Maha Lahouel, Sana Mokni, Mohamed Denguezli
No abstract text is available yet for this article.
September 2020: American Journal of Tropical Medicine and Hygiene
Hanna Câmara da Justa, Fernando Hitomi Matsubara, Elidiana de-Bona, Zelinda Schemczssen Graeff, Nayanne Louise Costacurta Polli, Thiago Lopes de Mari, Marianna Boia-Ferreira, João Carlos Minozzo, Ana Carolina Martins Wille, Andrea Senff-Ribeiro, Luiza Helena Gremski, Silvio Sanches Veiga
Bites evoked by Brown spiders (Loxosceles genus) are associated with skin injuries (cutaneous rash, itching, swelling, erythema and dermonecrosis) and systemic manifestations. Transcriptome analyses of Loxosceles venom glands showed that the venom has a complex composition containing toxins such as phospholipases-D, metalloproteases and hyaluronidases. Here, by screening the RNA from L. intermedia venom glands, we cloned a novel allergen toxin, and named LALLT (LoxoscelesAllergen-Like Toxin). Sequence analysis showed that LALLT is closely related to allergens from other spiders and RNA screening indicated the presence of LALLT orthologues in the venom of other Loxosceles spiders...
August 29, 2020: International Journal of Biological Macromolecules
Ryan C Earwood, Jay Ladde, Philip A Giordano
Latrodectus geometricus, also known as the brown widow or brown button spider, is an unrenowned relative of the American black widow. While brown widow envenomation is generally thought of as mild, it does have the potential to lead to moderate or severe features similar to black widow bites. We report a case of brown widow envenomation that led to a moderate reaction including rash, local pain, pain radiating proximally in the extremity and nausea. Poison control was consulted for aid in spider identification...
July 13, 2020: Curēus
Tuğba Erat, Aysun Yahşi, Cem Çanakçı, Aybike Korkmaz, Ceyda Karahan, Talia İleri, Savaş Serel, Huban Atilla, Nihal Kundakçı, Halil Özdemir, Erdal İnce, Ergin Çiftçi
BACKGROUND: Loxoscelism is caused by the bite of a specific spider type called the Loxosceles genus. In Turkey, most cases are seen after L. rufescens bites. Clinical manifestation of the bites ranges from local cutaneous reaction to severe ulcerative necrosis. Systemic loxoscelism may also occur. CASE: Herein, we report a previously healthy five-year-old male patient who developed a secondary hemophagocytic lymphohistiocytosis after a presumed brown spider bite...
2020: Turkish Journal of Pediatrics
M P Ramirez-Cruz, S C Smolinske, B J Warrick, W F Rayburn, S A Seifert
Envenomations during pregnancy have consequences affecting both maternal and fetal outcomes. U.S. poison center data on envenomations offers a comparative view of envenomations in pregnant and non-pregnant women. The National Poison Data System of the American Association of Poison Control Centers was searched for cases of envenomation during pregnancy between January 1, 2009 and December 31, 2018 and compared with exposures to non-pregnant females of childbearing age. Odds ratios and descriptive statistics were used where appropriate...
August 6, 2020: Toxicon: Official Journal of the International Society on Toxinology
John W Downs, Kevin T Gould, Ryan C Mclaughlin, Kirk L Cumpston, S Rutherfoord Rose
INTRODUCTION: Loxosceles reclusa (LR), commonly known as the brown recluse spider, is endemic to the south central United States. We present a case of LR envenomation in a healthy adult male outside the usual geographic range, with atypical dermatologic and delayed, prolonged systemic loxoscelism (LX). This case demonstrates the importance of expanding the depth of knowledge of LR envenomations. CASE REPORT: A previously healthy 27 year-old male presented to an emergency department (ED) in central Virginia two hours after a LR envenomation to his left proximal arm...
August 6, 2020: Clinical Toxicology
Yasmeen J Bhat, Saniya Akhtar, Muzaffar Ahmad, Iffat Hassan, Rohi Wani
Background: Acute generalized exanthematous pustulosis (AGEP) is a type of severe cutaneous adverse reaction that is characterized by the rapid development of nonfollicular, sterile pustules on an erythematous base. Objectives: The aim of our study was to enroll all cases of AGEP reporting to our department over a period of one year and to find out the clinical and etiological profile of the patients. Materials and Methods: All the patients reporting to our department with clinical features suggestive of AGEP were enrolled for the study...
May 2020: Indian Dermatology Online Journal
Christos Gogos, Vasileios Sachpekidis, Foteini Davora, Georgios Bompotis
No abstract text is available yet for this article.
June 2020: European Heart Journal. Case Reports
Ali Hameed Ali, Mandip Singh Kang, Jaafar Aldahwi, Candice Reyes
We report a patient with antineutrophilic cytoplasmic antibody (ANCA) vasculitis that was preceded by witnessed black widow spider bites. The patient initially presented with a diffuse painful skin rash that developed after a few hours post bite. He was treated initially with topical ointment for the suspected bite. However, subsequently a few days later the patient returned to the hospital with similar, but more progressive rash with haemoptysis and acute hypoxic respiratory failure requiring supplemental oxygen...
June 17, 2020: BMJ Case Reports
Leonard J Hoenig
Spiders have long been admired for the beauty of their webs. They are celebrated in popular culture as well as in medical eponyms. This contribution provides the historical background for three spider-related eponyms: nevus araneus (spider angioma), arachnodactyly, and the arachnoid mater. Nevus araneus was first named and described by Sir Erasmus Wilson in 1842. Arachnodactyly was described in 1896 by Antoine Marfan using the term pattes d'araignée, which means spider legs. In 1902, Emile Charles Achard proposed the term arachnodactyly for this clinical finding...
March 2020: Clinics in Dermatology
A Piscopo, F Massari, P Scicchitano, M Sanasi, M De Palo, P Caldarola, M Liccese, G Calculli
The black widow spider (BWS) is a venomous spider whose bite can cause various clinical conditions that range from local damage to serious systemic complications, including death. Cases of myocarditis following a BWS bite are rare but they can be fatal on occasion. However, the prognostic significance of the bite and presentation of myocarditis is unknown. Our case involved a 50-year-old man who presented with myocarditis after being bitten by a BWS and subsequently admitted to the intensive care unit for cardiac monitoring...
May 27, 2020: Cardiology and Therapy
Daniel R Merrill, Brit Long
Spider bites are a common emergency department complaint, accounting for ~21% of noncanine bites, injuries, and stings. Military service members, more so than most civilian personnel, are exposed to conditions that place them at increased risk for envenomation, stings, and bites. We present the case of an active duty service member working in a relatively austere environment who presented to a level 1 trauma center with a lesion consistent with a bite from a brown recluse spider, or Loxosceles reclusa.
May 27, 2020: Military Medicine
Sabrina Karim-Silva, Alessandra Becker-Finco, Isabella Gizzi Jiacomini, Fanny Boursin, Arnaud Leroy, Magali Noiray, Juliana de Moura, Nicolas Aubrey, Philippe Billiald, Larissa M Alvarenga
Envenoming due to Loxosceles spider bites still remains a neglected disease of particular medical concern in the Americas. To date, there is no consensus for the treatment of envenomed patients, yet horse polyclonal antivenoms are usually infused to patients with identified severe medical conditions. It is widely known that venom proteins in the 30-35 kDa range with sphingomyelinase D (SMasesD) activity, reproduce most of the toxic effects observed in loxoscelism. Hence, we believe that monoclonal antibody fragments targeting such toxins might pose an alternative safe and effective treatment...
April 16, 2020: Toxins
Giuseppe Di Paola, Marco Cirronis, Giulia Scaravaggi, Luigi Castorani, Valeria M Petrolini, Carlo A Locatelli
INTRODUCTION: Latrodectism is a rare, but potentially severe, clinical syndrome caused by spider of the genus Latrodectus. L. tredecimguttatus is widespread in Italy and its bite cause the injection of α-latrotoxin that cause depletion of acetylcholine at motor nerve endings and release of catecholamines at adrenergic nerve endings. We describe the first clinical case of L. tredecimguttatus poisoning successfully treated with L. mactans antivenom from North America. CASE REPORT: A healthy 60-year-old patient was admitted to the emergency department after unknown insect sting or arachnid/snake bite...
March 13, 2020: Toxicon: Official Journal of the International Society on Toxinology
M Gitterle
Pathogenic biofilms are considered a potential major obstacle to healing chronic wounds. The six-month evaluation period in this study assessed the effect of a single treatment of the HYBENX® (HYB) Root Canal Cleanser on chronic wounds, especially its ease of use, safety, potential for shortening duration of Inflammatory Phase, and promotion of granulation. HYB gel was applied to the wound bed and periwound skin for 10 seconds. Gel was removed by cotton gauze pads and low-pressure saline rinsing. Standard wound dressings based on wound etiology, location, and exudate characteristics were applied...
January 2020: Journal of Biological Regulators and Homeostatic Agents
M Osché, L Gusdorf, B Cribier, J-N Scrivener
BACKGROUND: Acute localized exanthematous pustulosis (ALEP) is a rare variant of acute generalized exanthematous pustulosis and is also defined by diagnostic criteria established by the EuroSCAR study group. Some twenty cases of ALEP have been described in the literature. PATIENTS AND METHODS: A 61-year-old woman suddenly developed erythematous and edematous lesions after subcutaneous heparin calcium injections in the thighs, with bullous detachment at the center of the lesions and multiple vesicles and non-follicular pustules on the edges...
February 3, 2020: Annales de Dermatologie et de Vénéréologie
Dwin Grashof, Christina N Zdenek, James S Dobson, Nicholas J Youngman, Francisco Coimbra, Melisa Benard-Valle, Alejandro Alagon, Bryan G Fry
Envenomations are complex medical emergencies that can have a range of symptoms and sequelae. The only specific, scientifically-validated treatment for envenomation is antivenom administration, which is designed to alleviate venom effects. A paucity of efficacy testing exists for numerous antivenoms worldwide, and understanding venom effects and venom potency can help identify antivenom improvement options. Some spider venoms can produce debilitating injuries or even death, yet have been largely neglected in venom and antivenom studies because of the low venom yields...
January 30, 2020: Toxins
Zhili Deng, Yaling Wang, Wei Shi, Lei Zhou, San Xu, Ji Li, Yiya Zhang
The Haplopelma hainanum is a species of theraphosid spider from China. Its large size and charming appearance make this species a popular pet. According to a previous study, theraphosid spider bites can induce pain, erythema, and edema in humans and can present more severely in domestic animals. The pathological consequences of envenomation by H. hainanum remain unclear. In this study, we investigated the effects and mechanisms of H. hainanum envenomation in mice. We showed that the venom induced slight swelling, intense inflammatory response, and increased the microvascular density in mice skin...
2020: PeerJ
Alexander Zink, Alexandra Zink, Michael Gebhardt, Reinhard Engst, Johannes Ring
No abstract text is available yet for this article.
January 14, 2020: Acta Dermato-venereologica
Werdah Iqbal
A 13-year-old cat was presented to a clinic in Texas with an open draining lesion and severe swelling of the left foreleg. Initial diagnosis was a brown recluse spider bite and treatment was undertaken accordingly. A few weeks later, the cat was returned to the clinic with further swelling of the left foreleg. A diagnosis of a high-grade soft tissue sarcoma with an increased risk of metastasis was made based on a histopathology report. The cat was euthanized following the diagnosis as the cat had a fair to poor prognosis...
January 2020: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
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