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JOURNAL ARTICLE
Ke Yu, Chi Xu, Feng Wang, Hua Wang
Breast cancer is a prevalent ailment among women, and the inflammatory response plays a crucial role in the management and prediction of breast cancer (BRCA). However, the new subtypes based on inflammation in BRCA research are still undefined. The databases including The Cancer Genome Atlas and gene expression omnibus were utilized to gather clinical data and somatic mutation information for approximately 1069 BRCA patients. Through Consensus Clustering, novel subtypes linked to inflammation were identified...
May 10, 2024: Medicine (Baltimore)
#2
JOURNAL ARTICLE
Shaho Ghahremani Dehbokri, Saeed Noorolyai, Elham Baghbani, Nilofar Moghaddamneshat, Tohid Javaheri, Behzad Baradaran
BACKGROUND: Breast cancer (BC) is one of the most common cancers in the world. Despite the many advances that have been made in treating patients, many patients are still resistant to treatment. CD44 is one of the surface glycoproteins of BC cells that plays an important role in the proliferation of these cells and inhibition of their apoptosis. Therefore, targeting it can be a treatment way for BC patients. METHODS: In this study, the effect of anti-CD44 siRNA on the proliferation, apoptosis, and migration rate of MDA-MB-231 and 4T1 cells was investigated...
May 10, 2024: Molecular Biology Reports
#3
JOURNAL ARTICLE
Pablo Graván, Sara Rojas, Darina Francesca Picchi, Francisco Galisteo-González, Patricia Horcajada, Juan Antonio Marchal
The recent description of well-defined molecular subtypes of breast cancer has led to the clinical development of a number of successful molecular targets. Particularly, triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with historically poor outcomes, mainly due to the lack of effective targeted therapies. Recent progresses in materials science have demonstrated the impressive properties of metal-organic framework nanoparticles (NPs) as antitumoral drug delivery systems. Here, in a way to achieve efficient bio-interfaces with cancer cells and improve their internalization, benchmarked MIL-100(Fe) NPs were coated with cell membranes (CMs) derived from the human TNBC cell line MDA-MB-468...
April 30, 2024: Nanomaterials
#4
JOURNAL ARTICLE
Joe Anthony H Manzano, Elian Angelo Abellanosa, Jose Paolo Aguilar, Simone Brogi, Chia-Hung Yen, Allan Patrick G Macabeo, Nicanor Austriaco
Bisindole alkaloids are a source of inspiration for the design and discovery of new-generation anticancer agents. In this study, we investigated the cytotoxic and antiproliferative activities of three spirobisindole alkaloids from the traditional anticancer Philippine medicinal plant Voacanga globosa , along with their mechanisms of action. Thus, the alkaloids globospiramine ( 1 ), deoxyvobtusine ( 2 ), and vobtusine lactone ( 3 ) showed in vitro cytotoxicity and antiproliferative activities against the tested cell lines (L929, KB3...
April 30, 2024: Cells
#5
JOURNAL ARTICLE
Shubham Rastogi, Mohd Nazam Ansari, Abdulaziz S Saeedan, Sachin Yadav, Dinesh Kumar, Sunil Kumar Singh, Alok Mukerjee, Manjari Singh, Gaurav Kaithwas
Inhibition of prolylhydroxylase-2 (PHD-2) in both normoxic and hypoxic cells is a critical component of solid tumours. The present study aimed to identify small molecules with PHD-2 activation potential. Virtually screening 4342 chemical compounds for structural similarity to R59949 and docking with PHD-2. To find the best drug candidate, hits were assessed for drug likeliness, antihypoxic and antineoplastic potential. The selected drug candidate's PHD-2 activation, cytotoxic and apoptotic potentials were assessed using 2-oxoglutarate, MTT, AO/EtBr and JC-1 staining...
May 2024: Chemical Biology & Drug Design
#6
REVIEW
Rishabh, Manni Rohilla, Seema Bansal, Nitin Bansal, Samrat Chauhan, Sheenam Sharma, Navjyoti Goyal, Sumeet Gupta
In females, Alzheimer's disease (AD) incidences increases as compared to males due to estrogen deficiency after menopause. Estrogen therapy is the mainstay therapy for menopause and associated complications. Estrogen, a hormone with multifaceted physiological functions, has been implicated in AD pathophysiology. Estrogen plays a crucial role in amyloid precursor protein (APP) processing and overall neuronal health by regulating various factors such as brain-derived neurotrophic factor (BDNF), intracellular calcium signalling, death domain-associated protein (Daxx) translocation, glutamatergic excitotoxicity, Voltage-Dependent Anion Channel, Insulin-Like Growth Factor 1 Receptor, estrogen-metabolising enzymes and apolipoprotein E (ApoE) protein polymorphisms...
May 10, 2024: European Journal of Neuroscience
#7
JOURNAL ARTICLE
Mehmet Ali Yucel, Ercan Adal, Mine Buga Aktekin, Ceylan Hepokur, Nicola Gambacorta, Orazio Nicolotti, Oztekin Algul
Vascular endothelial growth factor receptor 2 (VEGFR-2) stands as a prominent therapeutic target in oncology, playing a critical role in angiogenesis, tumor growth, and metastasis. FDA-approved VEGFR-2 inhibitors are associated with diverse side effects. Thus, finding novel and more effective inhibitors is of utmost importance. In this study, a deep learning (DL) classification model was first developed and then employed to select putative active VEGFR-2 inhibitors from an in-house chemical library including 187 druglike compounds...
May 10, 2024: ChemMedChem
#8
REVIEW
Ji Li, Shuangqing Lu, Feihu Chen, Hui Zhu
BACKGROUND: Extracellular vesicles (EVs) are small, transparent vesicles that can be found in various biological fluids and are derived from the amplification of cell membranes. Recent studies have increasingly demonstrated that EVs play a crucial regulatory role in tumorigenesis and development, including the progression of metastatic tumors in distant organs. Brain metastases (BMs) are highly prevalent in patients with lung cancer, breast cancer, and melanoma, and patients often experience serious complications and are often associated with a poor prognosis...
2024: Frontiers in Immunology
#9
JOURNAL ARTICLE
Yilun Li, Xiaolu Yang, Cuizhi Geng, Yunjiang Liu, Tiantian Tang, Lina Zhang, Fei Liu, Meng Zhang, Jun Hao, Li Ma
OBJECTIVE: The aim of this study was to identify the molecular subtypes of breast cancer based on chromatin regulator-related genes. METHODS: The RNA sequencing data of The Cancer Genome Atlas-Breast Cancer cohort were obtained from the official website, while the single-cell data were downloaded from the Gene Expression Omnibus database (GSE176078). Validation was performed using the Molecular Taxonomy of Breast Cancer International Consortium dataset. Furthermore, the immune characteristics, tumor stemness, heterogeneity, and clinical characteristics of these molecular subtypes were analyzed...
2024: Frontiers in Immunology
#10
JOURNAL ARTICLE
Changzhi Huang, Jiayi Lu, Jing Yang, Zhenling Wang, Dong Hang, Zan Fu
PURPOSE: Cystatin C (CysC), beyond its biomarker role of renal function, has been implicated in various physical and pathological activities. However, the impact of serum CysC on cancer mortality in a general population remains unknown. We aimed to examine the associations of serum CysC concentrations with total mortality and mortality of 12 site-specific cancers. METHODS: We included 241,008 participants of the UK Biobank cohort with CysC measurements who had normal creatinine-based estimated glomerular filtration rates and were free of cancer and renal diseases at baseline (2006-2010)...
2024: Frontiers in Molecular Biosciences
#11
JOURNAL ARTICLE
Min Zheng, Wenjing Liu, Rou Zhang, Dewei Jiang, Yujie Shi, Yingying Wu, Fei Ge, Ceshi Chen
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer. Breast cancer stem cells (BCSCs) are believed to play a crucial role in the carcinogenesis, therapy resistance, and metastasis of TNBC. It is well known that inflammation promotes stemness. Several studies have identified breast cancer-associated gene 2 (BCA2) as a potential risk factor for breast cancer incidence and prognosis. However, whether and how BCA2 promotes BCSCs has not been elucidated. Here, we demonstrated that BCA2 specifically promotes lipopolysaccharide (LPS)-induced BCSCs through LPS induced SOX9 expression...
2024: International Journal of Biological Sciences
#12
JOURNAL ARTICLE
Honglei Hu, Shuting Zheng, Chenxi He, Yinfei Zheng, Qiming Wei, Siwen Chen, Zede Wu, Yikai Xu, Bingxia Zhao, Chenggong Yan
Radiotherapy-induced immune activation holds great promise for optimizing cancer treatment efficacy. Here, we describe a clinically used radiosensitizer hafnium oxide (HfO2 ) that was core coated with a MnO2 shell followed by a glucose oxidase (GOx) doping nanoplatform (HfO2 @MnO2 @GOx, HMG) to trigger ferroptosis adjuvant effects by glutathione depletion and reactive oxygen species production. This ferroptosis cascade potentiation further sensitized radiotherapy by enhancing DNA damage in 4T1 breast cancer tumor cells...
May 9, 2024: Journal of Nanobiotechnology
#13
REVIEW
Deepika Soni, Zubina Anjum, Khalid Raza, Saurabh Verma
Breast cancer is the most frequently diagnosed disease causing most deaths in women worldwide. Chemotherapy and neo-adjuvant therapy are the standard method of treatment in early stages of breast cancer. However drug resistance in breast cancer limit the use of these methods for treatment. Research focus is now shifted towards identifying natural phytochemicals with lower toxicity. This review illustrates the NF κB interaction with different signaling pathways in normal condition, breast cancer and other cancer and thus represent a potential target for treatment...
May 9, 2024: Cell Biochemistry and Biophysics
#14
JOURNAL ARTICLE
S Taylor Head, Felipe Dezem, Andrei Todor, Jingjing Yang, Jasmine Plummer, Simon Gayther, Siddhartha Kar, Joellen Schildkraut, Michael P Epstein
Transcriptome-wide association studies (TWASs) have investigated the role of genetically regulated transcriptional activity in the etiologies of breast and ovarian cancer. However, methods performed to date have focused on the regulatory effects of risk-associated SNPs thought to act in cis on a nearby target gene. With growing evidence for distal (trans) regulatory effects of variants on gene expression, we performed TWASs of breast and ovarian cancer using a Bayesian genome-wide TWAS method (BGW-TWAS) that considers effects of both cis- and trans-expression quantitative trait loci (eQTLs)...
May 2, 2024: American Journal of Human Genetics
#15
REVIEW
Precious Barnes, Abraham Mensah, Leonard Derkyi-Kwarteng, Ernest Adankwa, Elvis Agbo, Ewura Seidu Yahaya, Benjamin Amoani, George Adjei, Samuel Mingyigilougu Apewe Ka-Chungu, Patrick Kafui Akakpo, Faustina Pappoe, Kwabena Dankwa, Daniel Amoako-Sakyi, Samuel Victor Nuvor, Dorcas Obiri-Yeboah, Roland Osei Saahene
Breast cancer is the most prevalent cancer among African women, with high mortality rates in Ghana. Nuclear factor kappa B (NF-kB) has been associated with tumor progression in breast cancer. However, its clinical validation is controversial and understudied with no known published data on NF-kB (p65) among breast cancer patients in Ghana and other African countries. This study assessed the prognostic significance of NF-kB(p65) expression and its association with various clinicopathological features in breast cancer patients...
May 9, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
#16
JOURNAL ARTICLE
Zishan Zang, Yifei Yin, Chunlan Liu, Qiang Zhu, Xuandong Huang, Hong Li, Rongxi Yang
Some benign and malignant breast tumours are similar in pathological morphology, which are difficult to be distinguished in clinical diagnosis. In this study, we intended to explore novel biomarkers for differential diagnosis of benign and malignant breast tumours. Methylation EPIC 850K beadchip and RNA-sequencing were used to analyse 29 tissue samples from patients with early-stage breast cancer (BC) and benign breast tumours for differently methylated and expressed genes. The altered methylation of IL21R was semi-quantitatively validated in an independent study with 566 tissue samples (279 BC vs...
December 2024: Epigenetics: Official Journal of the DNA Methylation Society
#17
MULTICENTER STUDY
Javier Retamales, Adrián Daneri-Navarro, Nora Artagaveytia, Daniela Alves da Quinta, Eliana Abdelhay, Osvaldo L Podhajcer, Carlos Velázquez, Diego Giunta, Susanne Crocamo, Adriana Garibay-Escobar, Alicia Del Toro-Arreola, Robinson Rodriguez, Marta Aghazarian, Elsa Alcoba, Isabel Alonso, Renata Binato, Alicia I Bravo, Juan Canton-Romero, Dirce M Carraro, Mónica Castro, Juan Castro-Cervantes, Sandra Cataldi, Natalia Camejo, Laura Cortes-Sanabria, Maria Flores-Marquez, Guillermo Laviña, Eduardo Musetti, Benedicta Caserta, Mauricio Cerda, Alicia Colombo, Raul Delgadillo-Cristerna, Marisa Dreyer Breitenbach, Elmer Fernandez, Jorge Fernandez, Ramon Franco-Topete, Carolina Gabay, Fancy Gaete, Jorge Gamboa, Ricardo García-Gaeta, Mariana Gomez Del Toro, Leivy P Gonzalez-Ramirez, Marisol Guerrero, Manuel Herrera-Miramontes, Alejandra Lopez-Vasquez, Silvina Maldonado, Andrés Morán-Mendoza, Gilberto Morgan-Villela, Maria Aparecida Nagai, Nancy Navarro-Ruiz, Antonio Oceguera-Villanueva, Miguel Angel Ortiz, Jael Quintero, Antonio Quintero-Ramos, Gladys Ramirez-Rosales, Maritza Ramos-Ramirez, Marcia Maria Chiquitelli Marques, Ernesto Rivera Claisse, Diego Rodriguez-Gonzalez, Ana Romero-Gomez, Cristina Rosales, Efraín Salas-Gonzalez, Verónica Sanchotena, Laura Segovia, Aída A Silva-García, Olivia Valenzuela-Antelo, Laura Venegas-Godinez, Livia Zagame, Jorge Gomez, Andrea S Llera, Bettina Müller
PURPOSE: Breast cancer mortality rates in Latin America (LA) are higher than those in the United States, possibly because of advanced disease presentation, health care disparities, or unfavorable molecular subtypes. The Latin American Cancer Research Network was established to address these challenges and to promote collaborative clinical research. The Molecular Profiling of Breast Cancer Study (MPBCS) aimed to evaluate the clinical characteristics and treatment outcomes of LA participants with locally advanced breast cancer (LABC)...
May 2024: JCO global oncology
#18
JOURNAL ARTICLE
Cheng-Chiao Huang, Chia-Ming Hsu, Min-Wu Chao, Kai-Cheng Hsu, Tony Eight Lin, Shih-Chung Yen, Huang-Ju Tu, Shiow-Lin Pan
Dysregulation of RNA splicing processes is intricately linked to tumorigenesis in various cancers, especially breast cancer. Cdc2-like kinase 2 (CLK2), an oncogenic RNA-splicing kinase pivotal in breast cancer, plays a significant role, particularly in the context of triple-negative breast cancer (TNBC), a subtype marked by substantial medical challenges due to its low survival rates. In this study, we employed a structure-based virtual screening (SBVS) method to identify potential CLK2 inhibitors with novel chemical structures for treating TNBC...
June 2024: Protein Science
#19
JOURNAL ARTICLE
Jincong Q Freeman, James L Li, Susan G Fisher, Katharine A Yao, Sean P David, Dezheng Huo
IMPORTANCE: Declining treatment negatively affects health outcomes among patients with cancer. Limited research has investigated national trends of and factors associated with treatment declination or its association with overall survival (OS) among patients with breast cancer. OBJECTIVES: To examine trends and racial and ethnic disparities in treatment declination and racial and ethnic OS differences stratified by treatment decision in US patients with breast cancer...
May 1, 2024: JAMA Network Open
#20
JOURNAL ARTICLE
Sahar Khorsand-Dehkordi, Abbas Doosti
This study investigates the role of genes related to breast cancer in apoptosis control. A melittin nucleic acid sequence was synthesized and introduced into a pcDNA3.1(+) Mammalian Expression Plasmid. The cloning accuracy was assessed using PCR testing and enzyme digestion techniques. The vectors were transfected into cells using LipofectamineTM2000. The transfection efficacy of MCF-7 and 4T1 cells was evaluated using fluorescence and bright-field imaging. Pure melittin produced from bee venom had a notable hemolytic impact, with lower hemolytic activity levels than the positive control, Triton X-100...
May 9, 2024: Biochemical Genetics
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