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JOURNAL ARTICLE
Harry L Hébert, Mathilde M V Pascal, Blair H Smith, David Wynick, David L H Bennett
Chronic pain (CP) is a common and often debilitating disorder that has major social and economic impacts. A subset of patients develop CP that significantly interferes with their activities of daily living and requires a high level of healthcare support. The challenge for treating physicians is in preventing the onset of refractory CP or effectively managing existing pain. To be able to do this, it is necessary to understand the risk factors, both genetic and environmental, for the onset of CP and response to treatment, as well as the pathogenesis of the disorder, which is highly heterogenous...
September 2023: Pain Reports
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JOURNAL ARTICLE
Paris S Salazar-Hamm, William L Johnson, Robert A Nofchissey, Jacqueline R Salazar, Publio Gonzalez, Samuel M Goodfellow, Jonathan L Dunnum, Steven B Bradfute, Blas Armién, Joseph A Cook, Daryl B Domman, Darrell L Dinwiddie
BACKGROUND: Hantaviruses are negative-stranded RNA viruses that can sometimes cause severe disease in humans; however, they are maintained in mammalian host populations without causing harm. In Panama, sigmodontine rodents serve as hosts to transmissible hantaviruses. Due to natural and anthropogenic forces, these rodent populations are having increased contact with humans. METHODS: We extracted RNA and performed Illumina deep metatranscriptomic sequencing on Orthohantavirus seropositive museum tissues from rodents...
January 12, 2024: PLoS Neglected Tropical Diseases
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JOURNAL ARTICLE
Andrea B Troxel, Marie-Abele C Bind, Thomas J Flotte, Carlos Cordon-Cardo, Lauren A Decker, Aloke V Finn, Robert F Padera, R Ross Reichard, James R Stone, Natalie L Adolphi, Faye Victoria C Casimero, John F Crary, Jamie Elifritz, Arline Faustin, Saikat Kumar B Ghosh, Amanda Krausert, Maria Martinez-Lage, Jonathan Melamed, Roger A Mitchell, Barbara A Sampson, Alan C Seifert, Aylin Simsir, Cheryle Adams, Stephanie Haasnoot, Stephanie Hafner, Michelle A Siciliano, Brittany B Vallejos, Phoebe Del Boccio, Michelle F Lamendola-Essel, Chloe E Young, Deepshikha Kewlani, Precious A Akinbo, Brendan Parent, Alicia Chung, Teresa C Cato, Praveen C Mudumbi, Shari Esquenazi-Karonika, Marion J Wood, James Chan, Jonathan Monteiro, Daniel J Shinnick, Tanayott Thaweethai, Amber N Nguyen, Megan L Fitzgerald, Alice A Perlowski, Lauren E Stiles, Moira L Paskett, Stuart D Katz, Andrea S Foulkes
IMPORTANCE: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are poorly understood. The objectives of the Researching COVID to Enhance Recovery (RECOVER) tissue pathology study (RECOVER-Pathology) are to: (1) characterize prevalence and types of organ injury/disease and pathology occurring with PASC; (2) characterize the association of pathologic findings with clinical and other characteristics; (3) define the pathophysiology and mechanisms of PASC, and possible mediation via viral persistence; and (4) establish a post-mortem tissue biobank and post-mortem brain imaging biorepository...
2024: PloS One
#44
JOURNAL ARTICLE
Graham McLennan, Suzanne E Dale, Laura Gillim, Vivian Weinblatt, Robert Wallerstein, Stanley J Naides
Lyme disease in pregnancy is understudied. The few available reports of Borrelia infection during pregnancy collecting clinical outcomes, with or without confirmed fetal infection both in utero and neonatal, are limited to case reports and small series. Population-based studies are not available. We propose a prospective study of Borrelia infection during pregnancy based in obstetrical practices in both endemic and nonendemic areas, with long term follow-up of pregnancy outcomes and development assessment of offspring infected or exposed to Borrelia in utero using current serological, microscopic, culture, and molecular techniques...
2024: Methods in Molecular Biology
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JOURNAL ARTICLE
Stanley J Naides
Availability of relevant biological samples supports both basic science research and patient-centered clinical studies. Establishing a biorepository faces challenges at multiple levels. These tasks include defining mission definition and scope; selection of subjects and sample types; recruitment strategies; timing of collection in the patient's journey; sample logistics and processing; determining what clinical data to collect; ensuring sample integrity on transport, processing, and storage; defining governance structures and oversight responsibilities; clarifying sample provenance and ownership; establishing procedures for sample and data access; selecting testing to be performed routinely versus upon request, and management of results; data security; funding sources; and regulatory compliance...
2024: Methods in Molecular Biology
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JOURNAL ARTICLE
Alexandre How-Kit, Mourad Sahbatou, Lise M Hardy, Nicolas P Tessier, Valérie Schiavon, Hélène Le Buanec, Jean-Marc Sebaoun, Hélène Blanché, Jean-François Zagury, Jean-François Deleuze
The increasing aging of the human population is currently and for the coming decades a major public health issue in many countries, requiring the implementation of global public health policies promoting healthy and successful aging. Individuals are not equal in the face of aging and some can present exceptional healthspan and/or lifespan, which are notably influenced by both genetic and environmental factors. Research and studies on human aging, healthy aging and longevity should rely in particular on cohorts of long-lived individuals, also including biological samples allowing studies on the biology of aging and longevity...
December 23, 2023: GeroScience
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JOURNAL ARTICLE
Harvey D Blackburn, Emmanuel Lozada-Soto, Samuel R Paiva
National animal gene banks have acquired substantial quantities of germplasm that protect and preserve a wide range of livestock breeds. New challenges and growth opportunities are emerging. A key challenge will be increased gene bank use, but this requires increased characterization of phenotypes and genotypes for populations and collections.
December 22, 2023: Trends in Genetics: TIG
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JOURNAL ARTICLE
Anja Schweikert, Sarah Kenny, Irene Oglesby, Arlene Glasgow, Chiara de Santi, Ingrid Gensch, Nico Lachmann, Tifenn Desroziers, Camille Fletcher, Deborah Snijders, Nadia Nathan, Killian Hurley
BACKGROUND: Interstitial lung diseases (ILD) are a group of rare lung diseases with severe outcomes. The COST Innovator Grant aims to establish a first-of-a-kind open-access Biorepository of patient-derived induced pluripotent stem cells (iPSC) and to train researchers in the skills required to generate a robust preclinical model of ILD using these cells. This study aims to describe and evaluate the effectiveness of a training course designed to train researchers in iPSC techniques to model ILD...
December 20, 2023: Stem Cell Research & Therapy
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JOURNAL ARTICLE
Philip L McCarthy, Kristopher M Attwood, Xiaojun Liu, George L Chen, Hans Minderman, Amin Alousi, Asad Bashey, Robert Lowsky, David B Miklos, John Hansen, Peter Westervelt, Gregory Yanik, Edmund K Waller, Alan Howard, Bruce R Blazar, Paul K Wallace, Ran Reshef, Mary M Horowitz, Richard T Maziarz, John E Levine, Hemn Mohammadpour
Identifying plasma biomarkers early after allo-HCT may become crucial to prevent and treat severe aGvHD. We utilized samples from 203 allo-HCT patients selected from the Blood & Marrow Transplant Clinical Trials Network (BMT CTN) to identify new biomarker models to predict aGvHD and overall mortality. Two new biomarkers (Gal-3 and LAG-3), and previously identified biomarkers (ST2/IL33R, IL6, Reg3A, PD-1, TIM-3, TNFR1) were screened. Increased Gal-3 levels measured at Day +7 post-transplant predicted the development of aGvHD (grade 2-4) in the total population [AUC: 0...
December 18, 2023: Bone Marrow Transplantation
#50
JOURNAL ARTICLE
Meng Zhang, Madhuri Sankaranarayanapillai, Jingcheng Du, Yang Xiang, Frank J Manion, Marcelline R Harris, Cooper Stansbury, Huy Anh Pham, Cui Tao
BACKGROUND: With more clinical trials are offering optional participation in the collection of bio-specimens for biobanking comes the increasing complexity of requirements of informed consent forms. The aim of this study is to develop an automatic natural language processing (NLP) tool to annotate informed consent documents to promote biorepository data regulation, sharing, and decision support. We collected informed consent documents from several publicly available sources, then manually annotated them, covering sentences containing permission information about the sharing of either bio-specimens or donor data, or conducting genetic research or future research using bio-specimens or donor data...
December 15, 2023: BMC Bioinformatics
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JOURNAL ARTICLE
Aditya Vikram Pachisia, Alka Kumari, Shubham Mehta, Anam Ahmed, Ashish Chauhan, Ankit Agarwal, Vignesh Dwarkanathan, Sachin Rajpoot, Shubham Prasad, Sanjay Kumar, Saroj Kant Sinha, Divya Sharma, Mahender Rajput, Prasenjit Das, Sushil Falodia, Rakesh Kochhar, B S Ramakrishna, Vineet Ahuja, Govind Makharia
BACKGROUND AND AIM: While European Society of Pediatric Gastroenterology Hepatology and Nutrition advocates a no-biopsy pathway for the diagnosis of celiac disease (CeD) in children if IgA anti-tissue transglutaminase antibody (anti-tTG ab) titer is ≥10-fold upper limit of normal (ULN) and have a positive IgA anti-endomysial antibody (EMA); the data for anti-tTG Ab titer-based diagnosis of CeD in adults is still emerging. We planned to validate if IgA anti-tTG Ab titer ≥10-fold predicts villous abnormalities of modified Marsh grade ≥2 in Asian adult patients with CeD...
December 14, 2023: Journal of Gastroenterology and Hepatology
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JOURNAL ARTICLE
Michael Sciaudone, Renzo Carpena, Maritza Calderón, Patricia Sheen, Mirko Zimic, Jorge Coronel, Robert H Gilman, Natalie M Bowman
Tuberculosis remains one of the leading causes of death worldwide, especially in low- and middle-income countries. Tuberculosis treatment and control efforts are hindered by the difficulty in making the diagnosis, as currently available diagnostic tests are too slow, too expensive, or not sufficiently sensitive. Recombinase polymerase amplification (RPA) is a novel technique that allows for the amplification of DNA rapidly, at constant temperature, and with minimal expense. We calculated and compared the limit of detection, sensitivity, and specificity of two RPA-based assays for the diagnosis of pulmonary tuberculosis, using two sets of published primers...
2023: PloS One
#53
REVIEW
Francesca Farlie, Giles A Palmer, Jacques Cohen, Charles Calcagni, Anna Gorbunova, James Lawford Davies, Carol Loscher, Roisin O'Raghallaigh, Timothy Sharp, Daniela Smale, Pernilla Sörme, Cassandra L Thiel, Alessandra Alteri, Alison Campbell, Kirsty Crompton, Sharon Mortimer, Valerio Pisaturo, Annelies Tolpe, Mina Alikani
The healthcare industry is a major contributor to greenhouse gas emissions. Assisted reproductive technology is part of the larger healthcare sector, with its own heavy carbon footprint. The social, economic and environmental costs of this collective carbon footprint are becoming clearer, as is the impact on human reproductive health. Alpha Scientists in Reproductive Medicine and the International IVF Initiative collaborated to seek and formulate practical recommendations for sustainability in IVF laboratories...
January 2024: Reproductive Biomedicine Online
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JOURNAL ARTICLE
Pranav Gopalakrishnan, Ahmad Faryami, Carolyn A Harris
INTRODUCTION: The mechanisms of catheter obstruction are still poorly understood, but the literature suggests that resistance to fluid flow plays a significant role. We developed and assessed a gravity-driven device that measures flow through ventricular catheters. We used this device to quantitatively analyze the resistances of unused ventricular catheters used in the treatment of hydrocephalus; failed hydrocephalus catheters from our catheter biorepository were also evaluated quantitatively...
2023: PloS One
#55
JOURNAL ARTICLE
Jadesola Temitope Olayinka, Akanksha Nagarkar, Diana Junyue Ma, Neil B Wong, Andrew Romasco, Cesar Piedra-Mora, Linda Wrijil, Clement N David, Heather L Gardner, Nicholas A Robinson, Kelly L Hughes, Bruce Barton, Cheryl A London, Ramón M Almela, Jillian M Richmond
Cutaneous T-cell lymphoma (CTCL) is an uncommon type of lymphoma involving malignant skin-resident or skin-homing T cells. Canine epitheliotropic lymphoma (EL) is the most common form of CTCL in dogs, and it also spontaneously arises from T lymphocytes in the mucosa and skin. Clinically, it can be difficult to distinguish early-stage CTCLs apart from other forms of benign interface dermatitis (ID) in both dogs and people. Our objective was to identify novel biomarkers that can distinguish EL from other forms of ID, and perform comparative transcriptomics of human CTCL and canine EL...
2023: Frontiers in Veterinary Science
#56
JOURNAL ARTICLE
Zongqi Guo, Nikolas Zuchowicz, Jessica Bouwmeester, Amey S Joshi, Amanda L Neisch, Kieran Smith, Jonathan Daly, Michael L Etheridge, Erik B Finger, Suhasa B Kodandaramaiah, Thomas S Hays, Mary Hagedorn, John C Bischof
Vitrification-based cryopreservation is a promising approach to achieving long-term storage of biological systems for maintaining biodiversity, healthcare, and sustainable food production. Using the "cryomesh" system achieves rapid cooling and rewarming of biomaterials, but further improvement in cooling rates is needed to increase biosystem viability and the ability to cryopreserve new biosystems. Improved cooling rates and viability are possible by enabling conductive cooling through cryomesh. Conduction-dominated cryomesh improves cooling rates from twofold to tenfold (i...
November 28, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
#57
JOURNAL ARTICLE
S Robert Levine, Martin G Myers, Ryan Barunas, Dolly S Chang, Sanjoy Dutta, Ted Maddess, Jeffrey M Liebmann, Steve Sherman, Melvina Eydelman, Jennifer K Sun, Wiley Chambers, Kerstin Wickström, Ulrich F O Luhmann, Martin Pallinat, Adam Glassman, Lloyd Paul Aiello, Dorene S Markel, Thomas W Gardner
The Mary Tyler Moore Vision Initiative Diabetic Retinal Disease (DRD) Clinical Endpoints Workshop was held on October 22, 2022 to accelerate progress toward establishment of useful clinical and research endpoints and development of new therapeutics that have important relevance across the full spectrum of DRD pathology. More than 90 patient representatives, clinicians, scientists, funding and regulatory agencies, diagnostic, therapeutic and biotech industry representatives discussed the needs for new diagnostic and therapeutic approaches to prevent and restore retinal neurovascular unit integrity...
November 1, 2023: Translational Vision Science & Technology
#58
JOURNAL ARTICLE
Maryam Rafati, Derek Brown, Weiyin Zhou, Kristine M Jones, Wen Luo, Andrew St Martin, Youjin Wang, Meilun He, Stephen R Spellman, Tao Wang, H Joachim Deeg, Vikas Gupta, Stephanie J Lee, Yung-Tsi Bolon, Stephen J Chanock, Mitchell J Machiela, Wael Saber, Shahinaz M Gadalla
JAK2V617F is the most common driver mutation in primary or secondary myelofibrosis in which allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment. Knowledge of the prognostic utility of JAK2 alterations in the HCT setting is limited. We identified all patients with MF who received HCT between 2000 and 2016 and had a pre-HCT blood sample (N=973) available at the Center of International Blood and Marrow Transplant Research biorepository. PacBio sequencing and SNP-array genotyping were used to identify JAK2V617F mutation and associated mosaic chromosomal alterations (mCAs), respectively...
October 27, 2023: Blood Advances
#59
JOURNAL ARTICLE
Charlton Bassett, Hunter Triplett, Keegan Lott, Katherine M Howard, Karl Kingsley
This study sought to evaluate the expression of previously identified microRNAs known to regulate neuronal differentiation in mesenchymal stem cells (MSCs), including miR-27, miR-125, miR-128, miR-135, miR-140, miR-145, miR-218 and miR-410, among dental pulp stem cells (DPSCs) under conditions demonstrated to induce neuronal differentiation. Using an approved protocol, n = 12 DPSCs were identified from an existing biorepository and treated with basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF), which were previously demonstrated to induce neural differentiation markers including Sox1, Pax6 and NFM among these DPSCs...
November 9, 2023: Biomedicines
#60
JOURNAL ARTICLE
Stephen H Boyle, Julie Upchurch, Elizabeth J Gifford, Thomas S Redding, Elizabeth R Hauser, Deeksha Malhotra, Ashlyn Press, Kellie J Sims, Christina D Williams
Gulf War illness (GWI) is a chronic multisymptom disorder of unknown etiology that is believed to be caused by neurotoxicant exposure experienced during deployment to the Gulf War. Posttraumatic stress disorder (PTSD) covaries with GWI and is believed to play a role in GWI symptoms. The present study examined the association between self-reported military exposures and GWI, stratified by PTSD status, in veterans from the Gulf War Era Cohort and Biorepository who were deployed to the Persian Gulf during the war...
November 23, 2023: Journal of Traumatic Stress
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