Sagar Mehta, Tomisin John, Jordan J Feld, Hemant Shah, Nisa Mullaithilaga, Aaron Campigotto, Karen Leung, Binita M Kamath, Simon C Ling, Michelle Science, Vicky L Ng
BACKGROUND: We evaluated the proportion, clinical features, and outcomes of previously healthy children presenting to a large Canadian quaternary pediatric center with severe acute hepatitis of unknown etiology. METHODS: All patients with serum alanine aminotransferase (ALT) > 500 U/L or aspartate aminotransferase (AST) > 500 U/L between June 1, 2018, and May 31, 2022, at The Hospital for Sick Children, were identified. Subjects with only AST > 500 U/L were excluded...
October 1, 2023: Hepatology Communications