keyword
https://read.qxmd.com/read/38525823/primary-ntrk-rearranged-spindle-cell-neoplasm-of-the-gastrointestinal-tract-a-clinicopathological-and-molecular-analysis-of-8-cases
#1
JOURNAL ARTICLE
Xiaojiao Gao, Song Xu, Peipei Zhu, I Weng Lao, Lin Yu, Jian Wang
NTRK-rearranged spindle cell neoplasm occurs predominantly in the superficial or deep soft tissues of extremities or trunk. Occurrence in the visceral organs is extremely rare. Herein, we describe 8 cases of NTRK-rearranged spindle cell neoplasm that arose primarily in the gastrointestinal tract. Patients included 5 males and 3 females with age at presentation ranging from 6 to 63 years (median: 29.5 years). Tumors occurred in the colon (n=3), small intestine (n=2), rectum (n=2), and stomach (n=1). Tumor size ranged from 3...
March 25, 2024: American Journal of Surgical Pathology
https://read.qxmd.com/read/38524654/giant-retroperitoneal-myolipoma-mimicking-liposarcoma-report-of-a-resected-case-and-review-of-the-literature
#2
JOURNAL ARTICLE
Kosuke Mori, Takamichi Igarashi, Akira Noguchi, Miki Ito, Yasuhiro Nagaoka, Chitaru Takeshita, Naoya Takeda, Toru Watanabe, Isaku Yoshioka, Kenichi Hirabayashi, Tsutomu Fujii
Myolipomas are rare tumors that are often difficult to differentiate from liposarcoma. Herein, we report a case of resected giant myolipoma preoperatively diagnosed as liposarcoma. A 63-year-old woman was suspected of having a large retroperitoneal liposarcoma on October 202X. The patient was referred to our department for tumor resection and a histological diagnosis. After consultation with the urology, obstetric and gynecology, and vascular surgery departments, tumor resection was planned, including the potential resection of other organs...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38522885/multimodal-management-of-foregut-neuroendocrine-neoplasms
#3
REVIEW
Yichan Zhou, James Weiquan Li, Noriya Uedo
The foregut, which includes the esophagus, stomach and duodenum, represents one of the most common sites for neuroendocrine neoplasms. These are highly heterogenous with different risk of progression depending on location, cell-type of origin, size, grade and other factors. Various endoscopic and imaging modalities exist to inform therapeutic decision-making, which may be in the form of surgical or endoscopic resection and medical therapy depending on the extent of the disease after diagnostic evaluation. This narrative review aims to explore the literature on the multimodal management of such foregut neuroendocrine neoplasms...
February 2024: Best Practice & Research. Clinical Gastroenterology
https://read.qxmd.com/read/38519729/correction-ubiquitous-mitochondrial-creatine-kinase-promotes-the-progression-of-gastric-cancer-through-a-jnk-mapk-jun-hk2-axis-regulated-glycolysis
#4
Yushuai Mi, Quanhui Li, Bingtian Liu, Dehai Wang, Ziping Liu, Tianshi Wang, Yuan Wang, Yifeng Zang, Yan Zhou, Yugang Wen, Yinlu Ding
No abstract text is available yet for this article.
March 22, 2024: Gastric Cancer
https://read.qxmd.com/read/38519580/deep-learning-on-tertiary-lymphoid-structures-in-hematoxylin-eosin-predicts-cancer-prognosis-and-immunotherapy-response
#5
JOURNAL ARTICLE
Ziqiang Chen, Xiaobing Wang, Zelin Jin, Bosen Li, Dongxian Jiang, Yanqiu Wang, Mengping Jiang, Dandan Zhang, Pei Yuan, Yahui Zhao, Feiyue Feng, Yicheng Lin, Liping Jiang, Chenxi Wang, Weida Meng, Wenjing Ye, Jie Wang, Wenqing Qiu, Houbao Liu, Dan Huang, Yingyong Hou, Xuefei Wang, Yuchen Jiao, Jianming Ying, Zhihua Liu, Yun Liu
Tertiary lymphoid structures (TLSs) have been associated with favorable immunotherapy responses and prognosis in various cancers. Despite their significance, their quantification using multiplex immunohistochemistry (mIHC) staining of T and B lymphocytes remains labor-intensive, limiting its clinical utility. To address this challenge, we curated a dataset from matched mIHC and H&E whole-slide images (WSIs) and developed a deep learning model for automated segmentation of TLSs. The model achieved Dice coefficients of 0...
March 22, 2024: NPJ Precision Oncology
https://read.qxmd.com/read/38514987/clinicopathological-and-endoscopic-features-of-helicobacter-pylori-infection-negative-gastric-cancer-in-japan-a-retrospective-study
#6
JOURNAL ARTICLE
Kentaro Imamura, Kenshi Yao, Satoshi Nimura, Takao Kanemitsu, Masaki Miyaoka, Yoichiro Ono, Toshiharu Ueki, Hiroshi Tanabe
BACKGROUND/AIMS: Helicobacter pylori infection-negative gastric cancer (HPNGC) has not been systematically investigated in consecutive patients. Hence, this study aimed to investigate the clinicopathological and endoscopic features of HPNGC. METHODS: This single-center retrospective study selected participants from patients with gastric cancer who were treated at the Fukuoka University Chikushi Hospital between January 2013 and December 2021. Only patients diagnosed with HPNGC were enrolled, and their clinicopathological and endoscopic features were analyzed in detail...
March 22, 2024: Clinical Endoscopy
https://read.qxmd.com/read/38512553/correction-resistance-to-fgfr1-targeted-therapy-leads-to-autophagy-via-tak1-ampk-activation-in-gastric-cancer
#7
Rui Peng, Yan Chen, Liangnian Wei, Gang Li, Dongju Feng, Siru Liu, Runqiu Jiang, Shaojiang Zheng, Yun Chen
No abstract text is available yet for this article.
March 21, 2024: Gastric Cancer
https://read.qxmd.com/read/38511014/gastric-schwannoma-two-unusual-cases-with-usual-presentation-and-review-of-literature
#8
Monika Pohekar, Jakiyuddin Rampurwala, Sabireen, Rajesh S Shinde
Schwannomas, also known as neurilemmomas, are characteristically benign, slow growing neoplasms originating from Schwann cell sheath. Gastrointestinal schwannomas are very rare with stomach being the most affected organ representing approximately 0.2% of all gastric tumours. Malignant transformation is rarely reported in these tumors and complete surgical resection with negative margins is the recommended treatment. Herein, we report our experience of 2 cases of gastric submucosal spindle cell tumour (SMT), which were preoperatively assumed to be as gastrointestinal stromal tumor (GIST), however postoperatively confirmed as schwannoma on immunohistochemical examination...
March 2024: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/38509701/combined-dna-methylation-and-gastric-microbiome-marker-predicts-helicobacter-pylori-negative-gastric-cancer
#9
JOURNAL ARTICLE
Min-Jeong Kim, Han-Na Kim, Jonathan P Jacobs, Hyo-Joon Yang
BACKGROUND/AIMS: While DNA methylation and gastric microbiome are each associated with gastric cancer (GC), their combined role in predicting GC remains unclear. This study investigated the potential of a combined DNA methylation and gastric microbiome signature to predict Helicobacter pylori -negative GC. METHODS: In this case-control study, we conducted quantitative methylation-specific polymerase chain reaction to measure the methylation levels of DKK3 , SFRP1 , EMX1 , NKX6-1 , MIR124-3 , and TWIST1 in the gastric mucosa from 75 H...
March 21, 2024: Gut and Liver
https://read.qxmd.com/read/38508280/efficacy-of-the-traction-method-in-gastric-endoscopic-submucosal-dissection-a-randomized-controlled-trial
#10
JOURNAL ARTICLE
Jun Kinoshita, Mikitaka Iguchi, Takao Maekita, Ke Wan, Toshio Shimokawa, Kazuhiro Fukatsu, Shinya Taki, Fumiaki Kuwashima, Masaki Takao, Masayuki Kitano
BACKGROUND/AIMS: To overcome the technical difficulties associated with gastric ESD, a novel traction device that can alter the direction of traction was developed. Here, we compared the efficacy and safety of conventional ESD with that of traction-assisted gastric ESD. METHODS: Patients with a single gastric epithelial neoplasm were randomized to receive conventional (n=75) or traction-assisted (n=73) gastric ESD. The primary outcome was ESD procedure time. RESULTS: There were no differences between the conventional and traction-assisted groups with respect to treatment results or complications...
March 18, 2024: Gastrointestinal Endoscopy
https://read.qxmd.com/read/38504747/gel-immersion-endoscopic-mucosal-resection-for-early-gastric-neoplasms-a-multicenter-case-series-study
#11
JOURNAL ARTICLE
Hidenori Kimura, Yoichi Yamamoto, Yohei Yabuuchi, Kohei Shigeta, Masao Yoshida, Soichiro Nagao, Akito Noguchi, Yukihiro Morita, Shuhei Shintani, Osamu Inatomi, Hiroyuki Ono, Akira Andoh
Several cases have been reported that suggest the efficacy of gel immersion endoscopic mucosal resection (GI-EMR) for gastric neoplasms. However, no study has evaluated treatment outcomes of GI-EMR for gastric neoplasms. This study aimed to investigate the efficacy and safety of GI-EMR for early gastric neoplasms. Nine patients (17 lesions) undergoing gastric GI-EMR were included, with a median lesion size of 10 mm (interquartile range [IQR] 5-13 mm). All lesions were protruding or flat elevated. The median procedure time was 3 minutes (IQR 2-5) and en bloc resection was achieved in all cases...
March 2024: Endoscopy International Open
https://read.qxmd.com/read/38503223/staging-laparoscopy-with-peritoneal-lavage-to-identify-peritoneal-metastases-and-free-intraperitoneal-cancer-cells-in-the-management-of-locally-advanced-gastric-cancer
#12
JOURNAL ARTICLE
B Huang, V Rampulla, M Ri, M Lindblad, M Nilsson, I Rouvelas, F Klevebro
INTRODUCTION: Gastric cancer often presents in advanced stage with a significant risk for peritoneal dissemination. Staging laparoscopy can be used to detect peritoneal carcinomatosis (PC+) and free cancer cells in peritoneal lavage cytology (CY+). The current study aimed to present the outcomes of staging laparoscopy and the prognosis of PC+ and CY+ in a Swedish high-volume center. MATERIALS AND METHODS: A cohort study including all consecutive patients with locally advanced gastric cancer who underwent staging laparoscopy between February 2008 and October 2022...
March 13, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38503143/viewing-the-immune-checkpoint-vista-landscape-and-outcomes-across-cancers
#13
JOURNAL ARTICLE
D Nishizaki, R Kurzrock, H Miyashita, J J Adashek, S Lee, M Nikanjam, R N Eskander, H Patel, G P Botta, M K Nesline, S Pabla, J M Conroy, P DePietro, J K Sicklick, S Kato
BACKGROUND: Optimizing immune checkpoint inhibitor (ICI) therapy may require identification of co-targetable checkpoint pathways via immune profiling. Herein, we analyzed the transcriptomic expression and clinical correlates of V-domain immunoglobulin suppressor of T-cell activation (VISTA), a promising targetable checkpoint. PATIENTS AND METHODS: RNA sequencing was carried out on 514 tissues reflecting diverse advanced/metastatic cancers. Expression of eight immune checkpoint markers [lymphocyte-activation gene 3 (LAG-3), tumor necrosis factor receptor superfamily 14 (TNFRSF14), programmed cell death protein 1 (PD-1), programmed death-ligand 1 (PD-L1), programmed death-ligand 2 (PD-L2), B- and T-lymphocyte attenuator (BTLA), T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), cytotoxic T-lymphocyte antigen 4 (CTLA-4)], in addition to VISTA, was analyzed, along with clinical outcomes...
March 18, 2024: ESMO Open
https://read.qxmd.com/read/38502275/superior-lymph-node-harvest-by-fluorescent-lymphography-during-minimally-invasive-gastrectomy-for-gastric-cancer-patients-with-high-body-mass-index
#14
JOURNAL ARTICLE
Ki-Yoon Kim, Jawon Hwang, Sung Hyun Park, Minah Cho, Yoo Min Kim, Hyoung-Il Kim, Woo Jin Hyung
BACKGROUND: Fluorescent lymphography (FL) using indocyanine green (ICG) allows for the visualization of all draining lymph nodes (LNs), thereby increasing LN retrieval. However, no studies have assessed the efficacy of FL in high body mass index (BMI) gastric cancer patients, even as LN yield decreases with increasing BMI in gastrectomy. This study aimed to investigate the influence of FL on LN retrieval in high BMI gastric cancer patients. METHODS: Gastric cancer patients who underwent laparoscopic or robotic gastrectomies from 2013 to 2021 were included...
March 19, 2024: Gastric Cancer
https://read.qxmd.com/read/38494821/-a-case-of-conversion-surgery-for-stage-%C3%A2-atp-producing-gastric-cancer-with-distant-metastasis
#15
JOURNAL ARTICLE
Yosuke Egami, Keijiro Sugimura, Shinsuke Katsuyama, Toru Masuzawa, Kiminori Yanagisawa, Mitsuru Kinoshita, Ryo Ikeshima, Go Shinke, Masayuki Hiraki, Yoshiaki Ohmura, Taishi Hata, Yutaka Takeda, Kohei Murata
We report a case in which a patient with advanced gastric cancer with liver metastasis and bulky N showed marked tumor shrinkage with chemotherapy, and underwent conversion surgery. A 77-year-old male. Patient was referred to our department because of advanced gastric cancer. Upper gastrointestinal endoscopy revealed type 2 advanced cancer in the posterior wall of the gastric antrum. Abdominal CT showed thickening of the gastric wall in the same region and bulky lymph node enlargement and para-aortic lymphadenopathy behind the stomach...
March 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38491836/cancer-incidence-among-armenians-in-california
#16
JOURNAL ARTICLE
Ani S Movsisyan Vernon, Jeffrey S Hoch, Laura Fejerman, Theresa H Keegan
INTRODUCTION: California is home to the largest population of Armenians in the United States. The historical categorization of Armenians as 'White' or 'Some Other Race' in population databases has likely masked cancer incidence patterns in this population. This is the first study considering cancer incidence among Armenians in California. METHODS: We used the Armenian Surname List and birthplace information in the California Cancer Registry to identify Armenians with cancer diagnosed during 1988-2019...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38489111/adjuvant-treatment-for-locally-advanced-gastric-cancer-an-asian-perspective
#17
REVIEW
Hyung-Don Kim, Min-Hee Ryu, Yoon-Koo Kang
Standard adjuvant treatment for locally advanced gastric cancer (LAGC) is regionally different. Whereas perioperative chemotherapy is the standard in Western populations, D2 gastrectomy followed by adjuvant chemotherapy has been the standard in East Asia. Recently, the pivotal phase 3 PRODIGY and RESOLVE studies have demonstrated survival benefits of adding neoadjuvant chemotherapy to surgery followed by adjuvant chemotherapy over up-front surgery followed by adjuvant chemotherapy in Asian patients. Based on these results, neoadjuvant chemotherapy is considered one of the viable options for patients with LAGC...
March 15, 2024: Gastric Cancer
https://read.qxmd.com/read/38487833/prediction-of-cancer-incidence-and-mortality-in-korea-2024
#18
JOURNAL ARTICLE
Kyu-Won Jung, Mee Joo Kang, Eun Hye Park, E Hwa Yun, Hye-Jin Kim, Jeong-Eun Kim, Hyun-Joo Kong, Jeong-Soo Im, Hong Gwan Seo
PURPOSE: This study aimed to report the projected cancer incidence and mortality for the year 2024 to estimate Korea's current cancer burden. MATERIALS AND METHODS: Cancer incidence data from 1999 to 2021 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2022 were acquired from Statistics Korea. Cancer incidence and mortality were projected by fitting a linear regression model to observed age-specific cancer rates against their respective years and multiplying the projected age-specific rates by the anticipated age-specific population for 2024...
March 11, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38487832/cancer-statistics-in-korea-incidence-mortality-survival-and-prevalence-in-2021
#19
JOURNAL ARTICLE
Eun Hye Park, Kyu-Won Jung, Nam Ju Park, Mee Joo Kang, E Hwa Yun, Hye-Jin Kim, Jeong-Eun Kim, Hyun-Joo Kong, Jeong-Soo Im, Hong Gwan Seo
PURPOSE: The current study provides national cancer statistics and their secular trends in Korea, including incidence, mortality, survival, and prevalence in 2021. MATERIALS AND METHODS: Incidence, survival, and prevalence rates of cancer were calculated using the Korea National Cancer Incidence Database, from 1999 to 2021, with survival follow-up until December 31, 2022. Deaths from cancer were assessed using causes-of-death data obtained from Statistics Korea...
March 13, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38486303/successful-multidisciplinary-treatment-for-synchronous-advanced-esophageal-and-cecal-cancers-after-total-gastrectomy-with-reconstruction-by-jejunal-interposition
#20
JOURNAL ARTICLE
Yuta Sato, Yoshihiro Tanaka, Kazuo Yamamoto, Takeshi Horaguchi, Masahiro Fukada, Yuki Sengoku, Itaru Yasufuku, Ryuichi Asai, Jesse Yu Tajima, Shigeru Kiyama, Takazumi Kato, Katsutoshi Murase, Nobuhisa Matsuhashi
BACKGROUND: Esophageal squamous cell carcinoma is characterized by field cancerization, wherein multiple cancers occur in the esophagus, head and neck, and stomach. Synchronous esophageal and colorectal cancers are also encountered with a certain frequency. A good prognosis can be expected if the tumors in both locations can be safely and completely removed. For patients with multiple cancers that occur simultaneously with esophageal cancer, it is necessary to perform a staged operation, taking into consideration the associated surgical invasiveness...
March 14, 2024: World Journal of Surgical Oncology
keyword
keyword
105952
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.