Joanna Magdalena Kaczmarek, Karolina Anna Graczykowska, Iwona Szymkuć-Bukowska, Ewa Łoś-Rycharska, Aneta Krogulska
Lymphedema is a localized form of tissue swelling, characterized by a progressive accumulation of a tissue fluid in the interstitial compartment as a result of the lymphatic system dysfunction. It is a rare disease in the pediatric population and in the majority of cases it is a consequence of an abnormal formation of the lymphatic system, which is called primary lymphedema. Although its epidemiology is not precise, it is assumed that 1:100 000 children suffer from primary lymphedema. The diagnosis can be made by a proper clinical examination after ruling out secondary causes of lymphedema, particularly in cases with a more asymmetric swelling of the extremities...
July 13, 2020: Klinische Pädiatrie
Charlotte Gimpel, Carsten Bergmann, Florian Brinkert, Metin Cetiner, Ulrich Gembruch, Dieter Haffner, Markus Kemper, Jens König, Max Liebau, Rolf Felix Maier, Jun Oh, Lars Pape, Silke Riechardt, Udo Rolle, Rainer Rossi, Joachim Stegmann, Udo Vester, Constantin von Kaisenberg, Stefanie Weber, Franz Schaefer
This consensus-based guideline was developed by all relevant German pediatric medical societies. Ultrasound is the standard imaging modality for pre- and postnatal kidney cysts and should also exclude extrarenal manifestations in the abdomen and internal genital organs. MRI has selected indications. Suspicion of a cystic kidney disease should prompt consultation of a pediatric nephrologist. Prenatal management must be tailored to very different degrees of disease severity. After renal oligohydramnios, we recommend delivery in a perinatal center...
July 13, 2020: Klinische Pädiatrie
Michael J Rybak, Jennifer Le, Thomas Lodise, Donald Levine, John Bradley, Catherine Liu, Bruce Mueller, Manjunath Pai, Annie Wong-Beringer, John C Rotschafer, Keith Rodvold, Holly D Maples, Benjamin M Lomaestro
No abstract text is available yet for this article.
July 13, 2020: Journal of the Pediatric Infectious Diseases Society
Katrin Menke, Melanie Schwermer, Jürgen Eisenbraun, Alexander Schramm, Tycho Jan Zuzak
BACKGROUND: Mistletoe therapy is frequently administered as a supportive treatment in diverse pediatric cancer entities including brain tumors. Medulloblastoma is the most common brain tumor in childhood. Its high risk to metastasize and its long-term sequelae caused by aggressive chemo- or radiotherapies are still challenging. MATERIAL AND METHODS: Effects of a lectin-rich mistletoe extract, abnobaVISCUM Fraxini, were investigated in two medulloblastoma cell lines (Daoy and ONS-76)...
July 13, 2020: Complementary Medicine Research
Ombretta Melaiu, Valeria Lucarini, Roberto Giovannoni, Doriana Fruci, Federica Gemignani
Immune checkpoint inhibitors (ICIs) have shown unprecedented benefits in various adult cancers, and this success has prompted the exploration of ICI therapy even in childhood malignances. Although the use of ICIs as individual agents has achieved disappointing response rates, combinational therapies are likely to promise better results. However, only a subset of patients experienced prolonged clinical effects, thus suggesting the need to identify robust bio-markers that predict individual clinical response or resistance to ICI therapy as the main challenge...
July 10, 2020: Seminars in Cancer Biology
Marilyn Hockenberry, Tadala Mulemba, Aisha Nedege, Kitsiso Madumetse, Jennifer Higgins
Nursing specialization in the care of children with cancer provides the foundation for implementing successful childhood cancer and blood disorder treatment programs throughout the world. Excellence in nursing education is at the center of all that is needed to maximize cures for children with cancer in low- and middle-income countries (LMIC). While the burden of childhood cancer care is the highest in LMIC, opportunities for continuing nursing education and specialization are extremely limited. Capacity-building programs using distance-based learning opportunities have been successful in sub-Saharan Africa and provide insight into successful, continuing professional development...
July 13, 2020: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
Jessika Boles, Maile Jones, Jenna Dunbar, Jessica Cook
Legacy building interventions like plaster hand molds are offered in most children's hospitals, yet little is known about how the concept of legacy is understood and described by pediatric health care providers. Therefore, this study explored pediatric health care providers' perceptions of legacy at an academic medical center to ensure that future legacy interventions are evidence-informed and theoretically grounded. An electronic survey featuring three open-ended questions and two multiple-choice questions with an option for free text response was completed by 172 medical and psychosocial health care providers...
July 13, 2020: Clinical Pediatrics
Susan A Rethlefsen, Nicole M Mueske, Alexander Nazareth, Oussama Abousamra, Tishya A L Wren, Robert M Kay, Rachel Y Goldstein
Parents are frequently cautioned by therapists, teachers, physicians, and online resources about potential negative effects of w-sitting in children (including hip dysplasia), despite lack of evidence. To examine relationships between w-sitting and hip dysplasia, a prospective cohort study was conducted of 104 patients (196 hips), aged 9.9 (standard deviation = 5.7) years, who underwent hip/pelvis radiography at a pediatric tertiary care center. Measures of hip dysplasia were taken from radiographs. Parents/patients completed a questionnaire regarding the patients' sitting habits...
July 13, 2020: Clinical Pediatrics
Chunxia Wang, Yun Cui, Huijie Miao, Ting Sun, Ye Lu, Yucai Zhang
Vitronectin (VTN) is a key regulator of coagulation, but clinical relevance of serum VTN in pediatric sepsis remains poorly defined. The aim of this study was to access the value of serum VTN level on pediatric intensive care unit (PICU) admission in children with sepsis. Pediatric patients with sepsis were enrolled from January 2018 to December 2018. The serum VTN levels were determined on PICU admission, and the association of serum VTN level with PICU mortality and organ dysfunction was assessed. Serum VTN levels were significantly lower in nonsurvivors compared with survivors, in patients with septic shock compared with patients with sepsis, or in patients with sepsis-associated acute liver injury (ALI) compared with patients without ALI...
January 2020: Clinical and Applied Thrombosis/hemostasis
Kayleigh M Gallagher, Justine E Roderick, Shi Hao Tan, Tze King Tan, Leonard Murphy, Jun Yu, Rui Li, Kevin W O'Connor, Julie Zhu, Michael R Green, Takaomi Sanda, Michelle A Kelliher
Synthetic glucocorticoids (GCs), such as dexamethasone and prednisone, remain key components of therapy for patients with lymphoid malignancies. For pediatric patients with acute lymphoblastic leukemia (ALL), response to GCs remains the most reliable prognostic indicator; failure to respond to GC correlates with poor event-free survival. To uncover GC resistance mechanisms, we performed a genome-wide, survival-based short hairpin RNA screen and identified the orphan nuclear receptor estrogen-related receptor-β (ESRRB) as a critical transcription factor that cooperates with the GC receptor (GR) to mediate the GC gene expression signature in mouse and human ALL cells...
July 14, 2020: Blood Advances
Michael J Rybak, Jennifer Le, Thomas P Lodise, Donald P Levine, John S Bradley, Catherine Liu, Bruce A Mueller, Manjunath P Pai, Annie Wong-Beringer, John C Rotschafer, Keith A Rodvold, Holly D Maples, Benjamin Lomaestro
Recent clinical data on vancomycin pharmacokinetics and pharmacodynamics suggest a reevaluation of current dosing and monitoring recommendations. The previous 2009 vancomycin consensus guidelines recommend trough monitoring as a surrogate marker for the target area under the curve over 24 hours to minimum inhibitory concentration (AUC/MIC). However, recent data suggest that trough monitoring is associated with higher nephrotoxicity. This document is an executive summary of the new vancomycin consensus guidelines for vancomycin dosing and monitoring...
July 13, 2020: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Gedéon Prince Manouana, Eva Lorenz, Mirabeau Mbong Ngwese, Paul Alvyn Nguema Moure, Oumou Maiga Ascofaré, Charity Wiafe Akenten, John Amuasi, Njari Rakotozandrindrainy, Raphael Rakotozandrindrainy, Joyce Mbwana, John Lusingu, Natalie Byrne, Sophia Melhem, Jeannot Frejus Zinsou, Roméo Bayodé Adegbite, Benedikt Hogan, Doris Winter, Jurgen May, Peter Gottfried Kremsner, Steffen Borrmann, Daniel Eibach, Ayola Akim Adegnika
BACKGROUND: Cryptosporidium is a protozoan parasite that causes mild to severe diarrhoeal disease in humans. To date, several commercial companies have developed rapid immunoassays for the detection of Cryptosporidium infection. However, the challenge is to identify an accurate, simple and rapid diagnostic tool for the estimation of cryptosporidiosis burden. This study aims at evaluating the accuracy of CerTest Crypto, a commercialized rapid diagnostic test (RDT) for the detection of Cryptosporidium antigens in the stool of children presenting with diarrhoea...
July 13, 2020: PLoS Neglected Tropical Diseases
Anaïs Rameau, Albert Mudry
BACKGROUND: Within the span of a few decades, gastro-esophageal reflux (GER) evolved from a rare entity to the most commonly diagnosed upper gastro-intestinal disease, i.e. gastro-esophageal reflux disease (GERD). The boundaries of GERD remain matter of controversy and appear to be ever expanding in both children and adults. Our aim is to answer the questions: when did GER become a disease? And when did it become specifically a pediatric disease? METHODS: We performed a comprehensive historical review of the original medical literature using Medline and Google, along with a compilation of original and secondary texts in English, French and German...
July 2, 2020: International Journal of Pediatric Otorhinolaryngology
Ying-Ge Wang, Chang Lin, Sheng-Nan Ye, Yuan-Teng Xu, Xiao-Hong Lin, Xiao-Ying Ke, Jin-Xing Zheng, Ying Chen, Guo-Hao Chen
OBJECTIVE: To evaluate the correlation between obstructive sleep apnea syndrome (OSAS) and the development of thoracic deformity in Children. METHODS: A retrospective analysis was performed with the medical records of 39 pediatric OSAS patients with thoracic deformity and matching 39 without thoracic deformity as control group between January 2015 and June 2019. The contrast was performed with age, gender, height, weight, body mass index (BMI), apnea/hypopnea index (AHI), the lowest oxyhemoglobin saturation (loSpO2)at night, tonsil and adenoid size, Alkaline phosphatase (ALP)and trace elements and metals between two groups...
July 11, 2020: International Journal of Pediatric Otorhinolaryngology
Turki Al-Driweesh, Fatemah Altheyab, Mazyad Alenezi, Sultan Alanazy, Turki Aldrees
OBJECTIVE: To increase awareness and the index of suspicion regarding Grisel's syndrome among otolaryngologists after otolaryngology procedures. METHOD: We conducted a search of MEDLINE/PubMed for articles published through January 2020 utilizing the following terms: Grisel's syndrome, Grisel syndrome, and atlantoaxial subluxation alone and in combination with other terms like ENT, otolaryngology, head & neck, tonsillectomy, adenoidectomy, adenotonsillectomy, mastoidectomy, tympanoplasty, and tympanomastoidectomy...
June 27, 2020: International Journal of Pediatric Otorhinolaryngology
Mehdi Hasnaoui, Rihab Lahmar, Asma Ben Mabrouk, Mohamed Masmoudi, Khalifa Mighri, Nabil Driss
OBJECTIVE: The objective of this study is to compare the clinical presentation and the cancer staging of nasopharyngeal carcinoma (NPC) between pediatric and adult populations to highlight the main characteristics of this disease within the two subgroups. MATERIEL AND METHODS: It is a retrospective study including all patients with a primary diagnosis of NPC over a period of 19 years. The pediatric group included patients aged less then 16 years old. RESULTS: A total of 80 patients were included...
July 3, 2020: International Journal of Pediatric Otorhinolaryngology
S Jain, V Sharma, S K Patro, P Khera, T Yadav, S Tiwari, D Kaushal, K Soni, A Goyal
OBJECTIVE: To assess whether cochlear nerve (CN) cross-sectional area as measured with parasagittal magnetic resonance imaging (MRI) in prelingual pediatric deaf patients correlates with auditory performance after cochlear implantation. STUDY DESIGN: Prospective Cohort study. METHODS: Thirty-two prelingual children with bilateral profound sensorineural hearing loss (SNHL) who received unilateral cochlear implant were included in this study...
July 2, 2020: International Journal of Pediatric Otorhinolaryngology
Colin Decourt, Luc Duong
Segmentation of the left ventricle in magnetic resonance imaging (MRI) is important for assessing cardiac function. We present DT-GAN, a generative adversarial network (GAN) segmentation approach for the identification of the left ventricle in pediatric MRI. Segmentation of the left ventricle requires a large amount of annotated data; generating such data can be time-consuming and subject to observer variability. Additionally, it can be difficult to accomplish in a clinical setting. During the training of our GAN, we therefore introduce a semi-supervised semantic segmentation to reduce the number of images required for training, while maintaining a good segmentation accuracy...
June 29, 2020: Computers in Biology and Medicine
Paul J Hesketh, Mark G Kris, Ethan Basch, Kari Bohlke, Sally Y Barbour, Rebecca Anne Clark-Snow, Michael A Danso, Kristopher Dennis, L Lee Dupuis, Stacie B Dusetzina, Cathy Eng, Petra C Feyer, Karin Jordan, Kimberly Noonan, Dee Sparacio, Gary H Lyman
PURPOSE: To update the guideline to include new anticancer agents, antiemetics, and antiemetic regimens and to provide recommendations on the use of dexamethasone as a prophylactic antiemetic in patients receiving checkpoint inhibitors (CPIs). METHODS: ASCO convened an Expert Panel and updated the systematic review to include randomized controlled trials (RCTs) and meta-analyses of RCTs published between June 1, 2016, and January 24, 2020. To address the dexamethasone and CPI question, we conducted a systematic review of RCTs that evaluated the addition of a CPI to chemotherapy...
July 13, 2020: Journal of Clinical Oncology
Nancy F Bandstra, Parker L Huston, Kate Zvonek, Carly Heinz, Emily Piccione
Purpose Feeding challenges in children are common, at times reaching a severity that requires the placement and long-term use of enteral feedings. A significant barrier to advancing the oral eating of some tube-dependent children is the presence of oral aversion. Although some research exists regarding the treatment of tube-dependent children who are averse to food or the process of eating, specifically, there has yet to be an examination of children who are truly "orally" averse-resisting not just the presentation of food or liquid but also nonnutritive stimuli presented extra- or intra-orally...
July 13, 2020: Journal of Speech, Language, and Hearing Research: JSLHR
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