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JOURNAL ARTICLE
Yanjie Huang, Fangfang Dai, Liping Chen, Zhidian Li, Hua Liu, Yanxiang Cheng
BACKGROUND: Recurrent spontaneous abortion (RSA) is defined as the loss of two or more consecutive intrauterine pregnancies with the same sexual partner in the first trimester. Despite its significance, the etiology and underlying mechanisms of RSA remain elusive. Defective decidualization is proposed as one of the potential causes of RSA, with abnormal decidualization leading to disturbances in trophoblast invasion function. METHODS: Decidual samples were collected from both RSA patients and healthy controls to assess BMP4 expression...
April 29, 2024: Endocrinology
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JOURNAL ARTICLE
Sine Knorr, Jori Aalders, Martin Overgaard, Henrik Støvring, Elisabeth R Mathiesen, Peter Damm, Tine D Clausen, Ulla Bjerre-Christensen, Lise Lotte T Andersen, Christina Vinter, Allan Kofoed-Enevoldsen, Jeannet Lauenborg, Ulla Kampmann, Jens Fuglsang, Per G Ovesen, Trine T Christensen, Anne Sørensen, Lene Ringholm, Dorte M Jensen
INTRODUCTION: Despite technological developments and intensified care, pregnancies in women with pre-existing diabetes are still considered high-risk pregnancies. The rate of adverse outcomes in pregnancies affected by diabetes in Denmark is currently unknown, and there is a limited understanding of mechanisms contributing to this elevated risk. To address these gaps, the Danish Diabetes Birth Registry 2 (DDBR2) was established. The aims of this registry are to evaluate maternal and fetal-neonatal outcomes based on 5 years cohort data, and to identify pathophysiology and risk factors associated with short-term and long-term outcomes of pregnancies in women with pre-existing diabetes...
April 25, 2024: BMJ Open
#3
JOURNAL ARTICLE
Qianqian Gao, Guanying Xu, Guijie Wang, Wei Wang, Chao Zhu, Yang Shi, Changzhuang Guo, Jing Cong, Hongxia Ming, Dongmei Su, Xu Ma
BACKGROUND: Both the mother and the infant are negatively impacted by macrosomia. Macrosomia is three times as common in hyperglycemic mothers as in normal mothers. This study sought to determine why hyperglycemic mothers experienced higher macrosomia. Methods: Hematoxylin and Eosin staining was used to detect the placental structure of normal mother(NN), mothers who gave birth to macrosomia(NM), and mothers who gave birth to macrosomia and had hyperglycemia (DM). The gene expressions of different groups were detected by RNA-seq...
2024: Frontiers in Endocrinology
#4
JOURNAL ARTICLE
Lucile Ferreux, Mathilde Bourdon, Ahmed Chargui, Julie Firmin, Chloé Maignien, Pietro Santulli, Catherine Patrat, Khaled Pocate-Cheriet
BACKGROUND: The Live Birth Rate (LBR) after day 5 (D5) blastocyst transfer is significantly higher than that with D6 embryos in both fresh and frozen-vitrified embryo transfer cycles, according to the most recently published meta-analyses. Therefore, for women obtaining only D6 blastocysts, the chances of pregnancy may be lower but nonetheless sufficient to warrant transferring such embryos. The best strategy for transfer (i.e., in fresh versus frozen cycles) remains unclear and there is a paucity of data on this subject...
April 24, 2024: Reproductive Biology and Endocrinology: RB&E
#5
JOURNAL ARTICLE
LillyBelle K Deer, Ella-Marie P Hennessey, Jenalee R Doom, Robert J Gallop, M Camille Hoffman, Catherine H Demers, Benjamin L Hankin, Elysia Poggi Davis
BACKGROUND: Prenatal glucocorticoids are one of the most widely proposed prenatal programming mechanisms, yet few studies exist that measure fetal cortisol via neonatal hair. Neonatal hair provides a window into the fetal experience and represents cortisol accumulation in the third trimester of pregnancy. In the current study, we test the links between two types of anxiety over the course of gestation (pregnancy-related anxiety and general anxiety) with neonatal hair cortisol. METHOD: Pregnant individuals (N = 107) and their neonates (59...
April 6, 2024: Psychoneuroendocrinology
#6
RANDOMIZED CONTROLLED TRIAL
HaiXia Ding, Honghong Zhang, Rui Qiao, Ningxia Sun, Yixuan Ji, Wenjuan Pang, Wen Li, Qing Zhang
STUDY OBJECTIVE: To evaluate the efficacy and pregnancy outcomes of intrauterine balloon and intrauterine contraceptive devices in the prevention of adhesion reformation following hysteroscopic adhesiolysis in infertile women with moderate to severe intrauterine adhesion. DESIGN: A prospective, randomized, controlled trial study. SETTING: A tertiary university hospital. PATIENTS: A total of 130 patients with moderate (American Fertility Society [AFS] score of 5-8) and severe (AFS score of 9-12) intrauterine adhesions were recruited...
April 23, 2024: Reproductive Biology and Endocrinology: RB&E
#7
REVIEW
Eleni Memi, Polina Pavli, Papagianni Maria, Nikolaos Vrachnis, George Mastorakos
Progesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system, progesterone contributes to the control of luteinizing hormone and follicle-stimulating hormone secretion and their pulsatility, via its receptors on the kisspeptin, neurokinin B, and dynorphin neurons in the hypothalamus. Progesterone together with estradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; regulates normal menstrual bleeding; contributes to fertilization and pregnancy maintenance; participates in the onset of labor...
April 23, 2024: Reviews in Endocrine & Metabolic Disorders
#8
JOURNAL ARTICLE
Anke Tönjes, Marleen Würfel, Marcus Quinkler, Ulrich J Knappe, Jürgen Honegger, Nina Krause-Joppig, Konrad Bacher, Timo Deutschbein, Sylvère Störmann, Jochen Schopohl, Sebastian M Meyhöfer
CONTEXT: Acromegaly is a rare disease caused by excessive growth hormone (GH) secretion, mostly induced by pituitary adenomas. The care of pregnant women with acromegaly is challenging, in part due to existing clinical data being limited and not entirely consistent with regard to potential risks for mother and child. OBJECTIVE: To retrospectively examine data on pregnancy and maternal as well as neonatal outcomes in patients with acromegaly. DESIGN & METHODS: Retrospective data analysis from 47 pregnancies of 31 women treated in centers of the German Acromegaly Registry...
April 22, 2024: Reproductive Biology and Endocrinology: RB&E
#9
JOURNAL ARTICLE
Dan Zhao, Ning Yuan, Jianbin Sun, Xin Zhao, Xiaomei Zhang
INTRODUCTION: This study was aimed at establishing a pregnancy-specific lipid reference interval (RI) in pregnant women in a single-centre in the Beijing area of China, simultaneously exploring the predictive value of lipid levels in early pregnancy for gestational diabetes mellitus (GDM). MATERIAL AND METHODS: From October 2017 to August 2019, Peking University International Hospital established records for 1588 pregnant women, whose lipid profiles were determined during the first and third trimesters...
April 22, 2024: Endokrynologia Polska
#10
Shinnosuke Yanagisawa, Yoichi Oikawa, Mai Endo, Kazuyuki Inoue, Ritsuko Nakajima, Shigemitsu Yasuda, Masayasu Sato, Naoko Iwata, Haruki Fujisawa, Atsushi Suzuki, Yoshihisa Sugimura, Masashi Isshiki, Akira Shimada
BACKGROUND: Gestational diabetes insipidus (DI) is a very rare complication of pregnancy. We present a case of gestational DI combining two different types of DI. Case Presentation . A 39-year-old pregnant woman suddenly presented with thirst, polydipsia, and polyuria after 31 gestation weeks (GWs). Based on laboratory findings of hypotonic urine (78 mOsm/kgH2 O) with higher plasma osmolality (298 mOsm/kgH2 O) and higher serum sodium levels (149 mEq/L), gestational DI was suspected, and the clinical course was monitored without therapy until the results of a measurement of plasma arginine vasopressin (AVP) levels were available...
2024: Case Reports in Endocrinology
#11
REVIEW
Marinela Krizanac, Paola Berenice Mass Sanchez, Ralf Weiskirchen, Sarah K Schröder
The 25 kDa-sized protein Lipocalin 2 (LCN2) was originally isolated from human neutrophil granulocytes more than 30 years ago. LCN2 is an emerging player in innate immune defense, as it reduces bacterial growth due to its ability to sequester iron-containing bacterial siderophores. On the other hand, LCN2 also serves as a transporter for various hydrophobic substances due to its β-barrel shaped structure. Over the years, LCN2 has been detected in many other cell types including epithelial cells, astrocytes, and hepatocytes...
2024: Frontiers in Endocrinology
#12
Fabio Vescini, Giorgio Borretta, Iacopo Chiodini, Marco Boniardi, Marina Carotti, Elena Castellano, Cristiana Cipriani, Cristina Eller-Vainicher, Sandro Giannini, Maurizio Iacobone, Antonio Stefano Salcuni, Federica Saponaro, Stefano Spiezia, Annibale Versari, Guido Zavatta, Zuzana Mitrova, Rosella Saulle, Simona Vecchi, Debora Antonini, Michele Basile, Alexia Giovanazzi, Agostino Paoletta, Enrico Papini, Agnese Persichetti, Irene Samperi, Alessandro Scoppola, Roberto Novizio, Pietro Giorgio Calò, Filomena Cetani, Luisella Cianferotti, Sabrina Corbetta, Maria Luisa De Rimini, Alberto Falchetti, Giovanni Iannetti, Stefano Laureti, Celestino Pio Lombardi, Bruno Madeo, Claudio Marcocci, Sandro Mazzaferro, Vittorio Miele, Salvatore Minisola, Andrea Palermo, Jessica Pepe, Alfredo Scillitani, Laura Tonzar, Franco Grimaldi, Renato Cozzi, Roberto Attanasio
AIM: This guideline (GL) is aimed at providing a clinical practice reference for the management of sporadic primary hyperparathyroidism (PHPT) in adults. PHPT management in pregnancy was not considered. METHODS: This GL has been developed following the methods described in the Manual of the Italian National Guideline System. For each question, the panel appointed by Associazione Medici Endocrinology (AME) and Società Italiana dell'Osteoporosi, del Metabolismo Minerale e delle Malattie dello Scheletro (SIOMMMS) identified potentially relevant outcomes, which were then rated for their impact on therapeutic choices...
December 23, 2023: Endocrine, Metabolic & Immune Disorders Drug Targets
#13
REVIEW
Sree Vaishnavi Nalla, P Jayapradha, Lalruatmawii, K Nandheeswari, Pratik Naxine, G Vigneshwaran, Gaurav Rohilla, Itishree Dubey, Sapana Kushwaha
Germ cells are highly conserved in the gonads, nurtured to either develop into a gamete or self-renew into a stem cell reserve. Preserving the germ cell pool and protecting the reproductive organs is essential for maintaining an individual's fertility. Several factors, including a sedentary lifestyle, pollutants, hormonal disruption, drugs, and a disease condition, have been shown to impair normal reproductive function. Irisin has recently been identified as an adipomyokine involved in modulating physiological functions based on the body's metabolic status...
April 19, 2024: General and Comparative Endocrinology
#14
JOURNAL ARTICLE
Ilaria Stramazzo, Giorgio Mangino, Silvia Capriello, Giovanna Romeo, Silvia Martina Ferrari, Poupak Fallahi, Maria Flavia Bagaglini, Marco Centanni, Camilla Virili
BACKGROUND: CD20+ T cells represent up to 5% of circulating T lymphocytes. These cells have been shown to produce higher levels of IL-17A and IFN-γ than those of CD20- T lymphocytes. Some reports described the role of CD20+ T cells in autoimmune disorders such as multiple sclerosis and rheumatoid arthritis possibly due to their ability to produce these inflammatory cytokines. This study is aimed at describing the behavior of CD20+ T lymphocytes in the most frequent autoimmune disorder, i...
April 20, 2024: Journal of Endocrinological Investigation
#15
JOURNAL ARTICLE
Ann-Marie G de Lange, Esten H Leonardsen, Claudia Barth, Louise S Schindler, Arielle Crestol, Madelene C Holm, Sivaniya Subramaniapillai, Dónal Hill, Dag Alnæs, Lars T Westlye
Recent research shows prominent effects of pregnancy and the parenthood transition on structural brain characteristics in humans. Here, we present a comprehensive study of how parental status and number of children born/fathered links to markers of brain and cellular ageing in 36,323 UK Biobank participants (age range 44.57-82.06 years; 52% female). To assess global effects of parenting on the brain, we trained a 3D convolutional neural network on T1-weighted magnetic resonance images, and estimated brain age in a held-out test set...
April 2, 2024: Psychoneuroendocrinology
#16
REVIEW
Cynthia M Valerio, Raquel Beatriz Gonçalves Muniz, Luiz F Viola, Gabriela Bartzen Pereira, Rodrigo Oliveira Moreira, Marise Ribeiro de Sousa Berriel, Renan Magalhães Montenegro Júnior, Amélio F Godoy-Matos, Lenita Zajdenverg
INTRODUCTION: Lipodystrophies are a group of disorders characterized by selective and variable loss of adipose tissue, which can result in an increased risk of insulin resistance and its associated complications. Women with lipodystrophy often have a high frequency of polycystic ovary syndrome (PCOS) and may experience gynecological and obstetric complications. The objective of this study was to describe the gestational outcomes of patients with familial partial lipodystrophy type 2 (FPLD2) at a reference center with the aim of improving the understanding and management of pregnant women affected by this condition...
2024: Frontiers in Endocrinology
#17
JOURNAL ARTICLE
Xin Yan, Jianrui Jia, Wei Zheng, Xianxian Yuan, Jia Wang, Lirui Zhang, Guanghui Li
OBJECTIVE: To examine the effects of gestational weight gain on pregnancy outcomes and determine the optimal range of weight gain during pregnancy for Chinese women with type 2 diabetes mellitus. METHODS: This retrospective cohort study included 691 Chinese women with type 2 diabetes mellitus from 2012 to 2020. The study utilized a statistical-based approach to determine the optimal range of gestational weight gain. Additionally, multivariate logistic regression analysis was conducted to assess the impact of gestational weight gain on pregnancy outcomes...
2024: Frontiers in Endocrinology
#18
JOURNAL ARTICLE
Qin Xie, Xiaozhen Quan, Yanli Lan, Xuezhou Yang
BACKGROUND: Intra-uterine infusion treatments were reported to be beneficial to embryo implantation and pregnancy outcomes, and considered as potential therapies for infertile patients with recurrent implantation failure (RIF). Nevertheless, their efficiencies were controversial and there lack of consensus on which intrauterine treatment is the most effective. METHODS: All prospective trials (in Chinese or English) were searched in Databases PubMed, Cochrane, Web of Science, and CNKI from July 2013 to July 2023...
April 16, 2024: Reproductive Biology and Endocrinology: RB&E
#19
JOURNAL ARTICLE
Wen Zhao, Zeting Li, Bing Cai, Canquan Zhou, Qingyun Mai
BACKGROUND: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder associated with infertility and pregnancy complications. The pathogenesis of PCOS and its impact on reproductive function may be influenced by the source of androgens, including testosterone, free androgen, dehydroepiandrosterone sulfate (DHEAS). However, the differential effects of these androgen on pregnancy and neonatal outcomes and the cut-off value of East Asian population with PCOS remain unclear. METHODS: A retrospective cohort study was conducted at the Reproductive Medicine Center of the First Affiliated Hospital of Sun Yat-sen University from January 2015 to November 2022, involving 636 cycles of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI)...
April 16, 2024: Reproductive Biology and Endocrinology: RB&E
#20
JOURNAL ARTICLE
Deepali Gupta, Avi W Burstein, Kripa Shankar, Salil Varshney, Omprakash Singh, Sherri Osborne-Lawrence, Corine P Richard, Jeffrey M Zigman
Reducing ghrelin by ghrelin gene knockout (GKO), ghrelin-cell ablation, or high-fat diet feeding increases islet size and β-cell mass in male mice. Here, we determined if reducing ghrelin also enlarges islets in females, and if pregnancy-associated changes in islet size are related to reduced ghrelin. Islet size and β-cell mass were larger (P=0.057 for β-cell mass) in female GKO mice. Pregnancy was associated with reduced ghrelin and increased LEAP2 [a ghrelin receptor (GHSR) antagonist] in WT mice...
April 16, 2024: Endocrinology
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