Naren V Siva, Peter R Reynolds
AIM: This study reviews clinical outcomes after initiating a routine policy of preterm respiratory stabilisation using nasal High Flow (HF) in the delivery room (DR). METHOD: This was a retrospective observational cohort study in a single centre neonatal intensive care unit and included all neonates born before 32 weeks gestation between April 1st 2015 and March 31st 2020. Stabilisation measures and outcomes were recorded including oxygen requirements, admission temperature, surfactant administration, invasive ventilation within 72 hours of birth, bronchopulmonary dysplasia (BPD) and death...
February 27, 2021: Acta Paediatrica
Alyssa M Bamer, Kara McMullen, Steven E Wolf, Barclay T Stewart, Lewis Kazis, Camerin A Rencken, Dagmar Amtmann
PURPOSE: To examine agreement between pediatric burn survivor self- and caregiver proxy-report on multiple PROMIS domains and examine factors associated with differences between self- and proxy-reports. METHODS: Children 8-17 years of age and their caregivers completed PROMIS measures (physical function, depression, peer relationships, pain interference, and anger) between 6 months and 15 years after injury. Self- and proxy-report scores were compared using Wilcoxon sign rank test, Cohen's effect size, and intraclass correlation coefficients (ICC) and by agreement across severity of symptoms based on recommended cutoffs...
February 27, 2021: Quality of Life Research
Sara Bobillo-Perez, Clara Sorribes, Paula Gebellí, Nuria Lledó, Marta Castilla, Miquel Ramon, Javier Rodriguez-Fanjul
No abstract text is available yet for this article.
February 27, 2021: European Journal of Pediatrics
Paul L P Brand, Piet L Leroy, J Peter de Winter
No abstract text is available yet for this article.
February 27, 2021: European Journal of Pediatrics
Richard B Gunderman
No abstract text is available yet for this article.
February 27, 2021: Pediatric Radiology
Sharika Bamezai, Ryan M Aronberg, John M Park, Joseph J Gemmete
Chyluria is characterized by chyle in the urinary tract and often presents as milky-white urine. We present a case of chyluria from a lymphatic malformation in a 13-year-old boy diagnosed using dynamic intranodal contrast-enhanced magnetic resonance (MR) lymphangiography. This report demonstrates the utility of intranodal lymphangiography and interstitial lymphatic embolization to treat a pediatric patient presenting with persistent chyluria. Glue migration into the urinary collecting system is a potential complication of this procedure that can be mitigated by adjusting the n-butyl cyanoacrylate dilution with Lipiodol...
February 27, 2021: Pediatric Radiology
Adam J Oates, Jai Sidpra, Kshitij Mankad
The consequences of abusive head trauma (AHT) can be devastating for both the individual child and for wider society. Death is undoubtedly a very real possibility, but even for those children who survive, there is often very significant morbidity with the potential for gross motor and cognitive impairment, behavioural problems, blindness and epilepsy, which can greatly affect their quality of life. Caring for such children places a vast financial and infrastructural burden on society that frequently extends well into adulthood...
February 27, 2021: Pediatric Radiology
Nicolas Fernandez, Stefania Prada, Jeffrey Avansino, Julian Chavarriaga, Eduardo Hermida, Jaime Perez
INTRODUCTION AND OBJECTIVE: SARS-COV-2 pandemic has affected the population worldwide requiring social distancing, quarantine and isolation as strategies to control virus propagation. Initial measures to reduce the burden to the health care system during the pandemic included deferring elective surgery. These damage control measures did not take into account the mid- and long-term implications. Management of congenital anomalies can be time sensitive with delays resulting in permanent disability, morbidity and increased costs to the healthcare system...
February 27, 2021: Pediatric Surgery International
Hongzhen Jiang, Tianbao Luo, Benzhang Tao, Aijia Shang
BACKGROUND: Cerebellar medulloblastomas are the most common malignant tumors of the posterior fossa in childhood that frequently metastasize. Leptomeningeal dissemination and distant metastasis have been associated with medulloblastomas; however, intramedullary metastases are rare with very few case reports in the literature available. METHODS: We present a case of a 3-year-old girl with a medulloblastoma who underwent surgical resection of spinal intramedullary metastases...
February 27, 2021: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Julian Allen, Howard Panitch
Bronchopulmonary dysplasia (BPD) was first described by Northway et al in 1967. This article describes the evolution of our understanding of the pathophysiology of BPD and the approaches to treatments of this illness developed over the past fifty years. These interventions had their roots in the understanding of the principles of the surface tension present at air- liquid interfaces, which were developed over 150 years before BPD's initial description. Improving outcomes in neonatal care have led to greater survival of preterm and very preterm infants, and to an evolution of the pathogenesis and pathology of BPD, from an illness caused primarily by barotrauma and oxygen toxicity to one of interruption of lung development...
February 27, 2021: Pediatric Pulmonology
Rosemary Sutton, Luciano Dalla Pozza, Seong Lin Khaw, Chris Fraser, Tom Revesz, Janis Chamberlain, Richard Mitchell, Toby N Trahair, Caroline M Bateman, Nicola C Venn, Tamara Law, Erika Ong, Susan L Heatley, Barbara J McClure, Claus Meyer, Rolf Marschalek, Michelle J Henderson, Siobhan Cross, Deborah L White, Rishi S Kotecha
We report on the Australian experience of blinatumomab for treatment of 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukaemia (B-ALL) and high-risk genetics, resulting in a minimal residual disease (MRD) response rate of 58%, 2-year progression-free survival (PFS) of 39% and 2-year overall survival of 63%. In total, 83% (n = 20/24) proceeded to haematopoietic stem cell transplant, directly after blinatumomab (n = 12) or following additional salvage therapy (n = 8). Four patients successfully received CD19-directed chimeric antigen receptor T-cell therapy despite prior blinatumomab exposure...
February 26, 2021: Pediatric Blood & Cancer
Kenji Matsui, Tomohide Ibuki, Shimon Tashiro, Hidefumi Nakamura
Ethical considerations are more stringent in pediatric clinical research than in research targeting adults. However, in Japan, clear guidelines have yet to be presented on the necessary ethical considerations for clinical research involving children. The "Principles of Ethical Consideration Required for Clinical Research Involving Children" provide guiding principles for ethical considerations and the essential ways of thinking that all involved in clinical research on children need to understand in advance...
February 27, 2021: Pediatrics International: Official Journal of the Japan Pediatric Society
Reiko Muramatsu, Mutsuo Saga, Kazuhiro Muramatsu
No abstract text is available yet for this article.
February 27, 2021: Pediatrics International: Official Journal of the Japan Pediatric Society
Satomi Nishimoto, Shuichi Shimakawa, Miho Fukui, Motoko Ogino, Hikaru Tsuda-Kitahara, Hiromitsu Toshikawa, Shohei Nomura, Kayo Kunisada, Mitsuru Kashiwagi, Ryohei Miyamoto, Hiroshi Tamai, Akira Ashida
BACKGROUND: To assess the treatment response to conventional antiepileptic drugs and low-dose ACTH therapy for infantile spasms in children with Down syndrome. METHODS: We retrospectively investigated the response and relapse rates, electroencephalography findings, patient characteristics during drug withdrawal, and developmental outcome in 10 children with Down syndrome treated for infantile spasms in our hospital. RESULTS: All patients showed cessation of infantile spasms and achieved electroencephalographic normalization...
February 26, 2021: Pediatrics International: Official Journal of the Japan Pediatric Society
Yoshimi Murakami, Taku Omata, Hiromi Aoyama, Kazuo Kodama
No abstract text is available yet for this article.
February 27, 2021: Pediatrics International: Official Journal of the Japan Pediatric Society
Hironao Numabe, Kenjiro Kosaki
No abstract text is available yet for this article.
February 27, 2021: Pediatrics International: Official Journal of the Japan Pediatric Society
Andreas Beckmann, S Dittrich, C Arenz, O N Krogmann, A Horke, A Tengler, R Meyer, U M M Bauer, M Hofbeck
BACKGROUND:  Based on a quality assurance initiative of the German Society for Thoracic and Cardiovascular Surgery (DGTHG) and the German Society for Pediatric Cardiology and Congenital Heart Defects (DGPK), a voluntary registry was founded for assessment of treatment and outcomes of patients with congenital heart disease in Germany. This evaluation by the German Registry for cardiac operations and interventions in patients with congenital heart disease reports the data and the outcome over a 6-year period in patients undergoing invasive treatment...
December 2021: Thoracic and Cardiovascular Surgeon
Kaizhen Liu, Long Chen, Jing Xiong, Shuqin Xie, Yuan Hu, Yuan Shi
This study aimed to evaluate whether high-frequency oscillatory ventilation (HFOV) could reduce mortality and the incidence of bronchopulmonary dysplasia (BPD) of perinatal-onset neonatal acute respiratory distress syndrome (NARDS) compared with conventional mechanical ventilation (CMV). Medical records were collected and retrospectively analyzed. Among the 700 neonates with NARDS who needed invasive ventilation, 501 (71.6%) received CMV, while 199 (28.4%) received HFOV. One-to-one propensity score matching (127:127) was used to match the baseline characteristics of patients who received CMV and HFOV...
February 27, 2021: European Journal of Pediatrics
Maryline Chomton, Lucile Marsac, Anna Deho, Arielle Maroni, Guillaume Geslain, Karine Frannais-Haverland, Armelle Nicolas-Robin, Michaël Levy
During the first Covid-19 wave, our paediatric intensive care unit (PICU), like many others across the globe, was transformed into an adult ICU for patients with severe Covid-19, due to a shortage of adult ICU beds. Here, we provide a comprehensive description of all the conditions that must be fulfilled to successfully accomplish this transformation. Strong support from all hospital departments was crucial, as their activity was modified by the change. Healthcare workers from various units, notably the paediatric anaesthesiology department, worked in the adult ICU to ensure sufficient staffing...
February 26, 2021: European Journal of Pediatrics
Bingqing Zhang, Yang Sun, Na Xu, Wei Wang, Xiaoming Huang, Jialin Chen, Min Shen, Rongrong Wang, Xuejun Zeng, Xue Zhang
Deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive disease caused by ADA2 gene mutation that is characterized by three phenotype domains: vasculopathy and inflammation, hematological abnormality, and immunodeficiency. Most patients are pediatric patients; adult-onset patients are only occasionally reported. To describe a Chinese case of adult-onset DADA2 in a Chinese patient and explore the genotype and phenotype characteristics of adult-onset DADA2. We examined the clinical, serological, and genetic features of a Chinese adult-onset DADA2 patient...
February 26, 2021: Clinical Rheumatology
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