S S Sarycheva
The aim of this study was to estimate the effective doses (EDs) to children undergoing pediatric interventional cardiology examinations in hospitals of St.-Petersburg, to calculate associated dose conversion coefficients (DCCs) and to investigate their dependence of different parameters of the various procedures. Basic parameters of pediatric cardiology examinations and patient doses were studied in three main pediatric city hospitals. More than 300 examinations were under consideration. The technical, geometrical and dosimetric parameters, as well as patients' parameters, for each individual procedure were collected...
April 9, 2021: Radiation Protection Dosimetry
Grégoire Boulouis, Sarah Stricker, Sandro Benichi, Jean-François Hak, Florent Gariel, Manoelle Kossorotoff, Nicolas Garcelon, Annie Harroche, Quentin Alias, Lorenzo Garzelli, Fanny Bajolle, Nathalie Boddaert, Philippe Meyer, Thomas Blauwblomme, Olivier Naggara
OBJECTIVE: The clinical outcome of pediatric intracerebral hemorrhage (pICH) is rarely reported in a comprehensive way. In this cohort study, systematic review, and meta-analysis of patients with pICH, the authors aimed to describe the basic clinical outcomes of pICH. METHODS: Children who received treatment for pICH at the authors' institution were prospectively enrolled in the cohort in 2008; data since 2000 were retrospectively included, and data through October 2019 were analyzed...
April 9, 2021: Journal of Neurosurgery. Pediatrics
Patrick J Grover, Lauren Harris, Ayman M Qureshi, Adam Rennie, Fergus Robertson, Greg James
This is the eighth case report of a pediatric dissecting posterior inferior cerebellar artery aneurysm. The authors present the case of a 13-year-old boy who presented with posttraumatic posterior fossa subdural, subarachnoid, and intraventricular hemorrhage with hydrocephalus. Initial vascular imaging findings were negative; however, a high level of suspicion is necessary. The aneurysm was identified on day 20, after recurrence of hydrocephalus, and was treated with endovascular vessel sacrifice. The patient made a good recovery...
April 9, 2021: Journal of Neurosurgery. Pediatrics
Rahul Kumar, David S Hersh, Luke G F Smith, William E Gordon, Nickalus R Khan, Andrew J Gienapp, Busra Gungor, Michael J Herr, Brandy N Vaughn, L Madison Michael, Paul Klimo
OBJECTIVE: Neurosurgical residents receive exposure to the subspecialty of pediatric neurosurgery during training. The authors sought to determine resident operative experience in pediatric neurosurgery across Accreditation Council for Graduate Medical Education (ACGME)-accredited neurosurgical programs. METHODS: During 2018-2019, pediatric neurosurgical case logs for recent graduates or current residents who completed their primary pediatric exposure were collected from US continental ACGME training programs...
April 9, 2021: Journal of Neurosurgery. Pediatrics
Prachi N Patel, Matthew L Rohlfing, Jessica R Levi
Adenotonsillectomy is a common pediatric surgical procedure with a well-defined safety profile. Major complications from this procedure include bleeding/hemorrhage, infection, pain leading to dehydration, and airway obstruction or edema. Though rare, oral endotracheal intubation and oral retractor placement may result in injuries to the teeth and the surrounding soft tissue. We describe a rare case of delayed tooth decay in a 3-year-old female following an otherwise routine adenotonsillectomy.
March 31, 2021: American Journal of Otolaryngology
Michael S Weinstock, Amber D Shaffer, Amanda L Stapleton
PURPOSE: Pediatric cystic fibrosis (CF) patients have a variable onset, severity, and progression of sinonasal disease. The objective of this study was to identify genotypic and phenotypic factors associated with CF that are predictive of sinonasal disease, recurrent nasal polyposis, and failure to respond to standard treatment. METHODS: A retrospective case series was conducted of 30 pediatric patients with CF chronic rhinosinusitis with and without polyps. Patient specific mutations were divided by class and categorized into high risk (Class I-III) and low risk (Class IV-V)...
March 31, 2021: American Journal of Otolaryngology
Jithangi Wanigasinghe, Carukshi Arambepola, Shalini Sri Ranganathan, Kasun Jayasundara, Ashangi Weerasinghe, Piyumi Wickramarachchi
BACKGROUND: This article explores the role of initial treatment on control of spasms and other epilepsies at four years in children previously treated for West syndrome. METHODS: The Sri Lanka Infantile Spasm Study is a prospective clinical trial evaluating response to intra-muscular adrenocorticotropic hormone (ACTH) versus oral prednisolone. A previous report documented response through age 12 months. This article provides four-year follow-up data. RESULTS: At age four years, 65 of the original 97 were available for follow-up; another 13 had died, and 19 moved and could not be contacted...
March 8, 2021: Pediatric Neurology
Reza Pourmodheji, Zhenxiang Jiang, Christopher Tossas-Betancourt, C Alberto Figueroa, Seungik Baek, Lik-Chuan Lee
Microstructural changes in the pulmonary arteries associated with pulmonary arterial hypertension (PAH) is not well understood and characterized in humans. To address this issue, we developed and applied a patient-specific inverse finite element (FE) modeling framework to characterize mechanical and structural changes of the micro-constituents in the proximal pulmonary arteries using in-vivo pressure measurements and magnetic resonance images. The framework was applied using data acquired from a pediatric PAH patient and a heart transplant patient with normal pulmonary arterial pressure, which serves as control...
March 27, 2021: Journal of the Mechanical Behavior of Biomedical Materials
Juhye Roh, Sinyoung Kim, Eunmin Kwak, Jungyong Park, Younhee Park
INTRODUCTION: Cytomegalovirus (CMV) nucleic acid amplification testing is important for CMV infection diagnosis and management. CMV DNA is found in plasma and various other fluids, including urine. If CMV can be reliably detected in urine, it may be considered a non-invasive alternative to blood tests. The cobas 6800 system (Roche Diagnostics, Mannheim, Germany) is a Food and Drug Administration-approved testing platform for measuring CMV DNA in plasma. OBJECTIVE: To evaluate the analytical performance of the cobas 6800 system and compare the clinical feasibility of CMV detection in plasma and urine samples...
March 31, 2021: Journal of Clinical Virology
Yu Jeong Cho, Hyunhee Kwon, Yong Jae Kwon, Seong Chul Kim, Dae Yeon Kim, Jung-Man Namgoong
OBJECTIVE: Recently, sirolimus has emerged as a safe and effective treatment modality for unresectable vascular lesions. In this study, we investigated the effectiveness and safety of sirolimus based an early experience with patients with unresectable vascular anomalies. METHODS: Medical records and radiological images of all patients with unresectable vascular anomalies treated with sirolimus at our center between January 2018 and November 2019 were retrospectively reviewed...
April 6, 2021: Journal of Vascular Surgery. Venous and Lymphatic Disorders
Claire Guivarch, Anne-Sylvia Sacri, Corinne Levy, Alain Bocquet, Nathanaël Lapidus, Serge Hercberg, Pascale Hebel, Anne Chevé, Christian Copin, Morched Zouari, Laurent Gouya, Mariane de Montalembert, Jérémie F Cohen, Martin Chalumeau
OBJECTIVE: To assess the diagnostic accuracy and to develop prediction tools for iron deficiency in 2-year-old children. STUDY DESIGN: In a national cross-sectional study conducted in primary care pediatricians' practices throughout France, 2-year-old children were consecutively included (2016-2017). Multivariable logistic regression modeling and bootstrapping were used to develop several clinical models to predict ID (serum ferritin <12 μg/L). These models used the best criteria and combinations among the American Academy of Pediatrics' (AAP) criteria adapted to the European context (n=10), then all potential predictors (n=19)...
April 6, 2021: Journal of Pediatrics
Yanyan Ni, Helen O'Reilly, Samantha Johnson, Neil Marlow, Dieter Wolke
OBJECTIVE: To examine self-reported and parent-reported health-related quality of life (HRQL) in adults born extremely preterm compared with term-born controls and to evaluate trajectories of health status from adolescence to early adulthood. STUDY DESIGN: The EPICure study comprises all births <26 weeks of gestation in the United Kingdom (UK) and Ireland in 1995 and term-born controls recruited at age 6. 129 participants born extremely preterm and 65 controls were followed up at the 19-year assessment...
April 6, 2021: Journal of Pediatrics
Priyal O Patel, Adriane L Baylis, Scott E Hickey, Joseph Stanek, Richard E Kirschner, Margaret L Rand, Riten Kumar
OBJECTIVES: To prospectively quantify bleeding severity and elaborate hemorrhagic symptoms in children with 22q11.2 deletion syndrome (22q11DS) using two validated bleeding-assessment-tools (BATs), namely the pediatric bleeding questionnaire (PBQ) and the International Society on Thrombosis and Hemostasis BAT (ISTH-BAT). We additionally sought to compare subjects' bleeding scores to unaffected first-degree family members. STUDY DESIGN: Children with 22q11DS and unaffected first-degree family members were recruited for the study...
April 6, 2021: Journal of Pediatrics
Ravi M Patel, Jeanne E Hendrickson, Marianne E Nellis, Rebecca Birch, Ruchika Goel, Oliver Karam, Matthew S Karafin, Sheila J Hanson, Bruce S Sachais, Ronald George Hauser, Naomi L C Luban, Jerome Gottschall, Cassandra D Josephson, Martha Sola-Visner
OBJECTIVE: To estimate the incidence of blood product transfusion, including red blood cells, platelets, and plasma, and characterize pre-transfusion hematologic values for infants during their initial hospitalization after birth. STUDY DESIGN: Retrospective cohort study using data from 7 geographically diverse US academic and community hospitals that participated in the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) from 2013-2016...
April 6, 2021: Journal of Pediatrics
Francesca Minoia, Jessica Tibaldi, Valentina Muratore, Romina Gallizzi, Claudia Bracaglia, Alessia Arduini, Elif Comak, Olga Vougiouka, Ralf Trauzeddel, Giovanni Filocamo, Antonio Mastrangelo, Concetta Micalizzi, Ozgur Kasapcopur, Erbil Unsal, Toshiyuki Kitoh, Elena Tsitsami, Mikhail Kostik, Jana Pachlopnik Schmid, Seraina Prader, Guido Laube, Despoina Maritsi, Marija Jelusic, Susan Shenoi, Sebastiaan Vastert, Gianluigi Ardissino, Randy Q Cron, Angelo Ravelli
OBJECTIVE: To describe the clinical characteristics, treatment, and outcomes of a multinational cohort of patients with macrophage activation syndrome (MAS) and thrombotic microangiopathy (TMA). STUDY DESIGN: International pediatric rheumatologists were asked to collect retrospectively the data of patients with the co-occurrence of MAS and TMA. Clinical and laboratory features of patients with systemic juvenile idiopathic arthritis (sJIA)-associated MAS and TMA were compared with those of an historical cohort of patients with sJIA and MAS...
April 6, 2021: Journal of Pediatrics
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No abstract text is available yet for this article.
May 2021: Pediatric Pulmonology
Claire L Wittowski, Sarah Clowes Candadai, Marie E Perrone, Daniel F Gallego, Jessie H Conta, Jane A Dickerson
CONTEXT.—: Genomic molecular testing practices in a pediatric tertiary care institution. OBJECTIVE.—: To evaluate exome sequencing (ES) ordering practices and the effects of applying criteria to support ES stewardship. Exome sequencing can provide molecular diagnostic information for patients with known or suspected genetic diseases, but it is relatively expensive, and the cost is often borne by patients, institutions, and payers. DESIGN.—: We examined ordering patterns of ES approved by board-certified geneticists at our tertiary pediatric care center, as well as preauthorization outcomes for ES requests...
April 9, 2021: Archives of Pathology & Laboratory Medicine
Madeline M Lyons, Adam M Holzmeister, Teresa Cappello
CASE: A 12-year-old patient presented after a fall onto her upper extremity. She was found to have a mildly displaced clavicle fracture with a subclavian artery thrombosis. Given the reconstitution of flow distal to the thrombosis, the patient was treated nonoperatively in consultation with vascular surgery with anticoagulation and a sling for immobilization. CONCLUSION: This case highlights the importance of a thorough neurovascular examination even in a mildly displaced fracture...
April 9, 2021: JBJS Case Connector
Yukinori Yoshimura, Sumie Yamashita, Masahito Sato, Kosuke Iwano, Akira Kurita, Daisuke Hata
No abstract text is available yet for this article.
March 1, 2021: Pancreas
Liron Birimberg-Schwartz, Sara Rajiwate, Annie Dupuis, Tanja Gonska
OBJECTIVE: To examine the changes over time of pediatric acute pancreatitis (AP) severity, management, and disease outcomes at our academic tertiary center. METHODS: We reviewed 223 pediatric AP admissions (2002-2018) and used a time-to-event regression model to study changes over time. Disease outcomes were analyzed using a subgroup of 89 patients in whom only the AP event determined length of hospital stay and duration of opioid use. RESULTS: There was an increase in mild, but not severe, AP episodes over the examined period...
March 1, 2021: Pancreas
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