Jessica Paola Bahena-Lopez, Laura Vergara, Valeria De la Peña, Miguel A Gutiérrez-Gallardo, Paulina López-Ibargüen, Janeth Alejandra García, Héctor Carbajal-Contreras, Norma Vázquez, Ruth Rincón-Heredia, Felipe Masso, Norma A Bobadilla, María Castañeda-Bueno, David H Ellison, Gerardo Gamba, María Chávez-Canales
KS-WNK1 is an isoform of WNK1 kinase that is predominantly found in the distal convoluted tubule of the kidney. The precise physiological function of KS-WNK1 remains unclear. Some studies suggest that it could play a role in regulating potassium renal excretion by modulating the activity of the Na+ -Cl- cotransporter (NCC). However, changes in the potassium diet from normal to high failed to reveal a role for KS-WNK1, but under a normal potassium diet, the expression of KS-WNK1 is negligible. It is only detectable when mice are exposed to a low potassium diet...
January 25, 2024: American Journal of Physiology. Renal Physiology