Parmida Ranji, Emma Jonasson, Lisa Andersson, Stefan Filges, Manuel Luna Santamaría, Christoffer Vannas, Soheila Dolatabadi, Anna Gustafsson, Ola Myklebost, Joakim Håkansson, Henrik Fagman, Göran Landberg, Pierre Åman, Anders Ståhlberg
BACKGROUND: Myxoid liposarcoma (MLS) displays a distinctive tumor microenvironment and is characterized by the FUS::DDIT3 fusion oncogene, however, the precise functional contributions of these two elements remain enigmatic in tumor development. METHODS: To study the cell-free microenvironment in MLS, we developed an experimental model system based on decellularized patient-derived xenograft tumors. We characterized the cell-free scaffold using mass spectrometry...
April 26, 2024: Journal of Translational Medicine