Mariam Davtyan, Deborah Kacanek, Jessica Lee, Claire Berman, Ellen G Chadwick, Renee Smith, Liz Salomon, Toinette Frederick, For The Pediatric Hiv/Aids Cohort Study
Understanding factors associated with internalized HIV-related stigma among mothers living with HIV may improve health outcomes. We examined factors (age, race/ethnicity, education, income, employment, marital status, health limitations, and years since HIV diagnosis) associated with internalized HIV-related stigma among biological mothers of children enrolled in the Surveillance Monitoring for ART Toxicities study of the US-based Pediatric HIV/AIDS Cohort Study. Stigma was measured with the Internalized HIV Stigma Scale (IHSS), completed biennially at their child's 11-17-year visits...
September 27, 2023: AIDS Care
Andrés Humberto Uc-Cachón, Gloria María Molina-Salinas, Angel de Jesús Dzul-Beh, Rey Fernando Rosado-Manzano, Haziel Eleazar Dzib-Baak
BACKGROUND: Intensive care units (ICU) are the epicenter of antimicrobial resistance (AMR), and patients' infections are mainly caused by Gram-negative bacteria (GNB). OBJECTIVE: To describe the frequency and trends in AMR of GNB deriving from the clinical samples of ICU patients at a tertiary care hospital in Mérida, Yucatán. MATERIAL AND METHODS: Study which included the review of laboratory reports of all bacteriological samples collected from patients admitted to neonatal, pediatric and adult ICU from January 1 2019 to December 31 2021...
September 4, 2023: Revista Médica del Instituto Mexicano del Seguro Social
Garrett J Chan, Bradley A Stohr, Adeboye O Osunkoya, Nicole A Croom, Soo-Jin Cho, Ronald Balassanian, Vivek Charu, Gregory R Bean, Emily Chan
CONTEXT.—: Wilms tumor (WT) in adult patients is rare and has historically been a diagnostic and therapeutic conundrum, with limited data available in the literature. OBJECTIVE.—: To provide detailed diagnostic features, molecular profiling, and patient outcomes in a multi-institutional cohort of adult WT patients. DESIGN.—: We identified and retrospectively examined 4 adult WT cases. RESULTS.—: Two patients presented with metastatic disease, and diagnoses were made on fine-needle aspiration of their renal masses...
September 26, 2023: Archives of Pathology & Laboratory Medicine
Ruizhao Lyu, Rui Liu, Jianhua Wang, Yumo Jing
No abstract text is available yet for this article.
September 26, 2023: Anesthesiology
Kelly Tanner, Sara O'Rourke, Kristin Cunningham, Valerie Duffin, Nathalie Maitre
IMPORTANCE: Parent coaching (PC) is a best practice for young children with, or at high risk for, cerebral palsy (CP). Occupational therapy practitioners in outpatient settings encounter barriers to implementing PC. OBJECTIVE: To increase the documented use of PC in outpatient occupational therapy visits for children younger than age 2 yr with, or at high risk for, CP from 0% to 80%. DESIGN: Multicenter quality improvement (QI) initiative with a time-series design...
September 1, 2023: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
Lin Hou, Xuesong Song, Guang Yang, Zhiwen Li
No abstract text is available yet for this article.
September 26, 2023: Anesthesiology
Amy D Thompson, Fran Balamuth, Desiree N Neville, Laura L Chapman, Michael N Levas, Anupam B Kharbanda, John A Branda, Meagan M Ladell, Claire Loiselle, Lise E Nigrovic
In our prospective cohort of 192 children with a physician-diagnosed erythema migrans (EM) lesion, two-tier Lyme disease serology had higher sensitivity in children with multiple EM lesions (76.8% multiple lesions vs. 38.1% single EM; difference 38.7%, 95% CI 24.8 to 50.4%). The diagnosis of cutaneous Lyme disease should be based on careful physical examination rather than laboratory testing.
September 26, 2023: Journal of the Pediatric Infectious Diseases Society
Diane Nguyen, Rogers N Ssebunya, Kajal Hirani, Anna Mandalakas, Jennifer Benjamin, B Lee Ligon, Satid Thammasitboon
BACKGROUND: Disparities in scholarship exist between authors in low- or middle-income countries (LMIC) and high-income countries. Recognizing these disparities in our global network providing pediatric, adolescent, and maternal healthcare to vulnerable populations in LMIC, we sought to improve access and provide resources to address educational needs and ultimately impact the broader scholarship disparity. METHODS: We created a virtual community of practice (CoP) program underpinned by principles from starling murmuration to promote interdisciplinary scholarship...
September 27, 2023: Medical Teacher
Ricardo A Arbizu, Sean Trauernicht, Sergio Pinillos, Samuel Nurko, Leonel Rodriguez
OBJECTIVES: Antroduodenal manometry (ADM) measures antral and small bowel motility and is clinically used to evaluate upper gastrointestinal (UGI) symptoms. We aimed to evaluate its utility in guiding treatment, predicting response, and association with clinical findings. METHODS: Retrospective review of 200 children undergoing ADM. ADM interpretation and parameters were compared to outcomes (response to first therapy after ADM and overall response), predominant symptom (group A, abdominal distention and/or vomiting and group B, abdominal pain and/or nausea), etiology (idiopathic or with known comorbidity), and ADM indication (suspected chronic intestinal pseudo-obstruction -CIPO- or unexplained UGI symptoms)...
September 27, 2023: Journal of Pediatric Gastroenterology and Nutrition
(no author information available yet)
No abstract text is available yet for this article.
September 27, 2023: Journal of Pediatric Gastroenterology and Nutrition
Sarah Jane Schwarzenberg, Wendy C King, Simon C Ling, Karen F Murray, Douglas Mogul, Philip Rosenthal, Norberto Rodriguez-Baez, Jeffrey Teckman, Kathleen B Schwarz
BACKGROUND: Greater hepatitis-related symptomology is associated with lower health-related quality-of-life (HRQoL) among untreated youth with chronic hepatitis B (CHB). How HRQoL changes over time in this population is unknown. METHODS: Children from 7 hepatology centers in North America positive for hepatitis B surface antigen, not taking anti-viral therapy, were enrolled in the Hepatitis B Research Network (HBRN). A validated self-report HRQoL measure, the Child Health Questionnaire Child Report (CHQ-CF87), was completed annually by participants 10-17 years, with demographic variables, liver disease symptoms, and laboratory tests...
September 27, 2023: Journal of Pediatric Gastroenterology and Nutrition
Jennifer Davila, William B Mitchell, Kerry Morrone, Ellen J Silver, Caterina P Minniti, Henny H Billett, Payal C Desai, Sarah H O'Brien, Deepa Manwani
Patients with sickle cell disease (SCD) are predisposed to a hypercoagulable state due to alterations in the coagulation system. Despite concern for the development of venous thromboembolism (VTE) in this population, there are no standardized guidelines for routine thromboprophylaxis. The objective of this study was to assess thromboprophylaxis practices of adult and pediatric treaters of SCD before and during the coronavirus disease of 2019 (COVID-19) pandemic. A cross-sectional electronic survey was distributed to pediatric and adult hematology oncology practitioners through seven SCD-specific interest groups between May 29, 2020, and July 13, 2020...
September 21, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Sagar Mehta, Tomisin John, Jordan J Feld, Hemant Shah, Nisa Mullaithilaga, Aaron Campigotto, Karen Leung, Binita M Kamath, Simon C Ling, Michelle Science, Vicky L Ng
BACKGROUND: We evaluated the proportion, clinical features, and outcomes of previously healthy children presenting to a large Canadian quaternary pediatric center with severe acute hepatitis of unknown etiology. METHODS: All patients with serum alanine aminotransferase (ALT) > 500 U/L or aspartate aminotransferase (AST) > 500 U/L between June 1, 2018, and May 31, 2022, at The Hospital for Sick Children, were identified. Subjects with only AST > 500 U/L were excluded...
October 1, 2023: Hepatology Communications
Atu Agawu, Christina Kanagawa, Janeline Wong, Justine Shults, Chris Feudtner, Meenakshi Bewtra
OBJECTIVES: Previous studies have shown increasing hospitalizations for pediatric cholelithiasis, but recent trends are unknown. We conducted a national study of pediatric cholelithiasis to characterize recent hospitalization rate trends. METHODS: Retrospective repeated cross-sectional analysis of pediatric (age < 18) cholelithiasis-associated hospitalizations combining data from the 2006 through 2019 Kids Inpatient Database (KIDS) releases. The primary outcome of interest was the national hospitalization rate (per 100,000 children)...
September 26, 2023: Journal of Pediatric Gastroenterology and Nutrition
Suvi Virtanen, Tyra Lagerberg, Christine Takami Lageborn, Ralf Kuja-Halkola, Isabell Brikell, Anthony A Matthews, Paul Lichtenstein, Brian M D'Onofrio, Mikael Landén, Zheng Chang
IMPORTANCE: Antidepressants are increasingly prescribed to pediatric patients with unipolar depression, but little is known about the risk of treatment-emergent mania. Previous research suggests pediatric patients may be particularly vulnerable to this adverse outcome. OBJECTIVE: To estimate whether pediatric patients treated with antidepressants have an increased incidence of mania/hypomania compared with patients not treated with antidepressants and to identify patient characteristics associated with the risk of mania/hypomania...
September 27, 2023: JAMA Psychiatry
Ethan A Poweleit, Zachary L Taylor, Tomoyuki Mizuno, Samuel E Vaughn, Zeruesenay Desta, Jeffrey R Strawn, Laura B Ramsey
BACKGROUND AND OBJECTIVE: Escitalopram and sertraline are commonly prescribed for anxiety and depressive disorders in children and adolescents. The pharmacokinetics (PK) of these medications have been evaluated in adults and demonstrate extensive variability, but studies in pediatric patients are limited. Therefore, we performed a population PK analysis for escitalopram and sertraline in children and adolescents to characterize the effects of demographic, clinical, and pharmacogenetic factors on drug exposure...
September 27, 2023: Clinical Pharmacokinetics
Russell Rosenberg, Rogelio Braceras, Wayne Macfadden, Shawn Candler, Jed Black, Chad Ruoff
Narcolepsy is associated with disrupted nighttime sleep (DNS). Sodium oxybate (SXB; Xyrem® ), administered twice nightly, is indicated for the treatment of cataplexy and excessive daytime sleepiness in patients 7 years or older with narcolepsy. Recently, low-sodium oxybate (LXB, Xywav® ; for people 7 years of age and older), which contains 92% less sodium than SXB and is dosed twice nightly, and sodium oxybate for extended release (SXB-ER; Lumryz™; for adults), which contains equal sodium to SXB and is dosed once nightly, have also been approved to treat cataplexy or excessive daytime sleepiness in narcolepsy...
September 27, 2023: Neurology and Therapy
Takehisa Ueno, Motoshi Wada, Eri Ogawa, Toshiharu Matsuura, Yohei Yamada, Seisuke Sakamoto, Hiroomi Okuyama
INTRODUCTION: Intestinal transplantation (ITx) is the ultimate treatment for intestinal failure (IF). In Japan, most cases of IF are a result of pediatric disease, including secondary or congenital intestinal disease or allied disorders of Hirschsprung's disease. Here, we report the results of the Japanese ITx registry. METHODS: A web-based survey form was completed. We investigated the number, age, sex, indication, surgical procedure, immunosuppressants, postoperative course, and the effects of transplantation in patients who underwent cadaveric or living-donor ITx...
September 27, 2023: Pediatric Surgery International
Torsten Pietsch
Pediatric central nervous system (CNS) tumors differ in their relative frequency, location, histology, biological behavior and prognosis from tumors in adults. Accurate neuropathological classification of CNS tumors is essential for therapeutic decisions and inclusion in therapy optimization studies. Tissue samples are analyzed by standardized conventional histological, immunohistological and molecular pathological methods and diagnosed according to the current World Health Organization (WHO) classification for CNS tumors (2021)...
September 27, 2023: Pathologie (Heidelb)
Yang Liu, Yao Lin, Xiaolan Huang, Yaqi Li, Yanyan Liu, Lin Shi
UNLABELLED: The current study was designed to assess the association of serum transforming growth factor β1 (TGF-β1 ) with left ventricular hypertrophy (LVH) in children with primary hypertension. The present single-center prospective trial examined 182 patients diagnosed with primary hypertension in Children's Hospital, Capital Institute of Pediatrics, between January 2021 and September 2022. Clinical data were analyzed, and ambulatory blood pressure was assessed for 24 h...
September 27, 2023: European Journal of Pediatrics
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.