Zeinab Aryanian, Morvarid Najafi, Mahshid Ansari, Maryam Nassimi, Ifa Etesami, Sama Heidari, Azadeh Khayyat, Parvaneh Hatami
BACKGROUND: Alopecia areata is a chronic and relapsing condition that affects individuals of all age groups. Dermoscopy is a popular and non-invasive method for diagnosing alopecia areata. This study aimed to analyze dermoscopic findings and their relationship with age, gender, appearance, and clinical signs in children and adults. METHODS: This retrospective cross-sectional study was conducted on 124 children and adults diagnosed with alopecia areata who were referred to a Hospital in Iran between 2021 and 2022...
April 13, 2024: Journal of Cosmetic Dermatology
Jacqueline Crawford, Cassie McFarlane, Anita N Datta
Introduction: Frontal-predominant epileptiform discharges (EDs) include generalized spike-wave (GSW) and frontal spikes (FS). However, negative bi-frontal ED with simultaneous occipital positivity (BFOD) are rare, leading to questions regarding physiological generators. Methods: To determine the clinical significance of BFOD, electroclinical features of children with BFOD (n = 40) were compared to control patients with GSW (n = 102) and FS (n = 100). Results: Results are presented in the following order: BFOD, GSW, and FS...
April 13, 2024: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
Elise Poutrain, Marie Abelé-Naveau, Marion Baltora, Alexandre Villain, Ilyes Sakji, Geoffrey Strobbe, Guillaume Marliot
INTRODUCTION: Oral chemotherapies pediatrics are manufactured from injectable specialties in a controlled-atmosphere area. Packaged in Luer-Lock syringes, the transition to an ENFit™ connector became crucial to enable administration in surveyed patients. In parallel, a study was carried out to optimize and secure patient care by setting up a retrocession circuit. OBJECTIVE: To introduce the ENFit™ range of devices into the manufacturing process for oral or enteral chemotherapy syringes...
April 13, 2024: Journal of Oncology Pharmacy Practice
Wei Tang, Ke-Mi Wu, Qiong Zhou, Yan-Fei Tang, Jun-Fen Fu, Guan-Ping Dong, Chao-Chun Zou
OBJECTIVE: To characterize the phenotype spectrum, diagnosis, and response to growth-promoting therapy in patients with ACAN variants causing familial short stature. METHODS: Three families with ACAN variants causing short stature were reported. Similar cases in the literature were summarized, and the genotype and phenotype were analyzed. RESULTS: Three novel heterozygous variants, c.757+1G>A, (splicing), c.6229delG, p.(Asp2078Tfs*1), and c...
April 2024: Molecular Genetics & Genomic Medicine
Inderpreet Kaur Khalsa, Michelle M Florentine, Elizabeth N Liao, Jihyun Stephans, Dylan K Chan
OBJECTIVE: To identify geographic, sociodemographic, and clinical factors associated with parental self-efficacy in a diverse cohort of deaf or hard-of-hearing (DHH) children. STUDY DESIGN: Cross-sectional study. SETTING: Tertiary children's hospital. METHODS: Four hundred forty parents of DHH children aged 0 to 17 completed the 25-item Scale of Parental Involvement and Self-Efficacy (SPISE) survey from 2014 to 2022...
April 12, 2024: Otolaryngology—Head and Neck Surgery
Nils Hansson, Daniela Angetter-Pfeiffer
No abstract text is available yet for this article.
April 12, 2024: Acta Paediatrica
Maximilian Klink, Matthias Felber, Ulrike Zeilhofer, Mathias Hauri-Hohl, Markus Schmugge, Daniel Drozdov, Tayfun Güngör
BACKGROUND: Hematopoietic cell transplantation (HCT) is an established curative therapy for transfusion-dependent thalassemia (TDT) and sickle cell disease (SCD). The latest American Society of Hematology guidelines recommend myeloablative preparative regimen in patients under 18 years of age. PROCEDURE: The objective was to demonstrate safety and efficacy of a reduced intensity conditioning (RIC) regimen including high-dose fludarabine, anti-thymocyte globulin, and targeted busulfan as a single alkylator to sub-myeloablative exposures...
April 12, 2024: Pediatric Blood & Cancer
Jean de Ville de Goyet
No abstract text is available yet for this article.
May 2024: Pediatric Transplantation
Odelia Vingrovich, Shiri Cooper, Michael Gurevich, Aenov Cohen, Yael Mozer-Glassberg, Michal Rosenfeld Bar-Lev, Raanan Shamir, Orith Waisbourd-Zinman
BACKGROUND: Biliary strictures are a significant cause of morbidity and graft loss in pediatric liver transplant recipients. Risk factors for the development of biliary strictures are not fully established. We aimed to evaluate the incidence of biliary strictures and treatment modalities outcomes and to identify potential risk factors for occurrence. METHODS: Pediatric patients who underwent liver transplantation in the single tertiary pediatric liver transplant center in Israel were evaluated...
May 2024: Pediatric Transplantation
Firezer Haregu, R Jerome Dixon, Michael Porter, Michael McCulloch
BACKGROUND: Organ procurement organizations (OPOs) are responsible for the medical management of organ donors. Given the variability in pediatric donor heart utilization among OPOs, we examined factors that may explain this variability, including differences in donor medical management, organ quality, and candidate factors. METHODS: The Organ Procurement and Transplant Network database was queried for pediatric (<18 years) heart donors and candidates receiving pediatric donor heart offers from 2010 to 2019...
May 2024: Pediatric Transplantation
Katarzyna Smolińska, Aleksandra Szopa, Jan Sobczyński, Anna Serefko, Piotr Dobrowolski
Given the comprehensive examination of the role of fatty acid-rich diets in central nervous system development in children, this study bridges significant gaps in the understanding of dietary effects on neurodevelopment. It delves into the essential functions of fatty acids in neurodevelopment, including their contributions to neuronal membrane formation, neuroinflammatory modulation, neurogenesis, and synaptic plasticity. Despite the acknowledged importance of these nutrients, this review reveals a lack of comprehensive synthesis in current research, particularly regarding the broader spectrum of fatty acids and their optimal levels throughout childhood...
April 8, 2024: Nutrients
Raghavendra B Rao
Iron deficiency in the fetal and neonatal period (perinatal iron deficiency) bodes poorly for neurodevelopment. Given its common occurrence and the negative impact on brain development, a screening and treatment strategy that is focused on optimizing brain development in perinatal iron deficiency is necessary. Pediatric societies currently recommend a universal iron supplementation strategy for full-term and preterm infants that does not consider individual variation in body iron status and thus could lead to undertreatment or overtreatment...
April 8, 2024: Nutrients
Larissa Caetano Silva, Eduardo Yoshio Nakano, Renata Puppin Zandonadi
The objective of this cross-sectional study was to assess eating competence (EC) and the adherence to the division of responsibility in child feeding (sDOR) of Brazilian caregivers of children with celiac disease (CD). It also examined the association between EC and sDOR, children's adherence to a gluten-free diet, and sociodemographic data. This study administered a survey set that included sociodemographic data, health-related data, eating habits, and the instruments ecSI2.0TM BR and sDOR.2-6yTM BR, validated for a Brazilian population...
April 4, 2024: Nutrients
Stephanie Dijk, Megan Jarman, Zhengxiao Zhang, Morgan Lawley, Muzammil Ahmad, Ricardo Suarez, Laura Rossi, Min Chen, Jessica Wu, Matthew W Carroll, Anthony Otley, Mary Sherlock, David R Mack, Kevan Jacobson, Jennifer C deBruyn, Wael El-Matary, Colette Deslandres, Mohsin Rashid, Peter C Church, Thomas D Walters, Hien Q Huynh, Michael G Surette, Anne M Griffiths, Eytan Wine
Exclusive enteral nutrition (EEN) is effective in inducing remission in pediatric Crohn disease (CD). EEN alters the intestinal microbiome, but precise mechanisms are unknown. We hypothesized that pre-diagnosis diet establishes a baseline gut microbiome, which then mediates response to EEN. We analyzed prospectively recorded food frequency questionnaires (FFQs) for pre-diagnosis dietary patterns. Fecal microbiota were sequenced (16SrRNA) at baseline and through an 18-month follow-up period. Dietary patterns, Mediterranean diet adherence, and stool microbiota were associated with EEN treatment outcomes, disease flare, need for anti-tumor necrosis factor (TNF)-α therapy, and long-term clinical outcomes...
April 2, 2024: Nutrients
David Berlana, Juan López-Hellín, Alba Pau-Parra, Roser Ferrer-Costa
Aluminum contamination in parenteral nutrition (PN) solutions can lead to neurotoxicity, reduced bone mass, and liver toxicity, especially in pediatric patients. Ingredients commonly used in PN compounding, such as vitamins, trace elements, calcium, and phosphate salts, contain significant amounts of aluminum. This study aimed to compare aluminum concentrations in multichamber-bag (MCB) and compounded PN for adults and pediatrics. A prospective study assessed aluminum concentrations in various types of MCB and compared them with compounded PN formulations with similar compositions...
April 1, 2024: Nutrients
Valeria Calcaterra, Hellas Cena, Rachele De Giuseppe, Ginevra Biino, Roberta Grazi, Matteo Manuelli, Sara Zanelli, Veronica Tagi, Alessandra Vincenti, Gianvincenzo Zuccotti, Valentina Fabiano
BACKGROUND: The identification of vitamin D (VitD) deficiency in pediatric populations is essential for preventive healthcare. We refined and tested the Evaluation of Deficiency Questionnaire (EVIDENCe-Q) for its utility in detecting VitD insufficiency among children. PATIENTS AND METHODS: We enrolled 201 pediatric patients (aged between 3 and 18 years). Clinical evaluation and serum vitamin D levels were assessed in all subjects. The EVIDENCe-Q was updated to incorporate factors influencing VitD biosynthesis, intake, assimilation, and metabolism, with scores spanning from 0 (optimal) to 36 (poor)...
March 27, 2024: Nutrients
Roser Ayats-Vidal, Montserrat Bosque-García, Begoña Cordobilla, Oscar Asensio-De la Cruz, Miguel García-González, Susana Loureda-Pérez, Elena Fernández-López, Eva Robert-Barriocanal, Andrea Valiente-Planas, Joan Carles Domingo
A randomized, double-blind, and placebo-controlled study was conducted to assess the effect of dietary supplementation with high-rich docosahexaenoic acid (DHA) (Tridocosahexanoin-AOX® 70%) at 50 mg/kg/day in pediatric patients with cystic fibrosis (CF) as compared with placebo. The duration of supplementation was 12 months. A total of 22 patients were included, with 11 in the DHA group and 11 in the placebo group. The mean age was 11.7 years. The outcome variables were pulmonary function, exacerbations, sputum cellularity, inflammatory biomarkers in sputum and peripheral blood, and anthropometric variables...
March 27, 2024: Nutrients
Laura Pedretti, Davide Leardini, Edoardo Muratore, Gaia Capoferri, Serena Massa, Sofia Rahman, Susanna Esposito, Riccardo Masetti
Infections pose a significant threat to morbidity and mortality during treatments for pediatric cancer patients. Efforts to minimize the risk of infection necessitate preventive measures encompassing both environmental and host-focused strategies. While a substantial number of infections in oncologic patients originate from microorganisms within their native microbiological environment, such as the oral cavity, intestines, and skin, the concrete risk of bloodstream infections linked to the consumption of contaminated food and beverages in the community cannot be overlooked...
March 27, 2024: Nutrients
Monireh Saeid Nia, Lena Maria Floder, Jette Anika Seiler, Thomas Puehler, Nina Sophie Pommert, Rouven Berndt, David Meier, Stephanie L Sellers, Janarthanan Sathananthan, Xiling Zhang, Mario Hasler, Stanislav N Gorb, Gregor Warnecke, Georg Lutter
One of the most important medical interventions for individuals with heart valvular disease is heart valve replacement, which is not without substantial challenges, particularly for pediatric patients. Due to their biological properties and biocompatibility, natural tissue-originated scaffolds derived from human or animal sources are one type of scaffold that is widely used in tissue engineering. However, they are known for their high potential for immunogenicity. Being free of cells and genetic material, decellularized xenografts, consequently, have low immunogenicity and, thus, are expected to be tolerated by the recipient's immune system...
April 4, 2024: International Journal of Molecular Sciences
Justyna Szydlowska-Gladysz, Adrianna Edyta Gorecka, Julia Stepien, Izabela Rysz, Iwona Ben-Skowronek
This study examines the impact of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor 2 (IGF-2) on various aspects of children's health-from the realms of growth and puberty to the nuanced characteristics of metabolic syndrome, diabetes, liver pathology, carcinogenic potential, and cardiovascular disorders. A comprehensive literature review was conducted using PubMed, with a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method employing specific keywords related to child health, obesity, and insulin-like growth factors...
April 2, 2024: International Journal of Molecular Sciences
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