-ethoxy-sulfonate-surfactant
#20
JOURNAL ARTICLE
Johanna Majoinen, Lotta Gustavsson, Owies Wani, Samira Kiefer, Ville Liljeström, Orlando J Rojas, Patrice Rannou, Olli Ikkala
Cellulose nanocrystals (CNCs) are biobased colloidal nanorods that have unlocked new opportunities in the area of sustainable functional nanomaterials including structural films and coatings, biomedical devices, energy, sensing, and composite materials. While selective light reflection and sensing develop from the typical chiral nematic (cholesteric, Nem*) liquid crystallinity exhibited by CNCs, a wealth of technologies would benefit from a nematic liquid crystal (LC) with CNC uniaxial alignment. Therefore, this study answers the central question of whether surfactant complexation suppresses CNC chirality in favor of nematic lyotropic and thermotropic liquid crystallinity...
March 20, 2024: Biomacromolecules
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