Lung W Lau, Avinash Eranki, Haydar Celik, AeRang Kim, Peter C W Kim, Karun V Sharma, Pavel S Yarmolenko
Certain technical criteria must be met to ensure the treatment safety of magnetic resonance-guided high-intensity focused ultrasound. We retrospectively reviewed how our enrollment criteria were applied from 2014 to 2017 in a clinical trial of magnetic resonance-guided high-intensity focused ultrasound ablation of recurrent malignant and locally aggressive benign solid tumors. Among the 36 screened patients between 2014 and 2017, more than one-third were excluded for technical exclusion criteria such as the anatomic location and proximity to prosthetics...
March 30, 2020: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Michael J Rybak, Jennifer Le, Thomas P Lodise, Donald P Levine, John S Bradley, Catherine Liu, Bruce A Mueller, Manjunath P Pai, Annie Wong-Beringer, John C Rotschafer, Keith A Rodvold, Holly D Maples, Benjamin M Lomaestro
BACKGROUND: Recent vancomycin PK/PD and toxicodynamic studies enable a reassessment of the current dosing and monitoring guideline in an attempt to further optimize the efficacy and safety of vancomycin therapy. The area-under-the-curve to minimum inhibitory concentration (AUC/MIC) has been identified as the most appropriate pharmacokinetic/pharmacodynamic (PK/PD) target for vancomycin. The 2009 vancomycin consenus guidelines recommended specific trough concentrations as a surrogate marker for AUC/MIC...
March 29, 2020: Pharmacotherapy
Gollapalle Lakshminarayanashastry Viswanatha, Hanumanthappa Shylaja, Krishnadas Nandakumar, Marikunte Venkatanarasappa Venkataranganna, Nunna Bheema Lingeswara Prasad
BACKGROUND: This study was aimed to evaluate the beneficial role of inhalation budesonide(BUD) in improving the pulmonary functions, and reducing the hospital admission rate, worsening of asthma and commonly encountered adverse events in pediatric asthma. METHODS: The electronic search was performed using PubMed, Scopus, CENTRAL (Cochrane Central Register of Controlled Trials) and Google scholar databases to identify the randomized control trials(RCTs). RESULTS: 21 RCTs involving 12,787 subjects were included...
March 29, 2020: Pharmacological Reports: PR
Bhuvic Patel, Rukayat Taiwo, Albert H Kim, Gavin P Dunn
As cells replicate their DNA during mitosis, telomeres are shortened due to the inherent limitations of the DNA replication process. Maintenance of telomere length is critical for cancer cells to overcome cellular senescence induced by telomere shortening. Telomerase reverse transcriptase (TERT) is the rate-limiting catalytic subunit of telomerase, an RNA-dependent DNA polymerase that lengthens telomeric DNA to maintain telomere homeostasis. TERT promoter mutations, which result in the upregulation of TERT transcription, have been identified in several central nervous system (CNS) tumors, including meningiomas, medulloblastomas, and primary glial neoplasms...
January 2020: Neuro-oncology advances
Mohan S Gundeti, Miguel A Castellan
No abstract text is available yet for this article.
2020: Frontiers in Pediatrics
Garyfallia Syridou, Ioannis Drikos, Artemis Vintila, Antigoni Pegkou, Loukia Zografou, Panagiotis Roungas, Eleni Papa, Dimitris Kyriazopoulos, Olga Savelieva, Eleni Antonopoulou
Influenza virus primarily affects the respiratory system. It rarely causes extrapulmonary complications, with otitis media and febrile seizures being the most common in children. Acute glomerulonephritis as a complication of H1N1 influenza virus infection has been described only sporadically. Herein we present a case of acute glomerulonephritis in a previously healthy adolescent, in the context of infection with influenza A H1N1 virus. A 15-year old adolescent was admitted to our pediatric department due to fever, pharyngitis, cough, vomit, dizziness and fatigue...
2020: IDCases
Rami George Alrabaa, Matthew Simhon, R Kumar Kadiyala
The Outerbridge-Kashiwagi (O-K) procedure has conventionally been used for the treatment of osteoarthritis of the elbow and to treat posttraumatic sequelae including posttraumatic arthritis, stiffness, contracture, and ulnar neuritis. The procedure involves exposure of the posterior elbow joint as well creating a window posteriorly through the olecranon fossa to target anterior aspects of the elbow. Several case series have shown the O-K procedure to have good functional outcomes with minimal complications...
March 2020: Arthroscopy Techniques
Shigehito Emura, Noriyuki Yanagida, Sakura Sato, Ken-Ichi Nagakura, Tomoyuki Asaumi, Yu Okada, Yumi Koike, Kiyotake Ogura, Katsuhito Iikura, Motohiro Ebisawa
Background: Children who avoid cow's milk (CM) because of food allergy may show disturbed growth. Calcium insufficiency, in particular, was reported among those who completely avoided dairy products. We retrospectively examined whether oral immunotherapy (OIT) affected the stature of patients who had completely avoided CM owing to their severe CM allergy. Methods: The CM-OIT group included subjects who had completely avoided milk their entire lives and were administered OIT between 2009 and 2013...
March 2020: World Allergy Organization Journal
Jeffrey S Barrett
No abstract text is available yet for this article.
2020: Frontiers in Pharmacology
Thivanka Vishwani Manawadu, Eresha Jasinge, Meranthi Fernando, Pradeep Gamage, Anusha Varuni Gunarathne
Beta-ketothiolase (mitochondrial acetoacetyl-CoA thiolase, T2) deficiency is a rare genetic disorder of ketone utilization and isoleucine catabolism caused by mutations in the ACAT1 gene. Here we report the first Sri Lankan case of T2 deficiency confirmed by genetic analysis. A 4-year-old boy presented with the first episode of severe metabolic ketoacidosis after a febrile illness. On admission, the child was drowsy and had circulatory collapse needing intubation. Initial investigations were not detective of a cause and symptomatic management did not improve the condition...
April 2020: Indian Journal of Clinical Biochemistry: IJCB
Bineeta Kashyap, Neha Gupta, Pooja Dewan, Puneeta Hyanki, N P Singh
The utility of C-reactive protein (CRP) as a marker of disease severity, therapeutic response and prognosis in tuberculosis has been suggested. This study aims to determine the levels of high sensitivity CRP (hs CRP) among the pediatric tuberculosis cases. A case control study was conducted on 60 clinically diagnosed (clinical findings and radiography and/or contact history and/or Mantoux test) or microbiologically confirmed (smear and/or culture and/or Cartridge based Nucleic Acid Amplification test positive) pediatric tuberculosis cases ≤ 12 years...
April 2020: Indian Journal of Clinical Biochemistry: IJCB
Aiqin Liu, Baiyan Gong, Xiaohua Liu, Yujuan Shen, Yanchen Wu, Weizhe Zhang, Jianping Cao
BACKGROUND: Cryptosporidiosis is an emerging infectious disease of public health significance worldwide. The burden of disease caused by Cryptosporidium varies between and within countries/areas. To have a comprehensive understanding of epidemiological status and characteristics of human Cryptosporidium infection in China since the first report in 1987, a retrospective epidemiological analysis was conducted by presenting differences in the prevalence of Cryptosporidium by province, year, population, living environment and season and possible transmission routes and risk factors as well as genetic characteristics of Cryptosporidium in humans...
March 30, 2020: PLoS Neglected Tropical Diseases
Paola V Pedraza-Flechas, Rocío P Pereira-Ospina, Juan S Molinares-Mejía, José M Suescún-Vargas, Javier Y Pinzón-Salamanca
Background: Congenital hyperinsulinism is a disease of the glucose metabolism, relevant in pediatric endocrinology because of the elevated production of insulin according to blood glucose level, which leads to persistent severe hypoglycemia. This condition can produce important neurological sequelae in the patient due to the irreversible damage that occurs in the neuron caused by the exposure to hypoglycemia for short periods of time. Congenital hyperinsulinism diagnosis is not simple and it requires a high index of suspicion...
2020: Boletín Médico del Hospital Infantil de México
Fernando Jáuregui-Huerta, Diego Redolar-Ripoll, Juan C Cupul-García, Juan P Trillo-Gómez, Yaveth Ruvalcaba-Delgadillo
General anesthetics are crucial drugs for surgical interventions, which are indicated to induce analgesia, diminish pain, and reduce anxiety in order to facilitate invasive procedures. In pediatric patients, benefits of general anesthetics also include abolishment of motility. Besides their probed benefits on surgery, the recent warning of the Food and Drug Administration (FDA) on the use of general anesthetics in children yielded a controversy on their potential neurotoxic effects. In this review, the main facts of the cerebral development are studied, and the available evidence concerning the use of general anesthesia on the neuropsychological development of children is analyzed...
2020: Boletín Médico del Hospital Infantil de México
Geir Ogrim, Juri D Kropotov
Neuropsychiatric diagnoses like ADHD are based on subjective methods like interviews, rating scales and observations. There is a need for more brain-based supplements. Stimulant medication is the most common treatment for ADHD. Clinically useful predictors of response have so far not been reported. The aim of this paper is to describe the EEG based methods we apply to extract potential biomarkers for brain dysfunction. Examples relate to biomarkers for pediatric ADHD, and prediction of medication response. The main emphasis is on Event Related Potentials (ERPs)...
March 12, 2020: Journal of Visualized Experiments: JoVE
Concetta P Pelullo, Giorgia Della Polla, Francesco Napolitano, Gabriella Di Giuseppe, Italo F Angelillo
The cross-sectional study assessed the knowledge, attitudes, and practices regarding the recommended vaccinations and factors affecting such outcomes among a sample of healthcare workers (HCWs) in public hospitals in Italy. Only 14.1% knew all the recommended vaccinations for HCWs. Physicians and those who had received information about vaccinations from scientific journals, educational activities, or professional associations were more likely to have this knowledge, while those aged 36-45 were more likely to have less knowledge than those in the age group below 36 years...
March 26, 2020: Vaccines
Jean A Bernatchez, Emily Chen, Mitchell V Hull, Case W McNamara, James H McKerrow, Jair L Siqueira-Neto
Chagas disease, caused by the kinetoplastid parasite Trypanosoma cruzi , affects between 6 and 7 million people worldwide, with an estimated 300,000 to 1 million of these cases in the United States. In the chronic phase of infection, T. cruzi can cause severe gastrointestinal and cardiac disease, which can be fatal. Currently, only benznidazole is clinically approved by the FDA for pediatric use to treat this infection in the USA. Toxicity associated with this compound has driven the search for new anti-Chagas agents...
March 26, 2020: Microorganisms
Evrosina I Isaac, Andrea R Meisman, Kirstin Drucker, Stephanie Violante, Kathryn L Behrhorst, Alfonso Floyd, Jennifer M Rohan
Not only do racial and ethnic minority children and adolescents with chronic illness experience disparities in health status and health outcomes, they also experience significant healthcare disparities, including differences in healthcare coverage, access to care, and quality of care. It is well known that the interaction between psychosocial functioning, health behaviors and ethnic and racial disparities, ultimately leads to worse health and psychosocial outcomes in pediatric and AYA chronic illness patient populations, including increased rates of morbidity and mortality...
March 26, 2020: International Journal of Environmental Research and Public Health
Olaf Beck, Claudia Paret, Alexandra Russo, Jürgen Burhenne, Margaux Fresnais, Kevin Steimel, Larissa Seidmann, Daniel-Christoph Wagner, Nadine Vewinger, Nadine Lehmann, Maximilian Sprang, Nora Backes, Lea Roth, Marie Astrid Neu, Arthur Wingerter, Nicole Henninger, Khalifa El Malki, Henrike Otto, Francesca Alt, Alexander Desuki, Thomas Kindler, Joerg Faber
Osteosarcoma (OS) is the second most common cause of cancer-related death in pediatric patients. The insulin-like growth factor (IGF) pathway plays a relevant role in the biology of OS but no IGF targeted therapies have been successful as monotherapy so far. Here, we tested the effect of three IGF specific inhibitors and tested ceritinib as an off-target inhibitor, alone or in combination with dasatinib, on the proliferation of seven primary OS cells. Picropodophyllin, particularly in combination with dasatinib and the combination ceritinib/dasatinib were effective in abrogating the proliferation...
March 26, 2020: Cancers
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