Maha Al-Ghafry, Banu Aygun, Abena Appiah-Kubi, Adrianna Vlachos, Gholamabbas Ostovar, Christine Capone, Tod Sweberg, Nancy Palumbo, Pratichi Goenka, Lawrence W Wolfe, Jeffrey M Lipton, Suchitra S Acharya
The coagulopathy of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is well documented in adults, with increases in D-dimer and prothrombin time found to be strong predictors of mortality, and anticoagulation shown to decrease this mortality. Viscoelastic parameters such as elevations in maximum clot firmness (MCF) on rotational thromboelastometry (ROTEM) have correlated with a hypercoagulable state in adults with SARS-CoV-2. We report our experience in children infected with SARS-CoV-2, with noted elevations in D-dimer and MCF on ROTEM (indicating hypercoagulability)...
December 2020: Pediatric Blood & Cancer
Cristina F Contreras, Christine S Higham, Astrid Behnert, Kailyn Kim, Elliot Stieglitz, Sarah K Tasian
BACKGROUND: The treatment paradigm for patients with relapsed/refractory B-cell acute lymphoblastic leukemia (rrALL) has been revolutionized given recent clinical trials demonstrating remarkable success of immunotherapies and leading to drug approvals by United States and European agencies. We report experience with commercial blinatumomab and inotuzumab use at two North American pediatric oncology centers in children and adolescents/young adults with B-ALL. PROCEDURE: Patients 0-25 years old treated with the CD19 × CD3 bispecific T cell-engaging antibody blinatumomab and/or the CD22 antibody-drug conjugate inotuzumab from January 1, 2010, to June 1, 2018, were eligible...
October 24, 2020: Pediatric Blood & Cancer
Elif Oğuz, Berna Terzioğlu Bebitoğlu, Çağatay Nuhoğlu, Yasemin Çağ, Ajla Hodzic, Fatime Temel, Pelin Çırtlık, Ayşe Ela Kurtdan Dalkılıç
BACKGROUND: Antibiotics are widely used and inaccurate or inappropriate prescription of antibiotics causes a significant increase in the prevalence of multidrug-resistant bacterial infections among children. This research aimed to study antibiotic prescriptions in hospitalized pediatric patients and to determine the prevalence of inappropriate antimicrobial use and the main types of prescribing errors. METHODS: After obtaining the Ethics Committee approval, screening was conducted among 535 patients admitted to the Department of Pediatrics at Haydarpasa Numune Training and Research Hospital in the period of 01...
October 24, 2020: International Journal of Clinical Practice
Abigail Thompson, Nikolaus Steinbeis
Computational modelling can be used to precisely characterise the cognitive processes involved in attentional biases towards threat, yet so far has only been applied in the context of adult anxiety. Furthermore, studies investigating attentional biases in childhood anxiety have largely used tasks that conflate automatic and controlled attentional processes. By using a perceptual load paradigm, we separately investigate contributions from automatic and controlled processes to attentional biases towards negative stimuli and their association with pediatric anxiety...
October 24, 2020: Developmental Science
Christina Merakou, Irene Fylaktou, Amalia Sertedaki, Maria Dracopoulou, Antonis Voutetakis, Alexandra Efthymiadou, Athanasios Christoforidis, Catherine Dacou-Voutetakis, Dionisios Chrysis, Christina Kanaka-Gantenbein
CONTEXT: Isolated congenital hypoaldosteronism presents in early infancy with symptoms including vomiting, severe dehydration, salt wasting and failure to thrive. The main causes of this rare autosomal recessive disorder are pathogenic variants of the CYP11B2 gene leading to Aldosterone Synthase Deficiency. OBJECTIVE: To investigate the presence of CYP11B2 pathogenic variants in a cohort of patients with a clinical, biochemical and hormonal profile suggestive of Aldosterone Synthase Deficiency...
October 24, 2020: Journal of Clinical Endocrinology and Metabolism
Silvia Bloise, Vanessa Martucci, Alessia Marcellino, Saverio Mallardo, Riccardo Lubrano
No abstract text is available yet for this article.
October 24, 2020: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Miguel Mendivil-Perez, Carlos Velez-Pardo, Gloria E David-Yepes, Javier E Fox, Marlene Jimenez-Del-Rio
Despite some advances in the treatment of acute lymphoblastic (ALL) and myeloid leukemia (AML) in recent years, there is still a prominent percentage of pediatric patients with a reduced overall prognosis. Therefore, other therapeutic approaches are needed to treat those patients. In the present study, we report that the metal chelator TPEN affected ΔΨm and DNA content in isolated CD34+ refractory cells from bone marrow ALL (n = 7; B-cell, n = 4; T-cell, n = 3) and AML (n = 3) pediatric patients...
October 24, 2020: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Christopher S Hong, Greg Fliney, Adeniyi Fisayo, Yi An, Pallavi P Gopal, Antonio Omuro, Renelle Pointdujour-Lim, E Zeynep Erson-Omay, S Bulent Omay
Optic nerve glioma (ONG) is a rare, typically slow-growing WHO I grade tumor that affects the visual pathways. ONG is most commonly seen in the pediatric population, in association with neurofibromatosis type 1 syndrome. However, sporadic adult cases may also occur and may clinically behave more aggressively, despite benign histopathology. Genetic characterization of these tumors, particularly in the adult population, is lacking. A 39-year-old female presented with 1 month of progressive left-sided visual loss secondary to a enhancing mass along the left optic nerve sheath...
October 24, 2020: Brain Tumor Pathology
Haixia Feng, Tian Zhang, Weihui Yan, Lina Lu, Yijng Tao, Wei Cai, Ying Wang
PURPOSE: Vitamins and trace elements are essential nutrients for growth and intestinal adaptation in children with short bowel syndrome (SBS). This study aimed to assess micronutrients' status during and after weaning off PN in pediatric SBS. METHODS: This retrospective study evaluated the follow-up of 31 children with SBS between Jan 2010 and Sep 2019. Clinical data were reviewed from the patients' electric medical record. Serum electrolytes, trace elements, vitamin B12, vitamin D, and folate concentrations were collected before and after enteral autonomy...
October 24, 2020: Pediatric Surgery International
Leopoldo Mandic Ferreira Furtado, José Aloysio da Costa Val Filho, Alexandre Varella Giannetti
PURPOSE: Evidence supporting the effectiveness of endoscopic aqueductoplasty (EA) for the treatment of isolated fourth ventricle (IFV) is limited to small surgical series of cases. Additionally, studies adopted different radiological outcome criteria, which makes it difficult to compare outcomes accurately. Thus, we aimed to develop a radiological score (RS) as an alternative assessment method for EA. METHODS: The cases of 20 consecutive pediatric patients harboring IFV and treated by EA were retrospectively reviewed...
October 24, 2020: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Han Chen, Xin-Yu Li, Li-Ping Zhan, Jian-Pei Fang, Ke Huang, Yang Li, Wen-Jun Weng, Lv-Hong Xu, Hong-Gui Xu, Dun-Hua Zhou
BACKGROUND: Early-onset mixed chimerism (MC) with a high proportion of residual host cells is considered a signal of graft rejection in patients undergoing allogenic hematopoietic stem cell transplantation for transfusion-dependent thalassemia. In order to prevent graft rejection and minimize the risk of treatment-related graft-versus-host disease (GVHD), we established a hierarchical management system based on chimerism analysis. METHOD: This retrospective study provides a comprehensive review of the characteristics, interventions, and outcomes of the 38 patients who developed MC after transplantation among the 144 pediatric thalassemia patients between July 2007 and January 2019 at our center...
October 24, 2020: Pediatric Transplantation
Friederike Kogel, Dani Hakimeh, Pietro Sodani, Peter Lang, Jörn-Sven Kühl, Patrick Hundsdoerfer, Annette Künkele, Angelika Eggert, Lena Oevermann, Johannes H Schulte
HSCT is curative in SCD. Patients with HLA-identical sibling donor have an excellent outcome ranging from 90%-100% overall and event-free survival. However, due to the lack of matched sibling donors this option is out of reach for 70% of patients with SCD. The pool of potential donors needs to be extended. Transplantations from HLA-matched unrelated donors were reported to be less successful with shorter event-free survival and higher incidences of complications including graft-vs-host disease, especially in patients with advanced stage SCD...
October 24, 2020: Pediatric Transplantation
Yang Hu, Ming Zhao, Li Li, Jie Ding, Yu-Min Gui, Tan-Wei Wei
Retinoblastoma (Rb) is the most common pediatric malignant tumor of the eyes. Previous studies demonstrated that miR-491-3p is downregulated in various cancers. However, its function in Rb remains unknown. A total of 15 pairs of primary Rb tissues and adjacent noncancerous tissues were collected. Quantitative real-time PCR (qRT-PCR) was used to investigate the expression profiles of miR-491-3p. qRT-PCR, western blotting and in situ immunocytochemistry were performed to investigate the expression profiles of epithelial-mesenchymal transition-related proteins (E-cadherin, Vimentin and N-cadherin) in Rb tissues and Rb cell lines as well as cell morphology...
October 23, 2020: Biochemical Genetics
Margaret L Lawson, Kate C Verbeeten, Jennilea M Courtney, Brenda J Bradley, Karen McAssey, Cheril Clarson, Susan Kirsch, Jacqueline R Curtis, Farid H Mahmud, Christine Richardson, Tammy Cooper, Jason Chan, Ken Tang
OBJECTIVE: To determine whether timing of CGM initiation offering low glucose suspend (LGS) affects CGM adherence in children and youth starting insulin pump therapy. METHODS: A 5-site RCT of pump-naïve subjects (aged 5-18 years) with type 1 diabetes (T1D) for at least 1 year compared simultaneous pump and CGM initiation offering LGS vs. standard pump therapy with CGM initiation delayed for 6 months. Primary outcome was CGM adherence (hours per 28 days) (MiniMed™ Paradigm™ Veo™ system; CareLink™ Pro software) over 6 months after CGM initiation...
October 23, 2020: Pediatric Diabetes
Raphael Werner, Christian Benden
For infants, children, and adolescents with progressive advanced lung disease, lung transplantation represents the ultimate therapy option. Fortunately, outcomes after pediatric lung transplantation have improved in recent years now producing good long-term outcomes, no less than comparable to adult lung transplantation. The field of pediatric lung transplantation has rapidly advanced; thus, this review aims to update on important issues such as transplant referral and assessment, and extra-corporal life support as "bridge to transplantation"...
October 23, 2020: Clinical Transplantation
Faraz Ahmad, Lee Treanor, Trevor A McGrath, Daniel Walker, Matthew D F McInnes, Nicola Schieda
BACKGROUND: Ferumoxytol has been studied as an alternative to gadolinium-based MRI contrast agents, but regulatory body warnings currently limit its use. PURPOSE: Estimate the adverse event rate in patients undergoing MRI with ferumoxytol as a contrast agent. STUDY TYPE: Systematic review. POPULATION: Thirty-nine studies including 5411 ferumoxytol administrations in 4336 patients. ASSESSMENT: Multiple databases were searched for studies using ferumoxytol as an off-label MRI contrast agent in any patient population as of April 2020...
October 24, 2020: Journal of Magnetic Resonance Imaging: JMRI
Muhammed Shareef, Mona P Nasrallah, Natally AlArab, Lamya A Atweh, Catherina Zadeh, Roula Hourani
OBJECTIVE: To determine the incidence of pituitary incidentalomas in the pediatric population and among its different age subgroups as well as to identify the characteristics of these lesions. Additionally, we aim to give a perspective on the management and follow-up of these patients. DESIGN AND PATIENTS: We retrospectively studied MRI of children aged 18 years or below who underwent MRI with sellar region within their field of view between January 2010 and December 2018...
October 23, 2020: Clinical Endocrinology
Supriya Mahajan, Bikrant Bihari Lal, Vikrant Sood, Vikas Khillan, Rajeev Khanna, Seema Alam
OBJECTIVE: To study the clinico-bacteriological profile of ascitic fluid infection (AFI) and its impact on outcome in childhood chronic liver disease (CLD). METHODS: It was a retrospective study on pediatric CLD patients requiring an ascitic tap. Logistic regression was performed to study the predictive factors for AFI. RESULTS: Two hundred and fifty-two (30.9%) of 814 children with CLD underwent ascitic tap on suspicion of AFI of whom 79 (31...
October 24, 2020: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
Andrea Sisti, Maria T Huayllani, Daniel Boczar, David J Restrepo, Gabriela Cinotto, Xiaona Lu, Roberto Cuomo, Luca Grimaldi, Giuseppe Nisi, Antonio J Forte
BACKGROUND: There are many instances in which sacrificing the umbilicus is unavoidable. Umbilical reconstruction (umbiliconeoplasty) is an important surgical procedure to complete the abdomen's reconstruction and to give again a pleasant cosmetic appearance. OBJECTIVES: To provide a complete overview of all surgical techniques for umbiliconeoplasty described in the literature. METHODS: PubMed database was queried using 'umbilical and reconstruction', 'umbilicus and reconstruction', 'navel and reconstruction', 'umbiliconeoplasty', 'neo-omphaloplasty' or 'umbilicaneoplasty' to select the papers dealing with the reconstruction of the umbilicus...
October 23, 2020: Aesthetic Plastic Surgery
Ming Luo, Diwei Wu, Xuanhe You, Zhipeng Deng, Limin Liu, Yueming Song, Shishu Huang
The pathophysiology behind the instigation and progression of scoliosis in Chiari malformation type I (CMI) patients has not been elucidated yet. This study aims to explore the initiating and progressive factors for scoliosis secondary to CMI. Pediatric patients with CMI were retrospectively reviewed for radiological characteristics of tonsillar herniation, craniocervical anomaly, syrinx morphology, and scoliosis. Subgroup analyses of the presence of syrinx, scoliosis, and curve progression were also performed...
October 23, 2020: Neurosurgical Review
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