Matteo Nardin, Monica Verdoia, Simone Nardin, Davide Cao, Mauro Chiarito, Elvin Kedhi, Gennaro Galasso, Gianluigi Condorelli, Giuseppe De Luca
Vitamin D is rightly recognized as an essential key factor in the regulation of calcium and phosphate homeostasis, affecting primary adequate bone mineralization. In the last decades, a more complex and wider role of vitamin D has been postulated and demonstrated. Cardiovascular diseases have been found to be strongly related to vitamin D levels, especially to its deficiency. Pre-clinical studies have suggested a direct role of vitamin D in the regulation of several pathophysiological pathways, such as endothelial dysfunction and platelet aggregation; moreover, observational data have confirmed the relationship with different conditions, including coronary artery disease, heart failure, and hypertension...
March 30, 2024: Biomedicines